Resting state functional connectivity between two major language nodes
Left picture displays two major language network nodes: Inferior frontal gyrus node (IFG), and middle temporal gyrus node (MTG) and possible paths connecting them (simplified); Bottom right picture shows hemodynamic fluctuations within each node. These fluctuations are very synchronous in healthy individuals; Top right picture shows hemodynamic fluctuations within each node in patients with primary progressive aphasia (PPA). Contrary to healthy individuals, these fluctuations are not as synchronous.
Resting state functional connectivity between two major language nodes
Left picture displays two major language network nodes: Inferior frontal gyrus node (IFG), and middle temporal gyrus node (MTG) and possible paths connecting them (simplified); Bottom right picture shows hemodynamic fluctuations within each node. These fluctuations are very synchronous in healthy individuals; Top right picture shows hemodynamic fluctuations within each node in patients with primary progressive aphasia (PPA). Contrary to healthy individuals, these fluctuations are not as synchronous.
Resting state functional connectivity maps
Maps (in yellow and orange) display connectivity between inferior frontal gyrus (IFG) and the rest of the language network within the left brain hemisphere. The left picture depicts the map in a group of healthy individuals. The right picture depicts the map in a group of individuals with primary progressive aphasia (PPA).
Resting state functional connectivity maps
Maps (in yellow and orange) display connectivity between inferior frontal gyrus (IFG) and the rest of the language network within the left brain hemisphere. The left picture depicts the map in a group of healthy individuals. The right picture depicts the map in a group of individuals with primary progressive aphasia (PPA).

Based at Cognitive Neurology and Alzheimer Disease Center, our laboratory uses multimodal neuroimaging, especially functional magnetic resonance imaging (fMRI), to study the underlying neural mechanisms of language impairment (aphasia) and impairment in other areas of cognition. Currently the major focus of the lab is Primary Progressive Aphasia (PPA). Our long term goal is to understand the pathophysiology of PPA and to use that information to develop and evaluate effective treatments for aphasia.

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Borna Bonakdarpour, MD

Borna Bonakdarpour, MD
Assistant Professor of Neurology (Behavioral Neurology)

Borna Bonakdarpour Laboratory

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