Our laboratory is utilizing state-of-the-art intravital imaging techniques, including multi-photon and spinning disc microscopy, as well as multiple animal models of intestinal inflammation and disease, supplemented by in-vitro biochemical and molecular approaches to study leukocyte (neutrophil, monocyte/macrophage) trafficking in mucosal tissues. We are particularly interested in exploring the roles of innate immune cells in regulating intestinal homeostasis, wound healing, host pathogen interactions and cancer development.
Sumagin R, Prizant H, Lomakina E, Waugh RE, Sarelius IH LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ. J Immunol 2010 Dec 1;185(11):7057-66 PMID: 21037096, PMCID: PMC3004223
Hyun YM, Sumagin R, Sarangi PP, Lomakina E, Overstreet MG, Baker CM, Fowell DJ, Waugh RE, Sarelius IH, Kim M Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels. J Exp Med 2012 Jul 2;209(7):1349-62 PMID: 22711877, PMCID: PMC3405502
Sumagin R, Brazil JC, Nava P, Nishio H, Alam A, Luissint AC, Weber DA, Neish AS, Nusrat A, Parkos CA Neutrophil interactions with epithelial-expressed ICAM-1 enhances intestinal mucosal wound healing. Mucosal Immunol 2016 Jan 6; PMID: 26732677