Our laboratory is utilizing state-of-the-art intravital imaging techniques, including multi-photon and spinning disc microscopy, as well as multiple animal models of intestinal inflammation and disease, supplemented by in-vitro biochemical and molecular approaches to study leukocyte (neutrophil, monocyte/macrophage) trafficking in mucosal tissues. We are particularly interested in exploring the roles of innate immune cells in regulating intestinal homeostasis, wound healing, host pathogen interactions and cancer development.
Slater TW, Finkielsztein A, Mascarenhas LA, Mehl LC, Butin-Israeli V, Sumagin R Neutrophil Microparticles Deliver Active Myeloperoxidase to Injured Mucosa To Inhibit Epithelial Wound Healing. J Immunol 2017 Apr 1;198(7):2886-2897 PMID: 28242649, PMCID: PMC5360559
Butin-Israeli V, Houser MC, Feng M, Thorp EB, Nusrat A, Parkos CA, Sumagin R Deposition of microparticles by neutrophils onto inflamed epithelium: a new mechanism to disrupt epithelial intercellular adhesions and promote transepithelial migration. FASEB J 2016 Dec;30(12):4007-4020 PMID: 27553226, PMCID: PMC5102120
Sumagin R, Brazil JC, Nava P, Nishio H, Alam A, Luissint AC, Weber DA, Neish AS, Nusrat A, Parkos CA Neutrophil interactions with epithelial-expressed ICAM-1 enhances intestinal mucosal wound healing. Mucosal Immunol 2016 Jan 6; PMID: 26732677