Northwestern University Feinberg School of Medicine

Karen Ridge Lab

Publications

Learn more about the work that we do in the Karin Ridge Laboratory through our recent publications.

Lung interstitial macrophages: Establishing identity and uncovering heterogeneity
Koch CM, Chiu SF, Misharin AV, Ridge KM
Am J Respir Cell Mol Biol. 2017 Jul;57(1):7-9. doi: 10.1165/rcmb.2017-0150ED
PMID: 28665216

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span
Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H
J Exp Med. 2017 Jul 10. pii: jem.20162152. doi: 10.1084/jem.20162152
PMID: 28694385 

SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis
Jablonski RP, Kim SJ, Cheresh P, Williams DB, Morales-Nebreda L, Cheng Y, Yeldandi A, Bhorade S, Pardo A, Selman M, Ridge K, Gius D, Budinger GR, Kamp DW
FASEB Journal. 2017 Jun; 31(6): 2520-2532. doi:http://dx.doi.org/10.1096/fj.201601077R.
PMID: 28258190 PMCID: 28258190 ISSN: 0892-6638

FXYD5 is an essential mediator of the inflammatory response during lung injury
Brazee PL, Soni PN, Tokhtaeva E, Magnani N, Yemelyanov A, Perlman HR, Ridge KM, Sznajder JI, Vagin O, Dada LA
Frontiers in Immunology. 2017 Jun; 8(JUN): doi:http://dx.doi.org/10.3389/fimmu.2017.00623.
PMID: 28620381 PMCID: 28620381

The role of NOD-like receptors in pulmonary infection
Wiese KM, Coates BM, Ridge KM
Am J Respir Cell Mol Biol. 2017 Feb 3. doi: 10.1165/rcmb.2016-0375TR. 
PMID: 28157451

Acute lung injury, repair, and remodeling: Pulmonary endothelial and epithelial biology
Zhao, Yutong; Ridge, Karen; Zhao, Jing
Mediators of Inflammation. 2017 Jan;2017:doi:http://dx.doi.org/10.1155/2017/9081521.
PMID: 28392632 PMCID: 28392632 ISSN: 0962-9351

Mitochondrial catalase overexpressed transgenic mice are protected against lung fibrosis in part via preventing alveolar epithelial cell mitochondrial DNA damage
Kim Seok Jo, Cheresh Paul, Jablonski Renea P., Morales-Nebreda Luisa, Cheng Yuan, Hogan Erin, Yeldandi Anjana, Chi Monica, Piseaux Raul, Ridge Karen, Michael Hart C., Chandel Navdeep, Scott Budinger G. R., Kamp David W.
Free Radical Biology and Medicine. 2016 Dec;101:9.doi:http://dx.doi.org/10.1016/j.freeradbiomed.2016.11.007.
PMID: 27840320 ISSN: 0891-5849

The O-glycosylated ectodomain of FXYD5 impairs adhesion by disrupting cell-cell trans-dimerization of Na,K-ATPase β1 subunits
Elmira Tokhtaeva, Haying Sun, Nimrod Deiss-Yehiely, Yi Wen, Pritin N. Soni, Nieves M. Gabrielli, Elizabeth A. Marcus, Karen M. Ridge, George Sachs, Mónica Vazquez-Levin, Jacob I. Sznajder, Olga Vagin, Laura A. Dada.
Journal of Cell Science. 2016 129: 2394-2406; doi: 10.1242/jcs.186148.

Flow cytometry reveals similarities between lung macrophages in humans and mice
Bharat Ankit, Bhorade Sangeeta M., Morales-Nebreda Luisa, McQuattie-Pimentel Alexandra C., Soberanes Saul, Ridge Karen, DeCamp Malcolm M., Mestan Karen K., Perlman Harris, Budinger G. R Scott, Misharin Alexander V.
American Journal of Respiratory Cell and Molecular Biology. 2016 Jan;54(1):3.
ISSN: 1044-1549

Methods for determining the cellular functions of vimentin intermediate filaments
Ridge Karen M., Shumaker Dale, Robert Amélie, Hookway Caroline, Gelfand Vladimir I., Janmey Paul A., Lowery Jason, Guo Ming, Weitz David A., Kuczmarski Edward, Goldman Robert D.
2016 Jan;38.doi:http://dx.doi.org/10.1016/bs.mie.2015.09.036.

Influenza a virus infection, innate immunity, and childhood
Coates Bria M., Staricha Kelly L., Wiese Kristin M., Ridge Karen M.
JAMA Pediatrics. 2015 Oct;169(10):8.doi:http://dx.doi.org/10.1001/jamapediatrics.2015.1387.
ISSN: 2168-6203

Corrigendum: [The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation (Nat. Immunol.) (2015) 16:458''466]
Zhang Qiao, Kuang Hong, Chen Cong, Yan Jie, Do-Umehara Hanh Chi, Liu Xin Yuan, Dada Laura, Ridge Karen M., Chandel Navdeep S., Liu Jing.
Nature Immunology. 2015 Jul 20;16(7):1.doi:http://dx.doi.org/10.1038/ni0715-785b.
ISSN: 1529-2908

The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation
Zhang Qiao, Kuang Hong, Chen Cong, Yan Jie, Do-Umehara Hanh Chi, Liu Xin Yuan, Dada Laura, Ridge Karen M., Chandel Navdeep S., Liu Jing.
Nature Immunology. 2015 May 28;16(5):9.doi:http://dx.doi.org/10.1038/ni.3130.
PMID: 25799126 PMCID: 25799126 ISSN: 1529-2908

Influenza virus-induced lung injury: Pathogenesis and implications for treatment
Herold Susanne, Becker Christin, Ridge Karen M., Budinger G. R Scott.
European Respiratory Journal. 2015 May;45(5):16.doi:http://dx.doi.org/10.1183/09031936.00186214.
ISSN: 0903-1936

Lung-specific loss of a3 laminin worsens bleomycin-induced pulmonary fibrosis
Morales-Nebreda Luisa I., Rogel Micah R., Eisenberg Jessica L., Hamill Kevin J., Soberanes Saul, Nigdelioglu Recep, Chi Monica, Cho Takugo, Radigan Kathryn A., Ridge Karen M., Misharin Alexander V., Woychek Alex, Hopkinson Susan, Perlman Harris, Mutlu Gokhan M., Pardo Annie, Selman Moises, Jones Jonathan C R, Scott Budinger G. R.
American Journal of Respiratory Cell and Molecular Biology. 2015 Apr;52(4):10.doi:http://dx.doi.org/10.1165/rcmb.2014-0057OC.
ISSN: 1044-1549

Vimentin regulates activation of the NLRP3 inflammasome
Dos Santos Gimena, Rogel Micah R., Baker Margaret A., Troken James R., Urich Daniela, Morales-Nebreda Luisa, Sennello Joseph A., Kutuzov Mikhail A., Sitikov Albert, Davis Jennifer M., Lam Anna P., Cheresh Paul, Kamp David, Shumaker Dale K., Budinger G. R Scott, Ridge Karen M.
Nature Communications. 2015 Mar 12;6:doi:http://dx.doi.org/10.1038/ncomms7574.

Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice
Cheresh Paul, Morales-Nebreda Luisa, Kim Seok Jo, Yeldandi Anjana, Williams David B., Cheng Yuan, Mutlu Gökhan M., Scott Budinger G. R., Ridge Karen, Schumacker Paul T., Bohr Vilhelm A., Kamp David W.
American Journal of Respiratory Cell and Molecular Biology. 2015 Jan;52(1):12.doi:http://dx.doi.org/10.1165/rcmb.2014-0038OC.
ISSN: 1044-1549

Intratracheal administration of influenza virus is superior to intranasal administration as a model of acute lung injury
Morales-Nebreda Luisa, Chi Monica, Lecuona Emilia, Chandel Navdeep S., Dada Laura A., Ridge Karen, Soberanes Saul, Nigdelioglu Recep, Sznajder Jacob I., Mutlu Gökhan M., Budinger G. R Scott, Radigan Kathryn A.
Journal of Virological Methods. 2014 Dec;209:5.doi:http://dx.doi.org/10.1016/j.jviromet.2014.09.004.
PMID: 25239366 PMCID: 25239366 ISSN: 0166-0934

Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling
Weisel Friederike Christine, Kloepping Christina, Pichl Alexandra, Sydykov Akylbek, Kojonazarov Baktybek, Wilhelm Jochen, Roth Markus, Ridge Karen Marie, Igarashi Kazuei, Nishimura Kazuhiro, Maison Wolfgang, Wackendorff Claudia, Klepetko Walter, Jaksch Peter, Ghofrani Hossein Ardeschir, Grimminger Friedrich, Seeger Werner, Schermuly Ralph Theo, Weissmann Norbert, Kwapiszewska Grazyna.
Circulation. 2014 Apr 8;129(14):14.doi:http://dx.doi.org/10.1161/CIRCULATIONAHA.113.006402.
PMID: 24470481 ISSN: 0009-7322

Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells
Kim Seok Jo, Cheresh Paul, Williams David, Cheng Yuan, Ridge Karen, Schumacker Paul T., Weitzman Sigmund, Bohr Vilhelm A., Kamp David W.
Journal of Biological Chemistry. 2014 Feb 28;289(9):12.doi:http://dx.doi.org/10.1074/jbc.M113.515130.
PMID: 24429287 PMCID: 24429287 ISSN: 0021-9258

Structure and biomechanics of the endothelial transcellular circumferential invasion array in tumor invasion
Arvanitis Constadina, Khuon Satya, Spann Rachel, Ridge Karen M., Chew Teng Leong.
PLoS One. 2014 Feb 24;9(2):doi:http://dx.doi.org/10.1371/journal.pone.0089758.
PMID: 24587014 PMCID: 24587014

The role of Vimentin intermediate filaments in the progression of lung cancer
Kidd Martha E., Shumaker Dale K., Ridge Karen M.
American Journal of Respiratory Cell and Molecular Biology. 2014 Jan;50(1):6.doi:http://dx.doi.org/10.1165/rcmb.2013-0314TR.
PMID: 23980547 PMCID: 23980547 ISSN: 1044-1549

Asbestos-induced alveolar epithelial cell apoptosis: The role of endoplasmic reticulum stress response
Kamp David W., Liu Gang, Cheresh Paul, Kim Seok Jo, Mueller Amanda, Lam Anna P., Trejo Humberto, Williams David, Tulasiram Sandhya, Baker Margaret, Ridge Karen, Chandel Navdeep S., Beri Rohinee.
American Journal of Respiratory Cell and Molecular Biology. 2013 Dec;49(6):10.doi:http://dx.doi.org/10.1165/rcmb.2013-0053OC.
PMID: 23885834 PMCID: 23885834 ISSN: 1044-1549

Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-d
Do-Umehara Hanh Chi, Chen Cong, Urich Daniela, Zhou Liang, Qiu Ju, Jang Samuel, Zander Alia, Baker Margaret A., Eilers Martin, Sporn Peter H S, Ridge Karen M., Sznajder Jacob I., Budinger G. R Scott, Mutlu Gökhan M., Lin Anning, Liu Jing.
Nature Immunology. 2013 May;14(5):9.doi:http://dx.doi.org/10.1038/ni.2566.
PMID: 23525087 PMCID: 23525087 ISSN: 1529-2908

The inflammasome in lung diseases
dos Santos Gimena, Kutuzov Mikhail A., Ridge Karen M.
American Journal of Physiology - Lung Cellular and Molecular Physiology. 2012 Jan;303(8):doi:http://dx.doi.org/10.1152/ajplung.00225.2012.
PMID: 22904168 PMCID: 22904168 ISSN: 1040-0605

Particulate matter air pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway
Soberanes Saul, Gonzalez Angel, Urich Daniela, Chiarella Sergio E., Radigan Kathryn A., Osornio-Vargas Alvaro, Joseph Joy, Kalyanaraman Balaraman, Ridge Karen M., Chandel Navdeep S., Mutlu Gökhan M., De Vizcaya-Ruiz Andrea, Budinger G. R Scott.
Scientific Reports. 2012 Jan;2:doi:http://dx.doi.org/10.1038/srep00275.
PMID: 22355787 PMCID: 22355787

Vimentin is sufficient and required for wound repair and remodeling in alveolar epithelial cells
Rogel Micah R., Soni Pritin N., Troken James R., Sitikov Albert, Trejo Humberto E., Ridge Karen M.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2011 Nov;25(11):11.doi:http://dx.doi.org/10.1096/fj.10-170795.
PMID: 21803859 PMCID: 21803859 ISSN: 0892-663