Investigating mechanisms driving repair and recovery from viral pneumonia.

The Ridge Lab

Regulatory T cells fluorescently labeled for vimentin

Our research focuses on mechanisms that drive repair and recovery from viral pneumonia. We aim to identify the molecular signaling that modulates the transition from the initial phases of acute lung injury to the later phases of resolution and repair. We are particularly interested in the role played by the intermediate filament protein vimentin in activation of inflammasome, cGAS-STING, and other signaling pathways in macrophages and regulatory T cells (Tregs).

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Lab Leadership

Karen M. Ridge, PhD
Ernest S. Bazley Professor of Pulmonary Sciences
Professor of Medicine (Pulmonary and Critical Care) and Cell & Developmental Biology

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A headshot of Dr. Ridge
Mse Lng wih Inflenza

Mouse Lung with Influenza

Influenza A virus nucleoprotein (green) in influenza-infected mouse lung

Alvelar epihelial cells

Alveolar epithelial cells

Type 1 (T1-alpha, red) and 2 (pro-SP-C, green) alveolar epithelial cells in a mouse lung

 

Vimenin and NLRP3

Vimentin and NLRP3

Proximity ligation assay between vimentin and NLRP3 in mouse macrophage

Mse Lng wih Inflenza

Mouse Lung with Influenza

Influenza A virus NS1 protein (brown) in influenza-infected mouse lung

Vimenin in Reglary T Cells

Vimentin in Regulatory T Cells

Vimentin intermediate filaments (green) in induced regulatory T cells