Vimentin in Non–Small Cell Lung CancerVimentin (green) and keratin (red) in tumor cell from mouse model of lung adenocarcinomaVimentin in Non–Small Cell Lung CancerVimentin (green) and keratin (red) in tumor cell from mouse model of lung adenocarcinoma
Vimentin in Alveolar Type 2 CellsVimentin (green) and keratin (red) in rat alveolar type 2 cells treated with TGF-betaVimentin in Alveolar Type 2 CellsVimentin (green) and keratin (red) in rat alveolar type 2 cells treated with TGF-beta
Vimentin and NLRP3Proximity ligation assay between vimentin and NLRP3 in mouse macrophageVimentin and NLRP3Proximity ligation assay between vimentin and NLRP3 in mouse macrophage
Vimentin and Cell MigrationScratch assay at 6 hr of tumor cells from wild-type and vimentin knockout miceVimentin and Cell MigrationScratch assay at 6 hr of tumor cells from wild-type and vimentin knockout mice
About Our Lab
We investigate the type 3 intermediate filament protein vimentin and its role in pulmonary health and disease. We focus on the involvement of vimentin in innate immunity, especially Nod-like receptor signaling, and how this may change in the lungs across the lifespan. We also explore how vimentin functions in the resolution of acute lung injury and the development of pulmonary fibrosis, as well as its role in non–small cell lung cancer.
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Collaborators
G.R. Scott Budinger, MD
Chief, Division of Medicine-Pulmonary
Professor in Medicine-Pulmonary and Cell and Molecular Biology
Vladimir I. Gelfand, PhD
Professor in Cell and Molecular Biology
Robert Goldman, PhD
Chair, Department of Cell and Molecular Biology
Professor in Cell and Molecular Biology and Medicine-Pulmonary
Jing Liu, PhD
Assistant Professor in Medicine-Pulmonary
Alexander Misharin, MD, PhD
Research Assistant Professor in Medicine-Pulmonary
Jacob I. Sznajder, MD
Professor in Medicine-Pulmonary and Cell and Molecular Biology
