Northwestern University Feinberg School of Medicine

Peter Lab


Apoptosis is a fundamental process to regulate homeostasis of all tissues and to eliminate unwanted cells specifically in the immune system. Various parts of apoptosis signaling pathways have been characterized. Specifically in apoptosis pathways initiated by members of the death receptor family such as CD95 (APO-1/Fas) proteins that either contain a death domain (DD) or a death effector domain (DED) have been found to be essential. In addition, it has become clear in recent years that death receptors such as CD95 and all of its signaling components have nonapoptotic activities that in the context of cancer can cause tumor promotion and progression. The group of Marcus Peter studies the activities of death receptors and their signaling components in apoptosis and the relevance of their nonapoptotic activities in cancer development. In addition, the Peterlab is interested in the role of microRNAs in various aspects of carcinogenesis.