Northwestern University Feinberg School of Medicine

Ozdinler Lab

About Our Lab

The overall goal of the Ozdinler Lab is to understand the cellular and molecular basis of selective neuronal vulnerability. The lab primarily focuses on the corticospinal motor neurons (CSMN), the neurons that are important for the initiation and modulation of voluntary movement. CSMN degeneration is a key feature in many motor neuron diseases, such as amyotrophic lateral sclerosis (ALS), hereditary spastic paraplegia (HSP), and primary lateral sclerosis (PLS). 

Selected Publications

Pathophysiological and diagnostic implications of cortical dysfunction in ALS. Geevasinga N, Menon P, Ozdinler PH, Kiernan MC, Vucic S. Nat Rev Neurol. 2016 September 23. PMID:27658852

Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms.Gautam M, Jara JH, Sekerkova G, Yasvoina MV, Martina M, Özdinler PH.Hum Mol Genet. 2016 Jan 10. PMID: 26755825

Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex.Jara JH, Stanford MJ, Zhu Y, Tu M, Hauswirth WW, Bohn MC, DeVries SH, Özdinler PH. Gene Ther. 2015 Dec 24. PMID: 26704722

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    P. Hande Ozdinler, PhD

    P. Hande Ozdinler, PhD
    Assistant Professor in Neurology - Ken and Ruth Davee Department

    Related Links

     Les Turner ALS Research and Patient Center