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About Our Lab
The overall goal of the Ozdinler Lab is to understand the cellular and molecular basis of selective neuronal vulnerability. The lab primarily focuses on the corticospinal motor neurons (CSMN), the neurons that are important for the initiation and modulation of voluntary movement. CSMN degeneration is a key feature in many motor neuron diseases, such as amyotrophic lateral sclerosis (ALS), hereditary spastic paraplegia (HSP), and primary lateral sclerosis (PLS).
Pathophysiological and diagnostic implications of cortical dysfunction in ALS. Geevasinga N, Menon P, Ozdinler PH, Kiernan MC, Vucic S. Nat Rev Neurol. 2016 September 23. PMID:27658852
Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms.Gautam M, Jara JH, Sekerkova G, Yasvoina MV, Martina M, Özdinler PH.Hum Mol Genet. 2016 Jan 10. PMID: 26755825
Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex.Jara JH, Stanford MJ, Zhu Y, Tu M, Hauswirth WW, Bohn MC, DeVries SH, Özdinler PH. Gene Ther. 2015 Dec 24. PMID: 26704722View more publications