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About Our Lab
The overall goal of the Ozdinler Lab is to understand the cellular and molecular basis of selective neuronal vulnerability. The lab primarily focuses on the corticospinal motor neurons (CSMN), the neurons that are important for the initiation and modulation of voluntary movement. CSMN degeneration is a key feature in many motor neuron diseases, such as amyotrophic lateral sclerosis (ALS), hereditary spastic paraplegia (HSP), and primary lateral sclerosis (PLS).
Evidence for an early innate immune response in the motor cortex of ALS. Jara JH, Genç B, Stanford MJ, Pytel P, Roos RP, Weintraub S, Mesulam MM, Bigio EH, Miller RJ, Özdinler PH J Neuroinflammation 2017 Jun 26 PMID: 28651542
Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS. Genç B, Jara JH, Lagrimas AK, Pytel P, Roos RP, Mesulam MM, Geula C, Bigio EH, Özdinler PH. Sci Rep. 2017 Feb 06. PMID:28165465
Pathophysiological and diagnostic implications of cortical dysfunction in ALS. Geevasinga N, Menon P, Ozdinler PH, Kiernan MC, Vucic S. Nat Rev Neurol. 2016 September 23. PMID:27658852
Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms.Gautam M, Jara JH, Sekerkova G, Yasvoina MV, Martina M, Özdinler PH.Hum Mol Genet. 2016 Jan 10. PMID: 26755825
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