Northwestern University Feinberg School of Medicine

Melissa Brown Lab

Publications

Learn more about the work that we do in the Melissa Brown Laboratory through our recent publications.

  1. Russi AE, Walker-Caulfield ME, Guo Y, Lucchinetti CF, Brown MA  Meningeal mast cell-T cell crosstalk regulates T cell encephalitogenicity.  J Autoimmun  2016 Sep;73:100-10. doi:10.1016/j.jaut.2016.06.015
  2. Russi AE, Walker-Caulfield ME, Brown MA  Mast cell inflammasome activity in the meninges regulates EAE disease severity.  Clin Immunol  2016 Apr 21;. pii:S1521-6616(16)30068-7
  3. Hatfield JK, Brown MA  Group 3 innate lymphoid cells accumulate and exhibit disease-induced activation in the meninges in EAE.  Cell Immunol  2015 Oct;297(2):69-79. doi:10.1016/j.cellimm.2015.06.006
  4. Russi AE, Walker-Caulfield ME, Ebel ME, Brown MA  Cutting edge: c-Kit signaling differentially regulates type 2 innate lymphoid cell accumulation and susceptibility to central nervous system demyelination in male and female SJL mice.  J Immunol  2015 Jun 15;194(12):5609-13. doi:10.4049/jimmunol.1500068
  5. Walker-Caulfield ME, Hatfield JK, Brown MA  Dynamic changes in meningeal inflammation correspond to clinical exacerbations in a murine model of relapsing-remitting multiple sclerosis.  J Neuroimmunol  2015 Jan 15;278:112-22. doi:10.1016/j.jneuroim.2014.12.009
  6. Russi AE, Brown MA  The meninges: new therapeutic targets for multiple sclerosis.  Transl Res  2015 Feb;165(2):255-69. doi:10.1016/j.trsl.2014.08.005
  7. Wong LY, Hatfield JK, Brown MA  Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development.  J Biol Chem  2013 Dec 06;288(49):35170-9. doi:10.1074/jbc.M113.481440
  8. Rao KN, Smuda C, Gregory GD, Min B, Brown MA  Ikaros limits basophil development by suppressing C/EBP-α expression.  Blood  2013 Oct 10;122(15):2572-81. doi:10.1182/blood-2013-04-494625
  9. Peng H, Katsnelson J, Yang W, Brown MA, Lavker RM  FIH-1/c-kit signaling: a novel contributor to corneal epithelial glycogen metabolism.  Invest Ophthalmol Vis Sci  2013 Apr 17;54(4):2781-6. doi:10.1167/iovs.12-11512
  10. Christy AL, Walker ME, Hessner MJ, Brown MA  Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE.  J Autoimmun  2013 May;42:50-61. doi:10.1016/j.jaut.2012.11.003
  11. Brown MA, Hatfield JK  Mast Cells are Important Modifiers of Autoimmune Disease: With so Much Evidence, Why is There Still Controversy?  Front Immunol  2012;3:147. doi:10.3389/fimmu.2012.00147
  12. Walker ME, Hatfield JK, Brown MA  New insights into the role of mast cells in autoimmunity: evidence for a common mechanism of action?  Biochim Biophys Acta  2012 Jan;1822(1):57-65. doi:10.1016/j.bbadis.2011.02.009
  13. Sayed BA, Walker ME, Brown MA  Cutting edge: mast cells regulate disease severity in a relapsing-remitting model of multiple sclerosis.  J Immunol  2011 Mar 15;186(6):3294-8. doi:10.4049/jimmunol.1003574
  14. Sayed BA, Christy AL, Walker ME, Brown MA  Meningeal mast cells affect early T cell central nervous system infiltration and blood-brain barrier integrity through TNF: a role for neutrophil recruitment?  J Immunol  2010 Jun 15;184(12):6891-900. doi:10.4049/jimmunol.1000126
  15. Quirion MR, Gregory GD, Umetsu SE, Winandy S, Brown MA  Cutting edge: Ikaros is a regulator of Th2 cell differentiation.  J Immunol  2009 Jan 15;182(2):741-5
  16. Rao KN, Brown MA  Mast cells: multifaceted immune cells with diverse roles in health and disease.  Ann N Y Acad Sci  2008 Nov;1143:83-104. doi:10.1196/annals.1443.023
  17. Brown MA, Sayed BA, Christy A  Mast cells and the adaptive immune response.  J Clin Immunol  2008 Nov;28(6):671-6. doi:10.1007/s10875-008-9247-7
  18. Brown MA  IL-4 production by T cells: you need a little to get a lot.  J Immunol  2008 Sep 01;181(5):2941-2
  19. Sayed BA, Christy A, Quirion MR, Brown MA  The master switch: the role of mast cells in autoimmunity and tolerance.  Annu Rev Immunol  2008;26:705-39. doi:10.1146/annurev.immunol.26.021607.090320
  20. Christy AL, Brown MA  The multitasking mast cell: positive and negative roles in the progression of autoimmunity.  J Immunol  2007 Sep 01;179(5):2673-9
  21. Sayed BA, Brown MA  Mast cells as modulators of T-cell responses.  Immunol Rev  2007 Jun;217:53-64
  22. Gregory GD, Raju SS, Winandy S, Brown MA  Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE.  J Clin Invest  2006 May;116(5):1327-36