Northwestern University Feinberg School of Medicine

Melissa Brown Lab


Learn more about the work that we do in the Melissa Brown Laboratory through our recent publications.

  1. Russi AE, Walker-Caulfield ME, Guo Y, Lucchinetti CF, Brown MA  Meningeal mast cell-T cell crosstalk regulates T cell encephalitogenicity.  J Autoimmun  2016 Sep;73:100-10. doi:10.1016/j.jaut.2016.06.015
  2. Russi AE, Walker-Caulfield ME, Brown MA  Mast cell inflammasome activity in the meninges regulates EAE disease severity.  Clin Immunol  2016 Apr 21;. pii:S1521-6616(16)30068-7
  3. Hatfield JK, Brown MA  Group 3 innate lymphoid cells accumulate and exhibit disease-induced activation in the meninges in EAE.  Cell Immunol  2015 Oct;297(2):69-79. doi:10.1016/j.cellimm.2015.06.006
  4. Russi AE, Walker-Caulfield ME, Ebel ME, Brown MA  Cutting edge: c-Kit signaling differentially regulates type 2 innate lymphoid cell accumulation and susceptibility to central nervous system demyelination in male and female SJL mice.  J Immunol  2015 Jun 15;194(12):5609-13. doi:10.4049/jimmunol.1500068
  5. Walker-Caulfield ME, Hatfield JK, Brown MA  Dynamic changes in meningeal inflammation correspond to clinical exacerbations in a murine model of relapsing-remitting multiple sclerosis.  J Neuroimmunol  2015 Jan 15;278:112-22. doi:10.1016/j.jneuroim.2014.12.009
  6. Russi AE, Brown MA  The meninges: new therapeutic targets for multiple sclerosis.  Transl Res  2015 Feb;165(2):255-69. doi:10.1016/j.trsl.2014.08.005
  7. Wong LY, Hatfield JK, Brown MA  Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development.  J Biol Chem  2013 Dec 06;288(49):35170-9. doi:10.1074/jbc.M113.481440
  8. Rao KN, Smuda C, Gregory GD, Min B, Brown MA  Ikaros limits basophil development by suppressing C/EBP-α expression.  Blood  2013 Oct 10;122(15):2572-81. doi:10.1182/blood-2013-04-494625
  9. Peng H, Katsnelson J, Yang W, Brown MA, Lavker RM  FIH-1/c-kit signaling: a novel contributor to corneal epithelial glycogen metabolism.  Invest Ophthalmol Vis Sci  2013 Apr 17;54(4):2781-6. doi:10.1167/iovs.12-11512
  10. Christy AL, Walker ME, Hessner MJ, Brown MA  Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE.  J Autoimmun  2013 May;42:50-61. doi:10.1016/j.jaut.2012.11.003
  11. Brown MA, Hatfield JK  Mast Cells are Important Modifiers of Autoimmune Disease: With so Much Evidence, Why is There Still Controversy?  Front Immunol  2012;3:147. doi:10.3389/fimmu.2012.00147
  12. Walker ME, Hatfield JK, Brown MA  New insights into the role of mast cells in autoimmunity: evidence for a common mechanism of action?  Biochim Biophys Acta  2012 Jan;1822(1):57-65. doi:10.1016/j.bbadis.2011.02.009
  13. Sayed BA, Walker ME, Brown MA  Cutting edge: mast cells regulate disease severity in a relapsing-remitting model of multiple sclerosis.  J Immunol  2011 Mar 15;186(6):3294-8. doi:10.4049/jimmunol.1003574
  14. Sayed BA, Christy AL, Walker ME, Brown MA  Meningeal mast cells affect early T cell central nervous system infiltration and blood-brain barrier integrity through TNF: a role for neutrophil recruitment?  J Immunol  2010 Jun 15;184(12):6891-900. doi:10.4049/jimmunol.1000126
  15. Quirion MR, Gregory GD, Umetsu SE, Winandy S, Brown MA  Cutting edge: Ikaros is a regulator of Th2 cell differentiation.  J Immunol  2009 Jan 15;182(2):741-5
  16. Rao KN, Brown MA  Mast cells: multifaceted immune cells with diverse roles in health and disease.  Ann N Y Acad Sci  2008 Nov;1143:83-104. doi:10.1196/annals.1443.023
  17. Brown MA, Sayed BA, Christy A  Mast cells and the adaptive immune response.  J Clin Immunol  2008 Nov;28(6):671-6. doi:10.1007/s10875-008-9247-7
  18. Brown MA  IL-4 production by T cells: you need a little to get a lot.  J Immunol  2008 Sep 01;181(5):2941-2
  19. Sayed BA, Christy A, Quirion MR, Brown MA  The master switch: the role of mast cells in autoimmunity and tolerance.  Annu Rev Immunol  2008;26:705-39. doi:10.1146/annurev.immunol.26.021607.090320
  20. Christy AL, Brown MA  The multitasking mast cell: positive and negative roles in the progression of autoimmunity.  J Immunol  2007 Sep 01;179(5):2673-9
  21. Sayed BA, Brown MA  Mast cells as modulators of T-cell responses.  Immunol Rev  2007 Jun;217:53-64
  22. Gregory GD, Raju SS, Winandy S, Brown MA  Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE.  J Clin Invest  2006 May;116(5):1327-36