About Our Lab
Our laboratory uses the rodent of model of Multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE) to study how innate immune cells contribute to the inflammatory damage associated with this disease. Our goal is uncover basic immune mechanisms that mediate disease and use this information to develop new and more specific targeted therapies for MS.
Russi AE, Walker-Caulfield ME, Ebel ME, Brown MA
Cutting Edge: c-Kit Signaling Differentially Regulates Type 2 Innate Lymphoid Cell Accumulation and Susceptibility to Central Nervous System Demyelination in Male and Female SJL Mice.
J Immunol PubMed:25972476
Walker-Caulfield ME, Hatfield JK, Brown MA
Dynamic changes in meningeal inflammation correspond to clinical exacerbations in a murine model of relapsing-remitting multiple sclerosis.
J Neuroimmunol PubMed:25595260
Russi AE, Brown MA
The meninges: new therapeutic targets for multiple sclerosis.
Transl Res PubMed:25241937
Christy AL, Walker ME, Hessner MJ, Brown MA
Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE.
J Autoimmun PubMed:23267561