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Northwestern University Feinberg School of Medicine
Youngblood Lab

Publications

Learn more about our work in the Youngblood Lab through our recent publications.

  1. Wang P, Wang J, Wang Q, Youngblood MW, Cheng Y, Tao B, Wong JH, Luan Y, Yu S, Swaroop A  et al.  Spatial chromatin architecture and accessibility co-profiling of mammalian tissues.  Nat Methods  2026 Sep 01;. doi:10.1038/s41592-026-03217-4
  2. Singh R, Koempel A, French B, Crawford C, Perlow HK, Rauh S, Kutuk T, Beyer S, Grecula J, Blakaj D  et al.  Improved Progression-Free Survival Following Dose-Escalated Versus Standard-Dose Postoperative Radiation Therapy for High-Risk Meningiomas: An International Multicenter Individual Patient-Level Meta-Analysis (FIRESTORM).  Int J Radiat Oncol Biol Phys  2026 Jul 01;125(3):696-705. doi:10.1016/j.ijrobp.2026.03.036
  3. Fares J, Ahrendsen JT, Congivaram HT, Santana-Santos L, Oyon D, Dixit K, Youngblood MW, Chandler JP  CLIP2::MET fusion identifies a molecularly distinct glioneuronal tumor.  Discov Oncol  2026 Jun 17;17(1). pii:1251
  4. Aggarwal A, Youngblood MW, Picart T, Najem H, Oten S, Cady MA, Magill ST, Horbinski CM, Chandler JP, Heimberger AB  et al.  Meningioma cell reprogramming and microenvironment interactions underlie brain invasion.  Neuro Oncol  2026 Apr 01;28(4):926-938. doi:10.1093/neuonc/noaf292
  5. Youngblood MW, Tripathi S, Najem H, Congivaram H, Gomez M, Sears TK, Hurley L, Billingham LK, Silvers C, Wang W  et al.  STING activation induces cytotoxic and immune responses in meningiomas via inflammatory cell death pathways.  Nat Commun  2026 Feb 12;17(1). pii:2685
  6. Duckett D, Santana-Santos L, McCord M, Smith V, Lopes MBS, Youngblood MW, Magill ST, Chandler JP, Heimberger AB, Lukas R  et al.  Development, validation, and utility of a clinically applicable methylation classifier for recurrence risk prediction in meningiomas.  Acta Neuropathol Commun  2025 Dec 29;13(1):259. pii:259
  7. Youngblood MW, Kumari A, Kang YT, Gould A, Habashy K, Gomez M, Lingamarla H, Morey T, Chen L, Congivaram H  et al.  Dynamic release of extracellular particles after opening of the blood-brain barrier predicts glioblastoma susceptibility to paclitaxel.  Nat Commun  2025 Dec 16;16(1):11045. pii:11045
  8. Sadagopan NS, Gomez M, Tripathi S, Billingham LK, DeLay SL, Cady MA, Congivaram HTS, Chia TY, Wan H, Wang S  et al.  NOTCH3 drives fatty acid oxidation and ferroptosis resistance in aggressive meningiomas.  J Neurooncol  2025 Dec;175(3):979-991. doi:10.1007/s11060-025-05208-5
  9. Yalcin K, Alanya H, Gultekin B, Samper Figuera D, Barak T, Miyagishima DF, Youngblood MW, Hjerthen MG, Brooks A, Samuel Lopez N  et al.  Subgroup of meningiomas involving FOS and FOSB gene fusions.  Nat Commun  2025 Nov 26;16(1):10532. pii:10532
  10. Groff KJ, Patel RV, Feng Y, Ghosh HS, Millares Chavez MA, O'Brien J, Chen WC, Nitturi V, Save AV, Youngblood MW  et al.  The effect of TERT promoter mutation on predicting meningioma outcomes: a multi-institutional cohort analysis.  Lancet Oncol  2025 Sep;26(9):1178-1190. doi:10.1016/S1470-2045(25)00422-X
  11. Fares J, Jamshidi P, Congivaram HT, Oyon D, Bautista MM, Kern RC, Brat DJ, Youngblood MW, Chandler JP  Primary papillary epithelial tumor of the sella harboring an EZH2 Y646F mutation.  Acta Neuropathol  2025 Jul 15;150(1):4. pii:4
  12. Sadagopan NS, Gomez M, Tripathi S, Billingham LK, DeLay SL, Cady MA, Congivaram HTS, Chia TY, Wan H, Wang S  et al.  NOTCH3 Drives Fatty Acid Oxidation and Ferroptosis Resistance in Aggressive Meningiomas.  Res Sq  2025 Jun 04;. pii:rs.3.rs-6779386
  13. Wang Q, Wang J, Mathur R, Youngblood MW, Jin Q, Hou Y, Stasiak LA, Luan Y, Zhao H, Hilz S  et al.  Spatial 3D genome organization reveals intratumor heterogeneity in primary glioblastoma samples.  Sci Adv  2025 Mar 14;11(11):eadn2830. pii:eadn2830
  14. Morshed RA, Nguyen MP, Youngblood MW, Perlow HK, Lucas CG, Patel AJ, Palmer JD, Chandler JP, Theodosopoulos PV, Magill ST  et al.  Gene Expression Changes Associated With Recurrence After Gross Total Resection of Newly Diagnosed World Health Organization Grade 1 Meningioma.  Neurosurgery  2025 Mar 01;96(3):521-528. doi:10.1227/neu.0000000000003133
  15. Nguyen MP, Morshed RA, Youngblood MW, Perlow HK, Lucas CG, Patel AJ, Palmer JD, Horbinski CM, Magill ST, Chen WC  et al.  A targeted gene expression biomarker predicts clinic low-risk meningioma recurrence.  Neuro Oncol  2025 Feb 10;27(2):445-454. doi:10.1093/neuonc/noae198
  16. Gould A, Luan Y, Hou Y, Korobova FV, Chen L, Arrieta VA, Amidei C, Ward R, Gomez C, Castro B  et al.  Endothelial response to blood-brain barrier disruption in the human brain.  JCI Insight  2024 Dec 26;10(4). pii:e187328
  17. Thirunavu V, Drumm M, McCord M, Steffens A, Youngblood MW, Nandoliya KR, Smith H, Walshon J, McCortney K, Magill ST  et al.  Optimizing the use of Ki-67 proliferative index as a prognostic biomarker in meningiomas using digital analysis.  J Neurosurg  2024 Dec 01;141(6):1644-1654. doi:10.3171/2024.4.JNS232857
  18. Nandoliya KR, Congivaram H, Youngblood MW, Chen WC, Chaliparambil RK, Horbinski CM, Choudhury A, Brat DJ, Chandler JP, Magill ST  et al.  Clinical and methylomic features of spinal meningiomas.  J Neurooncol  2024 Nov;170(2):277-287. doi:10.1007/s11060-024-04736-w
  19. Schwartz C, Ueberschaer MF, Rautalin I, Grauvogel J, Bissolo M, Masalha W, Steiert C, Schnell O, Beck J, Ebel F  et al.  Frailty indices predict mortality, complications and functional improvements in supratentorial meningioma patients over 80 years of age.  J Neurooncol  2024 Oct;170(1):89-100. doi:10.1007/s11060-024-04780-6
  20. Joy Trybula S, Nandoliya KR, Youngblood MW, Karras CL, Fernandez LG, Oyon DE, Texakalidis P, Khan OH, Lesniak MS, Tate MC  et al.  Predictors of salvage therapy for parasagittal meningiomas treated with primary surgery, radiosurgery, or surgery plus adjuvant radiotherapy.  J Clin Neurosci  2024 Jun;124:102-108. doi:10.1016/j.jocn.2024.04.024
  21. Khazanchi R, Nandoliya KR, Shahin MN, Rae AI, Chaliparambil RK, Bowden SG, Alwakeal A, Lopez Ramos CG, Stedelin B, Youngblood MW  et al.  Obesity and meningioma: a US population-based study paired with analysis of a multi-institutional cohort.  J Neurosurg  2024 Jun 01;140(6):1558-1567. doi:10.3171/2023.11.JNS23732
  22. Trybula SJ, Youngblood MW, Karras CL, Murthy NK, Heimberger AB, Lukas RV, Sachdev S, Kalapurakal JA, Chandler JP, Brat DJ  et al.  The Evolving Classification of Meningiomas: Integration of Molecular Discoveries to Inform Patient Care.  Cancers (Basel)  2024 Apr 30;16(9). pii:1753
  23. Habashy KJ, Dmello C, Chen L, Arrieta VA, Kim KS, Gould A, Youngblood MW, Bouchoux G, Burdett KB, Zhang H  et al.  Paclitaxel and Carboplatin in Combination with Low-intensity Pulsed Ultrasound for Glioblastoma.  Clin Cancer Res  2024 Apr 15;30(8):1619-1629. doi:10.1158/1078-0432.CCR-23-2367
  24. Shahin MN, Horak VJ, Kemeny H, Youngblood MW, Lam SK, Raskin JS  Neurosurgery trainee well-being in a pediatric neurosurgery hospital: baseline data to motivate toward implementing change.  J Neurosurg Pediatr  2024 Mar 01;33(3):295-299. doi:10.3171/2023.11.PEDS23482
  25. Tripathi S, Najem H, Dussold C, Pacheco S, Miska J, McCortney K, Steffens A, Walshon J, Winkowski D, Cloney M  et al.  Cancer-associated fibroblast-secreted collagen is associated with immune inhibitor receptor LAIR1 in gliomas.  J Clin Invest  2024 Feb 15;134(4). pii:e176613
  26. Schwartz C, Rautalin I, Grauvogel J, Bissolo M, Masalha W, Steiert C, Schnell O, Beck J, Ebel F, Bervini D  et al.  Surgical Outcome of Patients With Supratentorial Meningiomas Aged 80 Years or Older-Retrospective International Multicenter Study.  Neurosurgery  2024 Feb 01;94(2):399-412. doi:10.1227/neu.0000000000002673
  27. Mathur R, Wang Q, Schupp PG, Nikolic A, Hilz S, Hong C, Grishanina NR, Kwok D, Stevers NO, Jin Q  et al.  Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective.  Cell  2024 Jan 18;187(2):446-463.e16. doi:10.1016/j.cell.2023.12.013
  28. Sadagopan NS, Nandoliya KR, Youngblood MW, Horbinski CM, Ahrendsen JT, Magill ST  A novel BRAF::PTPRN2 fusion in meningioma: a case report.  Acta Neuropathol Commun  2023 Dec 08;11(1):194. pii:194
  29. Chen WC, Choudhury A, Youngblood MW, Polley MC, Lucas CG, Mirchia K, Maas SLN, Suwala AK, Won M, Bayley JC  et al.  Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses.  Nat Med  2023 Dec;29(12):3067-3076. doi:10.1038/s41591-023-02586-z
  30. Patel NP, Youngblood MW, LoPresti MA, Alden TD  Cervical corpectomy in a pediatric patient with chondrodysplasia punctata and C5 dysplasia with spinal cord compression: illustrative case.  J Neurosurg Case Lessons  2023 Nov 20;6(21). pii:CASE23302
  31. Nandoliya KR, Winterhalter EJ, Karras CL, Khazanchi R, Youngblood MW, Texakalidis P, Chandler JP, Magill ST  Repeat Surgery for Vestibular Schwannomas: An Institutional Case Series.  J Neurol Surg Rep  2023 Oct;84(4):e140-e143. doi:10.1055/s-0043-1776124
  32. Youngblood MW, Erson-Omay Z, Li C, Najem H, Coșkun S, Tyrtova E, Montejo JD, Miyagishima DF, Barak T, Nishimura S  et al.  Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas.  Nat Commun  2023 Oct 07;14(1):6279. pii:6279
  33. Nandoliya KR, Khazanchi R, Winterhalter EJ, Youngblood MW, Karras CL, Sonabend AM, Micco AG, Chandler JP, Magill ST  Validating the VS-5 Score for Predicting Outcomes After Vestibular Schwannoma Resection in an Institutional Cohort.  World Neurosurg  2023 Aug;176:e77-e82. doi:10.1016/j.wneu.2023.04.123
  34. Liu T, Wang J, Yang H, Jin Q, Wang X, Fu Y, Luan Y, Wang Q, Youngblood MW, Lu X  et al.  Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma.  Cancer Res  2023 May 02;83(9):1517-1530. doi:10.1158/0008-5472.CAN-22-1858
  35. Youngblood MW, Tran AN, Wang W, An S, Scholtens D, Zhang L, O'Shea K, Pokorny JL, Magill ST, Sachdev S  et al.  Docetaxel targets aggressive methylation profiles and serves as a radiosensitizer in high-risk meningiomas.  Neuro Oncol  2023 Mar 14;25(3):508-519. doi:10.1093/neuonc/noac206
  36. Krushelnytskyy MD, Youngblood MW, Lesniak MS, Kemeny HR, Fernandez LG, Burdett KLB, Zhang H, Alden TD, Dahdaleh NS  Optimizing the patient handoff and progress note documentation efficiency in the EPIC EMR system within a neurosurgery residency: A quality improvement initiative.  J Clin Neurosci  2022 Nov;105:86-90. doi:10.1016/j.jocn.2022.09.007
  37. Robert SM, Vetsa S, Nadar A, Vasandani S, Youngblood MW, Gorelick E, Jin L, Marianayagam N, Erson-Omay EZ, Günel M  et al.  Correction to: The integrated multiomic diagnosis of sporadic meningiomas: a review of its clinical implications.  J Neurooncol  2022 Jan;156(2):215. doi:10.1007/s11060-021-03937-x
  38. Robert SM, Vetsa S, Nadar A, Vasandani S, Youngblood MW, Gorelick E, Jin L, Marianayagam N, Erson-Omay EZ, Günel M  et al.  The integrated multiomic diagnosis of sporadic meningiomas: a review of its clinical implications.  J Neurooncol  2022 Jan;156(2):205-214. doi:10.1007/s11060-021-03874-9
  39. Zhang DY, Gould A, Happ HC, Youngblood MW, Dmello C, Kang SJ, Canney M, Stupp R, Carvill GL, Sonabend AM  Ultrasound-mediated blood-brain barrier opening increases cell-free DNA in a time-dependent manner.  Neurooncol Adv  2021;3(1):vdab165. pii:vdab165
  40. Yeung J, Yaghoobi V, Miyagishima D, Vesely MD, Zhang T, Badri T, Nassar A, Han X, Sanmamed MF, Youngblood M  et al.  Targeting the CSF1/CSF1R axis is a potential treatment strategy for malignant meningiomas.  Neuro Oncol  2021 Nov 02;23(11):1922-1935. doi:10.1093/neuonc/noab075
  41. Trybula SJ, Youngblood MW, Kemeny HR, Clark JR, Karras CL, Hartsell WF, Tomita T  Radiation Induced Cavernomas in the Treatment of Pediatric Medulloblastoma: Comparative Study Between Proton and Photon Radiation Therapy.  Front Oncol  2021;11:760691. pii:760691
  42. Jin L, Youngblood MW, Gupte TP, Vetsa S, Nadar A, Barak T, Yalcin K, Aguilera SM, Mishra-Gorur K, Blondin NA  et al.  Type of bony involvement predicts genomic subgroup in sphenoid wing meningiomas.  J Neurooncol  2021 Sep;154(2):237-246. doi:10.1007/s11060-021-03819-2
  43. Gupte TP, Li C, Jin L, Yalcin K, Youngblood MW, Miyagishima DF, Mishra-Gorur K, Zhao AY, Antonios J, Huttner A  et al.  Clinical and genomic factors associated with seizures in meningiomas.  J Neurosurg  2021 Sep 01;135(3):835-844. doi:10.3171/2020.7.JNS201042
  44. Youngblood MW, Miyagishima DF, Jin L, Gupte T, Li C, Duran D, Montejo JD, Zhao A, Sheth A, Tyrtova E  et al.  Associations of meningioma molecular subgroup and tumor recurrence.  Neuro Oncol  2021 May 05;23(5):783-794. doi:10.1093/neuonc/noaa226