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Defining key signaling pathways in cardiac development and cardiomyocyte maintenance in the setting of pathological stress.

The Wilsbacher Lab

The goal of our research is to define key signaling pathways in cardiac development and cardiomyocyte maintenance in the setting of pathological stress. Currently, the laboratory investigates the G protein-coupled receptor sphingosine-1-phosphate receptor 1 (S1P1) and its unexpected role in cardiomyocyte proliferation and cardiac development. We aim to identify the signaling mechanisms that underlie these cardiac developmental effects and to investigate whether S1P1 signaling contributes to cardiac remodeling in the adult heart.

Explore Our Research

Immunofluorescence studies highlight structural changes in adult myocardium in the setting of pathological stress

Selected Publications

Sphingosine 1-phosphate receptor-1 in cardiomyocytes is required for normal cardiac development

Sphingosine 1-phosphate receptor-1 in cardiomyocytes is required for normal cardiac development. Clay H*, Wilsbacher LD*, Wilson SJ, Duong DN, McDonald M, Lam I, Park KE, Chun J, Coughlin SR. *Equal contributors. Dev Biol. 2016 Jun 19. doi: 10.1016/j.ydbio.2016.06.024. [Epub ahead of print]. PMID: 27333774

Genetics of Cardiac Developmental Disorders: Cardiomyocyte Proliferation and Growth and Relevance to Heart Failure

Genetics of Cardiac Developmental Disorders: Cardiomyocyte Proliferation and Growth and Relevance to Heart Failure. Wilsbacher L and McNally EM. Annu Rev Pathol. 2016 May 23;11:395-419. PMID: 26925501

 

Meet the Wilsbacher Lab Team

News & Events

Healthcare Provider Genomics Education Week

National Human Genome Research Institute (NHGRI) 2021 Healthcare Provider Genomics Education Week was held June 7-11, 2021.

Webinar

Register for the NHGRI-AHA Joint Webinar, Vascular Genetics: Approaches to Aortopathies and Arteriopathies, on June 11, 2021, at 8 a.m. CT.

AHA BCVS Scienific Sessins

AHA BCVS Scientific Sessions

AHA BCVS Scientific Sessions 2021 was held virtually Aug. 23-25, 2021.