About Our Lab

The goal of our research is to define key signaling pathways in cardiac development and cardiomyocyte maintenance in the setting of pathological stress. Currently, the laboratory investigates the G protein-coupled receptor sphingosine-1-phosphate receptor 1 (S1P₁) and its unexpected role in cardiomyocyte proliferation and cardiac development. We aim to identify the signaling mechanisms that underlie these cardiac developmental effects and to investigate whether S1P₁ signaling contributes to cardiac remodeling in the adult heart.

Selected publications

Sphingosine 1-phosphate receptor-1 in cardiomyocytes is required for normal cardiac development. Clay H*, Wilsbacher LD*, Wilson SJ, Duong DN, McDonald M, Lam I, Park KE, Chun J, Coughlin SR. *Equal contributors. Dev Biol. 2016 Jun 19. doi: 10.1016/j.ydbio.2016.06.024. [Epub ahead of print]. PMID: 27333774

Genetics of Cardiac Developmental Disorders: Cardiomyocyte Proliferation and Growth and Relevance to Heart Failure. Wilsbacher L and McNally EM. Annu Rev Pathol. 2016 May 23;11:395-419. PMID: 26925501

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