About Our Lab
Accurate chromosome segregation requires the successful and error-free association between kinetochores of the chromosomes and the plus-ends of microtubules of the mitotic spindle. Errors in this event lead to chromosome loss and aneuploidy which is a hallmark of cancer cells and leads to birth defects during human embryonic development. Research in the past several years has provided conclusive evidence that the Ndc80 kinetochore complex is crucial for this process but we still do not clearly understand how this complex is coupled to dynamic microtubule plus-ends during mitotic metaphase and anaphase in vertebrate cells.
We also do not have an accurate picture of how the kinetochore microtubule attachment mechanisms are coordinated seamlessly with the spindle assembly checkpoint, the essential surveillance mechanism that controls the fidelity of the chromosome segregation process. Studying the intricacies of these mutually linked phenomena will not only provide valuable information pertaining to the understanding of cancer initiation and progression but also lead to the identification of novel biomarkers and targets which in turn is likely to yield better diagnostic and therapeutic tools to combat this dreaded disease.
Cell Division: The Unattached Kinetochore Wears an Expansive RZZ Coat.
Suzuki A and Varma D. Curr Biol. 2018 Nov 5;28(21):R1250-R1252. doi: 10.1016/j.cub.2018.10.001.
Cdt1 stabilizes kinetochore-microtubule attachments via an Aurora B kinase-dependent mechanism.
Agarwal S, Smith KP, Zhou Y, Suzuki A, McKenney RJ and Varma D. J Cell Biol. 2018 Aug 28. pii: jcb.201705127. doi: 10.1083/jcb.201705127
Antagonism between the dynein and Ndc80 complexes at kinetochores controls the stability of kinetochore-microtubule attachments during mitosis.
Amin MA, McKenney RJ, Varma D.
J Biol. Chem. 2018 Feb 23. pii: jbc.RA117.001699. doi: 10.1074/jbc.RA117.001699.
Targeting mitotic pathways for endocrine-related cancer therapeutics.
Agarwal S and Varma D.
Endocrine-related Cancer. 2017, June, 24(9), T65-T82
The RZZ complex requires the N-terminus of KNL1 to mediate optimal Mad1 kinetochore localization in human cells.
Caldas GV, Lynch TR, Anderson R, Afreen S, Varma D*, DeLuca JG*.
Open Biol. 2015 Nov;5(11). pii: 150160.
08.01.17 - New Tech, Melissa, joins the lab
06.15.17 - Shivangi’s Cancer review is accepted
01.01.17 - Master’s student Yu and Yiyi joins
06.15.2016 - Suchi's last day
11.05.2015 - Sana/Dileep Open Biology paper published
10.02.2015 - Shivangi/Dileep Bioarchitecture review published
09.22.2015 - Amin joins the lab
06.15.2015 - Suchi joins the lab
06.01.2015 - Shivangi joins the lab
05.29.2015 - Liz's last day
04.20.2015 - Sana/Dileep’s dispatch published
01.25.2015 - Sana joins the lab