Our Work

The goal of our lab is to better understand the connectivity and excitability changes that occur in the spinal cord after spinal cord injury. Specifically, we are interested in the changes that affect mobility. To do this, our lab uses a variety of in vitro and in vivo techniques to systematically measure both cellular changes within the spinal cord and gross motor output measures resulting from those changes. Explore our techniques.

Our current projects are focused on both understanding and treating involuntary muscle contractions or spasms, that develop after spinal cord injury. Some of these projects are highlighted here:

• Effects of Injury Severity on Spasms
  Characterizing spasms based on spinal cord injury location and severity.
• Calcium Channel Blocker
  Exploring a potential new therapy targeting the CaV1.3 channel on motoneurons.
• Deep Dorsal Horn Interneurons
  Researching how DDH neurons with bursting behavior could be involved in triggering the EPSPs due to loss of inhibition in the chronically 5-HT-deprived spinal cord.

For more on our work, please explore the links below:

• Conferences & Societies: Where we've recently presented
• Publications: Recent publications from the Tysseling Lab
• Funding: Current funding and grants for the lab