Enhancing functional recovery after spinal cord injury.

The Tysseling Lab at Northwestern University Feinberg School of Medicine investigates the neural mechanisms that drive motor dysfunction after spinal cord injury. Using animal models, we identify injury-induced changes that impair movement, such as altered protein expression and neuronal excitability.

We develop targeted therapies to restore motor function and evaluate their effects both in vitro at the cellular level and in vivo through behavioral outcomes. Our research focuses on ventral motoneurons, dorsal interneurons, spinal reflexes, motor unit activity, muscle activation during locomotion and hyperreflexia.