The abc Laboratory is directed at understanding neurovascular function in health and disease. Specifically, we have been studying the association between cerebral blood flow regulation, structural changes in the brain and the clinical outcomes of acute and chronic cerebrovascular injury. In acute neurovascular disorders, we have validated several novel indices of cerebral blood flow regulation which can now be used to predict the development of vasospasm in subarachnoid hemorrhage and hematoma expansion in patients with intraparenchymal hemorrhage.
- Tchalla A, Wellenius GA, Boyer S, Travison TG, Habtemariam D, Gagnon M, Iloputaife I, Sorond FA, Dantoine T, Lipsitz LA High levels of an endothelial dysfunction marker (sVCAM-1) are associated with injurious and recurrent falls and mortality over a 5-year interval in an older population. Exp Gerontol 2018 Jun;106:1-7. pii:S0531-5565(17)30078-5
- Liotta EM, Romanova AL, Lizza BD, Rasmussen-Torvik LJ, Kim M, Francis B, Sangha RS, Carroll TJ, Ganger D, Ladner DP, Naidech AM, Paparello JJ, Prabhakaran S, Sorond FA, Maas MB Osmotic Shifts, Cerebral Edema, and Neurologic Deterioration in Severe Hepatic Encephalopathy. Crit Care Med 2018 Feb;46(2):280-289. doi:10.1097/CCM.0000000000002831