Investigating the effect of cerebrovascular mechanisms on aging
Our Mission
The ABC Laboratory is directed at understanding neurovascular function in health and disease. Specifically, we study the association between cerebral blood flow regulation, structural changes in the brain and the clinical outcomes of acute and chronic cerebrovascular injury. In acute neurovascular disorders, we have validated several novel indices of cerebral blood flow regulation, which can now be used to predict the development of vasospasm in subarachnoid hemorrhage and hematoma expansion in patients with intraparenchymal hemorrhage.
Principal Investigator
Farzaneh Sorond, MD, PhD
Vice Dean of Faculty Affairs
Dean Richard H. Young and Ellen Stearns Young Professor
Professor, Neurology (Stroke and Vascular Neurology, Neurocritical Care)
Recent Publications and Happenings
Our team celebrated Iranian New Year!
McDonald Cell Stem Cell 2018
Here we studied the molecular mechanisms of endothelial cell regeneration in adult vessels. Using a model of aortic injury, we found that regeneration occurs at the edges of the wounded area with equal strength and regardless of flow direction. Through a robust proliferative response, the wound closes by efforts of a rapidly dividing cell population that expresses Atf3.
Mack Nat. Comm. 2017
Here we showed that Notch1 is expressed at high levels in adult large arteries with polarized distribution downstream flow direction. Reversion of flow direction promotes relocation of Notch1 to the other pole of the cells, indicating that Notch is a mechanosensor. Inactivation of Noth1 affects the integrity of endothelial barrier and promotes endothelial proliferation.