Northwestern University Feinberg School of Medicine

Thomas Hope Lab


Learn more about the work that we do in the Hope Laboratory through our recent publications.

  1. Yoh SM, Mamede JI, Lau D, Ahn N, Sánchez-Aparicio MT, Temple J, Tuckwell A, Fuchs NV, Cianci GC, Riva L  et al.  Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA.  Mol Cell  2022 Jun 28;. pii:S1097-2765(22)00555-X
  2. Madden PJ, Thomas Y, Blair RV, Samer S, Doyle M, Midkiff CC, Doyle-Meyers LA, Becker ME, Arif MS, McRaven MD  et al.  An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques.  bioRxiv  2022 Mar 23;. pii:2022.02.25.481974
  3. Buchanan LB, Shao Z, Jiang YC, Lai A, Hope TJ, Carias AM, Prodger JL  Quantitative Immunofluorescent Imaging of Immune Cells in Mucosal Tissues.  Methods Mol Biol  2022;2440:143-164. doi:10.1007/978-1-0716-2051-9_9
  4. El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A  et al.  Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2.  Nat Commun  2022 01 20;13(1):405. doi:10.1038/s41467-021-27893-2
  5. Madden PJ, Arif MS, Becker ME, McRaven MD, Carias AM, Lorenzo-Redondo R, Xiao S, Midkiff CC, Blair RV, Potter EL  et al.  Development of an In Vivo Probe to Track SARS-CoV-2 Infection in Rhesus Macaques.  Front Immunol  2021;12:810047. doi:10.3389/fimmu.2021.810047
  6. Nyanhete TE, Edwards RJ, LaBranche CC, Mansouri K, Eaton A, Dennison SM, Saunders KO, Goodman D, Janowska K, Spreng RL  et al.  Polyclonal Broadly Neutralizing Antibody Activity Characterized by CD4 Binding Site and V3-Glycan Antibodies in a Subset of HIV-1 Virus Controllers.  Front Immunol  2021;12:670561. doi:10.3389/fimmu.2021.670561
  7. Beddingfield BJ, Maness NJ, Fears AC, Rappaport J, Aye PP, Russell-Lodrigue K, Doyle-Meyers LA, Blair RV, Carias AM, Madden PJ  et al.  Effective Prophylaxis of COVID-19 in Rhesus Macaques Using a Combination of Two Parenterally-Administered SARS-CoV-2 Neutralizing Antibodies.  Front Cell Infect Microbiol  2021;11:753444. doi:10.3389/fcimb.2021.753444
  8. Taylor RA, McRaven MD, Carias AM, Anderson MR, Matias E, Araínga M, Allen EJ, Rogers KA, Gupta S, Kulkarni V  et al.  Localization of infection in neonatal rhesus macaques after oral viral challenge.  PLoS Pathog  2021 11;17(11):e1009855. doi:10.1371/journal.ppat.1009855
  9. Schieffer RJ, Bryndza Tfaily E, D'Aquila R, Greene GJ, Carballo-Diéguez A, Giguere R, Tagliaferri Rael C, Kiser PF, Hope TJ  Conjoint Analysis of User Acceptability of Sustained Long-Acting Pre-Exposure Prophylaxis for HIV.  AIDS Res Hum Retroviruses  2022 04;38(4):336-345. doi:10.1089/AID.2021.0075
  10. Frank I, Cigoli M, Arif MS, Fahlberg MD, Maldonado S, Calenda G, Pegu A, Yang ES, Rawi R, Chuang GY  et al.  Blocking α4β7 integrin delays viral rebound in SHIVSF162P3-infected macaques treated with anti-HIV broadly neutralizing antibodies.  Sci Transl Med  2021 08 18;13(607). pii:eabf7201
  11. Maric D, Grimm WA, Greco N, McRaven MD, Fought AJ, Veazey RS, Hope TJ  Th17 T Cells and Immature Dendritic Cells Are the Preferential Initial Targets after Rectal Challenge with a Simian Immunodeficiency Virus-Based Replication-Defective Dual-Reporter Vector.  J Virol  2021 09 09;95(19):e0070721. doi:10.1128/JVI.00707-21
  12. Rael CT, Lopez-Ríos J, McKenna SA, Das D, Dolezal C, Abascal E, Carballo-Diéguez A, Schnall R, Hope TJ, Bauermeister J  et al.  Transgender Women's Barriers, Facilitators, and Preferences on Tailored Injection Delivery Strategies to Administer Long-Acting Injectable Cabotegravir (CAB-LA) for HIV Pre-exposure Prophylaxis (PrEP).  AIDS Behav  2021 Dec;25(12):4180-4192. doi:10.1007/s10461-021-03357-y
  13. Carias AM, Schneider JR, Madden P, Lorenzo-Redondo R, Araínga M, Pegu A, Cianci GC, Maric D, Villinger F, Mascola JR  et al.  Anatomic Distribution of Intravenously Injected IgG Takes Approximately 1 Week to Achieve Stratum Corneum Saturation in Vaginal Tissues.  J Immunol  2021 07 15;207(2):505-511. doi:10.4049/jimmunol.2100253
  14. Pollara J, Tay MZ, Edwards RW, Goodman D, Crowley AR, Edwards RJ, Easterhoff D, Conley HE, Hoxie T, Gurley T  et al.  Functional Homology for Antibody-Dependent Phagocytosis Across Humans and Rhesus Macaques.  Front Immunol  2021;12:678511. doi:10.3389/fimmu.2021.678511
  15. Taylor RA, Xiao S, Carias AM, McRaven MD, Thakkar DN, Araínga M, Allen EJ, Rogers KA, Kumarapperuma SC, Gong S  et al.  PET/CT targeted tissue sampling reveals virus specific dIgA can alter the distribution and localization of HIV after rectal exposure.  PLoS Pathog  2021 06;17(6):e1009632. doi:10.1371/journal.ppat.1009632
  16. Martin-Sancho L, Lewinski MK, Pache L, Stoneham CA, Yin X, Becker ME, Pratt D, Churas C, Rosenthal SB, Liu S  et al.  Functional landscape of SARS-CoV-2 cellular restriction.  Mol Cell  2021 06 17;81(12):2656-2668.e8. pii:S1097-2765(21)00313-0
  17. Romano JW, Baum MM, Demkovich ZR, Diana F, Dobard C, Feldman PL, Garcia-Lerma JG, Grattoni A, Gunawardana M, Ho DK  et al.  Tenofovir Alafenamide for HIV Prevention: Review of the Proceedings from the Gates Foundation Long-Acting TAF Product Development Meeting.  AIDS Res Hum Retroviruses  2021 06;37(6):409-420. doi:10.1089/AID.2021.0028
  18. Herrera C, McRaven MD, Laing KG, Dennis J, Hope TJ, Shattock RJ  Early Colorectal Responses to HIV-1 and Modulation by Antiretroviral Drugs.  Vaccines (Basel)  2021 Mar 08;9(3). pii:231
  19. Mamede JI, Griffin J, Gambut S, Hope TJ  A New Generation of Functional Tagged Proteins for HIV Fluorescence Imaging.  Viruses  2021 02 28;13(3). pii:386
  20. Berard AR, Miller C, Araínga M, Broedlow CA, Noël-Romas L, Schifanella L, Hensley-McBain T, Roederer A, Driscoll CB, Coronado E  et al.  Simian Immunodeficiency Virus Susceptibility, Immunology, and Microbiome in the Female Genital Tract of Adolescent Versus Adult Pigtail Macaques.  AIDS Res Hum Retroviruses  2021 07;37(7):510-522. doi:10.1089/AID.2020.0271
  21. Karunakaran D, Simpson SM, Su JT, Bryndza-Tfaily E, Hope TJ, Veazey R, Dobek G, Qiu J, Watrous D, Sung S  et al.  Design and Testing of a Cabotegravir Implant for HIV Prevention.  J Control Release  2021 02 10;330:658-668. pii:S0168-3659(20)30748-3
  22. Klein K, Nankya I, Nickel G, Ratcliff AN, Meadows AAJ, Hathaway N, Bailey JA, Stieh DJ, Cheeseman HM, Carias AM  et al.  Deep Gene Sequence Cluster Analyses of Multi-Virus-Infected Mucosal Tissue Reveal Enhanced Transmission of Acute HIV-1.  J Virol  2021 01 13;95(3). pii:e01737-20
  23. Carter SD, Mamede JI, Hope TJ, Jensen GJ  Correlated cryogenic fluorescence microscopy and electron cryo-tomography shows that exogenous TRIM5α can form hexagonal lattices or autophagy aggregates in vivo.  Proc Natl Acad Sci U S A  2020 11 24;117(47):29702-29711. doi:10.1073/pnas.1920323117
  24. Hope TJ, Klatt NR, Sacha JB, Cannon PM  Timothy Ray Brown: The Serendipitous Hero of HIV Cure Research.  AIDS Res Hum Retroviruses  2020 11;36(11):883-885. doi:10.1089/AID.2020.0253
  25. Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M  et al.  Recommendations for measuring HIV reservoir size in cure-directed clinical trials.  Nat Med  2020 09;26(9):1339-1350. doi:10.1038/s41591-020-1022-1
  26. Clerc I, Moussa DA, Vahlas Z, Tardito S, Oburoglu L, Hope TJ, Sitbon M, Dardalhon V, Mongellaz C, Taylor N  Entry of glucose- and glutamine-derived carbons into the citric acid cycle supports early steps of HIV-1 infection in CD4 T cells.  Nat Metab  2019 07;1(7):717-730. doi:10.1038/s42255-019-0084-1
  27. Rael CT, Lentz C, Carballo-Diéguez A, Giguere R, Dolezal C, Feller D, D'Aquila RT, Hope TJ  Understanding the Acceptability of Subdermal Implants as a Possible New HIV Prevention Method: Multi-Stage Mixed Methods Study.  J Med Internet Res  2020 07 27;22(7):e16904. doi:10.2196/16904
  28. Maldonado RJK, Rice B, Chen EC, Tuffy KM, Chiari EF, Fahrbach KM, Hope TJ, Parent LJ  Visualizing Association of the Retroviral Gag Protein with Unspliced Viral RNA in the Nucleus.  mBio  2020 04 07;11(2). pii:e00524-20
  29. Carias AM, Hope TJ  Barriers of Mucosal Entry of HIV/SIV.  Curr Immunol Rev  2019;15(1):4-13. doi:10.2174/1573395514666180604084404
  30. Ventura JD, Beloor J, Allen E, Zhang T, Haugh KA, Uchil PD, Ochsenbauer C, Kieffer C, Kumar P, Hope TJ  et al.  Longitudinal bioluminescent imaging of HIV-1 infection during antiretroviral therapy and treatment interruption in humanized mice.  PLoS Pathog  2019 12;15(12):e1008161. doi:10.1371/journal.ppat.1008161
  31. Schneider JR, Shen X, Orlandi C, Nyanhete T, Sawant S, Carias AM, Smith AD, Kelleher NL, Veazey RS, Lewis GK  et al.  A MUC16 IgG Binding Activity Selects for a Restricted Subset of IgG Enriched for Certain Simian Immunodeficiency Virus Epitope Specificities.  J Virol  2020 02 14;94(5). pii:e01246-19
  32. Rael CT, Martinez M, Giguere R, Bockting W, MacCrate C, Mellman W, Valente P, Greene GJ, Sherman SG, Footer KHA  et al.  Transgender Women's Concerns and Preferences on Potential Future Long-Acting Biomedical HIV Prevention Strategies: The Case of Injections and Implanted Medication Delivery Devices (IMDDs).  AIDS Behav  2020 May;24(5):1452-1462. doi:10.1007/s10461-019-02703-5
  33. Gray CM, O'Hagan KL, Lorenzo-Redondo R, Olivier AJ, Amu S, Chigorimbo-Murefu N, Harryparsad R, Sebaa S, Maziya L, Dietrich J  et al.  Impact of chemokine C-C ligand 27, foreskin anatomy and sexually transmitted infections on HIV-1 target cell availability in adolescent South African males.  Mucosal Immunol  2020 01;13(1):118-127. doi:10.1038/s41385-019-0209-6
  34. Sultana T, Mamede JI, Saito A, Ode H, Nohata K, Cohen R, Nakayama EE, Iwatani Y, Yamashita M, Hope TJ  et al.  Multiple Pathways To Avoid Beta Interferon Sensitivity of HIV-1 by Mutations in Capsid.  J Virol  2019 12 01;93(23). pii:e00986-19
  35. Rael CT, Martinez M, Giguere R, Bockting W, MacCrate C, Mellman W, Valente P, Greene GJ, Sherman SG, Footer KHA  et al.  Knowledge About Oral PrEP Among Transgender Women in New York City.  AIDS Behav  2019 Oct;23(10):2779-2783. doi:10.1007/s10461-019-02584-8
  36. Schönfeld M, Knackmuss U, Chandorkar P, Hörtnagl P, Hope TJ, Moris A, Bellmann-Weiler R, Lass-Flörl C, Posch W, Wilflingseder D  Co- but not Sequential Infection of DCs Boosts Their HIV-Specific CTL-Stimulatory Capacity.  Front Immunol  2019;10:1123. doi:10.3389/fimmu.2019.01123
  37. Buckner LR, Drobnis EZ, Augustine MS, Rogers LK, Akers J, Mott PD, Hope TJ, Quayle AJ, Schust DJ  Cervical and systemic concentrations of long acting hormonal contraceptive (LARC) progestins depend on delivery method: Implications for the study of HIV transmission.  PLoS One  2019;14(5):e0214152. doi:10.1371/journal.pone.0214152
  38. Hensley-McBain T, Wu MC, Manuzak JA, Cheu RK, Gustin A, Driscoll CB, Zevin AS, Miller CJ, Coronado E, Smith E  et al.  Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection.  PLoS Pathog  2019 04;15(4):e1007672. doi:10.1371/journal.ppat.1007672
  39. Dabee S, Barnabas SL, Lennard KS, Jaumdally SZ, Gamieldien H, Balle C, Happel AU, Murugan BD, Williamson AL, Mkhize N  et al.  Defining characteristics of genital health in South African adolescent girls and young women at high risk for HIV infection.  PLoS One  2019;14(4):e0213975. doi:10.1371/journal.pone.0213975
  40. Pollara J, Jones DI, Huffman T, Edwards RW, Dennis M, Li SH, Jha S, Goodman D, Kumar A, LaBranche CC  et al.  Bridging Vaccine-Induced HIV-1 Neutralizing and Effector Antibody Responses in Rabbit and Rhesus Macaque Animal Models.  J Virol  2019 05 15;93(10). pii:e02119-18
  41. Li L, Zhou J, Wang W, Huang L, Tu J, Baiamonte L, Stark M, Mills M, Hope TJ, Drobnis EZ  et al.  Effects of three long-acting reversible contraceptive methods on HIV target cells in the human uterine cervix and peripheral blood.  Reprod Biol Endocrinol  2019 Feb 22;17(1):26. doi:10.1186/s12958-019-0469-8
  42. Tay MZ, Kunz EL, Deal A, Zhang L, Seaton KE, Rountree W, Eudailey JA, Heptinstall J, McRaven MD, Matias E  et al.  Rare Detection of Antiviral Functions of Polyclonal IgA Isolated from Plasma and Breast Milk Compartments in Women Chronically Infected with HIV-1.  J Virol  2019 04 01;93(7). pii:e02084-18
  43. Calder BJ, Schieffer RJ, Bryndza Tfaily E, D'Aquila R, Greene GJ, Carballo-Diéguez A, Giguere R, Kiser PF, Hope TJ  Qualitative Consumer Research on Acceptance of Long-Acting Pre-Exposure Prophylaxis Products Among Men Having Sex with Men and Medical Practitioners in the United States.  AIDS Res Hum Retroviruses  2018 10;34(10):849-856. doi:10.1089/AID.2018.0214
  44. Hope TJ  Inflammation weakens HIV prevention.  Nat Med  2018 04 10;24(4):384-385. doi:10.1038/nm.4534
  45. Wills S, Hwang KK, Liu P, Dennison SM, Tay MZ, Shen X, Pollara J, Lucas JT, Parks R, Rerks-Ngarm S  et al.  HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis.  J Virol  2018 04 01;92(7). pii:e01552-17
  46. Barnabas SL, Dabee S, Passmore JS, Jaspan HB, Lewis DA, Jaumdally SZ, Gamieldien H, Masson L, Muller E, Maseko VD  et al.  Converging epidemics of sexually transmitted infections and bacterial vaginosis in southern African female adolescents at risk of HIV.  Int J STD AIDS  2018 05;29(6):531-539. doi:10.1177/0956462417740487
  47. Carter SD, Mageswaran SK, Farino ZJ, Mamede JI, Oikonomou CM, Hope TJ, Freyberg Z, Jensen GJ  Distinguishing signal from autofluorescence in cryogenic correlated light and electron microscopy of mammalian cells.  J Struct Biol  2018 01;201(1):15-25. pii:S1047-8477(17)30177-6
  48. Mamede JI, Cianci GC, Anderson MR, Hope TJ  Early cytoplasmic uncoating is associated with infectivity of HIV-1.  Proc Natl Acad Sci U S A  2017 08 22;114(34):E7169-E7178. doi:10.1073/pnas.1706245114
  49. Schneider JR, Carias AM, Bastian AR, Cianci GC, Kiser PF, Veazey RS, Hope TJ  Long-term direct visualization of passively transferred fluorophore-conjugated antibodies.  J Immunol Methods  2017 11;450:66-72. pii:S0022-1759(16)30305-2
  50. Planas D, Zhang Y, Monteiro P, Goulet JP, Gosselin A, Grandvaux N, Hope TJ, Fassati A, Routy JP, Ancuta P  HIV-1 selectively targets gut-homing CCR6+CD4+ T cells via mTOR-dependent mechanisms.  JCI Insight  2017 Aug 03;2(15). doi:10.1172/jci.insight.93230