Northwestern University Feinberg School of Medicine

Thomas Hope Lab

Publications

Learn more about the work that we do in the Farzaneh Sorond Laboratory through our recent publications.

  1. Pollara J, Jones DI, Huffman T, Edwards RW, Dennis M, Li SH, Jha S, Goodman D, Kumar A, LaBranche CC, Montefiori DC, Fouda GG, Hope TJ, Tomaras GD, Staats HF, Ferrari G, Permar SR  Bridging vaccine-induced HIV-1 neutralizing and effector antibody responses in rabbit and rhesus macaque animal models.  J Virol  2019 Mar 06;. pii:JVI.02119-18
  2. Li L, Zhou J, Wang W, Huang L, Tu J, Baiamonte L, Stark M, Mills M, Hope TJ, Drobnis EZ, Quayle AJ, Schust DJ  Effects of three long-acting reversible contraceptive methods on HIV target cells in the human uterine cervix and peripheral blood.  Reprod Biol Endocrinol  2019 Feb 22;17(1):26. doi:10.1186/s12958-019-0469-8
  3. Tay MZ, Kunz EL, Deal A, Zhang L, Seaton KE, Rountree W, Eudailey JA, Heptinstall J, McRaven MD, Matias E, McGuire E, Yates NL, Perez LG, Montefiori DC, Overman RG, Hope TJ, Shen X, Kalilani L, Fouda GG, Tomaras GD, Permar SR  Rare Detection of Antiviral Functions of Polyclonal IgA Isolated from Plasma and Breast Milk Compartments in HIV-1 Chronically Infected Women.  J Virol  2019 Jan 30;. pii:JVI.02084-18
  4. Calder BJ, Schieffer RJ, Bryndza Tfaily E, D'Aquila R, Greene GJ, Carballo-Diéguez A, Giguere R, Kiser PF, Hope TJ  Qualitative Consumer Research on Acceptance of Long-Acting Pre-Exposure Prophylaxis Products Among Men Having Sex with Men and Medical Practitioners in the United States.  AIDS Res Hum Retroviruses  2018 Oct;34(10):849-856. doi:10.1089/AID.2018.0214
  5. Hope TJ  Inflammation weakens HIV prevention.  Nat Med  2018 Apr 10;24(4):384-385. doi:10.1038/nm.4534
  6. Wills S, Hwang KK, Liu P, Dennison SM, Tay MZ, Shen X, Pollara J, Lucas JT, Parks R, Rerks-Ngarm S, Pitisuttithum P, Nitayapan S, Kaewkungwal J, Thomas R, Kim JH, Michael NL, Robb ML, McRaven M, Montefiori DC, Hope TJ, Liao HX, Moody MA, Ferrari G, Haynes BF, Alam SM, Bonsignori M, Tomaras GD  HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis.  J Virol  2018 04 01;92(7). pii:e01552-17
  7. Barnabas SL, Dabee S, Passmore JS, Jaspan HB, Lewis DA, Jaumdally SZ, Gamieldien H, Masson L, Muller E, Maseko VD, Mkhize N, Mbulawa Z, Williamson AL, Gray CM, Hope TJ, Chiodi F, Dietrich J, Gray G, Bekker LG,   Converging epidemics of sexually transmitted infections and bacterial vaginosis in southern African female adolescents at risk of HIV.  Int J STD AIDS  2018 05;29(6):531-539. doi:10.1177/0956462417740487
  8. Carter SD, Mageswaran SK, Farino ZJ, Mamede JI, Oikonomou CM, Hope TJ, Freyberg Z, Jensen GJ  Distinguishing signal from autofluorescence in cryogenic correlated light and electron microscopy of mammalian cells.  J Struct Biol  2018 Jan;201(1):15-25. pii:S1047-8477(17)30177-6
  9. Mamede JI, Cianci GC, Anderson MR, Hope TJ  Early cytoplasmic uncoating is associated with infectivity of HIV-1.  Proc Natl Acad Sci U S A  2017 08 22;114(34):E7169-E7178. doi:10.1073/pnas.1706245114
  10. Schneider JR, Carias AM, Bastian AR, Cianci GC, Kiser PF, Veazey RS, Hope TJ  Long-term direct visualization of passively transferred fluorophore-conjugated antibodies.  J Immunol Methods  2017 11;450:66-72. pii:S0022-1759(16)30305-2
  11. Planas D, Zhang Y, Monteiro P, Goulet JP, Gosselin A, Grandvaux N, Hope TJ, Fassati A, Routy JP, Ancuta P  HIV-1 selectively targets gut-homing CCR6+CD4+ T cells via mTOR-dependent mechanisms.  JCI Insight  2017 Aug 03;2(15). doi:10.1172/jci.insight.93230
  12. Shacklett BL, Derdeyn CA, Folayan MO, Landovitz RJ, Anthony C, Behrens AJ, Hope TJ, Landais E, Leal L, Marrazzo JM, Morris L, Mugo N, Ngure K, Noseda V, Ranasinghe S, Tully DC, Voronin Y, Warren M, Wibmer CK, Xie IY, Scarlatti G, Thyagarajan B  HIVR4P 2016, Partnering for Prevention: Conference Summary and Highlights.  AIDS Res Hum Retroviruses  2017 08;33(8):749-759. doi:10.1089/AID.2017.0125
  13. Hope TJ  Upcoming Implementation of NIH Funding Caps Invites Researcher Feedback.  AIDS Res Hum Retroviruses  2017 06;33(6):iii. doi:10.1089/aid.2017.29004.tjh
  14. Cale EM, Gorman J, Radakovich NA, Crooks ET, Osawa K, Tong T, Li J, Nagarajan R, Ozorowski G, Ambrozak DR, Asokan M, Bailer RT, Bennici AK, Chen X, Doria-Rose NA, Druz A, Feng Y, Joyce MG, Louder MK, O'Dell S, Oliver C, Pancera M, Connors M, Hope TJ, Kepler TB, Wyatt RT, Ward AB, Georgiev IS, Kwong PD, Mascola JR, Binley JM  Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop.  Immunity  2017 05 16;46(5):777-791.e10. pii:S1074-7613(17)30176-0
  15. Duan L, McRaven MD, Liu W, Shu X, Hu J, Sun C, Veazey RS, Hope TJ, Zhang HF  Colposcopic imaging using visible-light optical coherence tomography.  J Biomed Opt  2017 05 01;22(5):56003. doi:10.1117/1.JBO.22.5.056003
  16. Xiao S, Coppeta JR, Rogers HB, Isenberg BC, Zhu J, Olalekan SA, McKinnon KE, Dokic D, Rashedi AS, Haisenleder DJ, Malpani SS, Arnold-Murray CA, Chen K, Jiang M, Bai L, Nguyen CT, Zhang J, Laronda MM, Hope TJ, Maniar KP, Pavone ME, Avram MJ, Sefton EC, Getsios S, Burdette JE, Kim JJ, Borenstein JT, Woodruff TK  A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle.  Nat Commun  2017 03 28;8:14584. doi:10.1038/ncomms14584
  17. Hope TJ  Can a Traditional Chinese Medicine Contribute to a Cure for HIV?  AIDS Res Hum Retroviruses  2017 02;33(2):89. doi:10.1089/aid.2017.29001.hop
  18. Chehoud C, Stieh DJ, Bailey AG, Laughlin AL, Allen SA, McCotter KL, Sherrill-Mix SA, Hope TJ, Bushman FD  Associations of the vaginal microbiota with HIV infection, bacterial vaginosis, and demographic factors.  AIDS  2017 04 24;31(7):895-904. doi:10.1097/QAD.0000000000001421
  19. Greene GJ, Swann G, Fought AJ, Carballo-Diéguez A, Hope TJ, Kiser PF, Mustanski B, D'Aquila RT  Preferences for Long-Acting Pre-exposure Prophylaxis (PrEP), Daily Oral PrEP, or Condoms for HIV Prevention Among U.S. Men Who Have Sex with Men.  AIDS Behav  2017 May;21(5):1336-1349. doi:10.1007/s10461-016-1565-9
  20. Carias AM, Allen SA, Fought AJ, Kotnik Halavaty K, Anderson MR, Jimenez ML, McRaven MD, Gioia CJ, Henning TR, Kersh EN, Smith JM, Pereira LE, Butler K, McNicholl SJ, Hendry RM, Kiser PF, Veazey RS, Hope TJ  Increases in Endogenous or Exogenous Progestins Promote Virus-Target Cell Interactions within the Non-human Primate Female Reproductive Tract.  PLoS Pathog  2016 09;12(9):e1005885. doi:10.1371/journal.ppat.1005885
  21. Tay MZ, Liu P, Williams LD, McRaven MD, Sawant S, Gurley TC, Xu TT, Dennison SM, Liao HX, Chenine AL, Alam SM, Moody MA, Hope TJ, Haynes BF, Tomaras GD  Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses.  PLoS Pathog  2016 08;12(8):e1005817. doi:10.1371/journal.ppat.1005817
  22. Dharan A, Talley S, Tripathi A, Mamede JI, Majetschak M, Hope TJ, Campbell EM  KIF5B and Nup358 Cooperatively Mediate the Nuclear Import of HIV-1 during Infection.  PLoS Pathog  2016 06;12(6):e1005700. doi:10.1371/journal.ppat.1005700
  23. Schommers P, Martrus G, Matschl U, Sirignano M, Lütgehetmann M, Richert L, Hope TJ, Fätkenheuer G, Altfeld M  Changes in HIV-1 Capsid Stability Induced by Common Cytotoxic-T-Lymphocyte-Driven Viral Sequence Mutations.  J Virol  2016 08 15;90(16):7579-7586. doi:10.1128/JVI.00867-16
  24. Yildiz-Arslan S, Coon JS, Hope TJ, Kim JJ  Transcriptional Profiling of Human Endocervical Tissues Reveals Distinct Gene Expression in the Follicular and Luteal Phases of the Menstrual Cycle.  Biol Reprod  2016 06;94(6):138. doi:10.1095/biolreprod.116.140327
  25. Cheeseman HM, Carias AM, Evans AB, Olejniczak NJ, Ziprin P, King DF, Hope TJ, Shattock RJ  Expression Profile of Human Fc Receptors in Mucosal Tissue: Implications for Antibody-Dependent Cellular Effector Functions Targeting HIV-1 Transmission.  PLoS One  2016;11(5):e0154656. doi:10.1371/journal.pone.0154656
  26. Mirmonsef P, Hotton AL, Gilbert D, Gioia CJ, Maric D, Hope TJ, Landay AL, Spear GT  Glycogen Levels in Undiluted Genital Fluid and Their Relationship to Vaginal pH, Estrogen, and Progesterone.  PLoS One  2016;11(4):e0153553. doi:10.1371/journal.pone.0153553
  27. Stieh DJ, Matias E, Xu H, Fought AJ, Blanchard JL, Marx PA, Veazey RS, Hope TJ  Th17 Cells Are Preferentially Infected Very Early after Vaginal Transmission of SIV in Macaques.  Cell Host Microbe  2016 Apr 13;19(4):529-40. doi:10.1016/j.chom.2016.03.005
  28. Gunn B, Schneider J, Shansab M, Bastian AR, Fahrbach K, Smith A, Mahan A, Karim M, Licht A, Zvonar I, Tedesco J, Anderson M, Chapel A, Suscovich T, Malaspina D, Streeck H, Walker BD, Kim A, Lauer G, Altfeld M, Pillai S, Szleifer I, Kelleher NL, Kiser PF, Hope TJ, Alter G  Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16.  Mucosal Immunol  2016 11;9(6):1549-1558. doi:10.1038/mi.2016.8
  29. Veazey RS, Pilch-Cooper HA, Hope TJ, Alter G, Carias AM, Sips M, Wang X, Rodriguez B, Sieg SF, Reich A, Wilkinson P, Cameron MJ, Lederman MM  Prevention of SHIV transmission by topical IFN-β treatment.  Mucosal Immunol  2016 11;9(6):1528-1536. doi:10.1038/mi.2015.146
  30. Imam S, Talley S, Nelson RS, Dharan A, O'Connor C, Hope TJ, Campbell EM  TRIM5α Degradation via Autophagy Is Not Required for Retroviral Restriction.  J Virol  2016 Jan 13;90(7):3400-10. doi:10.1128/JVI.03033-15
  31. Mamede JI, Hope TJ  Detection and Tracking of Dual-Labeled HIV Particles Using Wide-Field Live Cell Imaging to Follow Viral Core Integrity.  Methods Mol Biol  2016;1354:49-59. doi:10.1007/978-1-4939-3046-3_4
  32. Hope TJ  VIROLOGY. Visualizing trans-infection.  Science  2015 Oct 30;350(6260):511-2. doi:10.1126/science.aad5409
  33. Hope TJ, Marrazzo JM  A Shot in the Arm for HIV Prevention? Recent Successes and Critical Thresholds.  AIDS Res Hum Retroviruses  2015 Nov;31(11):1055-9. doi:10.1089/AID.2015.0310
  34. Campbell EM, Hope TJ  HIV-1 capsid: the multifaceted key player in HIV-1 infection.  Nat Rev Microbiol  2015 Aug;13(8):471-83. doi:10.1038/nrmicro3503
  35. Archary D, Liebenberg LJ, Werner L, Tulsi S, Majola N, Naicker N, Dlamini S, Hope TJ, Samsunder N, Abdool Karim SS, Morris L, Passmore JA, Garrett NJ  Randomized Cross-Sectional Study to Compare HIV-1 Specific Antibody and Cytokine Concentrations in Female Genital Secretions Obtained by Menstrual Cup and Cervicovaginal Lavage.  PLoS One  2015;10(7):e0131906. doi:10.1371/journal.pone.0131906
  36. Wong RW, Mamede JI, Hope TJ  Impact of Nucleoporin-Mediated Chromatin Localization and Nuclear Architecture on HIV Integration Site Selection.  J Virol  2015 Oct;89(19):9702-5. doi:10.1128/JVI.01669-15
  37. Takeda E, Kono K, Hulme AE, Hope TJ, Nakayama EE, Shioda T  Fluorescent image analysis of HIV-1 and HIV-2 uncoating kinetics in the presence of old world monkey TRIM5α.  PLoS One  2015;10(3):e0121199. doi:10.1371/journal.pone.0121199
  38. Dinh MH, Anderson MR, McRaven MD, Cianci GC, McCoombe SG, Kelley ZL, Gioia CJ, Fought AJ, Rademaker AW, Veazey RS, Hope TJ  Visualization of HIV-1 interactions with penile and foreskin epithelia: clues for female-to-male HIV transmission.  PLoS Pathog  2015 Mar;11(3):e1004729. doi:10.1371/journal.ppat.1004729
  39. Hulme AE, Kelley Z, Foley D, Hope TJ  Complementary Assays Reveal a Low Level of CA Associated with Viral Complexes in the Nuclei of HIV-1-Infected Cells.  J Virol  2015 May;89(10):5350-61. doi:10.1128/JVI.00476-15
  40. Allen SA, Carias AM, Anderson MR, Okocha EA, Benning L, McRaven MD, Kelley ZL, Lurain J, Veazey RS, Hope TJ  Characterization of the Influence of Semen-Derived Enhancer of Virus Infection on the Interaction of HIV-1 with Female Reproductive Tract Tissues.  J Virol  2015 May;89(10):5569-80. doi:10.1128/JVI.00309-15
  41. Chen S, Yi J, Dong B, Sun C, Kiser PF, Hope TJ, Zhang HF  Imaging endocervical mucus anatomy and dynamics in macaque female reproductive track using optical coherence tomography.  Quant Imaging Med Surg  2015 Feb;5(1):40-5. doi:10.3978/j.issn.2223-4292.2014.11.03
  42. Sarma T, Koutsouris A, Yu JZ, Krbanjevic A, Hope TJ, Rasenick MM  Activation of microtubule dynamics increases neuronal growth via the nerve growth factor (NGF)- and Gαs-mediated signaling pathways.  J Biol Chem  2015 Apr 17;290(16):10045-56. doi:10.1074/jbc.M114.630632
  43. Belmadani A, Ren D, Bhattacharyya BJ, Rothwangl KB, Hope TJ, Perlman H, Miller RJ  Identification of a sustained neurogenic zone at the dorsal surface of the adult mouse hippocampus and its regulation by the chemokine SDF-1.  Hippocampus  2015 Nov;25(11):1224-41. doi:10.1002/hipo.22428
  44. Arslan SY, Yu Y, Burdette JE, Pavone ME, Hope TJ, Woodruff TK, Kim JJ  Novel three dimensional human endocervix cultures respond to 28-day hormone treatment.  Endocrinology  2015 Apr;156(4):1602-9. doi:10.1210/en.2014-1840
  45. Tjernlund A, Carias AM, Andersson S, Gustafsson-Sanchez S, Röhl M, Petersson P, Introini A, Hope TJ, Broliden K  Progesterone-based intrauterine device use is associated with a thinner apical layer of the human ectocervical epithelium and a lower ZO-1 mRNA expression.  Biol Reprod  2015 Mar;92(3):68. doi:10.1095/biolreprod.114.122887
  46. Hulme AE, Hope TJ  Live Cell Imaging of Retroviral Entry.  Annu Rev Virol  2014 Nov;1(1):501-15. doi:10.1146/annurev-virology-031413-085502
  47. Hulme AE, Kelley Z, Okocha EA, Hope TJ  Identification of capsid mutations that alter the rate of HIV-1 uncoating in infected cells.  J Virol  2015 Jan;89(1):643-51. doi:10.1128/JVI.03043-14
  48. Stieh DJ, Maric D, Kelley ZL, Anderson MR, Hattaway HZ, Beilfuss BA, Rothwangl KB, Veazey RS, Hope TJ  Vaginal challenge with an SIV-based dual reporter system reveals that infection can occur throughout the upper and lower female reproductive tract.  PLoS Pathog  2014 Oct;10(10):e1004440. doi:10.1371/journal.ppat.1004440
  49. Chang HC, Bayeva M, Taiwo B, Palella FJ, Hope TJ, Ardehali H  Short communication: high cellular iron levels are associated with increased HIV infection and replication.  AIDS Res Hum Retroviruses  2015 Mar;31(3):305-12. doi:10.1089/aid.2014.0169
  50. Carias AM, Hope TJ  Phagocytosis: cell biology view of antiviral function.  Curr Opin HIV AIDS  2014 May;9(3):271-7. doi:10.1097/COH.0000000000000050