Northwestern University Feinberg School of Medicine

Thomas Hope Lab


Learn more about the work that we do in the Farzaneh Sorond Laboratory through our recent publications.

  1. Taylor RA, Xiao S, Carias AM, McRaven MD, Thakkar DN, Araínga M, Allen EJ, Rogers KA, Kumarapperuma SC, Gong S  et al.  PET/CT targeted tissue sampling reveals virus specific dIgA can alter the distribution and localization of HIV after rectal exposure.  PLoS Pathog  2021 Jun 01;17(6):e1009632. doi:10.1371/journal.ppat.1009632
  2. Martin-Sancho L, Lewinski MK, Pache L, Stoneham CA, Yin X, Becker ME, Pratt D, Churas C, Rosenthal SB, Liu S  et al.  Functional landscape of SARS-CoV-2 cellular restriction.  Mol Cell  2021 Apr 13;. pii:S1097-2765(21)00313-0
  3. Romano JW, Baum MM, Demkovich ZR, Diana F, Dobard C, Feldman PL, Garcia-Lerma JG, Grattoni A, Gunawardana M, Ho DK  et al.  Tenofovir Alafenamide for HIV Prevention: Review of the Proceedings from the Gates Foundation Long-Acting TAF Product Development Meeting.  AIDS Res Hum Retroviruses  2021 Jun;37(6):409-420. doi:10.1089/AID.2021.0028
  4. Herrera C, McRaven MD, Laing KG, Dennis J, Hope TJ, Shattock RJ  Early Colorectal Responses to HIV-1 and Modulation by Antiretroviral Drugs.  Vaccines (Basel)  2021 Mar 08;9(3). pii:231
  5. Mamede JI, Griffin J, Gambut S, Hope TJ  A New Generation of Functional Tagged Proteins for HIV Fluorescence Imaging.  Viruses  2021 02 28;13(3). pii:386
  6. Berard AR, Miller C, Araínga M, Broedlow CA, Noël-Romas L, Schifanella L, Hensley-McBain T, Roederer A, Driscoll C, Coronado E  et al.  SIV susceptibility, immunology and microbiome in the female genital tract of adolescent versus adult pigtail macaques.  AIDS Res Hum Retroviruses  2021 Jan 15;. doi:10.1089/AID.2020.0271
  7. Karunakaran D, Simpson SM, Su JT, Bryndza-Tfaily E, Hope TJ, Veazey R, Dobek G, Qiu J, Watrous D, Sung S  et al.  Design and Testing of a Cabotegravir Implant for HIV Prevention.  J Control Release  2021 Feb 10;330:658-668. pii:S0168-3659(20)30748-3
  8. Klein K, Nankya I, Nickel G, Ratcliff AN, Meadows AAJ, Hathaway N, Bailey JA, Stieh DJ, Cheeseman HM, Carias AM  et al.  Deep Gene Sequence Cluster Analyses of Multi-Virus-Infected Mucosal Tissue Reveal Enhanced Transmission of Acute HIV-1.  J Virol  2021 01 13;95(3). pii:e01737-20
  9. Carter SD, Mamede JI, Hope TJ, Jensen GJ  Correlated cryogenic fluorescence microscopy and electron cryo-tomography shows that exogenous TRIM5α can form hexagonal lattices or autophagy aggregates in vivo.  Proc Natl Acad Sci U S A  2020 11 24;117(47):29702-29711. doi:10.1073/pnas.1920323117
  10. Hope TJ, Klatt NR, Sacha JB, Cannon PM  Timothy Ray Brown: The Serendipitous Hero of HIV Cure Research.  AIDS Res Hum Retroviruses  2020 11;36(11):883-885. doi:10.1089/AID.2020.0253
  11. Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M  et al.  Recommendations for measuring HIV reservoir size in cure-directed clinical trials.  Nat Med  2020 09;26(9):1339-1350. doi:10.1038/s41591-020-1022-1
  12. Clerc I, Moussa DA, Vahlas Z, Tardito S, Oburoglu L, Hope TJ, Sitbon M, Dardalhon V, Mongellaz C, Taylor N  Entry of glucose- and glutamine-derived carbons into the citric acid cycle supports early steps of HIV-1 infection in CD4 T cells.  Nat Metab  2019 07;1(7):717-730. doi:10.1038/s42255-019-0084-1
  13. Rael CT, Lentz C, Carballo-Diéguez A, Giguere R, Dolezal C, Feller D, D'Aquila RT, Hope TJ  Understanding the Acceptability of Subdermal Implants as a Possible New HIV Prevention Method: Multi-Stage Mixed Methods Study.  J Med Internet Res  2020 07 27;22(7):e16904. doi:10.2196/16904
  14. Maldonado RJK, Rice B, Chen EC, Tuffy KM, Chiari EF, Fahrbach KM, Hope TJ, Parent LJ  Visualizing Association of the Retroviral Gag Protein with Unspliced Viral RNA in the Nucleus.  mBio  2020 04 07;11(2). pii:e00524-20
  15. Carias AM, Hope TJ  Barriers of Mucosal Entry of HIV/SIV.  Curr Immunol Rev  2019;15(1):4-13. doi:10.2174/1573395514666180604084404
  16. Ventura JD, Beloor J, Allen E, Zhang T, Haugh KA, Uchil PD, Ochsenbauer C, Kieffer C, Kumar P, Hope TJ  et al.  Longitudinal bioluminescent imaging of HIV-1 infection during antiretroviral therapy and treatment interruption in humanized mice.  PLoS Pathog  2019 12;15(12):e1008161. doi:10.1371/journal.ppat.1008161
  17. Schneider JR, Shen X, Orlandi C, Nyanhete T, Sawant S, Carias AM, Smith AD, Kelleher NL, Veazey RS, Lewis GK  et al.  A MUC16 IgG Binding Activity Selects for a Restricted Subset of IgG Enriched for Certain Simian Immunodeficiency Virus Epitope Specificities.  J Virol  2020 02 14;94(5). pii:e01246-19
  18. Rael CT, Martinez M, Giguere R, Bockting W, MacCrate C, Mellman W, Valente P, Greene GJ, Sherman SG, Footer KHA  et al.  Transgender Women's Concerns and Preferences on Potential Future Long-Acting Biomedical HIV Prevention Strategies: The Case of Injections and Implanted Medication Delivery Devices (IMDDs).  AIDS Behav  2020 May;24(5):1452-1462. doi:10.1007/s10461-019-02703-5
  19. Gray CM, O'Hagan KL, Lorenzo-Redondo R, Olivier AJ, Amu S, Chigorimbo-Murefu N, Harryparsad R, Sebaa S, Maziya L, Dietrich J  et al.  Impact of chemokine C-C ligand 27, foreskin anatomy and sexually transmitted infections on HIV-1 target cell availability in adolescent South African males.  Mucosal Immunol  2020 01;13(1):118-127. doi:10.1038/s41385-019-0209-6
  20. Sultana T, Mamede JI, Saito A, Ode H, Nohata K, Cohen R, Nakayama EE, Iwatani Y, Yamashita M, Hope TJ  et al.  Multiple Pathways To Avoid Beta Interferon Sensitivity of HIV-1 by Mutations in Capsid.  J Virol  2019 12 01;93(23). pii:e00986-19
  21. Rael CT, Martinez M, Giguere R, Bockting W, MacCrate C, Mellman W, Valente P, Greene GJ, Sherman SG, Footer KHA  et al.  Knowledge About Oral PrEP Among Transgender Women in New York City.  AIDS Behav  2019 Oct;23(10):2779-2783. doi:10.1007/s10461-019-02584-8
  22. Schönfeld M, Knackmuss U, Chandorkar P, Hörtnagl P, Hope TJ, Moris A, Bellmann-Weiler R, Lass-Flörl C, Posch W, Wilflingseder D  Co- but not Sequential Infection of DCs Boosts Their HIV-Specific CTL-Stimulatory Capacity.  Front Immunol  2019;10:1123. doi:10.3389/fimmu.2019.01123
  23. Buckner LR, Drobnis EZ, Augustine MS, Rogers LK, Akers J, Mott PD, Hope TJ, Quayle AJ, Schust DJ  Cervical and systemic concentrations of long acting hormonal contraceptive (LARC) progestins depend on delivery method: Implications for the study of HIV transmission.  PLoS One  2019;14(5):e0214152. doi:10.1371/journal.pone.0214152
  24. Hensley-McBain T, Wu MC, Manuzak JA, Cheu RK, Gustin A, Driscoll CB, Zevin AS, Miller CJ, Coronado E, Smith E  et al.  Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection.  PLoS Pathog  2019 04;15(4):e1007672. doi:10.1371/journal.ppat.1007672
  25. Dabee S, Barnabas SL, Lennard KS, Jaumdally SZ, Gamieldien H, Balle C, Happel AU, Murugan BD, Williamson AL, Mkhize N  et al.  Defining characteristics of genital health in South African adolescent girls and young women at high risk for HIV infection.  PLoS One  2019;14(4):e0213975. doi:10.1371/journal.pone.0213975
  26. Pollara J, Jones DI, Huffman T, Edwards RW, Dennis M, Li SH, Jha S, Goodman D, Kumar A, LaBranche CC  et al.  Bridging Vaccine-Induced HIV-1 Neutralizing and Effector Antibody Responses in Rabbit and Rhesus Macaque Animal Models.  J Virol  2019 05 15;93(10). pii:e02119-18
  27. Li L, Zhou J, Wang W, Huang L, Tu J, Baiamonte L, Stark M, Mills M, Hope TJ, Drobnis EZ  et al.  Effects of three long-acting reversible contraceptive methods on HIV target cells in the human uterine cervix and peripheral blood.  Reprod Biol Endocrinol  2019 Feb 22;17(1):26. doi:10.1186/s12958-019-0469-8
  28. Tay MZ, Kunz EL, Deal A, Zhang L, Seaton KE, Rountree W, Eudailey JA, Heptinstall J, McRaven MD, Matias E  et al.  Rare Detection of Antiviral Functions of Polyclonal IgA Isolated from Plasma and Breast Milk Compartments in Women Chronically Infected with HIV-1.  J Virol  2019 04 01;93(7). pii:e02084-18
  29. Calder BJ, Schieffer RJ, Bryndza Tfaily E, D'Aquila R, Greene GJ, Carballo-Diéguez A, Giguere R, Kiser PF, Hope TJ  Qualitative Consumer Research on Acceptance of Long-Acting Pre-Exposure Prophylaxis Products Among Men Having Sex with Men and Medical Practitioners in the United States.  AIDS Res Hum Retroviruses  2018 10;34(10):849-856. doi:10.1089/AID.2018.0214
  30. Hope TJ  Inflammation weakens HIV prevention.  Nat Med  2018 04 10;24(4):384-385. doi:10.1038/nm.4534
  31. Wills S, Hwang KK, Liu P, Dennison SM, Tay MZ, Shen X, Pollara J, Lucas JT, Parks R, Rerks-Ngarm S  et al.  HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis.  J Virol  2018 04 01;92(7). pii:e01552-17
  32. Barnabas SL, Dabee S, Passmore JS, Jaspan HB, Lewis DA, Jaumdally SZ, Gamieldien H, Masson L, Muller E, Maseko VD  et al.  Converging epidemics of sexually transmitted infections and bacterial vaginosis in southern African female adolescents at risk of HIV.  Int J STD AIDS  2018 05;29(6):531-539. doi:10.1177/0956462417740487
  33. Carter SD, Mageswaran SK, Farino ZJ, Mamede JI, Oikonomou CM, Hope TJ, Freyberg Z, Jensen GJ  Distinguishing signal from autofluorescence in cryogenic correlated light and electron microscopy of mammalian cells.  J Struct Biol  2018 01;201(1):15-25. pii:S1047-8477(17)30177-6
  34. Mamede JI, Cianci GC, Anderson MR, Hope TJ  Early cytoplasmic uncoating is associated with infectivity of HIV-1.  Proc Natl Acad Sci U S A  2017 08 22;114(34):E7169-E7178. doi:10.1073/pnas.1706245114
  35. Schneider JR, Carias AM, Bastian AR, Cianci GC, Kiser PF, Veazey RS, Hope TJ  Long-term direct visualization of passively transferred fluorophore-conjugated antibodies.  J Immunol Methods  2017 11;450:66-72. pii:S0022-1759(16)30305-2
  36. Planas D, Zhang Y, Monteiro P, Goulet JP, Gosselin A, Grandvaux N, Hope TJ, Fassati A, Routy JP, Ancuta P  HIV-1 selectively targets gut-homing CCR6+CD4+ T cells via mTOR-dependent mechanisms.  JCI Insight  2017 Aug 03;2(15). doi:10.1172/jci.insight.93230
  37. Shacklett BL, Derdeyn CA, Folayan MO, Landovitz RJ, Anthony C, Behrens AJ, Hope TJ, Landais E, Leal L, Marrazzo JM  et al.  HIVR4P 2016, Partnering for Prevention: Conference Summary and Highlights.  AIDS Res Hum Retroviruses  2017 08;33(8):749-759. doi:10.1089/AID.2017.0125
  38. Hope TJ  Upcoming Implementation of NIH Funding Caps Invites Researcher Feedback.  AIDS Res Hum Retroviruses  2017 06;33(6):iii. doi:10.1089/aid.2017.29004.tjh
  39. Cale EM, Gorman J, Radakovich NA, Crooks ET, Osawa K, Tong T, Li J, Nagarajan R, Ozorowski G, Ambrozak DR  et al.  Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop.  Immunity  2017 05 16;46(5):777-791.e10. pii:S1074-7613(17)30176-0
  40. Duan L, McRaven MD, Liu W, Shu X, Hu J, Sun C, Veazey RS, Hope TJ, Zhang HF  Colposcopic imaging using visible-light optical coherence tomography.  J Biomed Opt  2017 05 01;22(5):56003. doi:10.1117/1.JBO.22.5.056003
  41. Xiao S, Coppeta JR, Rogers HB, Isenberg BC, Zhu J, Olalekan SA, McKinnon KE, Dokic D, Rashedi AS, Haisenleder DJ  et al.  A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle.  Nat Commun  2017 03 28;8:14584. doi:10.1038/ncomms14584
  42. Hope TJ  Can a Traditional Chinese Medicine Contribute to a Cure for HIV?  AIDS Res Hum Retroviruses  2017 02;33(2):89. doi:10.1089/aid.2017.29001.hop
  43. Chehoud C, Stieh DJ, Bailey AG, Laughlin AL, Allen SA, McCotter KL, Sherrill-Mix SA, Hope TJ, Bushman FD  Associations of the vaginal microbiota with HIV infection, bacterial vaginosis, and demographic factors.  AIDS  2017 04 24;31(7):895-904. doi:10.1097/QAD.0000000000001421
  44. Greene GJ, Swann G, Fought AJ, Carballo-Diéguez A, Hope TJ, Kiser PF, Mustanski B, D'Aquila RT  Preferences for Long-Acting Pre-exposure Prophylaxis (PrEP), Daily Oral PrEP, or Condoms for HIV Prevention Among U.S. Men Who Have Sex with Men.  AIDS Behav  2017 May;21(5):1336-1349. doi:10.1007/s10461-016-1565-9
  45. Carias AM, Allen SA, Fought AJ, Kotnik Halavaty K, Anderson MR, Jimenez ML, McRaven MD, Gioia CJ, Henning TR, Kersh EN  et al.  Increases in Endogenous or Exogenous Progestins Promote Virus-Target Cell Interactions within the Non-human Primate Female Reproductive Tract.  PLoS Pathog  2016 09;12(9):e1005885. doi:10.1371/journal.ppat.1005885
  46. Tay MZ, Liu P, Williams LD, McRaven MD, Sawant S, Gurley TC, Xu TT, Dennison SM, Liao HX, Chenine AL  et al.  Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses.  PLoS Pathog  2016 08;12(8):e1005817. doi:10.1371/journal.ppat.1005817
  47. Dharan A, Talley S, Tripathi A, Mamede JI, Majetschak M, Hope TJ, Campbell EM  KIF5B and Nup358 Cooperatively Mediate the Nuclear Import of HIV-1 during Infection.  PLoS Pathog  2016 06;12(6):e1005700. doi:10.1371/journal.ppat.1005700
  48. Schommers P, Martrus G, Matschl U, Sirignano M, Lütgehetmann M, Richert L, Hope TJ, Fätkenheuer G, Altfeld M  Changes in HIV-1 Capsid Stability Induced by Common Cytotoxic-T-Lymphocyte-Driven Viral Sequence Mutations.  J Virol  2016 08 15;90(16):7579-7586. doi:10.1128/JVI.00867-16
  49. Yildiz-Arslan S, Coon JS, Hope TJ, Kim JJ  Transcriptional Profiling of Human Endocervical Tissues Reveals Distinct Gene Expression in the Follicular and Luteal Phases of the Menstrual Cycle.  Biol Reprod  2016 06;94(6):138. doi:10.1095/biolreprod.116.140327
  50. Cheeseman HM, Carias AM, Evans AB, Olejniczak NJ, Ziprin P, King DF, Hope TJ, Shattock RJ  Expression Profile of Human Fc Receptors in Mucosal Tissue: Implications for Antibody-Dependent Cellular Effector Functions Targeting HIV-1 Transmission.  PLoS One  2016;11(5):e0154656. doi:10.1371/journal.pone.0154656