Publications
Learn more about the work that we do in the Hope Laboratory through our recent publications.
- Becker ME, Martin-Sancho L, Simons LM, McRaven MD, Chanda SK, Hultquist JF, Hope TJ Live imaging of airway epithelium reveals that mucociliary clearance modulates SARS-CoV-2 spread. Nat Commun 2024 Nov 02;15(1):9480. pii:9480
- Kim J, Bose D, Araínga M, Haque MR, Fennessey CM, Caddell RA, Thomas Y, Ferrell DE, Ali S, Grody E et al. Publisher Correction: TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo. Nat Commun 2024 Oct 10;15(1):8787. pii:8787
- Tagliaferri Rael C, Giguere R, Bryndza Tfaily E, Sutton S, Horn E, Schieffer RJ, Hendrix C, D'Aquila RT, Hope TJ The Global Impact of Diversifying PrEP Options: Results of an International Discrete Choice Experiment of Existing and Potential PrEP Strategies with Gay and Bisexual Men and Physicians. AIDS Res Hum Retroviruses 2024 Oct;40(10):591-605. doi:10.1089/AID.2023.0120
- Taylor RA, Xiao S, Carias AM, McRaven MD, Thakkar DN, Araínga M, Lorenzo-Redondo R, Allen EJ, Rogers KA, Kumarapperuma SC et al. PET/CT Targeted Tissue Sampling Reveals Intravenously Administered HGN194 IgG1 Affects HIV Distribution after Rectal Exposure. AIDS Res Hum Retroviruses 2024 Aug 28;. doi:10.1089/AID.2024.0019
- Kim J, Bose D, Araínga M, Haque MR, Fennessey CM, Caddell RA, Thomas Y, Ferrell DE, Ali S, Grody E et al. TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo. Nat Commun 2024 Feb 14;15(1):1348. pii:1348
- Gambut S, Hope TJ, Mamede JI Infectious Virus Tracking by Fluorescent Live Cell Imaging in Primary Cells. Methods Mol Biol 2024;2807:3-14. doi:10.1007/978-1-0716-3862-0_1
- Kime J, Bose D, Arainga M, Haque MR, Fennessey CM, Caddell RA, Thomas Y, Ferrell DE, Ali S, Grody E et al. TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo. bioRxiv 2023 Dec 15;. pii:2023.09.05.556422
- Samer S, Thomas Y, Araínga M, Carter C, Shirreff LM, Arif MS, Avita JM, Frank I, McRaven MD, Thuruthiyil CT et al. Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo. JCI Insight 2023 Nov 22;8(22). pii:e176882
- Vaidyanathan A, Taylor HE, Hope TJ, D'Aquila RT, Bartom ET, Hultquist JF, Peter ME Analysis of the Contribution of 6-mer Seed Toxicity to HIV-1-Induced Cytopathicity. J Virol 2023 Jul 27;97(7):e0065223. pii:e00652-23
- Williams LD, Shen X, Sawant SS, Akapirat S, Dahora LC, Tay MZ, Stanfield-Oakley S, Wills S, Goodman D, Tenney D et al. Viral vector delivered immunogen focuses HIV-1 antibody specificity and increases durability of the circulating antibody recall response. PLoS Pathog 2023 May;19(5):e1011359. pii:e1011359
- Maric D, Corbin L, Greco N, Lorenzo-Redondo R, McRaven MD, Veazey RS, Hope TJ Temporal and spatial characterization of HIV/SIV infection at anorectal mucosa using rhesus macaque rectal challenge model. bioRxiv 2023 Feb 23;. pii:2023.02.22.529624
- Ash MK, Bhimalli PP, Cho BK, Mattamana BB, Gambut S, Tarhoni I, Fhied CL, Reyes AF, Welninski SJ, Arivalagan J et al. Bulk IgG glycosylation predicts COVID-19 severity and vaccine antibody response. Cell Rep 2022 Dec 13;41(11):111799. doi:10.1016/j.celrep.2022.111799
- Tagliaferri Rael C, Giguere R, Sutton S, Horn E, Schieffer RJ, Greene GJ, D'Aquila R, Bryndza Tfaily E, Kiser PF, Hope TJ Preferences Among Physicians and Men Who Have Sex with Men (MSM) for a Long-Acting, Removable Implant for HIV Prevention: A Discrete Choice Study. AIDS Res Hum Retroviruses 2022 Dec;38(12):898-908. doi:10.1089/AID.2022.0035
- Samer S, Thomas Y, Araínga M, Carter C, Shirreff LM, Arif MS, Avita JM, Frank I, McRaven MD, Thuruthiyil CT et al. Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo. JCI Insight 2022 Nov 08;7(21). pii:e162290
- Yoh SM, Mamede JI, Lau D, Ahn N, Sánchez-Aparicio MT, Temple J, Tuckwell A, Fuchs NV, Cianci GC, Riva L et al. Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA. Mol Cell 2022 Aug 04;82(15):2871-2884.e6. doi:10.1016/j.molcel.2022.06.010
- Madden PJ, Thomas Y, Blair RV, Samer S, Doyle M, Midkiff CC, Doyle-Meyers LA, Becker ME, Arif MS, McRaven MD et al. An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques. Res Sq 2022 Apr 08;. pii:rs.3.rs-1479315
- Schieffer RJ, Bryndza Tfaily E, D'Aquila R, Greene GJ, Carballo-Diéguez A, Giguere R, Tagliaferri Rael C, Kiser PF, Hope TJ Conjoint Analysis of User Acceptability of Sustained Long-Acting Pre-Exposure Prophylaxis for HIV. AIDS Res Hum Retroviruses 2022 Apr;38(4):336-345. doi:10.1089/AID.2021.0075
- Madden PJ, Thomas Y, Blair RV, Samer S, Doyle M, Midkiff CC, Doyle-Meyers LA, Becker ME, Arif MS, McRaven MD et al. An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques. bioRxiv 2022 Mar 23;. pii:2022.02.25.481974
- El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A et al. Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2. Nat Commun 2022 Jan 20;13(1):405. pii:405
- Buchanan LB, Shao Z, Jiang YC, Lai A, Hope TJ, Carias AM, Prodger JL Quantitative Immunofluorescent Imaging of Immune Cells in Mucosal Tissues. Methods Mol Biol 2022;2440:143-164. doi:10.1007/978-1-0716-2051-9_9
- Madden PJ, Arif MS, Becker ME, McRaven MD, Carias AM, Lorenzo-Redondo R, Xiao S, Midkiff CC, Blair RV, Potter EL et al. Development of an In Vivo Probe to Track SARS-CoV-2 Infection in Rhesus Macaques. Front Immunol 2021;12:810047. pii:810047
- Nyanhete TE, Edwards RJ, LaBranche CC, Mansouri K, Eaton A, Dennison SM, Saunders KO, Goodman D, Janowska K, Spreng RL et al. Polyclonal Broadly Neutralizing Antibody Activity Characterized by CD4 Binding Site and V3-Glycan Antibodies in a Subset of HIV-1 Virus Controllers. Front Immunol 2021;12:670561. pii:670561
- Rael CT, Lopez-Ríos J, McKenna SA, Das D, Dolezal C, Abascal E, Carballo-Diéguez A, Schnall R, Hope TJ, Bauermeister J et al. Transgender Women's Barriers, Facilitators, and Preferences on Tailored Injection Delivery Strategies to Administer Long-Acting Injectable Cabotegravir (CAB-LA) for HIV Pre-exposure Prophylaxis (PrEP). AIDS Behav 2021 Dec;25(12):4180-4192. doi:10.1007/s10461-021-03357-y
- Beddingfield BJ, Maness NJ, Fears AC, Rappaport J, Aye PP, Russell-Lodrigue K, Doyle-Meyers LA, Blair RV, Carias AM, Madden PJ et al. Effective Prophylaxis of COVID-19 in Rhesus Macaques Using a Combination of Two Parenterally-Administered SARS-CoV-2 Neutralizing Antibodies. Front Cell Infect Microbiol 2021;11:753444. pii:753444
- Taylor RA, McRaven MD, Carias AM, Anderson MR, Matias E, Araínga M, Allen EJ, Rogers KA, Gupta S, Kulkarni V et al. Localization of infection in neonatal rhesus macaques after oral viral challenge. PLoS Pathog 2021 Nov;17(11):e1009855. pii:e1009855
- Maric D, Grimm WA, Greco N, McRaven MD, Fought AJ, Veazey RS, Hope TJ Th17 T Cells and Immature Dendritic Cells Are the Preferential Initial Targets after Rectal Challenge with a Simian Immunodeficiency Virus-Based Replication-Defective Dual-Reporter Vector. J Virol 2021 Sep 09;95(19):e0070721. pii:e00707-21
- Frank I, Cigoli M, Arif MS, Fahlberg MD, Maldonado S, Calenda G, Pegu A, Yang ES, Rawi R, Chuang GY et al. Blocking α4β7 integrin delays viral rebound in SHIVSF162P3-infected macaques treated with anti-HIV broadly neutralizing antibodies. Sci Transl Med 2021 Aug 18;13(607). pii:eabf7201
- Carias AM, Schneider JR, Madden P, Lorenzo-Redondo R, Araínga M, Pegu A, Cianci GC, Maric D, Villinger F, Mascola JR et al. Anatomic Distribution of Intravenously Injected IgG Takes Approximately 1 Week to Achieve Stratum Corneum Saturation in Vaginal Tissues. J Immunol 2021 Jul 15;207(2):505-511. doi:10.4049/jimmunol.2100253
- Berard AR, Miller C, Araínga M, Broedlow CA, Noël-Romas L, Schifanella L, Hensley-McBain T, Roederer A, Driscoll CB, Coronado E et al. Simian Immunodeficiency Virus Susceptibility, Immunology, and Microbiome in the Female Genital Tract of Adolescent Versus Adult Pigtail Macaques. AIDS Res Hum Retroviruses 2021 Jul;37(7):510-522. doi:10.1089/AID.2020.0271
- Martin-Sancho L, Lewinski MK, Pache L, Stoneham CA, Yin X, Becker ME, Pratt D, Churas C, Rosenthal SB, Liu S et al. Functional landscape of SARS-CoV-2 cellular restriction. Mol Cell 2021 Jun 17;81(12):2656-2668.e8. doi:10.1016/j.molcel.2021.04.008
- Taylor RA, Xiao S, Carias AM, McRaven MD, Thakkar DN, Araínga M, Allen EJ, Rogers KA, Kumarapperuma SC, Gong S et al. PET/CT targeted tissue sampling reveals virus specific dIgA can alter the distribution and localization of HIV after rectal exposure. PLoS Pathog 2021 Jun;17(6):e1009632. pii:e1009632
- Romano JW, Baum MM, Demkovich ZR, Diana F, Dobard C, Feldman PL, Garcia-Lerma JG, Grattoni A, Gunawardana M, Ho DK et al. Tenofovir Alafenamide for HIV Prevention: Review of the Proceedings from the Gates Foundation Long-Acting TAF Product Development Meeting. AIDS Res Hum Retroviruses 2021 Jun;37(6):409-420. doi:10.1089/AID.2021.0028
- Pollara J, Tay MZ, Edwards RW, Goodman D, Crowley AR, Edwards RJ, Easterhoff D, Conley HE, Hoxie T, Gurley T et al. Functional Homology for Antibody-Dependent Phagocytosis Across Humans and Rhesus Macaques. Front Immunol 2021;12:678511. pii:678511
- Herrera C, McRaven MD, Laing KG, Dennis J, Hope TJ, Shattock RJ Early Colorectal Responses to HIV-1 and Modulation by Antiretroviral Drugs. Vaccines (Basel) 2021 Mar 08;9(3). pii:231
- Mamede JI, Griffin J, Gambut S, Hope TJ A New Generation of Functional Tagged Proteins for HIV Fluorescence Imaging. Viruses 2021 Feb 28;13(3). pii:386
- Karunakaran D, Simpson SM, Su JT, Bryndza-Tfaily E, Hope TJ, Veazey R, Dobek G, Qiu J, Watrous D, Sung S et al. Design and Testing of a Cabotegravir Implant for HIV Prevention. J Control Release 2021 Feb 10;330:658-668. doi:10.1016/j.jconrel.2020.12.024
- Klein K, Nankya I, Nickel G, Ratcliff AN, Meadows AAJ, Hathaway N, Bailey JA, Stieh DJ, Cheeseman HM, Carias AM et al. Deep Gene Sequence Cluster Analyses of Multi-Virus-Infected Mucosal Tissue Reveal Enhanced Transmission of Acute HIV-1. J Virol 2021 Jan 13;95(3). pii:e01737-20
- Carter SD, Mamede JI, Hope TJ, Jensen GJ Correlated cryogenic fluorescence microscopy and electron cryo-tomography shows that exogenous TRIM5α can form hexagonal lattices or autophagy aggregates in vivo. Proc Natl Acad Sci U S A 2020 Nov 24;117(47):29702-29711. doi:10.1073/pnas.1920323117
- Hope TJ, Klatt NR, Sacha JB, Cannon PM Timothy Ray Brown: The Serendipitous Hero of HIV Cure Research. AIDS Res Hum Retroviruses 2020 Nov;36(11):883-885. doi:10.1089/AID.2020.0253
- Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M et al. Recommendations for measuring HIV reservoir size in cure-directed clinical trials. Nat Med 2020 Sep;26(9):1339-1350. doi:10.1038/s41591-020-1022-1
- Rael CT, Lentz C, Carballo-Diéguez A, Giguere R, Dolezal C, Feller D, D'Aquila RT, Hope TJ Understanding the Acceptability of Subdermal Implants as a Possible New HIV Prevention Method: Multi-Stage Mixed Methods Study. J Med Internet Res 2020 Jul 27;22(7):e16904. pii:e16904
- Rael CT, Martinez M, Giguere R, Bockting W, MacCrate C, Mellman W, Valente P, Greene GJ, Sherman SG, Footer KHA et al. Transgender Women's Concerns and Preferences on Potential Future Long-Acting Biomedical HIV Prevention Strategies: The Case of Injections and Implanted Medication Delivery Devices (IMDDs). AIDS Behav 2020 May;24(5):1452-1462. doi:10.1007/s10461-019-02703-5
- Maldonado RJK, Rice B, Chen EC, Tuffy KM, Chiari EF, Fahrbach KM, Hope TJ, Parent LJ Visualizing Association of the Retroviral Gag Protein with Unspliced Viral RNA in the Nucleus. mBio 2020 Apr 07;11(2). pii:e00524-20
- Schneider JR, Shen X, Orlandi C, Nyanhete T, Sawant S, Carias AM, Smith AD, Kelleher NL, Veazey RS, Lewis GK et al. A MUC16 IgG Binding Activity Selects for a Restricted Subset of IgG Enriched for Certain Simian Immunodeficiency Virus Epitope Specificities. J Virol 2020 Feb 14;94(5). pii:e01246-19
- Gray CM, O'Hagan KL, Lorenzo-Redondo R, Olivier AJ, Amu S, Chigorimbo-Murefu N, Harryparsad R, Sebaa S, Maziya L, Dietrich J et al. Impact of chemokine C-C ligand 27, foreskin anatomy and sexually transmitted infections on HIV-1 target cell availability in adolescent South African males. Mucosal Immunol 2020 Jan;13(1):118-127. doi:10.1038/s41385-019-0209-6
- Ventura JD, Beloor J, Allen E, Zhang T, Haugh KA, Uchil PD, Ochsenbauer C, Kieffer C, Kumar P, Hope TJ et al. Longitudinal bioluminescent imaging of HIV-1 infection during antiretroviral therapy and treatment interruption in humanized mice. PLoS Pathog 2019 Dec;15(12):e1008161. pii:e1008161
- Sultana T, Mamede JI, Saito A, Ode H, Nohata K, Cohen R, Nakayama EE, Iwatani Y, Yamashita M, Hope TJ et al. Multiple Pathways To Avoid Beta Interferon Sensitivity of HIV-1 by Mutations in Capsid. J Virol 2019 Dec 01;93(23). pii:e00986-19
- Rael CT, Martinez M, Giguere R, Bockting W, MacCrate C, Mellman W, Valente P, Greene GJ, Sherman SG, Footer KHA et al. Knowledge About Oral PrEP Among Transgender Women in New York City. AIDS Behav 2019 Oct;23(10):2779-2783. doi:10.1007/s10461-019-02584-8
- Clerc I, Moussa DA, Vahlas Z, Tardito S, Oburoglu L, Hope TJ, Sitbon M, Dardalhon V, Mongellaz C, Taylor N Entry of glucose- and glutamine-derived carbons into the citric acid cycle supports early steps of HIV-1 infection in CD4 T cells. Nat Metab 2019 Jul;1(7):717-730. doi:10.1038/s42255-019-0084-1
- Schönfeld M, Knackmuss U, Chandorkar P, Hörtnagl P, Hope TJ, Moris A, Bellmann-Weiler R, Lass-Flörl C, Posch W, Wilflingseder D Co- but not Sequential Infection of DCs Boosts Their HIV-Specific CTL-Stimulatory Capacity. Front Immunol 2019;10:1123. pii:1123