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Lab Members

Meet the Hope Lab team members. We welcome requests for information about our work and collaboration opportunities.


Principal Investigator

Thomas Hope

Thomas Hope, PhD

Professor of Cell and Developmental Biology, McCormick School of Engineering and Obstetrics and Gynecology

thope( at )

BS Biochemistry, Genetics & Development, University of Illinois Urbana-Champaign, 1983 PhD Immunology, University of California, Berkeley, 1988

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Research Associate Professor

Ann Marie Carias

Ann Marie Carias , PhD (Purple)

Research Professor of Cell and Developmental Biology

a-carias( at )

PhD, Northwestern University

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In short, I utilize non-human primate and human tissue models to assess male to female mucosal HIV transmission and broadly neutralizing antibody localization and distribution. I am especially interested in the potential mechanisms of how high progesterone environments affect both HIV transmission and in vivo antibody distribution.

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Research Assistant Professor

Ramon Lorenzo Redondo

Ramon Lorenzo Redondo, PhD

Assistant Professor of Medicine (Infectious Diseases)

ramon.lorenzo( at )

PhD, Universidad Autonoma de Madrid

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My work combines virology and evolutionary biology to study viral evolution and the interaction between viruses and the host during infection. My main interests are RNA viruses, molecular evolution, and genomics. The ultimate goal of my research is to understand the virus-host system and its evolutionary properties in order to develop the best treatments and prevention strategies for human viral infections. During my career, I have led published studies on the evolution of HIV-1 and contributed greatly to the field of RNA virus host-virus genetics. I utilize state-of-the-art sequencing technologies and a combination of evolutionary biology, bioinformatics, statistical modeling, complex data analysis, and phylogenetics to answer fundamental questions about viral population dynamics and viral interaction with the host. I am the director of bioinformatics of the Northwestern University Center for Pathogen Genomics and Microbial Evolution (CPGME) and a faculty member of Northwestern’s Institute of Global Health, the Third Coast Center for AIDS Research (TC CFAR), and the Buehler Center for Health Policy and Economics. I am involved in several fascinating projects focused on intra-host viral evolution, virus-host interaction, and viral population dynamics.

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Postdoctoral Fellows

Shoaib Arif

Shoaib Arif, PhD

shoaib.arif( at )

I am interested in identifying the HIV infected cells phenotypes during early days of infection and how the phenotypes change overtime leading to systemic infection. Since these studies are impossible in humans, we utilize rhesus macaque models to study virus transmission, persistence and rebound after treatment interruption. I am also involved in optimizing the workflow of PET/CT guided spatial transcriptomics utilizing 10x genomics platform to get insights into the tissue microenvironment harboring SIV-infected cells.

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K.M. Rifat Faysal

K.M. Rifat Faysal, PhD

kfaysal( at )

My work focuses on understanding the HIV capsid behavior that leads to a productive infection pathway. In my research I apply different physical and life sciences techniques and use the skills I achieved during my PhD work on developing HIV capsid stability assay to investigate the effect of drugs and small molecules.

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Muhammad R. Haque

Muhammad R. Haque, PhD

muhammad.haque( at )

In the field of HIV research, a major hurdle in eradicating the virus lies in the presence of the latent viral reservoir. My primary objective is to locate and quantify this reservoir, using innovative techniques and approaches. By understanding its characteristics and behavior, I strive to develop effective strategies that can ultimately lead to the elimination of the latent viral reservoir and contribute to the advancement of HIV treatment and prevention.

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MD  Hashem

MD Hashem, PhD

md.hashem( at )

I am working on the early lifecycle of HIV-1 transport. In my research, I utilize advanced imaging techniques such as confocal microscopy and platinum replica electron microscopy as well as several cellular approaches. By using all these strategies, I contribute to a better understanding of early events in the HIV-1 lifecycle, which can inform the development of new antiviral strategies and treatments.

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Ryan Moriarty

Ryan Moriarty, PhD

ryan.moriarty( at )

My work focuses on understanding early events in SIV reservoir establishment and viral rebound dynamics. In my research I utilize various imaging techniques and build up on the skills I gained during my PhD which include application of deep-sequencing techniques and molecularly barcoded pathogens to evaluate viral and mycobacterial population dynamics in nonhuman primates, specifically focusing on SIV/Mtb co-infection and post-treatment control of SIV.

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Thatiane  Russo

Thatiane Russo, PhD

thatiane.russo( at )

I am working in a virology field, specifically HIV-1. In my research, I utilize deconvolution and super-resolution microscopy as well as several lab techniques to analyze human and macaque tissues and biopsies. I am involved in analysis of shave-biopsy of glans, foreskin and shaft from two uninfected groups of living donors, circumcised and uncircumcised men. As the tissue samples were infected post collection with PA GFP-HIV-1 labelled Bal virus I am able to use deconvolution microscopy for virion count, proportion and depth of viral penetration. I also analyze immunofluorescence images of potential HIV-1 target cells in these tissues such as CD4+, CD3+ and CCR10+. My research contributes to a better understanding of how circumcision can change the barrier function of glans and shaft epithelium, as well as can decrease of HIV-1 acquisition in circumcised men.

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Yanique Thomas

Yanique Thomas, PhD

yanique.thomas( at )

I conduct positron emission tomography and computed tomography (PET/CT) analyses for various research projects, including studies on the dynamics of SIV infections from virus challenge, through long-term ART treatment, and viral rebound after ART cessation, utilizing a PET/CT 64Cu-FAB2 probe (7D3) in a rhesus macaque model. In these studies, a PET/CT-guided necropsy is used to direct the isolation of tissue samples containing infected cells for further analyses such as quantitative-PCR and immunofluorescence. I develop and utilize methods to quantitatively analyze the PET signals and to follow the establishment and progression of a viral reservoir within the whole body of an animal. I am also involved in a project focused on using 89Zr based PET/CT to visualize, quantify, and compare the biodistribution of broadly neutralizing antibodies in a whole-body rhesus macaque model. My portion of this work focuses on long-term, iterative imaging of an animal following antibody treatment, observing the distribution, accumulation, and rates of elimination of the radio-labeled antibodies.

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Graduate Students

Mark Becker

Mark Becker

m.becker( at )

I use live imaging of differentiated primary human airway epithelium cultures to study how mucociliary clearance shapes SARS-CoV-2 infection.

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Mohammad Anwar Siddique

Mohammad Anwar Siddique

MohammadSiddique2025( at )

My work focuses on understanding the kinetics and dynamics of Human Immunodeficiency Virus-1 (HIV-1) during the early stages of its life cycle. Using various cell biology approaches, I am investigating how the host cell microenvironment influences the rate and extent of post-entry events in HIV-1, such as the kinetics and dynamics of reverse transcription and capsid core uncoating.

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Claudia Carol Stroupe

Claudia Carol Stroupe

claudia.stroupe( at )

My research focuses on understanding the potential of the broadly neutralizing antibody ePGDM1400v9 to prevent HIV infection. I am evaluating the biodistribution and pharmacokinetics of ePGDM1400v9 and assessing how posttranslational modifications including glycosylation and Fc deletion alter antibody trafficking in the African Green Monkey model. I am also analyzing the relationship between the high-progesterone environment created during pregnancy and alterations to immune cell populations such as Th17 cells and mast cells by comparing intraepithelial ectocervical and vaginal tissues from pregnant and non-pregnant women.

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Kameron  Walker

Kameron Walker

kameron.walker( at )

I focus on understanding the modulation of mast cell environment by HIV proteins. I study changes in proliferation and inflammatory expression of mast cells as well as I`m interested in the use of mast cell therapies to relieve viral load and target the potential source of inflammation.

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Undergraduate Students

Sean Pascoe

Sean Pascoe

SeanPascoe2024( at )

My research is focused on using bioinformatic tools to help determine the roles of heterogeneous immune cell types in HIV infection in tissue. By using data from immunofluorescence and spatial transcriptomic assays, I aim to find meaningful patterns which have the potential to revolutionize our understanding of how HIV and SIV interact with the immune system outside of the blood. I am also interested in developing a method to fluorescently label cells that have integrated SIV DNA with an endonuclease-deficient Cas9 system.

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Lab Manager

Mike McRaven

Mike McRaven

m-mcraven( at )

Technical Staff

Ewa  Tfaily

Ewa Tfaily, PhD

Research Program Manager

ewa.tfaily( at )

Research Staff

Ed Allen

Ed Allen

Senior Research Technologist

edward.allen( at )

Flora Engelmann

Flora Engelmann

Research Technologist 3

flora.engelmann( at )

Amanda Kesler

Research Technologist 2

amanda.carey( at )

Christopher Thuruthiyil

Research Technologist 3

christopher.thuruthiyil( at )

Mary West

Research Technologist 2

mary.west( at )


Eileen Porter

Eileen Porter

Program Assistant 4

eileen.porter( at )