Publications

1. Kuehnle N, Osborne SM, Liang Z, Manzano M, Gottwein E  CRISPR screens identify novel regulators of cFLIP dependency and ligand-independent, TRAIL-R1-mediated cell death.  Cell Death Differ  2023 May;30(5):1221-1234. doi:10.1038/s41418-023-01133-0
2. Kuehnle N, Gottwein E  Druggable host gene dependencies in primary effusion lymphoma.  Curr Opin Virol  2022 Sep 28;56:101270. doi:10.1016/j.coviro.2022.101270
3. Wang C, Zhang L, Ke L, Ding W, Jiang S, Li D, Narita Y, Hou I, Liang J, Li S  et al.  Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors.  Nat Commun  2020 Dec 09;11(1):6318. pii:6318
4. Manzano M, Günther T, Ju H, Nicholas J, Bartom ET, Grundhoff A, Gottwein E  Kaposi's Sarcoma-Associated Herpesvirus Drives a Super-Enhancer-Mediated Survival Gene Expression Program in Primary Effusion Lymphoma.  mBio  2020 Aug 25;11(4). pii:e01457-20
5. Morrison K, Manzano M, Chung K, Schipma MJ, Bartom ET, Gottwein E  The Oncogenic Kaposi's Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family.  Cell Rep  2019 Dec 03;29(10):2961-2969.e6. doi:10.1016/j.celrep.2019.11.005
6. Patil A, Manzano M, Gottwein E  Genome-wide CRISPR screens reveal genetic mediators of cereblon modulator toxicity in primary effusion lymphoma.  Blood Adv  2019 Jul 23;3(14):2105-2117. doi:10.1182/bloodadvances.2019031732
7. Manzano M, Patil A, Waldrop A, Dave SS, Behdad A, Gottwein E  Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma.  Nat Commun  2018 Aug 15;9(1):3263. pii:3263
8. Patil A, Manzano M, Gottwein E  CK1α and IRF4 are essential and independent effectors of immunomodulatory drugs in primary effusion lymphoma.  Blood  2018 Aug 09;132(6):577-586. doi:10.1182/blood-2018-01-828418