Northwestern University Feinberg School of Medicine

Eva Gottwein Lab

About Our Lab

Our goal is to understand Kaposi’s Sarcoma-associated herpesvirus (KSHV) in the context of viral oncogenesis. Our main areas of investigation are mechanisms of KSHV-associated B cell transformation, mechanisms of KSHV-associated endothelial cell deregulation, the identification of drug targets for novel therapeutic strategies to treat KSHV-associated cancers, and targets and functions of KSHV-encoded microRNAs.

Selected Publications

Manzano M, Günther T, Ju H, Nicholas J, Bartom ET, Grundhoff A, Gottwein E  Kaposi's Sarcoma-Associated Herpesvirus Drives a Super-Enhancer-Mediated Survival Gene Expression Program in Primary Effusion Lymphoma.  mBio  2020 Aug 25;11(4). pii:e01457-20

Morrison K, Manzano M, Chung K, Schipma MJ, Bartom ET, Gottwein E  The Oncogenic Kaposi's Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family.  Cell Rep  2019 12 03;29(10):2961-2969.e6. pii:S2211-1247(19)31476-7

Patil A, Manzano M, Gottwein E  Genome-wide CRISPR screens reveal genetic mediators of cereblon modulator toxicity in primary effusion lymphoma.Blood Adv  2019 Jul 23;3(14):2105-2117. doi:10.1182/bloodadvances.2019031732

Manzano M, Patil A, Waldrop A, Dave SS, Behdad A, Gottwein E  Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma.Nat Commun  2018 08 15;9(1):3263. doi:10.1038/s41467-018-05506-9

Patil A, Manzano M, Gottwein E  CK1α and IRF4 are essential and independent effectors of immunomodulatory drugs in primary effusion lymphoma.Blood  2018 08 09;132(6):577-586. doi:10.1182/blood-2018-01-828418

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Eva Gottwein, PhD

Eva Gottwein, PhD
Associate Professor in Microbiology-Immunology

For more information, click here to visit our department page.

Postdoctoral Positions Available

Interested candidates with good scientific accomplishment are encouraged to apply. Your application should contain a short cover letter (0.5-1 page, stating yourarea of interest), three references with contact information, a CV, and bibliography. For more information click here.