Northwestern University Feinberg School of Medicine

Duncan Lab


Learn more about the work that we do in the Duncan laboratory through our recent publications.

  1. Duncan FE, Romar R, Gadea J, Kimelman D, Wallach HD, Woodruff TK, Jiménez-Movilla M  The use of a virtual journal club to promote cross-cultural learning in the reproductive sciences.  J Assist Reprod Genet  2018 Sep 24;. doi:10.1007/s10815-018-1309-z
  2. Chen ZJ, Hitt KM, Roh HH, Salas C, Hornick J, Duncan FE  Tubulin heterogeneity and spatial arrangement of the mouse meiotic spindle.  Mol Reprod Dev  2018 Sep 14;. doi:10.1002/mrd.23060
  3. Grover AR, Kimler BF, Duncan FE  Use of a Small Animal Radiation Research Platform (SARRP) facilitates analysis of systemic versus targeted radiation effects in the mouse ovary.  J Ovarian Res  2018 Aug 30;11(1):72. doi:10.1186/s13048-018-0442-8
  4. Ataman LM, Ma Y, Duncan FE, Uzzi B, Woodruff TK  Quantifying the growth of oncofertility.  Biol Reprod  2018 Aug 01;99(2):263-265. doi:10.1093/biolre/ioy068
  5. Manuel SL, Johnson BW, Frevert CW, Duncan FE  Revisiting the scientific method to improve rigor and reproducibility of immunohistochemistry in reproductive science.  Biol Reprod  2018 Apr 21;. doi:10.1093/biolre/ioy094
  6. Kimler BF, Briley SM, Johnson BW, Armstrong AG, Jasti S, Duncan FE  Radiation-induced ovarian follicle loss occurs without overt stromal changes.  Reproduction  2018 06;155(6):553-562. doi:10.1530/REP-18-0089
  7. Duncan FE, Gerton JL  Mammalian oogenesis and female reproductive aging.  Aging (Albany NY)  2018 Feb 05;10(2):162-163. doi:10.18632/aging.101381
  8. Armstrong AG, Kimler BF, Smith BM, Woodruff TK, Pavone ME, Duncan FE  Ovarian tissue cryopreservation in young females through the Oncofertility Consortium's National Physicians Cooperative.  Future Oncol  2018 Feb;14(4):363-378. doi:10.2217/fon-2017-0410
  9. Tao X, Landis JN, Krisher RL, Duncan FE, Silva E, Lonczak A, Scott RT, Zhan Y, Chu T, Scott RT, Treff NR  Mitochondrial DNA content is associated with ploidy status, maternal age, and oocyte maturation methods in mouse blastocysts.  J Assist Reprod Genet  2017 Dec;34(12):1587-1594. doi:10.1007/s10815-017-1070-8
  10. Duncan FE, Jasti S, Paulson A, Kelsh JM, Fegley B, Gerton JL  Age-associated dysregulation of protein metabolism in the mammalian oocyte.  Aging Cell  2017 Dec;16(6):1381-1393. doi:10.1111/acel.12676
  11. Duncan FE  Egg Quality during the Pubertal Transition-Is Youth All It's Cracked Up to Be?  Front Endocrinol (Lausanne)  2017;8:226. doi:10.3389/fendo.2017.00226
  12. Laronda MM, Rutz AL, Xiao S, Whelan KA, Duncan FE, Roth EW, Woodruff TK, Shah RN  A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice.  Nat Commun  2017 May 16;8:15261. doi:10.1038/ncomms15261
  13. Tan EP, Duncan FE, Slawson C  The sweet side of the cell cycle.  Biochem Soc Trans  2017 04 15;45(2):313-322. doi:10.1042/BST20160145
  14. Akasha AM, Kato A, Luan Y, Zhou LT, Duncan FE  Immunohistochemistry in the ovary: Moving beyond the brown and blue.  Mol Reprod Dev  2017 Mar;84(3):199. doi:10.1002/mrd.22773
  15. Goldman KN, Chenette D, Arju R, Duncan FE, Keefe DL, Grifo JA, Schneider RJ  mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy.  Proc Natl Acad Sci U S A  2017 03 21;114(12):3186-3191. doi:10.1073/pnas.1617233114
  16. McCracken JM, Chalise P, Briley SM, Dennis KL, Jiang L, Duncan FE, Pritchard MT  C57BL/6 Substrains Exhibit Different Responses to Acute Carbon Tetrachloride Exposure: Implications for Work Involving Transgenic Mice.  Gene Expr  2017 Jul 07;17(3):187-205. doi:10.3727/105221617X695050
  17. Que EL, Duncan FE, Bayer AR, Philips SJ, Roth EW, Bleher R, Gleber SC, Vogt S, Woodruff TK, O'Halloran TV  Zinc sparks induce physiochemical changes in the egg zona pellucida that prevent polyspermy.  Integr Biol (Camb)  2017 02 20;9(2):135-144. doi:10.1039/c6ib00212a
  18. Duncan FE, Zelinski M, Gunn AH, Pahnke JE, O'Neill CL, Songsasen N, Woodruff RI, Woodruff TK  Ovarian tissue transport to expand access to fertility preservation: from animals to clinical practice.  Reproduction  2016 12;152(6):R201-R210
  19. Briley SM, Jasti S, McCracken JM, Hornick JE, Fegley B, Pritchard MT, Duncan FE  Reproductive age-associated fibrosis in the stroma of the mammalian ovary.  Reproduction  2016 09;152(3):245-260. doi:10.1530/REP-16-0129
  20. Duncan FE, Kimler BF, Briley SM  Combating radiation therapy-induced damage to the ovarian environment.  Future Oncol  2016 Jul;12(14):1687-90. doi:10.2217/fon-2016-0121
  21. Duncan FE, Que EL, Zhang N, Feinberg EC, O'Halloran TV, Woodruff TK  The zinc spark is an inorganic signature of human egg activation.  Sci Rep  2016 04 26;6:24737. doi:10.1038/srep24737
  22. Zhang N, Duncan FE, Que EL, O'Halloran TV, Woodruff TK  The fertilization-induced zinc spark is a novel biomarker of mouse embryo quality and early development.  Sci Rep  2016 Mar 18;6:22772. doi:10.1038/srep22772
  23. Treff NR, Krisher RL, Tao X, Garnsey H, Bohrer C, Silva E, Landis J, Taylor D, Scott RT, Woodruff TK, Duncan FE  Next Generation Sequencing-Based Comprehensive Chromosome Screening in Mouse Polar Bodies, Oocytes, and Embryos.  Biol Reprod  2016 Apr;94(4):76. doi:10.1095/biolreprod.115.135483
  24. Duncan FE, Pavone ME, Gunn AH, Badawy S, Gracia C, Ginsberg JP, Lockart B, Gosiengfiao Y, Woodruff TK  Pediatric and Teen Ovarian Tissue Removed for Cryopreservation Contains Follicles Irrespective of Age, Disease Diagnosis, Treatment History, and Specimen Processing Methods.  J Adolesc Young Adult Oncol  2015 Dec;4(4):174-83. doi:10.1089/jayao.2015.0032
  25. Slawson C, Duncan FE  Sweet action: The dynamics of O-GlcNAcylation during meiosis in mouse oocytes.  Mol Reprod Dev  2015 Dec;82(12):915. doi:10.1002/mrd.22577
  26. Cordeiro MH, Kim SY, Ebbert K, Duncan FE, Ramalho-Santos J, Woodruff TK  Geography of follicle formation in the embryonic mouse ovary impacts activation pattern during the first wave of folliculogenesis.  Biol Reprod  2015 Oct;93(4):88. doi:10.1095/biolreprod.115.131227
  27. Xiao S, Duncan FE, Bai L, Nguyen CT, Shea LD, Woodruff TK  Size-specific follicle selection improves mouse oocyte reproductive outcomes.  Reproduction  2015 Sep;150(3):183-92. doi:10.1530/REP-15-0175
  28. Kong BY, Duncan FE, Que EL, Xu Y, Vogt S, O'Halloran TV, Woodruff TK  The inorganic anatomy of the mammalian preimplantation embryo and the requirement of zinc during the first mitotic divisions.  Dev Dyn  2015 Aug;244(8):935-47. doi:10.1002/dvdy.24285
  29. Hornick JE, Duncan FE, Sun M, Kawamura R, Marko JF, Woodruff TK  Age-associated alterations in the micromechanical properties of chromosomes in the mammalian egg.  J Assist Reprod Genet  2015 May;32(5):765-9. doi:10.1007/s10815-015-0453-y
  30. Xu Y, Duncan FE, Xu M, Woodruff TK  Use of an organotypic mammalian in vitro follicle growth assay to facilitate female reproductive toxicity screening.  Reprod Fertil Dev  2015 Feb 18;. doi:10.1071/RD14375
  31. Que EL, Bleher R, Duncan FE, Kong BY, Gleber SC, Vogt S, Chen S, Garwin SA, Bayer AR, Dravid VP, Woodruff TK, O'Halloran TV  Quantitative mapping of zinc fluxes in the mammalian egg reveals the origin of fertilization-induced zinc sparks.  Nat Chem  2015 Feb;7(2):130-9. doi:10.1038/nchem.2133
  32. Kong BY, Duncan FE, Que EL, Kim AM, O'Halloran TV, Woodruff TK  Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition.  Mol Hum Reprod  2014 Nov;20(11):1077-89. doi:10.1093/molehr/gau066
  33. Laronda MM, Duncan FE, Hornick JE, Xu M, Pahnke JE, Whelan KA, Shea LD, Woodruff TK  Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue.  J Assist Reprod Genet  2014 Aug;31(8):1013-28. doi:10.1007/s10815-014-0252-x
  34. Duncan FE, Woodruff TK  Keeping reproductive science visible, viable, and valuable-a call to rethink how we publish.  J Assist Reprod Genet  2014 May;31(5):509-10. doi:10.1007/s10815-014-0206-3
  35. Duncan FE, Derman B, Woodruff TK  A small field for fertile science: the low visibility of reproductive science in high impact journals.  J Assist Reprod Genet  2014 May;31(5):511-20. doi:10.1007/s10815-014-0205-4
  36. Duncan FE, Padilla-Banks E, Bernhardt ML, Ord TS, Jefferson WN, Moss SB, Williams CJ  Transducin-like enhancer of split-6 (TLE6) is a substrate of protein kinase A activity during mouse oocyte maturation.  Biol Reprod  2014 Mar;90(3):63. doi:10.1095/biolreprod.113.112565
  37. Waimey KE, Duncan FE, Su HI, Smith K, Wallach H, Jona K, Coutifaris C, Gracia CR, Shea LD, Brannigan RE, Chang RJ, Zelinski MB, Stouffer RL, Taylor RL, Woodruff TK  Future Directions in Oncofertility and Fertility Preservation: A Report from the 2011 Oncofertility Consortium Conference.  J Adolesc Young Adult Oncol  2013 Mar;2(1):25-30
  38. Hornick JE, Duncan FE, Shea LD, Woodruff TK  Multiple follicle culture supports primary follicle growth through paracrine-acting signals.  Reproduction  2013 Jan;145(1):19-32. doi:10.1530/REP-12-0233
  39. Duncan FE, Hornick JE, Lampson MA, Schultz RM, Shea LD, Woodruff TK  Chromosome cohesion decreases in human eggs with advanced maternal age.  Aging Cell  2012 Dec;11(6):1121-4. doi:10.1111/j.1474-9726.2012.00866.x
  40. Duncan FE, Hornick JE, Woodruff TK  Bipolar-to-monopolar spindle collapse in human eggs.  Mol Reprod Dev  2012 Sep;79(9):587. doi:10.1002/mrd.22069
  41. Hornick JE, Duncan FE, Shea LD, Woodruff TK  Isolated primate primordial follicles require a rigid physical environment to survive and grow in vitro.  Hum Reprod  2012 Jun;27(6):1801-10. doi:10.1093/humrep/der468
  42. Duncan FE, Jozefik JK, Kim AM, Hirshfeld-Cytron J, Woodruff TK  The Gynecologist Has a Unique Role in Providing Oncofertility Care to Young Cancer Patients.  US Obstet Gynecol  2011 Jan 01;6(1):24-34
  43. Hirshfeld-Cytron JE, Duncan FE, Xu M, Jozefik JK, Shea LD, Woodruff TK  Animal age, weight and estrus cycle stage impact the quality of in vitro grown follicles.  Hum Reprod  2011 Sep;26(9):2473-85. doi:10.1093/humrep/der183
  44. Chiang T, Duncan FE, Schindler K, Schultz RM, Lampson MA  Evidence that weakened centromere cohesion is a leading cause of age-related aneuploidy in oocytes.  Curr Biol  2010 Sep 14;20(17):1522-8. doi:10.1016/j.cub.2010.06.069
  45. Duncan FE, Schultz RM  Gene expression profiling of mouse oocytes and preimplantation embryos.  Methods Enzymol  2010;477:457-80. doi:10.1016/S0076-6879(10)77023-3
  46. Backs J, Stein P, Backs T, Duncan FE, Grueter CE, McAnally J, Qi X, Schultz RM, Olson EN  The gamma isoform of CaM kinase II controls mouse egg activation by regulating cell cycle resumption.  Proc Natl Acad Sci U S A  2010 Jan 05;107(1):81-6. doi:10.1073/pnas.0912658106
  47. Duncan FE, Chiang T, Schultz RM, Lampson MA  Evidence that a defective spindle assembly checkpoint is not the primary cause of maternal age-associated aneuploidy in mouse eggs.  Biol Reprod  2009 Oct;81(4):768-76. doi:10.1095/biolreprod.109.077909
  48. Duncan FE, Stein P, Williams CJ, Schultz RM  The effect of blastomere biopsy on preimplantation mouse embryo development and global gene expression.  Fertil Steril  2009 Apr;91(4 Suppl):1462-5. doi:10.1016/j.fertnstert.2008.07.1710
  49. Duncan FE, Moss SB, Williams CJ  Knockdown of the cAMP-dependent protein kinase (PKA) Type Ialpha regulatory subunit in mouse oocytes disrupts meiotic arrest and results in meiotic spindle defects.  Dev Dyn  2006 Nov;235(11):2961-8
  50. Duncan FE, Moss SB, Schultz RM, Williams CJ  PAR-3 defines a central subdomain of the cortical actin cap in mouse eggs.  Dev Biol  2005 Apr 01;280(1):38-47