Northwestern University Feinberg School of Medicine

Duncan Lab


Learn more about the work that we do in the Duncan lab through our 50 most recent publications, or through Dr. Duncan's Faculty and Northwestern Scholars profiles. 

  1. Zhang J, Goods BA, Pattarawat P, Wang Y, Haining T, Zhang Q, Shalek AK, Duncan FE, Woodruff TK, Xiao S  An ex vivo ovulation system enables the discovery of novel ovulatory pathways and non-hormonal contraceptive candidates.  Biol Reprod  2023 Jan 27;. pii:ioad009
  2. Chen YY, Chen S, Ok K, Duncan FE, O'Halloran TV, Woodruff TK  Zinc dynamics regulate early ovarian follicle development.  J Biol Chem  2023 Jan;299(1):102731. pii:102731
  3. Brieño-Enriquez MA, Duncan FE, Ghazi A, Klutstein M, Sebastiano V, Tyler J  Editorial: Germ cell development and reproductive aging.  Front Cell Dev Biol  2022;10:1051539. pii:1051539
  4. O'Neill KE, Maher JY, Laronda MM, Duncan FE, LeDuc RD, Lujan ME, Oktay KH, Pouch AM, Segars JH, Tsui EL  et al.  Anatomic nomenclature and 3-dimensional regional model of the human ovary: call for a new paradigm.  Am J Obstet Gynecol  2022 Sep 30;. pii:S0002-9378(22)00795-5
  5. Converse A, Zaniker EJ, Amargant F, Duncan FE  Recapitulating folliculogenesis and oogenesis outside the body: encapsulated in vitro follicle growth†.  Biol Reprod  2023 Jan 14;108(1):5-22. doi:10.1093/biolre/ioac176
  6. Babayev E, Xu M, Shea LD, Woodruff TK, Duncan FE  Follicle isolation methods reveal plasticity of granulosa cell steroidogenic capacity during mouse in vitro follicle growth.  Mol Hum Reprod  2022 Sep 29;28(10). pii:gaac033
  7. Ataman LM, Laronda MM, Gowett M, Trotter K, Anvari H, Fei F, Ingram A, Minette M, Suebthawinkul C, Taghvaei Z  et al.  Correction to: A synopsis of global frontiers in fertility preservation.  J Assist Reprod Genet  2022 Aug;39(8):1713-1714. doi:10.1007/s10815-022-02586-x
  8. Chen YY, Russo DD, Drake RS, Duncan FE, Shalek AK, Goods BA, Woodruff TK  Single-cell transcriptomics of staged oocytes and somatic cells reveal novel regulators of follicle activation.  Reproduction  2022 Aug 01;164(2):55-70. doi:10.1530/REP-22-0053
  9. Ataman LM, Laronda MM, Gowett M, Trotter K, Anvari H, Fei F, Ingram A, Minette M, Suebthawinkul C, Taghvaei Z  et al.  A synopsis of global frontiers in fertility preservation.  J Assist Reprod Genet  2022 Aug;39(8):1693-1712. doi:10.1007/s10815-022-02570-5
  10. Suebthawinkul C, Babayev E, Zhou LT, Lee HC, Duncan FE  Quantitative morphokinetic parameters identify novel dynamics of oocyte meiotic maturation and cumulus expansion†.  Biol Reprod  2022 Oct 11;107(4):1097-1112. doi:10.1093/biolre/ioac139
  11. Ataman-Millhouse LM, Monahan P, Willingham R, Vigone G, Soulakis M, Gadea J, Jiménez-Movilla M, Romar R, Cánovas S, Woodruff TK  et al.  Broadening the educational pipeline: the global landscape of master of science programs in reproductive science and medicine.  Biol Reprod  2022 Sep 12;107(3):664-675. doi:10.1093/biolre/ioac113
  12. Boiani M, Duncan FE,   A reproductive science perspective: deliberations on the stem cell guidelines update.  Mol Hum Reprod  2022 Apr 01;28(4). pii:gaac008
  13. Babayev E, Duncan FE  Age-associated changes in cumulus cells and follicular fluid: the local oocyte microenvironment as a determinant of gamete quality.  Biol Reprod  2022 Feb 22;106(2):351-365. doi:10.1093/biolre/ioab241
  14. Doherty CA, Amargant F, Shvartsman SY, Duncan FE, Gavis ER  Bidirectional communication in oogenesis: a dynamic conversation in mice and Drosophila.  Trends Cell Biol  2022 Apr;32(4):311-323. doi:10.1016/j.tcb.2021.11.005
  15. Duncan FE  Ex vivo recovery of mature eggs from unstimulated ovaries in pediatric fertility preservation: proceed with caution.  F S Rep  2021 Sep;2(3):267-268. doi:10.1016/j.xfre.2021.05.003
  16. Parkes WS, Amargant F, Zhou LT, Villanueva CE, Duncan FE, Pritchard MT  Hyaluronan and Collagen Are Prominent Extracellular Matrix Components in Bovine and Porcine Ovaries.  Genes (Basel)  2021 Jul 30;12(8). pii:1186
  17. Kusuhara A, Babayev E, Zhou LT, Singh VP, Gerton JL, Duncan FE  Immature Follicular Origins and Disrupted Oocyte Growth Pathways Contribute to Decreased Gamete Quality During Reproductive Juvenescence in Mice.  Front Cell Dev Biol  2021;9:693742. pii:693742
  18. Machlin JH, Barishansky SJ, Kelsh J, Larmore MJ, Johnson BW, Pritchard MT, Pavone ME, Duncan FE  Fibroinflammatory Signatures Increase with Age in the Human Ovary and Follicular Fluid.  Int J Mol Sci  2021 May 05;22(9). pii:4902
  19. Marvaldi C, Martin D, Conte JG, Gottardo MF, Pidre ML, Imsen M, Irizarri M, Manuel SL, Duncan FE, Romanowski V  et al.  Mitochondrial humanin peptide acts as a cytoprotective factor in granulosa cell survival.  Reproduction  2021 Apr 20;161(5):581-591. doi:10.1530/REP-20-0197
  20. Kristensen SG, Duncan FE  Autonomous follicle growth and the production of mature human eggs in vitro: with or without the ovary?  Hum Reprod  2021 Apr 20;36(5):1163-1165. doi:10.1093/humrep/deab052
  21. Lee HC, Balough JL, Roth EW, Vaccari S, Duncan FE  A decellularized oocyte-derived scaffold provides a "sperm safe" to preserve mammalian spermatozoa.  Andrology  2021 May;9(3):922-932. doi:10.1111/andr.12986
  22. Amargant F, Manuel SL, Larmore MJ, Johnson BW, Lawson M, Pritchard MT, Zelinski MB, Duncan FE  Sphingosine-1-phosphate and its mimetic FTY720 do not protect against radiation-induced ovarian fibrosis in the nonhuman primate†.  Biol Reprod  2021 May 07;104(5):1058-1070. doi:10.1093/biolre/ioab012
  23. Rogers HB, Zhou LT, Kusuhara A, Zaniker E, Shafaie S, Owen BC, Duncan FE, Woodruff TK  Dental resins used in 3D printing technologies release ovo-toxic leachates.  Chemosphere  2021 May;270:129003. pii:129003
  24. Baserga SJ, DiMario PJ, Duncan FE  Emerging Roles for the Nucleolus 2019.  J Biol Chem  2020 Apr 17;295(16):5535-5537. doi:10.1074/jbc.MT120.013346
  25. Woodruff TK, Ataman-Millhouse L, Acharya KS, Almeida-Santos T, Anazodo A, Anderson RA, Appiah L, Bader J, Becktell K, Brannigan RE  et al.  A View from the past into our collective future: the oncofertility consortium vision statement.  J Assist Reprod Genet  2021 Jan;38(1):3-15. doi:10.1007/s10815-020-01983-4
  26. Foley KG, Pritchard MT, Duncan FE  Macrophage-derived multinucleated giant cells: hallmarks of the aging ovary.  Reproduction  2021 Feb;161(2):V5-V9. doi:10.1530/REP-20-0489
  27. Amargant F, Manuel SL, Tu Q, Parkes WS, Rivas F, Zhou LT, Rowley JE, Villanueva CE, Hornick JE, Shekhawat GS  et al.  Ovarian stiffness increases with age in the mammalian ovary and depends on collagen and hyaluronan matrices.  Aging Cell  2020 Nov;19(11):e13259. pii:e13259
  28. Duncan FE, Schindler K, Schultz RM, Blengini CS, Stein P, Stricker SA, Wessel GM, Williams CJ  Unscrambling the oocyte and the egg: clarifying terminology of the female gamete in mammals.  Mol Hum Reprod  2020 Nov 01;26(11):797-800. doi:10.1093/molehr/gaaa066
  29. Hu Q, Duncan FE, Nowakowski AB, Antipova OA, Woodruff TK, O'Halloran TV, Wolfner MF  Zinc Dynamics during Drosophila Oocyte Maturation and Egg Activation.  iScience  2020 Jul 24;23(7):101275. pii:101275
  30. Quan N, Mara JN, Grover AR, Pavone ME, Duncan FE  Spatial Analysis of Growing Follicles in the Human Ovary to Inform Tissue Engineering Strategies.  Tissue Eng Part A  2020 Jul;26(13-14):733-746. doi:10.1089/ten.tea.2020.0051
  31. Mara JN, Zhou LT, Larmore M, Johnson B, Ayiku R, Amargant F, Pritchard MT, Duncan FE  Ovulation and ovarian wound healing are impaired with advanced reproductive age.  Aging (Albany NY)  2020 May 14;12(10):9686-9713. doi:10.18632/aging.103237
  32. Simon LE, Kumar TR, Duncan FE  In vitro ovarian follicle growth: a comprehensive analysis of key protocol variables†.  Biol Reprod  2020 Aug 21;103(3):455-470. doi:10.1093/biolre/ioaa073
  33. Lee HC, Edmonds ME, Duncan FE, O'Halloran TV, Woodruff TK  Zinc exocytosis is sensitive to myosin light chain kinase inhibition in mouse and human eggs.  Mol Hum Reprod  2020 Apr 24;26(4):228-239. doi:10.1093/molehr/gaaa017
  34. Rowley JE, Amargant F, Zhou LT, Galligos A, Simon LE, Pritchard MT, Duncan FE  Low Molecular Weight Hyaluronan Induces an Inflammatory Response in Ovarian Stromal Cells and Impairs Gamete Development In Vitro.  Int J Mol Sci  2020 Feb 04;21(3). pii:1036
  35. Balough JL, Fontaine ASE, Machlin JH, Rowley JE, Simon LE, Duncan FE, Hornick JE  The long view: Considering spindle orientation in image analysis.  Mol Reprod Dev  2020 Feb;87(2):205. doi:10.1002/mrd.23313
  36. Rowley JE, Rubenstein GE, Manuel SL, Johnson NL, Surgnier J, Kapitsinou PP, Duncan FE, Pritchard MT  Tissue-specific Fixation Methods Are Required for Optimal In Situ Visualization of Hyaluronan in the Ovary, Kidney, and Liver.  J Histochem Cytochem  2020 Jan;68(1):75-91. doi:10.1369/0022155419884879
  37. Simon LE, Liu Z, Bousfield GR, Kumar TR, Duncan FE  Recombinant FSH glycoforms are bioactive in mouse preantral ovarian follicles.  Reproduction  2019 Dec;158(6):517-527. doi:10.1530/REP-19-0392
  38. Quan N, Harris LR, Halder R, Trinidad CV, Johnson BW, Horton S, Kimler BF, Pritchard MT, Duncan FE  Differential sensitivity of inbred mouse strains to ovarian damage in response to low-dose total body irradiation†.  Biol Reprod  2020 Feb 12;102(1):133-144. doi:10.1093/biolre/ioz164
  39. Dipali SS, Ferreira CR, Zhou LT, Pritchard MT, Duncan FE  Histologic analysis and lipid profiling reveal reproductive age-associated changes in peri-ovarian adipose tissue.  Reprod Biol Endocrinol  2019 Jun 12;17(1):46. pii:46
  40. Zhou LT, Romar R, Pavone ME, Soriano-Úbeda C, Zhang J, Slawson C, Duncan FE  Disruption of O-GlcNAc homeostasis during mammalian oocyte meiotic maturation impacts fertilization.  Mol Reprod Dev  2019 May;86(5):543-557. doi:10.1002/mrd.23131
  41. Que EL, Duncan FE, Lee HC, Hornick JE, Vogt S, Fissore RA, O'Halloran TV, Woodruff TK  Bovine eggs release zinc in response to parthenogenetic and sperm-induced egg activation.  Theriogenology  2019 Mar 15;127:41-48. doi:10.1016/j.theriogenology.2018.12.031
  42. Singh VP, Yueh WT, Gerton JL, Duncan FE  Oocyte-specific deletion of Hdac8 in mice reveals stage-specific effects on fertility.  Reproduction  2019 Mar;157(3):305-316. doi:10.1530/REP-18-0560
  43. Smith BM, Duncan FE, Ataman L, Smith K, Quinn GP, Chang RJ, Finlayson C, Orwig K, Valli-Pulaski H, Moravek MB  et al.  The National Physicians Cooperative: transforming fertility management in the cancer setting and beyond.  Future Oncol  2018 Dec;14(29):3059-3072. doi:10.2217/fon-2018-0278
  44. Duncan FE, Romar R, Gadea J, Kimelman D, Wallach HD, Woodruff TK, Jiménez-Movilla M  The use of a virtual journal club to promote cross-cultural learning in the reproductive sciences.  J Assist Reprod Genet  2018 Dec;35(12):2141-2147. doi:10.1007/s10815-018-1309-z
  45. Grover AR, Kimler BF, Duncan FE  Use of a Small Animal Radiation Research Platform (SARRP) facilitates analysis of systemic versus targeted radiation effects in the mouse ovary.  J Ovarian Res  2018 Aug 30;11(1):72. pii:72
  46. Ataman LM, Ma Y, Duncan FE, Uzzi B, Woodruff TK  Quantifying the growth of oncofertility.  Biol Reprod  2018 Aug 01;99(2):263-265. doi:10.1093/biolre/ioy068
  47. Manuel SL, Johnson BW, Frevert CW, Duncan FE  Revisiting the scientific method to improve rigor and reproducibility of immunohistochemistry in reproductive science.  Biol Reprod  2018 Oct 01;99(4):673-677. doi:10.1093/biolre/ioy094
  48. Kimler BF, Briley SM, Johnson BW, Armstrong AG, Jasti S, Duncan FE  Radiation-induced ovarian follicle loss occurs without overt stromal changes.  Reproduction  2018 Jun;155(6):553-562. doi:10.1530/REP-18-0089
  49. Duncan FE, Gerton JL  Mammalian oogenesis and female reproductive aging.  Aging (Albany NY)  2018 Feb 05;10(2):162-163. doi:10.18632/aging.101381
  50. Armstrong AG, Kimler BF, Smith BM, Woodruff TK, Pavone ME, Duncan FE  Ovarian tissue cryopreservation in young females through the Oncofertility Consortium's National Physicians Cooperative.  Future Oncol  2018 Feb;14(4):363-378. doi:10.2217/fon-2017-0410