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Northwestern University Feinberg School of Medicine
Duncan Lab

Publications

Learn more about the work that we do in the Duncan Lab through our 50 most recent publications linked below or visit Dr. Duncan’s faculty profile.

  1. Amorim CA, Chuva De Sousa Lopes SM, Klutstein M, Brieño-Enriquez MA, Anderson RA, Duncan FE, De Vos M, Damdimopoulou P, Comizzoli P, Williams SA  et al.  Proceedings of the 1st European Ovary Workshop (EOW 2025) Lagos, Portugal - February 17-20, 2025.  Mol Hum Reprod  2026 Jun 26;. pii:gaag039
  2. Campo H, Tran U, Zhu Y, Lee HC, Duncan FE  Biocompatible designated Resin-3D-printed polymers exhibit reproductive toxicity prevented by Parylene-C.  bioRxiv  2026 Jun 10;. pii:2026.06.05.730268
  3. Converse A, Dipali SS, Schowe IP, Kelly EB, Jambunathan SS, Ocañas SR, Stout MB, Pritchard MT, Duncan FE  The post-reproductive ovary shifts from a reproductive to an immune-like organ.  Mol Hum Reprod  2026 Jun 10;. pii:gaag038
  4. Brunette MA, Burns K, Hoefgen H, Xiao S, Duncan FE, Laronda MM, Shikanov A, Zelinski M, Gomez-Lobo V  Advancing human ovarian biology in tandem with clinical care: considerations for collecting ovarian tissue for research after oophorectomy for tissue cryopreservation.  Front Endocrinol (Lausanne)  2026;17:1866925. pii:1866925
  5. Pea J, Zhu Y, Lee HC, Haky LR, Proudfoot J, Nelson R, Duncan FE  A phenotypic in vitro assay of mouse oocyte maturation identifies reversible blockers of meiotic progression for non-hormonal contraceptive discovery.  Hum Reprod Open  2026;2026(3):hoag051. pii:hoag051
  6. Oliveira SP, Ferreira CS, Zaniker-Gomez EJ, Charles M, Freitas LA, Felix FB, Pereira LAAC, de Castro WV, Pinho V, Duncan FE  et al.  In vitro and in vivo treatment with propranolol influences the number of early preantral follicles in mice†.  Biol Reprod  2026 Apr 13;114(4):1429-1444. doi:10.1093/biolre/ioag024
  7. Galligos A, Varberg JM, Yueh WT, Converse A, Malloy S, Aljubran F, Duncan FE, Gerton JL  Multicellular origins of murine ovarian inflammaging.  Commun Biol  2026 Mar 13;9(1). pii:593
  8. Zhou LT, Gokyer D, Akinboro S, Duncan FE, Babayev E  Acute anomalous high-temperature exposure impacts on mouse ovaries.  J Assist Reprod Genet  2026 Mar;43(3):997-1005. doi:10.1007/s10815-026-03801-9
  9. Eubanks AA, Goldman KN, Babayev E, Duncan FE, Widra E  Influencing ovarian aging in reproductive medicine: promise, evidence, and unresolved questions.  Fertil Steril  2026 Mar;125(3):387-398. doi:10.1016/j.fertnstert.2025.12.020
  10. Duncan FE, Babayev E  The ovarian stroma as a therapeutic target.  Science  2026 Feb 05;391(6785):552-553. doi:10.1126/science.aee7270
  11. Balough JL, O'Halloran TV, Duncan FE, Woodruff TK  Inorganic profiles of preimplantation embryos and the association of zinc with Nanog expression in the blastocyst.  Reproduction  2026 Jan 15;171(1). pii:xaaf014
  12. Duncan FE  The Legacy Series: shining light on our origins to inform the future of reproductive science and medicine.  Mol Hum Reprod  2026 Jan 07;32(1). pii:gaag011
  13. Monsivais D, Duncan FE, Boiani M,   Call for papers-shaping reproduction in 3D: organoids, assembloids, and emerging models.  Mol Hum Reprod  2026 Jan 07;32(1). pii:gaag012
  14. Dipali SS, Duncan FE  The ovarian stroma as a key regulator of follicular development and gamete quality across the reproductive lifespan.  Curr Top Dev Biol  2026;169:237-272. doi:10.1016/bs.ctdb.2026.04.005
  15. Dipali SS, Converse A, Gowett MQ, Kamat P, Zaniker EJ, Fennell A, Chou T, Pritchard MT, Zelinski M, Phillip JM  et al.  Self-Organizing Ovarian Somatic Organoids Preserve Cellular Heterogeneity and Reveal Cellular Contributions to Ovarian Aging.  Aging Cell  2026 Jan;25(1):e70333. pii:e70333
  16. Zaniker-Gomez EJ, Yan Z, Yang J, Russell DL, Zhang H, Sun SX, Duncan FE  Microscale pressure measurements and optical coherence tomography reveal time-dependent biomechanical stages of ovulation in mice.  iScience  2025 Dec 19;28(12):114086. pii:114086
  17. Watson MA, Devrukhkar PR, Murad NF, Wu F, Kim MJ, Anvari H, Tran U, Martin N, Tran T, Zaza G  et al.  Senescence-Linked Fibrosis in the Aging Human Ovary Revealed by p16-Based Histological Profiling and Spatial Transcriptomics.  bioRxiv  2025 Dec 08;. pii:2025.12.03.692228
  18. Zhou LT, Gokyer D, Madkins K, Beestrum M, Horton DE, Duncan FE, Babayev E  The effects of heat stress on the ovary, follicles, and oocytes: a systematic review†.  Biol Reprod  2025 Nov 14;113(5):1013-1028. doi:10.1093/biolre/ioaf150
  19. Campo H, Hashim PH, Zaniker-Gomez EJ, Gauthier S, Yan Z, Zhang HF, Ankrum JA, Duncan FE  Production and Use of Customizable Agarose Molds for Scaffold-Free Mouse Ovarian Follicle Culture.  J Vis Exp  2025 Oct 24;(224). doi:10.3791/68871
  20. Gokyer D, Salpeter N, Hughes L, Lee HC, Lohman MJ, Atazhanova T, Kleinhans A, Riley JK, Pavone M, Duncan FE  et al.  Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization.  J Vis Exp  2025 Oct 24;(224). doi:10.3791/69122
  21. Hughes L, Duncan FE, Babayev E  Ovarian aging: a missing diagnosis in reproductive medicine.  Nat Med  2025 Aug;31(8):2485-2487. doi:10.1038/s41591-025-03733-4
  22. Devrukhkar PR, Watson MA, Soygur B, Wu F, Bons J, Anvari H, Atazhanova T, Martin N, Tran T, Schneider K  et al.  A Comprehensive Multiomics Signature of Doxorubicin-Induced Cellular Senescence in the Postmenopausal Human Ovary.  Aging Cell  2025 Aug;24(8):e70111. pii:e70111
  23. Boiani M, Duncan FE  'Small but mighty': the Concise Communication comes to MHR.  Mol Hum Reprod  2025 Jul 03;31(3). pii:gaaf049
  24. VanBenschoten H, Nugmanova Z, Olmsted A, Annepureddy LD, Gingerich I, Kratka C, Huang R, Duncan FE, Kholod O, Goods BA  A pre-menopausal single-cell atlas for ovarian drug discovery.  bioRxiv  2025 Jun 27;. pii:2025.06.20.660779
  25. Huang R, Kratka CE, Pea J, McCann C, Nelson J, Bryan JP, Zhou LT, Russo DD, Zaniker-Gomez EJ, Gandhi AH  et al.  Single-cell and spatiotemporal profile of ovulation in the mouse ovary.  PLoS Biol  2025 Jun;23(6):e3003193. pii:e3003193
  26. Converse A, Perry MJ, Dipali SS, Isola JVV, Kelly EB, Varberg JM, Zelinski MB, Stout MB, Pritchard MT, Duncan FE  Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures.  PLoS Biol  2025 Jun;23(6):e3003204. pii:e3003204
  27. Amargant F, Magalhaes C, Pritchard MT, Duncan FE  Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse.  Geroscience  2025 Jun;47(3):3475-3495. doi:10.1007/s11357-024-01322-w
  28. Gargus ES, Sharma R, Gu R, Mulcahy C, Johnson BW, Song J, Lee J, Zelinski M, Duncan FE  Short-term moderate caloric restriction in the rhesus macaque attenuates markers of ovarian aging in select populations.  Aging (Albany NY)  2025 May 20;17(5):1164-1189. doi:10.18632/aging.206253
  29. Balough JL, O'Halloran TV, Duncan FE, Woodruff TK  Inorganic profiles of preimplantation embryos reveal a role for zinc in blastocyst development.  bioRxiv  2025 May 18;. pii:2025.05.14.654061
  30. Hashim PH, Perry MJ, Pritchard MT, Gerton JL, Duncan FE  Autonomous follicle quality control mechanisms: innate immune signaling capabilities of granulosa cells.  Reproduction  2025 May 01;169(5). pii:e250042
  31. Yano Maher JC, Zelinski MB, Oktay KH, Duncan FE, Segars JH, Lujan ME, Lou H, Yun BH, Hanfling SN, Schwartz LE  et al.  Classification system of human ovarian follicle morphology: recommendations of the National Institute of Child Health and Human Development - sponsored ovarian nomenclature workshop.  Fertil Steril  2025 May;123(5):761-778. doi:10.1016/j.fertnstert.2024.11.016
  32. Rogina B, Anderson R, LeBrasseur NK, Curran SP, Yousefzadeh MJ, Ghosh B, Duque G, Howlett S, Austad S, Demuth I  et al.  Symposia Report of The Annual Biological Sciences Section Meeting of the Gerontological Society of America 2023, Tampa, Florida.  J Gerontol A Biol Sci Med Sci  2025 Apr 07;80(5). pii:glaf026
  33. Ericsson V, Elam M, Sapao P, Nguyen LMT, Gill ME, Chodavarapu S, Córdova-Fletes C, Lafrenaye A, Hassan S, Mahendroo M  et al.  Regulation of Female Reproductive Aging by the Spag17 Gene.  bioRxiv  2025 Mar 03;. pii:2025.03.01.640648
  34. Zhou LT, Gokyer D, Madkins K, Beestrum M, Horton DE, Duncan FE, Babayev E  The Effects of Heat Stress on the Ovary, Follicles and Oocytes: A Systematic Review.  bioRxiv  2024 Dec 05;. pii:2024.12.04.626831
  35. Converse A, Perry MJ, Dipali SS, Isola JVV, Kelly EB, Varberg JM, Zelinski MB, Gerton JL, Stout MB, Pritchard MT  et al.  Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures.  bioRxiv  2024 Dec 05;. pii:2024.12.03.626649
  36. Balough JL, Dipali SS, Velez K, Kumar TR, Duncan FE  Hallmarks of female reproductive aging in physiologic aging mice.  Nat Aging  2024 Dec;4(12):1711-1730. doi:10.1038/s43587-024-00769-y
  37. Suryadevara V, Hudgins AD, Rajesh A, Pappalardo A, Karpova A, Dey AK, Hertzel A, Agudelo A, Rocha A, Soygur B  et al.  SenNet recommendations for detecting senescent cells in different tissues.  Nat Rev Mol Cell Biol  2024 Dec;25(12):1001-1023. doi:10.1038/s41580-024-00738-8
  38. Bomba-Warczak EK, Velez KM, Zhou LT, Guillermier C, Edassery S, Steinhauser ML, Savas JN, Duncan FE  Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan.  Elife  2024 Oct 31;13. pii:RP93172
  39. Zaniker EJ, Zhang J, Russo D, Huang R, Suritis K, Drake RS, Barlow-Smith E, Shalek AK, Woodruff TK, Xiao S  et al.  Follicle-intrinsic and spatially distinct molecular programs drive follicle rupture and luteinization during ex vivo mammalian ovulation.  Commun Biol  2024 Oct 23;7(1):1374. pii:1374
  40. Dipali SS, Gowett MQ, Kamat P, Converse A, Zaniker EJ, Fennell A, Chou T, Pritchard MT, Zelinski M, Phillip JM  et al.  Self-organizing ovarian somatic organoids preserve cellular heterogeneity and reveal cellular contributions to ovarian aging.  bioRxiv  2024 Aug 10;. pii:2024.08.10.607456
  41. Gokyer D, Akinboro S, Zhou LT, Kleinhans A, Laronda MM, Duncan FE, Riley JK, Goldman KN, Babayev E  The oocyte microenvironment is altered in adolescents compared to oocyte donors.  Hum Reprod Open  2024;2024(3):hoae047. pii:hoae047
  42. Wu H, Nguyen H, Hashim PH, Fogelgren B, Duncan FE, Ward WS  Oocyte-specific EXOC5 expression is required for mouse oogenesis and folliculogenesis.  Mol Hum Reprod  2024 Aug 05;30(8). pii:gaae026
  43. Zaniker EJ, Hashim PH, Gauthier S, Ankrum JA, Campo H, Duncan FE  Three-Dimensionally Printed Agarose Micromold Supports Scaffold-Free Mouse Ex Vivo Follicle Growth, Ovulation, and Luteinization.  Bioengineering (Basel)  2024 Jul 15;11(7). pii:719
  44. Amargant F, Vieira C, Pritchard MT, Duncan FE  Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse.  bioRxiv  2024 Jun 25;. pii:2024.06.21.600035
  45. Zaniker EJ, Zhang M, Hughes L, La Follette L, Atazhanova T, Trofimchuk A, Babayev E, Duncan FE  Shear wave elastography to assess stiffness of the human ovary and other reproductive tissues across the reproductive lifespan in health and disease†.  Biol Reprod  2024 Jun 12;110(6):1100-1114. doi:10.1093/biolre/ioae050
  46. Huang R, Kratka CE, Pea J, McCann C, Nelson J, Bryan JP, Zhou LT, Russo DD, Zaniker EJ, Gandhi AH  et al.  Single-cell and spatiotemporal profile of ovulation in the mouse ovary.  bioRxiv  2024 Jun 05;. pii:2024.05.20.594719
  47. Zhu Y, Kratka CR, Pea J, Lee HC, Kratka CE, Xu J, Marin D, Treff NR, Duncan FE  The severity of meiotic aneuploidy is associated with altered morphokinetic variables of mouse oocyte maturation.  Hum Reprod Open  2024;2024(2):hoae023. pii:hoae023
  48. Gokyer D, Akinboro S, Zhou LT, Kleinhans A, Laronda MM, Duncan FE, Riley JK, Goldman KN, Babayev E  The oocyte microenvironment is altered in adolescents compared to oocyte donors.  bioRxiv  2024 Apr 06;. pii:2024.04.04.588118
  49. Salvi A, Li W, Dipali SS, Cologna SM, Pavone ME, Duncan FE, Burdette JE  Follicular fluid aids cell adhesion, spreading in an age independent manner and shows an age-dependent effect on DNA damage in fallopian tube epithelial cells.  Heliyon  2024 Mar 30;10(6):e27336. pii:e27336
  50. Boiani M, Duncan FE  A new initiative for 2024: increasing peer review transparency at MHR.  Mol Hum Reprod  2024 Mar 28;30(4). pii:gaae014

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