Pioneering therapies for immune-related diseases.
The goal of the Choi Lab at Northwestern University Feinberg School of Medicine is to develop novel therapies for immune-related diseases by engineering novel solutions. To accomplish this, we first utilize high-dimensional approaches on human disease to identify targetable disease-promoting molecular defects. Second, we utilize engineering approaches to reverse these molecular changes.
The goal is to translate these findings to first-in-human clinical trials. Learn more about our lab's research.
Principal Investigator
Jaehyuk Choi, MD, PhD
Jack W. Graffin Associate Professor,
Dermatology (Medical Dermatology),
Biochemistry and Molecular Genetics
View Choi's Faculty Profile
Latest News
Scientists Discover Potential Biomarker in Rare Skin Cancer
Northwestern Medicine scientists have discovered increased immune cell activity in Merkel cell carcinoma tumors, which could help predict treatment response in patients and inform the development of new targeted therapies, according to findings published in the journal Cancer Discovery.
Scientists Discover a Cause of Lupus and a Possible Way to Reverse It
Northwestern Medicine and Brigham and Women’s Hospital scientists have discovered a molecular defect that promotes the pathologic immune response in systemic lupus erythematosus (known as lupus) and in a study published in Nature, show that reversing this defect may potentially reverse the disease.
Using Cancer’s Strength to Fight Against It
Northwestern Medicine scientists, along with collaborators University of California San Francisco (UCSF), may have found a way around the limitations of engineered T-cells by borrowing a few tricks from cancer itself, in findings published in Nature.