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Northwestern University Feinberg School of Medicine
Atique Ahmed Lab

Publications

Browse below to read the most recent publications featuring our lab's work, and view Dr. Ahmed's Full Bibliography for more.
  1. Shireman JM, White Q, Ni Z, Mohanty C, Cai Y, Zhao L, Agrawal N, Gonugunta N, Wang X, Mccarthy L  et al.  Genomic analysis of human brain metastases treated with stereotactic radiosurgery reveals unique signature based on treatment failure.  iScience  2024 Apr 19;27(4):109601. pii:109601
  2. Budhiraja S, McManus G, Baisiwala S, Perrault EN, Cho S, Saathoff M, Chen L, Park CH, Kazi HA, Dmello C  et al.  ARF4-mediated retrograde trafficking as a driver of chemoresistance in GBM.  Neuro Oncol  2024 Mar 20;. pii:noae059
  3. Rashidi A, Billingham LK, Zolp A, Chia TY, Silvers C, Katz JL, Park CH, Delay S, Boland L, Geng Y  et al.  Myeloid cell-derived creatine in the hypoxic niche promotes glioblastoma growth.  Cell Metab  2024 Jan 02;36(1):62-77.e8. doi:10.1016/j.cmet.2023.11.013
  4. Fares J, Petrosyan E, Kanojia D, Dmello C, Cordero A, Duffy JT, Yeeravalli R, Sahani MH, Zhang P, Rashidi A  et al.  Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases.  J Clin Invest  2023 Dec 15;133(24). pii:e161142
  5. Perrault EN, Shireman JM, Ali ES, Lin P, Preddy I, Park C, Budhiraja S, Baisiwala S, Dixit K, James CD  et al.  Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production.  Sci Adv  2023 May 19;9(20):eade7236. pii:eade7236
  6. Petrosyan E, Fares J, Fernandez LG, Yeeravalli R, Dmello C, Duffy JT, Zhang P, Lee-Chang C, Miska J, Ahmed AU  et al.  Endoplasmic Reticulum Stress in the Brain Tumor Immune Microenvironment.  Mol Cancer Res  2023 May 01;21(5):389-396. doi:10.1158/1541-7786.MCR-22-0920
  7. Shireman JM, White Q, Agrawal N, Ni Z, Chen G, Zhao L, Gonugunta N, Wang X, Mccarthy L, Kasulabada V  et al.  Genomic Analysis of Human Brain Metastases Treated with Stereotactic Radiosurgery Under the Phase-II Clinical Trial (NCT03398694) Reveals DNA Damage Repair at the Peripheral Tumor Edge.  medRxiv  2023 Apr 24;. pii:2023.04.15.23288491
  8. Preddy I, Nandoliya K, Miska J, Ahmed AU  Checkpoint: Inspecting the barriers in glioblastoma immunotherapies.  Semin Cancer Biol  2022 Nov;86(Pt 3):473-481. doi:10.1016/j.semcancer.2022.02.012
  9. Dmello C, Sonabend A, Arrieta VA, Zhang DY, Kanojia D, Chen L, Gould A, Zhang J, Kang SJ, Winter J  et al.  Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma.  Clin Cancer Res  2022 Jul 15;28(14):3156-3169. doi:10.1158/1078-0432.CCR-21-2563
  10. Xuan W, Hsu WH, Khan F, Dunterman M, Pang L, Wainwright DA, Ahmed AU, Heimberger AB, Lesniak MS, Chen P  Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma.  Cancer Immunol Res  2022 Jun 03;10(6):770-784. doi:10.1158/2326-6066.CIR-21-0559
  11. Cordero A, Ramsey MD, Kanojia D, Fares J, Petrosyan E, Schwartz CW, Burga R, Zhang P, Rashidi A, Castro B  et al.  Combination of tucatinib and neural stem cells secreting anti-HER2 antibody prolongs survival of mice with metastatic brain cancer.  Proc Natl Acad Sci U S A  2022 Jan 04;119(1). pii:e2112491119
  12. Baisiwala S, Budhiraja S, Goel C, Nandoliya KR, Saathoff MR, Ahmed AU  Spelling Out CICs: A Multi-Organ Examination of the Contributions of Cancer Initiating Cells' Role in Tumor Progression.  Stem Cell Rev Rep  2022 Jan;18(1):228-240. doi:10.1007/s12015-021-10195-x
  13. Fares J, Ahmed AU, Ulasov IV, Sonabend AM, Miska J, Lee-Chang C, Balyasnikova IV, Chandler JP, Portnow J, Tate MC  et al.  Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial.  Lancet Oncol  2021 Aug;22(8):1103-1114. doi:10.1016/S1470-2045(21)00245-X
  14. Easwaran TP, Lancki N, Henriquez M, Vortmeyer AO, Barbaro NM, Scholtens DM, Ahmed AU, Dey M  Molecular Classification of Gliomas is Associated with Seizure Control: A Retrospective Analysis.  Neuromolecular Med  2021 Jun;23(2):315-326. doi:10.1007/s12017-020-08624-0
  15. Shireman JM, Atashi F, Lee G, Ali ES, Saathoff MR, Park CH, Savchuk S, Baisiwala S, Miska J, Lesniak MS  et al.  De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma.  Brain  2021 May 07;144(4):1230-1246. doi:10.1093/brain/awab020
  16. Shireman JM, Ahmed AU  Separate and not equal: sex differences in JAM-A tumor suppression in glioblastoma.  Neuro Oncol  2020 Nov 26;22(11):1555-1556. doi:10.1093/neuonc/noaa218
  17. Baisiwala S, Hall RR, Saathoff MR, M Shireman J, Park C, Budhiraja S, Goel C, Warnke L, Hardiman C, Wang JY  et al.  LNX1 Modulates Notch1 Signaling to Promote Expansion of the Glioma Stem Cell Population during Temozolomide Therapy in Glioblastoma.  Cancers (Basel)  2020 Nov 25;12(12). pii:3505
  18. Caragher S, Miska J, Shireman J, Park CH, Muroski M, Lesniak MS, Ahmed AU  Temozolomide Treatment Increases Fatty Acid Uptake in Glioblastoma Stem Cells.  Cancers (Basel)  2020 Oct 26;12(11). pii:3126
  19. Kanojia D, Panek WK, Cordero A, Fares J, Xiao A, Savchuk S, Kumar K, Xiao T, Pituch KC, Miska J  et al.  BET inhibition increases βIII-tubulin expression and sensitizes metastatic breast cancer in the brain to vinorelbine.  Sci Transl Med  2020 Aug 26;12(558). pii:eaax2879
  20. Fares J, Kanojia D, Rashidi A, Ahmed AU, Balyasnikova IV, Lesniak MS  Diagnostic Clinical Trials in Breast Cancer Brain Metastases: Barriers and Innovations.  Clin Breast Cancer  2019 Dec;19(6):383-391. doi:10.1016/j.clbc.2019.05.018
  21. Fares J, Kanojia D, Cordero A, Rashidi A, Miska J, Schwartz CW, Savchuk S, Ahmed AU, Balyasnikova IV, Cristofanilli M  et al.  Current state of clinical trials in breast cancer brain metastases.  Neurooncol Pract  2019 Sep;6(5):392-401. doi:10.1093/nop/npz003
  22. Cordero A, Kanojia D, Miska J, Panek WK, Xiao A, Han Y, Bonamici N, Zhou W, Xiao T, Wu M  et al.  FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis.  Oncogene  2019 Sep;38(37):6445-6460. doi:10.1038/s41388-019-0893-4
  23. Baisiwala S, Auffinger B, Caragher SP, Shireman JM, Ahsan R, Lee G, Hasan T, Park C, Saathoff MR, Christensen AC  et al.  Chemotherapeutic Stress Induces Transdifferentiation of Glioblastoma Cells to Endothelial Cells and Promotes Vascular Mimicry.  Stem Cells Int  2019;2019:6107456. pii:6107456
  24. Miska J, Lee-Chang C, Rashidi A, Muroski ME, Chang AL, Lopez-Rosas A, Zhang P, Panek WK, Cordero A, Han Y  et al.  HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma.  Cell Rep  2019 Apr 02;27(1):226-237.e4. doi:10.1016/j.celrep.2019.03.029
  25. Hasan T, Caragher SP, Shireman JM, Park CH, Atashi F, Baisiwala S, Lee G, Guo D, Wang JY, Dey M  et al.  Interleukin-8/CXCR2 signaling regulates therapy-induced plasticity and enhances tumorigenicity in glioblastoma.  Cell Death Dis  2019 Mar 29;10(4):292. pii:292
  26. Caragher SP, Shireman JM, Huang M, Miska J, Atashi F, Baisiwala S, Hong Park C, Saathoff MR, Warnke L, Xiao T  et al.  Activation of Dopamine Receptor 2 Prompts Transcriptomic and Metabolic Plasticity in Glioblastoma.  J Neurosci  2019 Mar 13;39(11):1982-1993. doi:10.1523/JNEUROSCI.1589-18.2018
  27. Storey K, Leder K, Hawkins-Daarud A, Swanson K, Ahmed AU, Rockne RC, Foo J  Glioblastoma Recurrence and the Role of O6-Methylguanine-DNA Methyltransferase Promoter Methylation.  JCO Clin Cancer Inform  2019 Feb;3:1-12. pii:CCI.18.00062