What We Do
We study the molecular and physiological properties of receptor proteins that underlie excitatory synaptic transmission in the mammalian brain. Current research focuses primarily on understanding the roles of kainate receptors, a family of glutamate receptors whose diverse physiological functions include modulation of neurotransmission and induction of synaptic plasticity. We are also interested in exploring how kainate receptors might contribute to pathological processes such as epilepsy and pain. The laboratory investigates kainate receptor function using a diverse group of techniques that include patch-clamp electrophysiology, selective pharmacological compounds, molecular and cellular techniques, and gene-targeted mice.
Auxiliary proteins are the predominant determinants of differential efficacy of clinical candidates acting as AMPA receptor positive allosteric modulators published in Molecular Pharmacology. (February 28, 2020)
Kristine Watral defended her master's thesis and accepted a position as a technician in Catherine Woolley's lab. Congratulations Kristine - we'll miss you! (November 2019)
Phosphorylation of the HCN channel auxiliary subunit TRIP8b is altered in an animal model of temporal lobe epilepsy and modulates channel function published in the Journal of Biological Chemistry. (October 25, 2019)
Congratulations to Kendall, who successfully defended her graduate thesis! (June 12, 2019)
Geoff accepted the position of Director of the NUIN graduate program. (May 1, 2019)
Sakiko Taniguchi joined the lab as a postdoctoral researcher. (May 2019)
Phosphorylation of the HCN channel auxiliary subunit TRIP8b is altered in an animal model of temporal lobe epilepsy and modulates channel function
Foote KM, Lyman KA, Han Y, Michailidis IE, Heuermann RJ, Mandikian D, Trimmer JS, Swanson GT, Chetkovich DM.
Journal of Biological Chemistry. (October 2019)
Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy
Xu D, Robinson AP, Ishii T, Duncan DS, Alden TD, Goings GE, Ifergan I, Podojil JR, Penaloza-MacMaster P, Kearney JA, Swanson GT, Miller SD, Koh S.
The Journal of Experimental Medicine. (February 2018)
Excitatory synaptic input to hilar mossy cells under basal and hyperexcitable conditions
Hedrick TP, Nobis WP, Foote KM, Ishii T, Chetkovich DM, Swanson GT.
eNeuro. (November 2017)