Defining key signaling pathways in cardiac development and cardiomyocyte maintenance in the setting of pathological stress.

The goal of our research is to define key signaling pathways in cardiac development and cardiomyocyte maintenance in the setting of pathological stress. Currently, the laboratory investigates the G protein-coupled receptor sphingosine-1-phosphate receptor 1 (S1P₁) and its unexpected role in cardiomyocyte proliferation and cardiac development. We aim to identify the signaling mechanisms that underlie these cardiac developmental effects and to investigate whether S1P₁ signaling contributes to cardiac remodeling in the adult heart.

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