About Our Lab
The regulation of gene transcription by RNA polymerase II is critical for development and differentiation, and its misregulation contributes to the pathogenesis of many cancers, including leukemia. The overall goal of our laboratory is to define the molecular mechanisms underlying leukemogenesis and to identify potential targets for therapy through detailed studies of proteins and protein complexes that regulate chromatin modifications, transcription initiation, and transcription elongation.
A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation. Morgan MAJ, et al. Genes Dev. 2017
PAF1 regulation of promoter-proximal pause release via enhancer activation. Chen FX, et al. Science. 2017
SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expression. Cao K, et al Genes Dev. 2017
Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas. Piunti A, et al. Nat Med. 2017