About Our Lab

The regulation of gene transcription by RNA polymerase II is critical for development and differentiation, and its misregulation contributes to the pathogenesis of many cancers, including leukemia. The overall goal of our laboratory is to define the molecular mechanisms underlying leukemogenesis and to identify potential targets for therapy through detailed studies of proteins and protein complexes that regulate chromatin modifications, transcription initiation, and transcription elongation.

Read more about the Shilatifard Lab

Lab Positions Available

Recent Publications

Zic2 is an enhancer-binding factor required for embryonic stem cell specification. Luo Z, Gao X, Lin C, Smith ER, Marshall SA, Swanson SK, Florens L, Washburn MP, Shilatifard A. Mol Cell. 2015

Chromatin signatures of cancer. Morgan MA, Shilatifard A. Genes Dev. 2015 

A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation. Zhang P, Chaturvedi CP, Tremblay V, Cramet M, Brunzelle JS, Skiniotis G, Brand M, Shilatifard A, Couture JF. Genes Dev. 2015 

Stably paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor triptolide. Chen F, Gao X, Shilatifard A. Genes Dev. 2015 

Integrator Regulates Transcriptional Initiation and Pause Release following Activation. Gardini A, Baillat D, Cesaroni M, Hu D, Marinis JM, Wagner EJ, Lazar MA, Shilatifard A, Shiekhattar R. Mol Cell. 2014 

Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling. Herz HM, Morgan M, Gao X, Jackson J, Rickels R, Swanson SK, Florens L, Washburn MP, Eissenberg JC, Shilatifard A. Science. 2014 

View all publications

Ali Shilatifard, PhD

Ali Shilatifard, PhD
Robert Francis Furchgott Professor
Chair, Department of Biochemistry and Molecular Genetics

For more information, click here to visit our department page.