Northwestern University Feinberg School of Medicine

Sanjiv Shah Lab: HFpEF and Cardiac Mechanics

Lab Members

Meet the Shah Lab team members.  We welcome requests for information about our work and collaboration opportunities.

Principal Investigator

 
SanjivShah

Sanjiv Shah, MD
sanjiv.shah( at )northwestern.edu
Professor of Medicine
Director, T1 Center for Cardiovascular Developmental Therapeutics
Director, Northwestern HFpEF Program
Division of Cardiology, Department of Medicine - Northwestern University Feinberg School of Medicine
View Northwestern University Feinberg School of Medicine faculty profile

Bio: Dr. Shah is a Professor of Medicine and Director of the T1 Center for Cardiovascular Therapeutics at Northwestern University Feinberg School of Medicine. Dr. Shah’s research interests include understanding the physiology, mechanisms, and epidemiology of heart failure with preserved ejection fraction (HFpEF). Dr. Shah started the first dedicated HFpEF clinical program at Northwestern University in 2007, and has been a leading enroller in clinical trials for HFpEF since that time. Dr. Shah’s research interests also include the study of acquired and genetic risk factors for abnormal cardiac mechanics, and novel machine learning techniques for improved classification and therapeutic targeting of heart failure syndromes. Dr. Shah’s research is currently funded by multiple NIH and AHA grants, and he is also a steering committee member for several ongoing international heart failure clinical trials. Dr. Shah has published over 250 original papers, abstracts, book chapters, and review articles, and he is an Associate Editor for JAMA Cardiology. He has also received several teaching awards throughout his career, including the W. Proctor Harvey Teaching Award from the American College of Cardiology. 

Senior Lab Members

 
LaurenNelson

Lauren Nelson, MS, RDCS, FASE
lauren.nelson( at )northwestern.edu
Technical Director, Northwestern University Echocardiography Core Laboratory
Technical Director, T1 Center for Cardiovascular Developmental Therapeutics
Department of Medicine-Cardiology

Projects: MESA, CHART, PROMIS

Bio: Lauren grew up in Cape Girardeau, Missouri.  She attended the University of Missouri, where she obtained her Bachelor of Health Science degree, followed by a Master of Science degree with a focus in Diagnostic Medical Ultrasound.   She joined Dr. Shah’s lab as a research sonographer in 2010.  Lauren has served as the lead sonographer on several clinical trials and is also responsible for performing echo in rodents, dogs, and primates for a variety of heart failure studies.  In her capacity as technical director of the core laboratory, she has quantitated over 5,000 echos for projects relating to heart failure with preserved ejection fraction, scleroderma, and pulmonary hypertension.  She is also the resident expert on speckle tracking echocardiography, a high level echo analysis technique that is used to evaluate the deformation of atrial and ventricular tissue.  In 2015, Lauren became a Fellow of the American Society of Echocardiography.  She frequently presents on speckle tracking echocardiography and animal echocardiography and is also responsible for training new laboratory personnel in basic and advanced echocardiographic analysis techniques and cardiovascular anatomy and physiology.  Outside of the lab, Lauren enjoys reading, horseback riding, watching Mizzou football and basketball, and spending time with her young family and her dog, Charles Barkley.
Hamorabi Mkrdichian

Hamorabi Mkrdichian, CCRC, CPhT
hmkrdich( at )nm.org
Clinical Operations Manager
Bluhm Cardiovascular Institute

Projects: Tafamidis Extension, Tafamidis ATTR-ACT

Bio: Hamorabi is a Chicago native and attended the University of Illinois at Chicago for his undergraduate studies in Biology. After his studies, he began work in the Investigational Pharmacy at Northwestern Memorial Hospital managing investigational product for various oncology, cardiology, transplant, and infection disease studies across Northwestern University. Soon after, he shifted into a clinical research coordinator role at the Robert H. Lurie Comprehensive Cancer Center where he managed radiation oncology studies. He then stepped into a Project Manager role for the HFpEF program run by Dr. Sanjiv Shah.  Most recently, Hamorabi has transitioned to the Clinical Operations Manager in the Bluhm Cardiovascular Institute Clinical Trails Unit where he oversees the research staff and day to day operations of the group. Outside of Northwestern, Hamorabi can occasionally be found managing dance floors from the DJ booth at various establishments.

Post-Doctoral Fellow

 
HarnishPatel

Harnish Patel, MD
harnish.patel( at )northwestern.edu
Department of Medicine-Cardiology

Projects: KNOCKOUT, CHS, CPET laboratory

Bio: Harnish was born in Ahmedabad, India. He received his medical training at Pramukhswami Medical College-Sardar Patel University, Gujarat, India.  After graduation, he completed his internship at Shri Krishna Hospital and Medical Research Center, Gujarat, India (2013). He moved to the US after accepting a position as a research fellow in Internal medicine at Cleveland Clinic (2014). As a research fellow, he worked on projects regarding “Scintigraphy and Sphincter of Oddi Dysfunction” and “Survival of Home Parenteral Nutrition Treated Patients.” He published and presented couple of abstracts at the American College of Gastroenterology and Digestive Disease Week conferences. He soon accepted a position in Jesse Brown VA Medical Center at University of Illinois at Chicago (2015), where he investigated the mechanism of salt and water absorption in the large intestines of healthy and diseased patients. Starting in 2016, he joined Northwestern University as a post doctoral fellow in Dr. Shah’s lab with a focus on digitization and speckle tracking to assess associations of cardiac mechanics indices with novel biomarkers, GWAS indices, and outcomes (particularly incident heart failure). Aside from doing extensive research, he enjoys flying (about to get his pilot license!), adventurous outdoor activities-skydiving and spending time with friends and family.

Pre-Doctoral Fellow

 
JacobBurns

Jacob Burns
jacob.burns( at )northwestern.edu
Medical Student

Bio: Jacob grew up in New Jersey before moving to the midwest for college. He attended Northwestern University where he studied biological sciences. Jacob developed an interest in cardiac physiology while in college and was fortunate to begin working in Dr. Shah's lab. Jacob stayed at Northwestern for medical school and is currently a fourth year student.  In the lab, Jacob has worked on a number of research studies, with the goal of using clinical and echocardiographic parameters to better understand how various factors impact cardiac structure and function in patients with heart failure with preserved ejection fraction (HFpEF).  Most recently, his work in Dr. Shah's lab has focused on the pathophysiologic role of anemia in HFpEF.  Following medical school, Jacob plans to complete a residency in internal medicine and pursue a career in academic medicine. Outside of medical school Jacob enjoys biking, watching the Yankees, and hanging out with his dog, Ollie.

Research Sonographers

 
JulietRyan

Juliet Ryan, BS, RDCS, FASE
juliet.ryan1( at )northwestern.edu
Research Sonographer
Department of Medicine-Cardiology

Projects: PROMIS, AHA GRFW, MESA

Bio: Juliet grew up in the Southside of Chicago, Illinois, and attended Eastern Illinois University, where she obtained a bachelor’s degree in Administration/Therapeutic Recreation.  Later on, she studied exercise physiology courses at University Of Illinois at Chicago and echocardiography/electrocardiography at Medical Careers Institute where she began her career as a Cardiology Sonographer.  Juliet has worked at Northwestern Memorial Hospital Echo Lab for 10 years and has focused on research studies that eventually brought her to Dr. Shah’s Lab where she is in charge of administering echocardiograms and measurement/ strain analysis on multiple research studies. In addition to this, she enjoys sports, outdoor activities, music, spending time with family/friends and volunteering for military fundraisers.
Bonnie JKane

Bonnie J Kane, BS, RDCS, FASE
bkane( at )northwestern.edu
Research Sonographer
Department of Medicine-Cardiology

Projects: AHA, KNOCKOUT, MESA, MACS

Bio: Bonnie was born on Long Island but has lived most of her life in the Chicago suburbs. She graduated from Quinnipiac College (now University) in Hamden, Connecticut in 1980 with a BS in Laboratory Animal Technology. Early in her career she briefly worked as a Veterinary Technologist at an animal hospital and then moved to Northwestern University where she has been for 35 years. The first 8 years she worked as a Veterinary Technologist/Surgical Coordinator for the Center for Experimental Animal Resources. In 1990, Bonnie joined a Cardiovascular Research laboratory where she performed cardiovascular ultrasound exams for clinical and animal research studies, and eventually became the laboratory manager in 2005. Over the past 12 years, she continues as a sonographer for large multi-site studies for echo, carotid IMT and brachial flow-mediated dilation (FMD) studies (MESA, CARDIA, the HIV-CVD Collaborative) in addition to numerous smaller studies. She recently has joined the Shah laboratory, performing ultrasound scans for various studies including MESA, MACS, KNOCK-OUT and AHA-GRFW. She continues to be the only sonographer here at Northwestern University certified to perform the brachial flow mediated dilation (FMD) scans. Bonnie is a registered Diagnostic Cardiac Sonographer with the ARDMS and is a Fellow with the American Society of Echocardiography. She has presented at Echo Northwestern and the American Society of Echocardiography Scientific Sessions.
 
AllieRunning

Allie Running, MS, RDCS
allison.running( at )northwestern.edu
Research Sonographer
Department of Medicine-Cardiology

Projects: MESA, CHART, PROMIS, OLINK

Bio: Allie grew up in Brookfield, WI and is a huge Packer fan. She attended the University of Wisconsin Eau Claire where she received her Bachelor of Science degree, specialized in Kinesiology. Allie continued her education at Benedictine University where she received her Master of Science degree in Clinical Exercise Physiology. After working at Northwestern Memorial Hospital in Cardiac Diagnostics (Nuclear and Echo labs) for 3.5 years, she went back to school for Echocardiography. This is her first position working as a registered diagnostic cardiac sonographer. Allie’s hobbies include reading, swimming, seeing live music, and spending time with her friends and family.

Study Coordinators

 
NealPohlman

Neal Pohlman
neal.pohlman( at )nm.org
Clinical Research Coordinator
Bluhm Cardiovascular Institute

Projects: PROMIS, BMS, THAOS, PANACHE

Bio: Neal grew up in Columbus, Ohio and attended Oberlin College where he received a Bachelor of Arts in Biology. Prior to Northwestern, Neal worked with Dr. Matthew Ringel at Ohio State on investigating the role of regulator of calcineurin, RCAN1-4, in thyroid tumor metastasis and angiogenesis, as well as with Paul Janssen on a method to measure electrical potentials in developing cardiac tissue.  At Northwestern, Neal is involved with various clinical trials for heart failure, primarily the PROMIS trial that studies microvascular dysfunction and PANACHE which is a partial A-1 adenosine receptor agonist. In his free time, Neal enjoys playing soccer, cooking, reading, and traveling.
CynthiaSanchez

Cynthia Sanchez
csanche3( at )nm.org
Clinical Research Coordinator
Department of Medicine-Cardiology

Projects: ENDEAVOUR, LIBERTY, CHART, EMPEROR

Bio: Cynthia grew up in Denver, Colorado and received her undergraduate degree in Cognitive Neuroscience from the University of Denver. She joined Dr. Shah’s lab in 2013 and has worked on a variety of studies. Currently, Cynthia works on two research studies focusing on genetic cardiovascular diseases, LIBERTY and ENDEAVOUR. LIBERTY studies the effects of late INa inhibition on exercise capacity in patients with symptomatic hypertrophic cardiomyopathy. ENDEAVOUR studies the clinical benefit of using an siRNA inhibitor to reduce the hepatic production of TTR protein in patients with familial amyloidotic cardiomyopathy. Cynthia enjoys running, is an avid reader, and a huge football fan-Go Broncos!
 
DanRoshevsky

Dan Roshevsky, CCRC
droshevs( at )nm.org
Certified Clinical Research Coordinator
Bluhm Cardiovascular Institute

Projects: CLR325, REDUCE-I, REDUCE-II, DEFINE, PRESERVED-HF

Bio: Despite his lack of an accent, Dan grew up on Long Island, NY and attended Washington University in St Louis where he graduated with a Bachelor of Arts in Psychology and Biology.  He spent two of his undergraduate summers working with Dr. William R. Jacobs at his tuberculosis lab at Albert Einstein College of Medicine where he helped with knockout plasmid design and delivery.  Additionally, he spent a summer working with Dr. John Curci at the Washington University in St. Louis School of Medicine to study the use of doxycycline after endoluminal aneurysm repair.  After graduating from undergraduate studies, Dan worked as an oncology clinical research coordinator at The University of Chicago before moving to Northwestern University’s Robert H. Lurie Comprehensive Cancer Center.  He has been with the Bluhm Cardiovascular Institute since 2012 where he works on a range of trials including those for vascular disease, heart failure, regenerative medicine, and electrophysiology.  In his spare time he is an avid biker rider and also enjoys strength training with friends.  He is also working towards completing his Masters of Science in Health Informatics through Northwestern’s School of Professional Studies.
SheanoGold

Sheano Gold, CCRC
sgold( at )nm.org
Clinical Research Coordinator
Bluhm Cardiovascular Institute

Projects: PARAGON, INDIE

Bio: Sheano was born in Evansville, Indiana and moved to Chicago, Illinois at the age of 10.  He started working at Northwestern University in 1990 as a Clinical Research Coordinator in the Robert H. Lurie Cancer Center.  Sheano left Northwestern for a while to work as a Clinical Research Associate for Quintiles.  He then returned the Bluhm Cardiovascular Institute in April of 2017.  Currently, Sheano works on two research studies, INDIE and Paragon.  INDIE is a study, which uses an inorganic nitrite delivery to improve exercise capacity in HFpEF.  Paragon is a multicenter, randomized, double blind, parallel group, active-controlled study to evaluate the efficacy and safety of LCZ696 compared to valsartan, on morbidity and mortality in heart failure patients with preserved ejection fraction.  Sheano is married with twin sons, who are both in the US Navy.  In his free time, Sheano loves to watch basketball.  His favorite team is the Cleveland Cavaliers.
 
LarissaReinkensmeyer

Larissa Reinkensmeyer
larissa.reinkensmeyer( at )nm.org
Research Study Coordinator
Bluhm Cardiovascular Institute

Projects: INVESTED, DEFINE-HF, PRESERVED-HF, REDUCE II

Bio: Larissa grew up in Portland, Oregon. She attended the University of Illinois in Champaign-Urbana where she obtained her Bachelors of Science in Animal Science and Integrated Biology. She then moved, to Chicago to attend business school at Loyola University. Currently, Larissa works in the BCVI Clinical Trials Unit where she works on a variety of projects. She has been primarily focusing on INVESTED, which is a study comparing high-dose influenza vaccine to the standard-dose vaccine in regards to cardiopulmonary hospitalizations within flu season. In her free time, Larissa enjoys traveling, hiking, and exploring Chicago.

Research Assistants

 
MeganBach

Megan Bach
megan.bach( at )northwestern.edu
Research Study Assistant
Department of Medicine-Cardiology

Projects: CHS, GRFW

Bio: Megan grew up in Milwaukee, Wisconsin and attended Penn State, where she received a bachelor’s degree in Biology and a minor in French.  She joined Dr. Shah’s lab in the summer of 2017 and is currently working on two studies focusing on HFpEF, CHS and GRFW.  CHS is a longitudinal study looking to understand the structural and functional changes that occur to the heart muscle when developing HFpEF.  GRFW studies the differences in men and women with HFpEF and determining whether hormonal differences play a role in HFpEF development.  Megan enjoys outdoor activities, cooking, sports, and spending time with family and friends.
StephenDvorak

Stephen Dvorak
stephen.dvorak( at )northwestern.edu
Research Study Assistant
Department of Medicine-Cardiology

Projects: KNOCKOUT, VICTORY, CHS, GRFW

Bio: Stephen received his BA from Columbia College Chicago in Audio and Acoustics, then attended the University of Miami where he obtained his MFA in Creative Writing as a James A. Michener Fellow.  He joined Dr. Shah’s lab in 2017 after coordinating clinical research for the Department of Pediatric Hematology and Oncology at Rush University Medical Center.  He is currently the Northwestern University Pre-Health Professionals board President at Northwestern’s School of Professional Studies where he is completing a laboratory sciences certificate.

Program Assistant

 
MalloryBeckemeyer

Mallory Beckemeyer, MHA
mallory.beckemeyer( at )northwestern.edu
Program Assistant, Northwestern HFpEF Program
Department of Medicine-Cardiology

Bio: Mallory grew up in a small rural community in Northeast Missouri.  She attended the University of Missouri where she obtained her Bachelor of Science degree, followed by a Master of Health Administration degree.  Mallory also worked in healthcare at the University of Missouri for several years before moving to Evanston.  In January 2017, Mallory joined Dr. Shah’s lab as a program assistant.  She works with all lab members to help the lab run smoothly.  Outside of the lab, Mallory is a certified personal trainer and enjoys teaching group fitness classes, watching baseball, and spending time with her husband and dog, Goober.

Northwestern Faculty Collaborators

 
SadiyaKhan

Sadiya Khan, MD, MSc
s-khan-1( at )northwestern.edu
Assistant Professor of Medicine-Cardiology
View Northwestern University Feinberg School of Medicine faculty profile

JaneWilcox

Jane Wilcox, MD, MSc
jane-wilcox( at )fsm.northwestern.edu
Assistant Professor of Medicine-Cardiology
Director Myocardial Recovery Program
View Northwestern University Feinberg School of Medicine faculty profile

 
BenjaminFreed

Benjamin Freed, MD
bfreed( at )nm.org
Assistant Professor of Medicine-Cardiology
View Northwestern University Feinberg School of Medicine faculty profile

Additional Lab Members

 
AbigailBaldridge

Abigail Baldridge
abigail.baldridge( at )northwestern.edu
Biostatistician
Department of Preventive Medicine-Biostatistics

Projects: HyperGEN, TopCAT, RELAX, Berne Amish

Bio: Abi grew up in St. Paul, Minnesota and completed her undergraduate degree in Biomedical Engineering at Purdue University. After graduating, she worked for several years as an engineer for a medical devices company before moving back to the Midwest to attend Northwestern University for a master’s degree in Epidemiology and Biostatistics. While completing her master’s degree, she began working with faculty in the Department of Preventive Medicine, and took a full time position after graduation. She currently works with several investigators and faculty as biostatistician and project coordinator for a variety of studies, trials, and projects. Abi enjoys running, volleyball, reading, and being outdoors.
LaraMarteau

Lara Marteau
lara.marteau( at )northwestern.edu
Visiting Scholar

Projects: VICTORY

Bio: Lara grew up in Lille, a city in north France, where her medical studies commenced. After 6 years of medical school, she moved to Nantes, a city located in west France, to complete a Cardiology Fellowship. As a part of her fellowship, Lara decided to do a one-year basic science program and joined Dr. Sanjiv Shah’s lab in March 2018. Lara is working on VICTORY, a study examining the role of visceral congestion in heart failure patients. Outside of the lab, Lara enjoys traveling, meeting people, and is looking forward to exploring Chicago this summer. 

Lab Alumni

 

Dan Silverman, MD
Post-doctoral Fellow

Vinny Polsinelli
Medical Student

 
JeanetteCheng

Jeanette Cheng
Research Study Assistant
July 2015-May 2017

Projects: CHS, GRFW

Bio: Jeanette is finishing up her first year of medical school at University of Illinois at Chicago.
SenthilSelvaraj

Senthil Selvaraj, MD, MA
Pre-Doctoral Research Fellow
July 2011 - Sept 2012

Projects: HyperGEN Cardiac Mechanics Study and several Heart Failure with Preserved Ejection Fraction studies

Bio: Senthil is currently a first year cardiology fellow at the Hospital of the University of Pennsylvania. Previously, he completed his residency training, chief residency, and preventive cardiology fellowship at the Brigham and Women's Hospital.