About Our Lab
The Mazzulli Lab is interested in determining how protein misfolding and amyloid formation results in cell death. Many chronic neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease are characterized by the accumulation of misfolded proteins within the nervous system. We use patient neurons derived from induced pluripotent stem cells (iPSC) coupled with analytic biochemical techniques to study protein accumulation and lysosomal clearance mechanisms.
News and Events
BioMed21- Emerging Technology Toward Pathway-Based Human Brain Research, May 29-30th, Rio de Janeiro, Brazil. Presentation on the use of human-based research models for the study of neurodegenerative disorders.
Dr. Zunke to present her work on a-synuclein at the 13th International Conference on Alzheimer's & Parkinson's Diseases, in Vienna, Austria, on Saturday, April 1st, 2017
Mazzulli JR, Zunke F, Tsumeni T, Toker NJ, Jeon S, Burbulla LF, Patnaik S, Sidransky E, Marugan JJ, Sue CM, Krainc D. Activation of b-Glucocerebrosidase Reduces Pathological a-Synuclein and Restores Lysosomal Function in Parkinson’s Patient Midbrain Neurons, J. Neurosci, Jul 20, 2016. 36(29):7693-706. PMID: 27445146
Mazzulli JR, Zunke F, Isacson O, Studer L, Krainc D. α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models. Proceedings of National Academy of Sciences, Feb 2, 2016. 113(7):1931-6. PMID: 26839413
Mazzulli JR, Burbulla LF, Krainc D, Ischiropoulos H. Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence. Analytical Chemistry, Feb 3, 2016, PMID: 26813311
Mazzulli JR, Xu Y, Sun Y, Knight AL, Mclean PJ, Caldwell GA, Sidransky E, Grabowski G, Krainc D. Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell. July 2011; 146, 37-52. PMID: 21700325.
Tsika E, Moysidou M, Guo J, Cushman M, Gannon P, Sandaltzopoulos R, Giasson BI, Krainc D, Ischiropoulos H, and Mazzulli JR. Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration. J. Neurosci. 2010; 30:3409-3418. PMID: 20203200.