Northwestern University Feinberg School of Medicine

Laimonis Laimins Lab


Learn more about the work that we do in the Laimonis Laimins Laboratory through our recent publications.
  1. Hong S, Cheng S, Songock W, Bodily J, Laimins LA  Suppression of MicroRNA 424 Levels by Human Papillomaviruses Is Necessary for Differentiation-Dependent Genome Amplification.  J Virol  2017 Dec 15;91(24). pii:e01712-17
  2. Spriggs CC, Laimins LA  Human Papillomavirus and the DNA Damage Response: Exploiting Host Repair Pathways for Viral Replication.  Viruses  2017 Aug 18;9(8). pii:E232
  3. Spriggs CC, Laimins LA  FANCD2 Binds Human Papillomavirus Genomes and Associates with a Distinct Set of DNA Repair Proteins to Regulate Viral Replication.  MBio  2017 Feb 14;8(1). pii:e02340-16
  4. Hong S, Laimins LA  Manipulation of the innate immune response by human papillomaviruses.  Virus Res  2017 Mar 02;231:34-40. pii:S0168-1702(16)30700-6
  5. Langsfeld E, Laimins LA  Human papillomaviruses: research priorities for the next decade.  Trends Cancer  2016 May;2(5):234-240
  6. Gunasekharan VK, Li Y, Andrade J, Laimins LA  Post-Transcriptional Regulation of KLF4 by High-Risk Human Papillomaviruses Is Necessary for the Differentiation-Dependent Viral Life Cycle.  PLoS Pathog  2016 Jul;12(7):e1005747. doi:10.1371/journal.ppat.1005747
  7. Hong S, Cheng S, Iovane A, Laimins LA  STAT-5 Regulates Transcription of the Topoisomerase IIβ-Binding Protein 1 (TopBP1) Gene To Activate the ATR Pathway and Promote Human Papillomavirus Replication.  MBio  2015 Dec 22;6(6):e02006-15. doi:10.1128/mBio.02006-15
  8. Langsfeld ES, Bodily JM, Laimins LA  The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes.  PLoS Pathog  2015 Sep;11(9):e1005181. doi:10.1371/journal.ppat.1005181
  9. Galloway DA, Laimins LA  Human papillomaviruses: shared and distinct pathways for pathogenesis.  Curr Opin Virol  2015 Oct;14:87-92. doi:10.1016/j.coviro.2015.09.001
  10. Mehta K, Gunasekharan V, Satsuka A, Laimins LA  Human papillomaviruses activate and recruit SMC1 cohesin proteins for the differentiation-dependent life cycle through association with CTCF insulators.  PLoS Pathog  2015 Apr;11(4):e1004763. doi:10.1371/journal.ppat.1004763
  11. Hong S, Dutta A, Laimins LA  The acetyltransferase Tip60 is a critical regulator of the differentiation-dependent amplification of human papillomaviruses.  J Virol  2015 Apr;89(8):4668-75. doi:10.1128/JVI.03455-14
  12. Pattabiraman C, Hong S, Gunasekharan VK, Pranatharthi A, Bajaj J, Srivastava S, Krishnamurthy H, Ammothumkandy A, Giri VG, Laimins LA, Krishna S  CD66+ cells in cervical precancers are partially differentiated progenitors with neoplastic traits.  Cancer Res  2014 Nov 15;74(22):6682-92. doi:10.1158/0008-5472.CAN-14-1032
  13. Hong S, Laimins LA  Regulation of the life cycle of HPVs by differentiation and the DNA damage response.  Future Microbiol  2013 Dec;8(12):1547-57. doi:10.2217/fmb.13.127
  14. Mighty KK, Laimins LA  The role of human papillomaviruses in oncogenesis.  Recent Results Cancer Res  2014;193:135-48. doi:10.1007/978-3-642-38965-8_8
  15. Hong S, Laimins LA  The JAK-STAT transcriptional regulator, STAT-5, activates the ATM DNA damage pathway to induce HPV 31 genome amplification upon epithelial differentiation.  PLoS Pathog  2013;9(4):e1003295. doi:10.1371/journal.ppat.1003295
  16. Gunasekharan V, Laimins LA  Human papillomaviruses modulate microRNA 145 expression to directly control genome amplification.  J Virol  2013 May;87(10):6037-43. doi:10.1128/JVI.00153-13
  17. Regan JA, Laimins LA  Viral transformation of epithelial cells.  Methods Mol Biol  2013;945:449-65. doi:10.1007/978-1-62703-125-7_26
  18. Mighty KK, Laimins LA  p63 is necessary for the activation of human papillomavirus late viral functions upon epithelial differentiation.  J Virol  2011 Sep;85(17):8863-9. doi:10.1128/JVI.00750-11
  19. Bodily JM, Mehta KP, Cruz L, Meyers C, Laimins LA  The E7 open reading frame acts in cis and in trans to mediate differentiation-dependent activities in the human papillomavirus type 16 life cycle.  J Virol  2011 Sep;85(17):8852-62. doi:10.1128/JVI.00664-11
  20. Bodily JM, Mehta KP, Laimins LA  Human papillomavirus E7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylases.  Cancer Res  2011 Feb 01;71(3):1187-95. doi:10.1158/0008-5472.CAN-10-2626
  21. Bodily J, Laimins LA  Persistence of human papillomavirus infection: keys to malignant progression.  Trends Microbiol  2011 Jan;19(1):33-9. doi:10.1016/j.tim.2010.10.002
  22. Moody CA, Laimins LA  Human papillomavirus oncoproteins: pathways to transformation.  Nat Rev Cancer  2010 Aug;10(8):550-60. doi:10.1038/nrc2886
  23. Melar-New M, Laimins LA  Human papillomaviruses modulate expression of microRNA 203 upon epithelial differentiation to control levels of p63 proteins.  J Virol  2010 May;84(10):5212-21. doi:10.1128/JVI.00078-10
  24. Moody CA, Laimins LA  Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation.  PLoS Pathog  2009 Oct;5(10):e1000605. doi:10.1371/journal.ppat.1000605
  25. Nakamura M, Bodily JM, Beglin M, Kyo S, Inoue M, Laimins LA  Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses.  Virology  2009 May 10;387(2):442-8. doi:10.1016/j.virol.2009.02.036
  26. Regan JA, Laimins LA  Bap31 is a novel target of the human papillomavirus E5 protein.  J Virol  2008 Oct;82(20):10042-51. doi:10.1128/JVI.01240-08
  27. Wooldridge TR, Laimins LA  Regulation of human papillomavirus type 31 gene expression during the differentiation-dependent life cycle through histone modifications and transcription factor binding.  Virology  2008 May 10;374(2):371-80. doi:10.1016/j.virol.2007.12.011
  28. Moody CA, Fradet-Turcotte A, Archambault J, Laimins LA  Human papillomaviruses activate caspases upon epithelial differentiation to induce viral genome amplification.  Proc Natl Acad Sci U S A  2007 Dec 04;104(49):19541-6
  29. Hebner C, Beglin M, Laimins LA  Human papillomavirus E6 proteins mediate resistance to interferon-induced growth arrest through inhibition of p53 acetylation.  J Virol  2007 Dec;81(23):12740-7
  30. Hindmarsh PL, Laimins LA  Mechanisms regulating expression of the HPV 31 L1 and L2 capsid proteins and pseudovirion entry.  Virol J  2007 Feb 26;4:19
  31. Wilson R, Ryan GB, Knight GL, Laimins LA, Roberts S  The full-length E1E4 protein of human papillomavirus type 18 modulates differentiation-dependent viral DNA amplification and late gene expression.  Virology  2007 Jun 05;362(2):453-60
  32. Lee C, Wooldridge TR, Laimins LA  Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle.  Virology  2007 Feb 05;358(1):201-10