Northwestern University Feinberg School of Medicine
Alan Hauser Laboratory
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Publications

Learn more about the work that we do in the Alan Hauser Laboratory through our recent publications.
  1. Turner TL, Mitra SD, Kochan TJ, Pincus NB, Lebrun-Corbin M, Cheung BH, Gatesy SW, Afzal T, Nozick SH, Ozer EA  et al.  Taxonomic characterization of Pseudomonas hygromyciniae sp. nov., a novel species discovered from a commercially purchased antibiotic.  Microbiol Spectr  2023 Sep 22;:e0183821. doi:10.1128/spectrum.01838-21
  2. Atassi G, Medernach R, Scheetz M, Nozick S, Rhodes NJ, Murphy-Belcaster M, Murphy KR, Alisoltani A, Ozer EA, Hauser AR  Genomics of Aminoglycoside Resistance in Pseudomonas aeruginosa Bloodstream Infections at a United States Academic Hospital.  Microbiol Spectr  2023 Jun 15;11(3):e0508722. pii:e05087-22
  3. Inniss NL, Kochan TJ, Minasov G, Wawrzak Z, Chang C, Tan K, Shuvalova L, Kiryukhina O, Pshenychnyi S, Wu R  et al.  A Structural Systems Biology Approach to High-Risk CG23 Klebsiella pneumoniae.  Microbiol Resour Announc  2023 Feb 16;12(2):e0101322. pii:e01013-22
  4. Cherny KE, Muscat EB, Balaji A, Mukherjee J, Ozer EA, Angarone MP, Hauser AR, Sichel JS, Amponsah E, Kociolek LK  Association Between Clostridium innocuum and Antibiotic-Associated Diarrhea in Adults and Children: A Cross-sectional Study and Comparative Genomics Analysis.  Clin Infect Dis  2023 Feb 08;76(3):e1244-e1251. doi:10.1093/cid/ciac483
  5. Rohani R, Scheetz MH, Donnelly HK, Donayre A, Kang M, Diaz E, Dedicatoria K, Hauser AR, Ozer EA, Nozick S  et al.  Individual target pharmacokinetic/pharmacodynamic attainment rates among meropenem-treated patients admitted to the ICU with hospital-acquired pneumonia.  J Antimicrob Chemother  2022 Oct 28;77(11):2956-2959. doi:10.1093/jac/dkac245
  6. Pincus NB, Rosas-Lemus M, Gatesy SWM, Bertucci HK, Brunzelle JS, Minasov G, Shuvalova LA, Lebrun-Corbin M, Satchell KJF, Ozer EA  et al.  Functional and Structural Characterization of OXA-935, a Novel OXA-10-Family β-Lactamase from Pseudomonas aeruginosa.  Antimicrob Agents Chemother  2022 Oct 18;66(10):e0098522. pii:e00985-22
  7. Kochan TJ, Nozick SH, Medernach RL, Cheung BH, Gatesy SWM, Lebrun-Corbin M, Mitra SD, Khalatyan N, Krapp F, Qi C  et al.  Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates.  BMC Infect Dis  2022 Jul 07;22(1):603. pii:603
  8. Locci E, Liu J, Pais GM, Chighine A, Kahnamoei DA, Xanthos T, Chalkias A, Lee A, Hauser AR, Chang J  et al.  Urinary Metabolomics From a Dose-Fractionated Polymyxin B Rat Model of Acute Kidney Injury.  Int J Antimicrob Agents  2022 Jul;60(1):106593. doi:10.1016/j.ijantimicag.2022.106593
  9. Cherny KE, Balaji A, Mukherjee J, Goo YA, Hauser AR, Ozer E, Satchell KJF, Bachta KER, Kochan TJ, Mitra SD  et al.  Identification of Clostridium innocuum hypothetical protein that is cross-reactive with C. difficile anti-toxin antibodies.  Anaerobe  2022 Jun;75:102555. doi:10.1016/j.anaerobe.2022.102555
  10. Huang Y, Rana AP, Wenzler E, Ozer EA, Krapp F, Bulitta JB, Hauser AR, Bulman ZP  Aminoglycoside-resistance gene signatures are predictive of aminoglycoside MICs for carbapenem-resistant Klebsiella pneumoniae.  J Antimicrob Chemother  2022 Feb 02;77(2):356-363. doi:10.1093/jac/dkab381
  11. Bulman ZP, Krapp F, Pincus NB, Wenzler E, Murphy KR, Qi C, Ozer EA, Hauser AR  Genomic Features Associated with the Degree of Phenotypic Resistance to Carbapenems in Carbapenem-Resistant Klebsiella pneumoniae.  mSystems  2021 Oct 26;6(5):e0019421. pii:e00194-21
  12. Huang Y, Sokolowski K, Rana A, Singh N, Wang J, Chen K, Lang Y, Zhou J, Kadiyala N, Krapp F  et al.  Generating Genotype-Specific Aminoglycoside Combinations with Ceftazidime/Avibactam for KPC-Producing Klebsiella pneumoniae.  Antimicrob Agents Chemother  2021 Aug 17;65(9):e0069221. pii:e00692-21
  13. Allen JP, Snitkin E, Pincus NB, Hauser AR  Forest and Trees: Exploring Bacterial Virulence with Genome-wide Association Studies and Machine Learning.  Trends Microbiol  2021 Jul;29(7):621-633. doi:10.1016/j.tim.2020.12.002
  14. Pincus NB, Ozer EA, Allen JP, Nguyen M, Davis JJ, Winter DR, Chuang CH, Chiu CH, Zamorano L, Oliver A  et al.  Erratum for Pincus et al., "A Genome-Based Model to Predict the Virulence of Pseudomonas aeruginosa Isolates".  mBio  2021 Feb 23;12(1). pii:e00037-21
  15. Butler DA, Rana AP, Krapp F, Patel SR, Huang Y, Ozer EA, Hauser AR, Bulman ZP  Optimizing aminoglycoside selection for KPC-producing Klebsiella pneumoniae with the aminoglycoside-modifying enzyme (AME) gene aac(6')-Ib.  J Antimicrob Chemother  2021 Feb 11;76(3):671-679. doi:10.1093/jac/dkaa480
  16. Hreha TN, Foreman S, Duran-Pinedo A, Morris AR, Diaz-Rodriguez P, Jones JA, Ferrara K, Bourges A, Rodriguez L, Koffas MAG  et al.  The three NADH dehydrogenases of Pseudomonas aeruginosa: Their roles in energy metabolism and links to virulence.  PLoS One  2021;16(2):e0244142. pii:e0244142
  17. Lorenzo-Redondo R, Nam HH, Roberts SC, Simons LM, Jennings LJ, Qi C, Achenbach CJ, Hauser AR, Ison MG, Hultquist JF  et al.  A clade of SARS-CoV-2 viruses associated with lower viral loads in patient upper airways.  EBioMedicine  2020 Dec;62:103112. pii:103112
  18. Pincus NB, Bachta KER, Ozer EA, Allen JP, Pura ON, Qi C, Rhodes NJ, Marty FM, Pandit A, Mekalanos JJ  et al.  Long-term Persistence of an Extensively Drug-Resistant Subclade of Globally Distributed Pseudomonas aeruginosa Clonal Complex 446 in an Academic Medical Center.  Clin Infect Dis  2020 Sep 12;71(6):1524-1531. doi:10.1093/cid/ciz973
  19. Pincus NB, Ozer EA, Allen JP, Nguyen M, Davis JJ, Winter DR, Chuang CH, Chiu CH, Zamorano L, Oliver A  et al.  A Genome-Based Model to Predict the Virulence of Pseudomonas aeruginosa Isolates.  mBio  2020 Aug 25;11(4). pii:e01527-20
  20. Moir DT, Bowlin NO, Berube BJ, Yabut J, Mills DM, Nguyen GT, Aron ZD, Williams JD, Mecsas J, Hauser AR  et al.  A Structure-Function-Inhibition Analysis of the Pseudomonas aeruginosa Type III Secretion Needle Protein PscF.  J Bacteriol  2020 Aug 25;202(18). pii:e00055-20
  21. Lorenzo-Redondo R, Nam HH, Roberts SC, Simons LM, Jennings LJ, Qi C, Achenbach CJ, Hauser AR, Ison MG, Hultquist JF  et al.  A Unique Clade of SARS-CoV-2 Viruses is Associated with Lower Viral Loads in Patient Upper Airways.  medRxiv  2020 Jun 21;. pii:2020.05.19.20107144
  22. Kociolek LK, Espinosa RO, Gerding DN, Hauser AR, Ozer EA, Budz M, Balaji A, Chen X, Tanz RR, Yalcinkaya N  et al.  Natural Clostridioides difficile Toxin Immunization in Colonized Infants.  Clin Infect Dis  2020 May 06;70(10):2095-2102. doi:10.1093/cid/ciz582
  23. Liu J, Pais GM, Avedissian SN, Gilchrist A, Lee A, Rhodes NJ, Hauser AR, Scheetz MH  Evaluation of Dose-Fractionated Polymyxin B on Acute Kidney Injury Using a Translational In Vivo Rat Model.  Antimicrob Agents Chemother  2020 Apr 21;64(5). pii:e02300-19
  24. Allen JP, Ozer EA, Minasov G, Shuvalova L, Kiryukhina O, Satchell KJF, Hauser AR  A comparative genomics approach identifies contact-dependent growth inhibition as a virulence determinant.  Proc Natl Acad Sci U S A  2020 Mar 24;117(12):6811-6821. doi:10.1073/pnas.1919198117
  25. Bachta KER, Allen JP, Cheung BH, Chiu CH, Hauser AR  Systemic infection facilitates transmission of Pseudomonas aeruginosa in mice.  Nat Commun  2020 Jan 28;11(1):543. pii:543
  26. Kochan TJ, Ozer EA, Pincus NB, Fitzpatrick MA, Hauser AR  Complete Genome Sequence of Klebsiella pneumoniae Strain TK421, a Conjugative Hypervirulent Isolate.  Microbiol Resour Announc  2020 Jan 16;9(3). pii:e01408-19
  27. Bachta KER, Ozer EA, Pandit A, Marty FM, Mekalanos JJ, Hauser AR  Draft Genome Sequence of Pseudomonas aeruginosa Strain BWH047, a Sequence Type 235 Multidrug-Resistant Clinical Isolate Expressing High Levels of Colistin Resistance.  Microbiol Resour Announc  2019 Jul 18;8(29). pii:e00623-19
  28. Allen JP, Hauser AR  Diversity of Contact-Dependent Growth Inhibition Systems of Pseudomonas aeruginosa.  J Bacteriol  2019 Jul 15;201(14). pii:e00776-18
  29. Ozer EA, Nnah E, Didelot X, Whitaker RJ, Hauser AR  The Population Structure of Pseudomonas aeruginosa Is Characterized by Genetic Isolation of exoU+ and exoS+ Lineages.  Genome Biol Evol  2019 Jul 01;11(1):1780-1796. doi:10.1093/gbe/evz119
  30. Agard MJ, Ozer EA, Morris AR, Piseaux R, Hauser AR  A Genomic Approach To Identify Klebsiella pneumoniae and Acinetobacter baumannii Strains with Enhanced Competitive Fitness in the Lungs during Multistrain Pneumonia.  Infect Immun  2019 Jun;87(6). pii:e00871-18
  31. Walter JM, Ren Z, Yacoub T, Reyfman PA, Shah RD, Abdala-Valencia H, Nam K, Morgan VK, Anekalla KR, Joshi N  et al.  Multidimensional Assessment of the Host Response in Mechanically Ventilated Patients with Suspected Pneumonia.  Am J Respir Crit Care Med  2019 May 15;199(10):1225-1237. doi:10.1164/rccm.201804-0650OC
  32. Avedissian SN, Liu J, Rhodes NJ, Lee A, Pais GM, Hauser AR, Scheetz MH  A Review of the Clinical Pharmacokinetics of Polymyxin B.  Antibiotics (Basel)  2019 Mar 22;8(1). pii:31
  33. Hughes AJ, Knoten CA, Morris AR, Hauser AR  ASC acts in a caspase-1-independent manner to worsen acute pneumonia caused by Pseudomonas aeruginosa.  J Med Microbiol  2018 Aug;67(8):1168-1180. doi:10.1099/jmm.0.000782
  34. Rutherford V, Yom K, Ozer EA, Pura O, Hughes A, Murphy KR, Cudzilo L, Mitchell D, Hauser AR  Environmental reservoirs for exoS+ and exoU+ strains of Pseudomonas aeruginosa.  Environ Microbiol Rep  2018 Aug;10(4):485-492. doi:10.1111/1758-2229.12653
  35. Krapp F, Ozer EA, Qi C, Hauser AR  Case Report of an Extensively Drug-Resistant Klebsiella pneumoniae Infection With Genomic Characterization of the Strain and Review of Similar Cases in the United States.  Open Forum Infect Dis  2018 May;5(5):ofy074. pii:ofy074
  36. Kociolek LK, Ozer EA, Gerding DN, Hecht DW, Patel SJ, Hauser AR  Whole-genome analysis reveals the evolution and transmission of an MDR DH/NAP11/106 Clostridium difficile clone in a paediatric hospital.  J Antimicrob Chemother  2018 May 01;73(5):1222-1229. doi:10.1093/jac/dkx523
  37. Rhodes NJ, Cruce CE, O'Donnell JN, Wunderink RG, Hauser AR  Resistance Trends and Treatment Options in Gram-Negative Ventilator-Associated Pneumonia.  Curr Infect Dis Rep  2018 Mar 06;20(2):3. doi:10.1007/s11908-018-0609-x
  38. Zhang A, Veesenmeyer JL, Hauser AR  Phosphatidylinositol 4,5-Bisphosphate-Dependent Oligomerization of the Pseudomonas aeruginosa Cytotoxin ExoU.  Infect Immun  2018 Jan;86(1). pii:e00402-17