Northwestern University Feinberg School of Medicine

Alan Hauser Laboratory


Learn more about the work that we do in the Alan Hauser Laboratory through our recent publications.
  1. Prickett MH, Hauser AR, McColley SA, Cullina J, Potter E, Powers C, Jain M  Aminoglycoside resistance of Pseudomonas aeruginosa in cystic fibrosis results from convergent evolution in the mexZ gene.  Thorax  2017 Jan;72(1):40-47. doi:10.1136/thoraxjnl-2015-208027
  2. Ozer EA, Morris AR, Krapp F, Henry CS, Tyo KE, Lathem WW, Hauser AR  Draft Genome Sequence of a Multidrug-Resistant Klebsiella quasipneumoniae subsp. similipneumoniae Isolate from a Clinical Source.  Genome Announc  2016 May 26;4(3). doi:10.1128/genomeA.00422-16
  3. Hauser AR, Mecsas J, Moir DT  Beyond Antibiotics: New Therapeutic Approaches for Bacterial Infections.  Clin Infect Dis  2016 Jul 01;63(1):89-95. doi:10.1093/cid/ciw200
  4. Fitzpatrick MA, Ozer EA, Hauser AR  Utility of Whole-Genome Sequencing in Characterizing Acinetobacter Epidemiology and Analyzing Hospital Outbreaks.  J Clin Microbiol  2016 Mar;54(3):593-612. doi:10.1128/JCM.01818-15
  5. Berube BJ, Rangel SM, Hauser AR  Pseudomonas aeruginosa: breaking down barriers.  Curr Genet  2016 Feb;62(1):109-13. doi:10.1007/s00294-015-0522-x
  6. Rangel SM, Diaz MH, Knoten CA, Zhang A, Hauser AR  The Role of ExoS in Dissemination of Pseudomonas aeruginosa during Pneumonia.  PLoS Pathog  2015 Jun;11(6):e1004945. doi:10.1371/journal.ppat.1004945
  7. Zhang A, Rangel SM, Hauser AR  The great escape: Pseudomonas breaks out of the lung.  Microb Cell  ;2(10):409-411
  8. Tyson GH, Halavaty AS, Kim H, Geissler B, Agard M, Satchell KJ, Cho W, Anderson WF, Hauser AR  A novel phosphatidylinositol 4,5-bisphosphate binding domain mediates plasma membrane localization of ExoU and other patatin-like phospholipases.  J Biol Chem  2015 Jan 30;290(5):2919-37. doi:10.1074/jbc.M114.611251
  9. Tran CS, Rangel SM, Almblad H, Kierbel A, Givskov M, Tolker-Nielsen T, Hauser AR, Engel JN  The Pseudomonas aeruginosa type III translocon is required for biofilm formation at the epithelial barrier.  PLoS Pathog  2014 Nov;10(11):e1004479. doi:10.1371/journal.ppat.1004479
  10. Fitzpatrick MA, Ozer E, Bolon MK, Hauser AR  Influence of ACB complex genospecies on clinical outcomes in a U.S. hospital with high rates of multidrug resistance.  J Infect  2015 Feb;70(2):144-52. doi:10.1016/j.jinf.2014.09.004
  11. Ozer EA, Fitzpatrick MA, Hauser AR  Draft Genome Sequence of Acinetobacter baumannii Strain ABBL099, a Multidrug-Resistant Clinical Outbreak Isolate with a Novel Multilocus Sequence Type.  Genome Announc  2014 Sep 11;2(5). doi:10.1128/genomeA.00738-14
  12. Ozer EA, Allen JP, Hauser AR  Characterization of the core and accessory genomes of Pseudomonas aeruginosa using bioinformatic tools Spine and AGEnt.  BMC Genomics  2014 Aug 29;15:737. doi:10.1186/1471-2164-15-737
  13. Rangel SM, Logan LK, Hauser AR  The ADP-ribosyltransferase domain of the effector protein ExoS inhibits phagocytosis of Pseudomonas aeruginosa during pneumonia.  MBio  2014 Jun 10;5(3):e01080-14. doi:10.1128/mBio.01080-14
  14. Wang N, Ozer EA, Mandel MJ, Hauser AR  Genome-wide identification of Acinetobacter baumannii genes necessary for persistence in the lung.  MBio  2014 Jun 03;5(3):e01163-14. doi:10.1128/mBio.01163-14
  15. Allen JP, Ozer EA, Hauser AR  Different paths to pathogenesis.  Trends Microbiol  2014 Apr;22(4):168-9. doi:10.1016/j.tim.2014.02.013
  16. Hauser AR  Pseudomonas aeruginosa virulence and antimicrobial resistance: two sides of the same coin?  Crit Care Med  2014 Jan;42(1):201-2. doi:10.1097/CCM.0b013e3182a120cd
  17. Tyson GH, Hauser AR  Phosphatidylinositol 4,5-bisphosphate is a novel coactivator of the Pseudomonas aeruginosa cytotoxin ExoU.  Infect Immun  2013 Aug;81(8):2873-81. doi:10.1128/IAI.00414-13
  18. Howell HA, Logan LK, Hauser AR  Type III secretion of ExoU is critical during early Pseudomonas aeruginosa pneumonia.  MBio  2013 Mar 12;4(2):e00032-13. doi:10.1128/mBio.00032-13
  19. Halavaty AS, Borek D, Tyson GH, Veesenmeyer JL, Shuvalova L, Minasov G, Otwinowski Z, Hauser AR, Anderson WF  Structure of the type III secretion effector protein ExoU in complex with its chaperone SpcU.  PLoS One  2012;7(11):e49388. doi:10.1371/journal.pone.0049388
  20. Ozer EA, Allen JP, Hauser AR  Draft genome sequence of the Pseudomonas aeruginosa bloodstream isolate PABL056.  J Bacteriol  2012 Nov;194(21):5999. doi:10.1128/JB.01421-12
  21. Kung VL, Khare S, Stehlik C, Bacon EM, Hughes AJ, Hauser AR  An rhs gene of Pseudomonas aeruginosa encodes a virulence protein that activates the inflammasome.  Proc Natl Acad Sci U S A  2012 Jan 24;109(4):1275-80. doi:10.1073/pnas.1109285109