Northwestern University Feinberg School of Medicine

Geoffrey Swanson Lab

Articles

2017

Selective and regulated trapping of nicotinic receptor weak base ligands and relevance to smoking cessation.
Govind AP, Vallejo YF, Stolz JR, Yan JZ, Swanson GT, Green WN.
Elife. 2017 Jul 18;6. pii: e25651. doi: 10.7554/eLife.25651.

N-glycan content modulates kainate receptor functional properties.
Vernon CG, Copits BA, Stolz JR, Guzmán YF, Swanson GT.
J Physiol. 2017 Jul 17; doi: 10.1113/JP274790. [Epub ahead of print]

Neto2 Assembles with Kainate Receptors in DRG Neurons during Development and Modulates Neurite Outgrowth in Adult Sensory Neurons
Vernon CG, Swanson GT.
The Journal of Neuroscience. 2017 Mar 22, 

A gain-of-function mutation in the GRIK2 gene causes neurodevelopmental deficits
Guzmán YF, Ramsey K, Stolz JR, Craig DW, Huentelman MJ, Narayanan VN, Swanson GT.
Neurology: Genetics. 2017 Jan 31; doi: http:/​/​dx.​doi.​org/​10.​1212/​NXG.​0000000000000129.

2016

Transduction of group I mGluR-mediated synaptic plasticity by β-arrestin2 signalling
Eng AG, Kelver DAHedrick TPSwanson GT.
Nature Communications. 2016 Nov 25;7:13571; doi: 10.1038/ncomms13571.

2015

Identification of critical functional determinants of kainate receptor modulation by auxiliary protein Neto2
Griffith TN, Swanson GT.
Journal of Physiology. 2015 Sep; doi:10.1113/JP271103.

2014

Psychiatric Risk Factor ANK3/Ankyrin-G Nanodomains Regulate the Structure and Function of Glutamatergic Synapses
Smith KR, Kopeikina KJ, Fawcett-Patel JM, Leaderbrand K, Gao R, Schürmann B, Myczek K, Radulovic J, Swanson GT, Penzes P.
Neuron. 2014 Oct 22;84(2):399-415; doi:10.1016/j.neuron.2014.10.010.

Stephen F. Heinemann (1939–2014)
Elgoyhen AB, Swanson GT, Mulle C.
Neuron. 2014 Oct;84(1):15-17.

Modulation of ionotropic glutamate receptor function by vertebrate galectins
Copits BA, Vernon CG, Sakai R, Swanson GT.
Journal of Physiology. 2014 May 15;592(10):2079-2096.doi:10.1113/jphysiol.2013.269597.

Recent progress in neuroactive marine natural products
Sakai R, Swanson GT.
Natural Product Reports. 2014 Feb;31(2):273-309.doi:10.1039/c3np70083f.

2013

Isolation of novel prototype galectins from the marine ball sponge Cinachyrella sp. guided by their modulatory activity on mammalian glutamate-gated ion channels
Ueda T, Nakamura Y, Smith CM, Copits BA, Inoue A, Ojima T, Matsunaga S, Swanson GT, Sakai R.
Glycobiology. 2013 Apr;23(4):412-425.doi:10.1093/glycob/cws165.

Kainate receptor post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis
Copits BA, Swanson GT.
Journal of Biological Chemistry. 2013 Mar 29;288(13):8952-8965.doi:10.1074/jbc.M112.440719.

Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: Asymmetric synthesis, neuroactivity, and structural characterization
Juknaite L, Sugamata Y, Tokiwa K, Ishikawa Y, Takamizawa S, Eng A, Sakai R, Pickering DS, Frydenvang K, Swanson GT, Kastrup JS, Oikawa M.
Journal of Medicinal Chemistry. 2013 Mar 28;56(6):2283-2293.doi:10.1021/jm301590z.

Lateral thinking: CaMKII uncouples kainate receptors from mossy fibre synapses
Copits BA, Swanson GT.
EMBO Journal. 2013 Feb 20;32(4):487-489.doi:10.1038/emboj.2013.12.

A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents
Chen H, Wang CZ, Ding C, Wild C, Copits B, Swanson GT, Johnson KM, Zhou J.
ChemMedChem. 2013 Feb;8(2):226-230.doi:10.1002/cmdc.201200554.

Kainate receptor signaling in pain pathways
Bhangoo SK, Swanson GT.
Molecular Pharmacology. 2013 Feb;83(2):307-315.doi:10.1124/mol.112.081398.

2012

Afadin is required for maintenance of dendritic structure and excitatory tone
Srivastava DP, Copits BA, Xie Z, Huda R, Jones KA, Mukherji S, Cahill ME, VanLeeuwen J-E, Woolfrey KM, Rafalovich I, Swanson GT, Penzes P.
Journal of Biological Chemistry. 2012 Oct 19;287(43):35964-35974.doi:10.1074/jbc.M112.363358.

Dancing partners at the synapse: Auxiliary subunits that shape kainate receptor function
Copits BA, Swanson GT.
Nature Reviews Neuroscience. 2012 Oct;13(10):675-686.doi:10.1038/nrn3335.

Structure of a tetrameric galectin from Cinachyrella sp. (ball sponge)
Freymann DM, Nakamura Y, Focia PJ, Sakai R, Swanson GT.
Acta Crystallographica Section D: Biological Crystallography. 2012 Sep;68(9):1163-1174.doi:10.1107/S0907444912022834.

2011

A novel form of low-frequency hippocampal mossy fiber plasticity induced by bimodal mGlu1 receptor signaling
Frausto SF, Ito K, Marszalec W, Swanson GT.
Journal of Neuroscience. 2011 Nov 23;31(47):16897-16906.doi:10.1523/JNEUROSCI.1264-11.2011.

Isolation, amino acid sequence and biological activities of novel long-chain polyamine-associated peptide toxins from the sponge Axinyssa aculeata
Matsunaga S, Jimbo M, Gill MB, Lash-van Wyhe LL, Murata M, Nonomura K, Swanson GT, Sakai R.
ChemBioChem. 2011 Sep 19;12(14):2191-2200.doi:10.1002/cbic.201100329.

IQGAP1 regulates NR2A signaling, spine density, and cognitive processes
Gao C, Frausto SF, Guedea AL, Tronson NC, Jovasevic V, Leaderbrand K, Corcoran KA, Guzman YF, Swanson GT, Radulovic J.
Journal of Neuroscience. 2011 Jun 8;31(23):8533-8542.doi:10.1523/JNEUROSCI.1300-11.2011.

Synaptic targeting and functional modulation of GluK1 kainate receptors by the auxiliary neuropilin and tolloid-like (NETO) Proteins

Copits BA, Robbins JS, Frausto S, Swanson GT.
Journal of Neuroscience. 2011 May 18;31(20):7334-7340.doi:10.1523/JNEUROSCI.0100-11.2011.

Antinociceptive effects of MSVIII-19, a functional antagonist of the GluK1 kainate receptor

Qiu C-S, Wyhe LL-V, Sasaki M, Sakai R, Swanson GT, Gereau IV RW.
Pain. 2011 May;152(5):1052-1060.doi:10.1016/j.pain.2011.01.018.

Kainate receptors coming of age: Milestones of two decades of research

Contractor A, Mulle C, Swanson GT.
Trends in Neurosciences. 2011 Mar;34(3):154-163.doi:10.1016/j.tins.2010.12.002.

2010

Hippocampal NMDA receptor subunits differentially regulate fear memory formation and neuronal signal propagation
Gao C, Gill MB, Tronson NC, Guedea AL, Guzmán YF, Huh KH, Corcoran KA, Swanson GT, Radulovic J.
Hippocampus. 2010 Sep;20(9):1072-1082.doi:10.1002/hipo.20705.

Novel N -methylated 8-oxoisoguanines from pacific sponges with diverse neuroactivities

Sakurada T, Gill MB, Frausto S, Copits B, Noguchi K, Shimamoto K, Swanson GT, Sakai R.
Journal of Medicinal Chemistry. 2010 Aug 26;53(16):6089-6099.doi:10.1021/jm100490m.

A series of structurally novel heterotricyclic α-amino-3-hydroxyl-5- methyl-4-isoxazole-propionate receptor-selective antagonists

Gill MB, Frausto S, Ikoma M, Sasaki M, Oikawa M, Sakai R, Swanson GT.
British Journal of Pharmacology. 2010 Jul;160(6):1417-1429.doi:10.1111/j.1476-5381.2010.00784.x.

Improved synthesis and in vitro/in vivo activities of natural product-inspired, artificial glutamate analogs

Oikawa M, Ikoma M, Sasaki M, Gill MB, Swanson GT, Shimamoto K, Sakai R.
Bioorganic and Medicinal Chemistry. 2010 Jun;18(11):3795-3804.doi:10.1016/j.bmc.2010.04.044.

Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine

Leanne Lash-Van Wyhe L, Postila PA, Tsubone K, Sasaki M, Pentikäinen OT, Sakai R, Swanson GT.
Neuropharmacology. 2010 Mar;58(3):640-649.doi:10.1016/j.neuropharm.2009.11.013.

Exploring kainate receptor pharmacology using molecular dynamics simulations

Postila PA, Swanson GT, Pentikäinen OT.
Neuropharmacology. 2010 Feb;58(2):515-527.doi:10.1016/j.neuropharm.2009.08.019.

2009

High-Affinity Kainate Receptor Subunits Are Necessary for Ionotropic but Not Metabotropic Signaling
Fernandes HB, Catches JS, Petralia RS, Copits BA, Xu J, Russell TA, Swanson GT, Contractor A.
Neuron. 2009 Sep 24;63(6):818-829.doi:10.1016/j.neuron.2009.08.010.

Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis

Gill MB, Vivithanaporn P, Swanson GT.
Journal of Biological Chemistry. 2009 May 22;284(21):14503-14512.doi:10.1074/jbc.M900510200.

Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine
Frydenvang K, Lash LL, Naur P, Postila PA, Pickering DS, Smith CM, Gajhede M, Sasaki M, Sakai R, Pentikänen OT, Swanson GT, Kastrup JS.
Journal of Biological Chemistry. 2009 May 22;284(21):14219-14229.doi:10.1074/jbc.M808547200.

Ligands for ionotropic glutamate receptors.
Swanson GT, Sakai R.
Progress in molecular and subcellular biology. 2009 Jan;46:123-157.doi:10.1007/978-3-540-87895-7_5.

Targeting AMPA and kainate receptors in neurological disease: Therapies on the horizon?

Swanson GT.
Neuropsychopharmacology. 2009 Jan;34(1):249-250.doi:10.1038/npp.2008.158.

Regioselective domino metathesis of unsymmetrical 7-oxanorbornenes with electron-rich vinyl acetate toward biologically active glutamate analogues

Oikawa M, Ikoma M, Sasaki M, Gill MB, Swanson GT, Shimamoto K, Sakai R.
European Journal of Organic Chemistry. 2009 Jan;(32):5531-5548.doi:10.1002/ejoc.200900580.

2008

Rapid enhancement of two-step wiring plasticity by estrogen and NMDA receptor activity (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, 38, (14650-14655) DOI: 10.1073/pnas.0801581105)
Srivastava DP, Woolfrey K, Jones KA, Shum CY, Lash LL, Swanson GT, Penzes P.
Proceedings of the National Academy of Sciences of the United States of America. 2008 Dec 16;105(50):20045-.doi:10.1073/pnas.0810024105.

Regioselective domino metathesis of 7-oxanorbornenes and its application to the synthesis of biologically active glutamate analogues

Ikoma M, Oikawa M, Gill MB, Swanson GT, Sakai R, Shimamoto K, Sasaki M.
European Journal of Organic Chemistry. 2008 Nov;(31):5215-5220.doi:10.1002/ejoc.200800704.

Rapid enhancement of two-step wiring plasticity by estrogen and NMDA receptor activity

Srivastava DP, Woolfrey K, Jones KA, Shum CY, Lash LL, Swanson GT, Penzes P.
Proceedings of the National Academy of Sciences of the United States of America. 2008 Sep 23;105(38):14650-14655.doi:10.1073/pnas.0801581105.

Novel analogs and stereoisomers of the marine toxin neodysiherbaine with specificity for kainate receptors

Lash LL, Sanders JM, Akiyama N, Shoji M, Postila P, Pentikäinen OT, Sasaki M, Sakai R,Swanson GT.
Journal of Pharmacology and Experimental Therapeutics. 2008 Feb;324(2):484-496.doi:10.1124/jpet.107.129890.

2007

Critical roles for the M3-S2 transduction linker domain in kainate receptor assembly and postassembly trafficking
Vivithanaporn P, Lash LL, Marszalec W, Swanson GT.
Journal of Neuroscience. 2007 Sep 26;27(39):10423-10433.doi:10.1523/JNEUROSCI.2674-07.2007.

2006

Total synthesis and biological evaluation of neodysiherbaine A and analogues
Shoji M, Akiyama N, Tsubone K, Lash LL, Sanders JM, Swanson GT, Sakai R, Shimamoto K, Oikawa M, Sasaki M.
Journal of Organic Chemistry. 2006 Jul 7;71(14):5208-5220.doi:10.1021/jo0605593.

Intracellular trafficking of KA2 kainate receptors mediated by interactions with coatomer protein complex I (COPI) and 14-3-3 chaperone systems

Vivithanaporn P, Yan S, Swanson GT.
Journal of Biological Chemistry. 2006 Jun 2;281(22):15475-15484.doi:10.1074/jbc.M512098200.

Dysiherbaine: A new generation of excitatory amino acids of marine origin

Sakai R, Swanson GT, Sasaki M, Shimamoto K, Kamiya H.
Central Nervous System Agents in Medicinal Chemistry. 2006 Jan;6(2):83-108.doi:10.2174/187152406777441907.

Determination of binding site residues responsible for the subunit selectivity of novel marine-derived compounds on kainate receptors

Sanders JM, Pentikäinen OT, Settimo L, Pentikäinen U, Shoji M, Sasaki M, Sakai R, Johnson MS,Swanson GT.
Molecular Pharmacology. 2006 Jan;69(6):1849-1860.doi:10.1124/mol.106.022772.

2005

Divergent pharmacological activity of novel marine-derived excitatory amino acids on glutamate receptors
Sanders JM, Ito K, Settimo L, Pentikäinen OT, Shoji M, Sasaki M, Johnson MS, Sakai R, Swanson GT.
Journal of Pharmacology and Experimental Therapeutics. 2005 Sep;314(3):1068-1078.doi:10.1124/jpet.105.086389.

Ligand binding is a critical requirement for plasma membrane expression of heteromeric kainate receptors

Valluru L, Xu J, Zhu Y, Yan S, Contractor A, Swanson GT.
Journal of Biological Chemistry. 2005 Feb 18;280(7):6085-6093.doi:10.1074/jbc.M411549200.

2004

Attenuated plasticity of postsynaptic kainate receptors in hippocampal CA3 pyramidal neurons
Ito K, Contractor A, Swanson GT.
Journal of Neuroscience. 2004 Jul 7;24(27):6228-6236.doi:10.1523/JNEUROSCI.1302-04.2004.

Recording in the cerebellar slice.

Swanson GT, Contractor A.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]. 2004 Feb;Chapter 6:Unit 6.18.

A C-Terminal Determinant of GluR6 Kainate Receptor Trafficking
Yan S, Sanders JM, Xu J, Zhu Y, Contractor A, Swanson GT.
Journal of Neuroscience. 2004 Jan 21;24(3):679-691.doi:10.1523/JNEUROSCI.4985-03.2004.

2003

Cell Surface Expression of GluR5 Kainate Receptors is Regulated by an Endoplasmic Reticulum Retention Signal
Ren Z, Riley NJ, Needleman LA, Sanders JM, Swanson GT, Marshall J.
Journal of Biological Chemistry. 2003 Dec 26;278(52):52700-52709.doi:10.1074/jbc.M309585200.

Distribution of kainate receptor subunits at hippocampal mossy fiber synapses

Darstein M, Petralia RS, Swanson GT, Wenthold RJ, Heinemann SF.
Journal of Neuroscience. 2003 Sep 3;23(22):8013-8019.

Multiple trafficking signals regulate kainate receptor KA2 subunit surface expression

Ren Z, Riley NJ, Garcia EP, Sanders JM, Swanson GT, Marshall J.
Journal of Neuroscience. 2003 Jul 23;23(16):6608-6616.

Loss of kainate receptor-mediated heterosynaptic facilitation of mossy-fiber synapses in KA2 -/- mice

Contractor A, Sailer AW, Darstein M, Maron C, Xu J, Swanson GT, Heinemann SF.
Journal of Neuroscience. 2003 Jan 15;23(2):422-429.

2002

Trans-synaptic Eph receptor-ephrin signaling in hippocampal mossy fiber LTP
Contractor A, Rogers C, Maron C, Henkemeyer M, Swanson GT, Heinemann SF.
Science. 2002 Jun 7;296(5574):1864-1869.doi:10.1126/science.1069081.

Differential activation of individual subunits in heteromeric kainate receptors

Swanson GT, Green T, Sakai R, Contractor A, Che W, Kamiya H, Heinemann SF.
Neuron. 2002 May 16;34(4):589-598.doi:10.1016/S0896-6273(02)00676-1.

2001

An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing
Scott DB, Blanpied TA, Swanson GT, Zhang C, Ehlers MD.
Journal of Neuroscience. 2001 May;21(9):3063-3072.

Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus

Contractor A, Swanson G, Heinemann SF.
Neuron. 2001 Jan;29(1):209-216.doi:10.1016/S0896-6273(01)00191-X.

CNQX increases GABA-mediated synaptic transmission in the cerebellum by an AMPA/kainate receptor-independent mechanism

Brickley SG, Farrant M, Swanson GT, Cull-Candy SG.
Neuropharmacology. 2001 Jan;41(6):730-736.doi:10.1016/S0028-3908(01)00135-6.

Pharmacological properties of the potent epileptogenic amino acid dysiherbaine, a novel glutamate receptor agonist isolated from the marine sponge Dysidea herbacea

Sakai R, Swanson GT, Shimamoto K, Green T, Contractor A, Ghetti A, Tamura-Horikawa Y, Oiwa C, Kamiya H.
Journal of Pharmacology and Experimental Therapeutics. 2001 Jan;296(2):650-658.

2000

Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains
Schiffer HH, Swanson GT, Masliah E, Heinemann SF.
Journal of Neuroscience. 2000 Dec 15;20(24):9025-9033.

Identification of the kainate receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus

Contractor A, Swanson GT, Sailer A, O'Gorman S, Heinemann SF.
Journal of Neuroscience. 2000 Nov 15;20(22):8269-8278.

Subunit composition of kainate receptors in hippocampal interneurons

Mulle C, Sailer A, Swanson GT, Brana C, O'Gorman S, Bettler B, Heinemann SF.
Neuron. 2000 Jan;28(2):475-484.

1999

Generation and analysis of GluR5(Q636R) kainate receptor mutant mice
Sailer A, Swanson GT, Pérez-Otaño I, O'Leary L, Malkmus SA, Dyck RH, Dickinson-Anson H, Schiffer HH, Maron C, Yaksh TL, Gage FH, O'Gorman S, Heinemann SF.
Journal of Neuroscience. 1999 Oct 15;19(20):8757-8764.

Developing roles for kainate receptors in the cerebellum

Swanson GT.
Journal of Physiology. 1999 May 15;517(1):1-.doi:10.1111/j.1469-7793.1999.0001z.x.

1998

Heterogeneity of homomeric GluR5 kainate receptor desensitization expressed in HEK293 cells
Swanson GT, Heinemann SF.
Journal of Physiology. 1998 Dec 15;513(3):639-646.doi:10.1111/j.1469-7793.1998.639ba.x.

Kainate receptors exhibit differential sensitivities to (S)-5- Iodowillardiine

Swanson GT, Green T, Heinemann SF.
Molecular Pharmacology. 1998 May;53(5):942-949.

1997

Rat GluR7 and a carboxy-terminal splice variant, GluR7b, are functional kainate receptor subunits with a low sensitivity to glutamate
Schiffer HH, Swanson GT, Heinemann SF.
Neuron. 1997 Nov;19(5):1141-1146.

Identification of amino acid residues that control functional behavior in GluR5 and GluR6 kainate receptors

Swanson GT, Gereau IV RW, Green T, Heinemann SF.
Neuron. 1997 Oct;19(4):913-926.doi:10.1016/S0896-6273(00)80972-1.

Single-channel properties of recombinant AMPA receptors depend on RNA editing, splice variation, and subunit composition

Swanson GT, Kamboj SK, Cull-Candy SG.
Journal of Neuroscience. 1997 Jan;17(1):58-69.

1996

Effect of RNA editing and subunit co-assembly on single-channel properties of recombinant kainate receptors
Swanson GT, Feldmeyer D, Kaneda M, Cull-Candy SG.
Journal of Physiology. 1996 Apr;492(1):129-142.

1995

Intracellular spermine confers rectification on rat calcium-permeable AMPA and kainate receptors
Kamboj SK, Swanson GT, Cull-Candy SG.
Journal of Physiology. 1995 Jan;486(2):297-303.

Intracellular spermine confers rectification on rat calcium-permeable AMPA and kainate receptors

Kamboj SK, Swanson GT, Cull-Candy SG.
Journal of Physiology. 1995 Jan;486(2):2297-2303.

1994

Glia of the cholinergic electromotor nucleus of Torpedo are the source of the cDNA encoding a GAT-1-like GABA transporter
Swanson GT, Umbach JA, Gundersen CB.
Journal of Neurochemistry. 1994 Jul;63(1):1-12.