What We Do
We study the molecular and physiological properties of receptor proteins that underlie excitatory synaptic transmission in the mammalian brain. Current research focuses primarily on understanding the roles of kainate receptors, a family of glutamate receptors whose diverse physiological functions include modulation of neurotransmission and induction of synaptic plasticity. We are also interested in exploring how kainate receptors might contribute to pathological processes such as epilepsy and pain. The laboratory investigates kainate receptor function using a diverse group of techniques that include patch-clamp electrophysiology, selective pharmacological compounds, molecular and cellular techniques, and gene-targeted mice.
Selective and regulated trapping of nicotinic receptor weak base ligands and relevance to smoking cessation published in eLife. (July 18, 2017)
N-glycan content modulates kainate receptor functional properties published in The Journal of Physiology. (July 17, 2017)
Geoff gave a talk about the GRIK2 Lurcher project at the Brain Research Foundation’s 17th Annual Neuroscience Day. (April 7, 2017)
Neto2 Assembles with Kainate Receptors in DRG Neurons during Development and Modulates Neurite Outgrowth in Adult Sensory Neurons published in The Journal of Neuroscience. (March 22, 2017)
Yomayra made the big move to New York City. We will miss you, Yomy! (March 2017)
Erica Binelli joins the Swanson Lab as a graduate student. (March 2017)
Selective and regulated trapping of nicotinic receptor weak base ligands and relevance to smoking cessation
Govind AP, Vallejo YF, Stolz JR, Yan JZ, Swanson GT, Green WN.
eLife. (July 2017)
N-glycan content modulates kainate receptor functional properties
Vernon CG, Copits BA, Stolz JR, Guzmán YF, Swanson GT.
The Journal of Physiology. (July 2017)
Neto2 Assembles with Kainate Receptors in DRG Neurons during Development and Modulates Neurite Outgrowth in Adult Sensory Neurons
Vernon CG, Swanson GT.
The Journal of Neuroscience. (March 2017)
A gain-of-function mutation in the GRIK2 gene causes neurodevelopmental deficits
Guzmán YF, Ramsey K, Stolz JR, Craig DW, Huentelman MJ, Narayanan VN, Swanson GT.
Neurology: Genetics. (January 2017)