Northwestern University Feinberg School of Medicine

Geoffrey Swanson Lab

What We Do

We study the molecular and physiological properties of receptor proteins that underlie excitatory synaptic transmission in the mammalian brain. Current research focuses primarily on understanding the roles of kainate receptors, a family of glutamate receptors whose diverse physiological functions include modulation of neurotransmission and induction of synaptic plasticity. We are also interested in exploring how kainate receptors might contribute to pathological processes such as epilepsy and pain. The laboratory investigates kainate receptor function using a diverse group of techniques that include patch-clamp electrophysiology, selective pharmacological compounds, molecular and cellular techniques, and gene-targeted mice.

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News

A gain-of-function mutation in the GRIK2 gene causes neurodevelopmental deficits published in Neurology: Genetics (January 31, 2017).

Transduction of group I mGluR-mediated synaptic plasticity by β-arrestin2 signalling was published in Nature Communications (November 25, 2016).

Tristan and Yomy both presented posters at the Society for Neuroscience’s annual meeting in San Diego (November 12-16, 2016).

Tristan won first place in the poster competition at the annual symposium of the ASPET Great Lakes chapter for her poster entitled "Coordinated spiking in CA3 propagates to hilar mossy cells in juvenile mice but only rarely in adult mice" (July 7, 2016).

    Recent Publications

    A gain-of-function mutation in the GRIK2 gene causes neurodevelopmental deficits
    Guzmán YF, Ramsey K, Stolz JR, Craig DW, Huentelman MJ, Narayanan VN, Swanson GT.
    Neurology: Genetics. (January 2017)

    Transduction of group I mGluR-mediated synaptic plasticity by β-arrestin2 signalling
    Eng AG, Kelver DAHedrick TPSwanson GT.
    Nature Communications. (November 2016)

    Identification of critical functional determinants of kainate receptor modulation by auxiliary protein Neto2
    Griffith TN, Swanson GT.
    Journal of Physiology. (September 2015)

    Psychiatric risk factor ANK3/Ankyrin-G nanodomains regulate the structure and function of glutamatergic synapses
    Smith KR, Kopeikina KJ, Fawcett-Patel JM, Leaderbrand K, Gao R, Schürmann B, Myczek K, Radulovic J, Swanson GT, Penzes P.
    Neuron. (October 2014)

    View all publications

    Geoffrey T. Swanson, Ph.D.

    Geoffrey T. Swanson, Ph.D.
    Professor
    Department of Pharmacology

    For more information, click here to visit our department page.

    Research Opportunities in the Swanson Lab