What We Do
We study the molecular and physiological properties of receptor proteins that underlie excitatory synaptic transmission in the mammalian brain. Current research focuses primarily on understanding the roles of kainate receptors, a family of glutamate receptors whose diverse physiological functions include modulation of neurotransmission and induction of synaptic plasticity. We are also interested in exploring how kainate receptors might contribute to pathological processes such as epilepsy and pain. The laboratory investigates kainate receptor function using a diverse group of techniques that include patch-clamp electrophysiology, selective pharmacological compounds, molecular and cellular techniques, and gene-targeted mice.
Geoff gave a talk about the GRIK2 Lurcher project at the Brain Research Foundation’s 17th Annual Neuroscience Day. (April 7, 2017)
Neto2 Assembles with Kainate Receptors in DRG Neurons during Development and Modulates Neurite Outgrowth in Adult Sensory Neurons published in The Journal of Neuroscience. (March 22, 2017)
Yomayra made the big move to New York City. We will miss you, Yomy! (March 2017)
Erica Binelli joins the Swanson Lab as a graduate student. (March 2017)
Claire successfully defended her thesis, “Neto2 modulates kainate receptor properties and neurite outgrowth in DRG neurons”. Congratulations Claire! (March 3, 2017)
Neto2 Assembles with Kainate Receptors in DRG Neurons during Development and Modulates Neurite Outgrowth in Adult Sensory Neurons
Vernon CG, Swanson GT.
The Journal of Neuroscience. (March 2017)
A gain-of-function mutation in the GRIK2 gene causes neurodevelopmental deficits
Guzmán YF, Ramsey K, Stolz JR, Craig DW, Huentelman MJ, Narayanan VN, Swanson GT.
Neurology: Genetics. (January 2017)
Transduction of group I mGluR-mediated synaptic plasticity by β-arrestin2 signalling
Eng AG, Kelver DA, Hedrick TP, Swanson GT.
Nature Communications. (November 2016)
Identification of critical functional determinants of kainate receptor modulation by auxiliary protein Neto2
Griffith TN, Swanson GT.
Journal of Physiology. (September 2015)