Recent Publications
Learn more about the work that we do in the Ziarek Lab through our recent publications.
Links to each article's PubMed entry or journal website are included below. If you are unable to retrieve an article, please request a copy by email from joshua.ziarek@northwestern.edu.
- Shim J-G, Georgeva NN, Robson SA, Burdzhiev NT, Petrov OI, Cui J, Acharya A, Kuprov I, Gelev V, & Ziarek JJ. Chemical control of CSA geometry enables relaxation-optimized 19F-13C NMR probes. bioRxiv 2026.01.19.700399 [Preprint].
- Robson SA, Bumbak F, Bhattacharya S, van der Velden WJC, Vaidehi N, & Ziarek JJ. Mapping the Ligand-dependent Remodeling of the Conformational Entropy Landscape in Neurotensin Receptor 1 by NMR-guided Molecular Simulations. bioRxiv 2026.01.18.700126 [Preprint].
- Shriver TJ, Berndt S, Robson SA, Dixon AD, Liebscher I, & Ziarek JJ. The isolated Stachel peptide of the adhesion G protein-coupled receptor GPR126 is intrinsically disordered. bioRxiv 2026.01.16.700034 [Preprint].
- Shriver TJ, Kahraman K, Pan M, Dağ Ç, Tonelli M, Robson SA, & Ziarek JJ. Intrinsic conformational equilibria position arrestin-2 for activation. Protein Science, 2026 Jun;35(6):e70627.
- Bower JB, van der Velden WJC, Gomez KP, Pan, M, Bumbak F, Vaidehi N, & Ziarek JJ. 2025. Stabilization versus flexibility: detergent-dependent trade-offs in neurotensin receptor 1 GPCR ensembles. Protein Science, 2026 Feb;35(2):e70475.
- Dağ Ç, Lambert M, Kazar AE, Kahraman K, Göcenler O, Lee W, Ceylan CDT, Löhr F, Shim J-G, Hass AL, Dötsch V, Ziarek JJ, & Elgin ES. Dynamic hotspots in the Uba7 ubiquitin-fold domain direct UbcH8 recognition. Biochemistry, 2026 Mar 17;65(6):678-692.
- Roy SM, Acquarone E, Argyrousi EK, Zhang H, Staniszewski A, Inoue A, Ziarek JJ, Arancio O, & Watterson DM. 2025. Optimized 5-HT2b inhibitors for neuropsychiatric syndromes with cognitive dysfunction. Alzheimer's & Dementia, 11(1):e70073.
- Rai R, Dawodu OI, Meng J, Johnson SM, Vilseck JZ, Kelley MR, Ziarek JJ, & Georgiadis MM. 2025. Chemically induced partial unfolding of the multifunctional apurinic/apyrimidinic endonuclease I. Protein Science, 34(6):e70148.
- Manley O, Shriver TJ, Xu T, Melendrez IA, Palacios PM, Robso, SA, Guo Y, Kelleher NL, Ziarek JJ, & Rosenzweig AC. 2024. A multi-iron enzyme installs copper-binding oxazolonethioamide pairs on a nontypeable Haemophilus influenzae virulence factor. Proceedings of the National Academy of Sciences, 121 (28) e2408092121.
- Bower JB, Robson SA, & Ziarek JJ. 2024. Insights on the GPCR helix 8 solution structure and orientation using a neurotensin receptor 1 peptide. Protein Science, 33(6):e4976.
- Kahrama K, Robson SA, Gocenler O, Yenici CM, Tozkoparan CD, Klein JM, Haas AL, Ziarek JJ*, & Dağ Ç*. 2024. Characterizing the monomer-dimer equilibrium of UbcH8/Ube2L6: A combined SAXS and NMR study. ACS Omega. *Co-corresponding authors.
- Bumbak F, Bower JB, Zemmer SC, Inoue A, Paniagua JC, Pons M, Yan F, Ford J, Wu H, Robson SA, Bathgate RAD, Scott DJ, Gooley PR, & Ziarek JJ. 2023. Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314. Nature Communications, 14:3328.
- Bumbak F, Pons M, Inoue A, Paniagua JC, Yan F, Wu H, Robson SA, Bathgate RAD, Scott DJ, Gooley PR, & Ziarek JJ. 2023. Ligands tune the global and local motions of neurotensin receptor 1 (NTS1). Cell Reports, 42(1):112015.
- Dixon AD, Robson SA, Trinidad JC, & Ziarek JJ. 2022. A method for Selective 19F-labeling Absent of Probe Sequestration (SLAPS). Protein Science, 31:e4454.
- Dixon AD, Inoue A, Robson SA, Culhane KJ, Trinidad JC, Sivaramakrishnan S, Bumbak F, & Ziarek JJ. 2022. The effect of ligands and transducers on the Neurotensin receptor 1 (NTS1) conformational ensemble. Journal of the American Chemical Society, 144(23):10241-10250.
- Melland H, Bumbak F, Kolesnik-Taylor A, Ng-Cordell E, John A, Constantinou P, Joss S, Larsen M, Fagerberg C, Thies J, Emslie F, Willemsen M, Kleefstra T, Pfundt R, Barrick R, Chang R, Loong L, Alfadhel M, van der Smagt J, Nizon M, Kurian M, Scott DJ, Ziarek JJ, Gordon S, & Baker K. 2022. Expanding the genotype and phenotype spectrum of SYT1-associated neurodevelopmental disorder. Genetics in Medicine, 24(4):880-893.
- Robson SA, Dağ Ç, Wu H, & Ziarek JJ. 2021. TRACT revisited: An Algebraic Solution for Determining Overall Rotational Correlation Times from Cross-Correlated Relaxation Rates. Journal of Biomolecular NMR, 75(8-9):293-302.
- Chamness LM, Zelt NB, Harrington HR, Kuntz CP, Bender BJ, Penn WD, Ziarek JJ, Meiler J, & Schlebach JP. 2021. Molecular Basis for the Evolved Instability of a Human G-Protein Coupled Receptor. Cell Reports, 37(8):110046-110058.
- Gruenhagen T, Ziarek JJ, & Schlebach JP. 2018. Bicelle Size Modulates the Rate of Bacteriorhodopsin Folding. Protein Science, 27(6):1109-1112.
Explore Ziarek’s earlier research contributions during his training.