Publications
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2013 Feng F, Shangguan A, Kelly K, Wei J, Gruner K, Ye B, Wang W, Bhattacharya S, Tourtellotte WG, Varga J: Early growth response 3 (Egr-3) is induced by transforming growth factor-b and regulates fibrogenic gene expression. Am. J. Pathol., in press (2013). Quach DH, Oliveira-Fernandes M., Gruner K, Tourtellotte WG: A sympathetic neuron autonomous role for egr3-mediated gene regulation in dendrite morphogenesis and target tissue innervation. J. Neurosci. 33(10): 4570-83 (2013). PubMed Bhattacharyya S, Wei J, Tourtellotte WG, Hinchcliff M, Gottardi CG, Varga J: Fibrosis in systemic sclerosis: common and unique pathobiology. Fibrogensis Tissue Repair. 6:18 (2013). PubMed 2012 Bhalala OG, Pan L, Sahni V, McGuire TL, Gruner K, Tourtellotte WG, Kessler, JA: MicroRNA-21 regulates astrocytic response following spinal cord injury. J. Neurosci., 32(50): 17935-47 (2012). PubMed Bhattacharyya S, Fang F, Tourtellotte WG, Varga J: Egr-1: a new conductor for the tissue repair orchestra directs harmony (regeneration) or cacophony (fibrosis). J. Pathol. 229: 286-297 (2012). PubMed Enjin A, Leao KE, Mikulovic S, Merre PL, Tourtellotte WG, Kullander K: The serotonin receptor 1d, a novel marker for gamma motor neurons, is a regulator of sensorimotor function. Mol. Cell. Neurosci., 49:322-332 (2012). PubMed 2011 Bhattacharyya S, Wu M, Fang F, Tourtellotte WG, Feghali-Bostwick C, Varga J: Early growth response transcription factors: key mediators of fibrosis and novel targets for anti-fibrotic therapy. Mat. Biol., 30:235-242 (2011) PubMed Li L, Eldredge LC, Quach DH, Honasoge A, Gruner K, Tourtellotte WG: Egr3 dependent sympathetic target tissue innervation in the absence of neuron death. PLoS One, 6: e25696 (2011). (PMCID: 3182249). PubMed Bhattacharyya S, Sargent JL, Du P, Lin S, Tourtellotte WG, Takehara K, Whitfield ML, Varga J: Egr-1 induces a profibrotic injury/repair gene program associated with systemic sclerosis. PLoS One, 6: e23082 (2011). (PMCID: 3172216). PubMed Wei J, Bhattacharyya S, Tourtellotte WG, Varga J: Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy. Autoimmun. Rev., 10:267-275 (2011) (NIHMSID: 239543. PubMed 2010 Wei J, Bhattacharyya S, Tourtellotte WG, Varga J: Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy. Autoimmun. Rev., 10:267-275 (2011) (NIHMSID: 239543. PubMed Enjin A, Rabe N, Nakanishi S, Vallstedt A, Gezelius H, Lind M, Hjalt M,Tourtellotte WG, Bruder C, Eichele G, Whelan P and Kulander K. Identification of novel spinal cholinergic genetic subtypes disclose Chodl mand Pitx2 as markers for fast motor neurons and partition cells. J. Comp. Neurol., 518: 2284-2304 (2010). (NIHMSID: NIHMS239543). PubMed Matkowskyj KA, Wiseman WR, Robin JC, Norvell JP, Puthuman J, Nelson B, Peterson L, McGarry TJ and Tourtellotte WG: Therapy-related myelodysplastic syndrome presenting as fulminant heart failure secondary to myeloid sarcoma. J. Hematop, 3: 41-46 (2010) (PMCID: 2883902). PubMed Previous Wu M, Melichian DS, de la Garza M, Nair A, Shahrara S, Barr L, Sporn PH, Mustoe TA, Tourtellotte WG and Varga J. Essential roles for early growth response transcription factor Egr-1 in tissue fibrosis and wound healing. Am. J. Pathol., 175: 1041-1045 (2009). (PMCID: 2731123). PubMed Eldredge, LC, Gao XM, Quach DM, Li L, Han X, Lomasney J, andTourtellotte WG: Abnormal sympathetic nervous system development and physiological dysautonomia in Egr3-deficient mice. Development, 135(17): p. 2949-2957 (2008). (PMCID: 2613541). PubMed Gao X, Daughterty R and Tourtellotte WG: The low affinity neurotrophin receptor (p75NTR) is directly regulated by early growth response (Egr) transcriptional regulators. Mol. Cell. Neurosci., 36(4): 501-514 (2007) (Featured cover article). (PMCID: 2098703). PubMed Carter JH, Lefebvre JM, Wiest DL and Tourtellotte WG: Redundant role for early growth response (Egr) transcriptional regulators in thymocyte differentiation and survival. J. Immunol., 178: 6796-67805 (2007). PubMed Li L, Yun SH, Keblesh J, Trommer BL, Xiong H, Radulovic J and Tourtellotte WG: Egr3, a synaptic activity regulated transcription factor that is essential for learning and memory. Mol. Cell. Neurosci., 35: 76-88 (2007). (PMCID: 2683345). PubMed Li L, Carter J, Gao X, Whitehead J and Tourtellotte WG: The neuroplasticity associated Arc gene is a direct transcriptional target of early growth response (Egr) transcription factors. Mol. Cell. Biol., 25: 10286-10300 (2005). (PMCID: 1291244). PubMed Albert Y, Whitehead J, Eldredge L, Carter J, Gao X and Tourtellotte WG: Transcriptional regulation of myotube fate specification and intrafusal muscle fiber morphogenesis. J. Cell. Biol., 169: 257-268 (2005). (PMCID: 2171871). PubMed Skinner MA, Freemerman A, Somasunaram K, Safford SD, Heuckeroth RO,Tourtellotte WG, Goyeau D, Constantini F, Milbrandt JD: A human yeast artificial chromosome containing the RET protooncogene with the mutation associated with the Multiple Endocrine Neoplasia Type 2B syndrome supports the growth of kidneys but not enteric ganglia in ret-deficient mice. Am J. Pathol., 166: 265-274 (2005). PubMed Whitehead J, Keller-Peck C, Kucera J and Tourtellotte WG: Glial derived neurotrophic factor-dependent fusimotor neuron survival during development. Mech. Devel.,122: 27-41 (2005). PubMed Chen H-H, Tourtellotte WG, Frank E: Muscle spindle-derived neurotrophin 3 (NT3) regulates synaptic connectivity between muscle sensory and motor neurons. J. Neurosci., 22: 3512-3519 (2002). PubMed Chiesa R, Pestronk A, Schmidt RE, Tourtellotte WG, Ghetti B, Harris DA: Primary myopathy and accumulation of PrpSc-like molecules in peripheral tissues of transgenic mice expressing a prion protein insertional mutation. Neurobiol Dis, 8: 279-288 (2001). PubMed Tourtellotte WG, Keller-Peck C, Milbrandt J, Kucera J: Differentiation and maintenance of muscle spindles depends upon Egr3-mediated transcriptional regulatory activity. Dev Biol., 232: 388-399 (2001). PubMed Blanco G, Sanchez G, Melton RJ, Tourtellotte WG, Mercer RW: The alpha4 isoform of the Na,K-ATPase is expressed in the germ cells of the testes. J. Histochem. Cytochem. 8:1023-32 (2000). PubMed Tourtellotte WG, Nagarajan R, Bartke A, Milbrandt J: Redundant Function of Egr1 and Egr4 in Murine Luteinizing Hormone Regulation and Leydig Cell Steroidogenesis. Mol. Cell. Biol., 20, 5261-5268 (2000). PubMed O’Donovan K, Tourtellotte WG, Milbrandt J, Baraban, J: The Egr family of transcription factors: progress at the interface of systems and molecular neuroscience. Trends Neurosci 22, 167-173, 1999. PubMed Naughton CK, Tourtellotte WG, Smith DS, Milbrandt J: Prostate Apoptosis in Response to Castration in Wild-Type and Nerve Growth Factor-Induced Gene A-Deficient Mice. Prostate J., 1 :88-93 (1999). PubMed Tourtellotte WG, Nagarajan R, Auyeung A, Mueller C, Milbrandt J: Infertility associated with incomplete spermatogenic arrest and oligozoospermia in Egr4deficient mice. Development, 126, 5061-5071 (1999). PubMed Tourtellotte WG, Milbrandt J.: Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3. Nat. Genet. 20, 87-91 (1998). PubMed
Clifford DE, Arribas VE Jr, Storch GA, Tourtellotte WG, Wippold FJ: Magnetic resonance brain imaging lacks sensitivity for AIDS associated cytomegalovirus encephalitis. J. Neurovirol. 2, 397-403 (1996). PubMed Knudson CM, Tung KSK, Tourtellotte WG, Brown GAJ, Korsmeyer SJ: Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270, 96-98 (1996). PubMed Ilinsky IA, Tourtellotte WG, Kultas-Ilinsky K: Anatomical distinctions between the two basal ganglia afferent territories in the primate motor thalamus. Stereotact. Funct. Neurosurg. 60, 62-69 (1993). PubMed Tourtellotte WG, Van Hoesen GW: Computer-aided two-dimensional high-resolution axon tracing: an application using the anterograde tracer Phaseolus Vulgaris Leucoagglutinin (PHA-L). J. Neurosci. Methods 41, 101-112 (1992). PubMed Tourtellotte WG, Van Hoesen GW: The axonal origin of a subpopulation of dystrophic neurites in Alzheimer's disease. Neurosci. Lett. 129, 11-16 (1991). PubMed Tourtellotte WG: A versatile dual axis programmable stepping motor controller for a personal computer: A specific application and tutorial for implementing a computer controlled light microscope. J. Neurosci. Methods 35, 157-167 (1990). PubMed Tourtellotte WG, Van Hoesen GW, Hyman BT, Tikoo RT and Damasio AR: Alz-50 immunoreactivity in the thalamic reticular nucleus in Alzheimer's disease. Brain Res.515, 227-234 (1990). PubMed Tourtellotte WG, Lawrence DT, Getting PA and Van Hoesen GW: A graphics oriented personal computer based microscope charting system for neuroanatomical and neurochemical studies. J. Neurosci. Methods 29, 43-57 (1989). PubMed Shapshak P, Tourtellotte WW, Staugaitis S, Cowan T, Ingram T, Weil M, Bliss D, Tourtellotte WG: The quantitation of human immunoglobulin G and albumin in electroimmunodiffusion gels containing ionic and non-ionic detergents. Anal. Biochem. 132, 305-311 (1983). PubMed