Northwestern University Feinberg School of Medicine

Adam Sonabend Lab


Below you'll find a list of recent publications from the Sonabend Lab and its collaborators. For a more comprehensive list, please click here.
  1. Larkin CJ, Arrieta VA, Najem H, Li G, Zhang P, Miska J, Chen P, James CD, Sonabend AM, Heimberger AB  Myeloid Cell Classification and Therapeutic Opportunities Within the Glioblastoma Tumor Microenvironment in the Single Cell-Omics Era.  Front Immunol  2022;13:907605. doi:10.3389/fimmu.2022.907605
  2. Sita TL, Gopalakrishnan M, Rooney MK, Ho A, Savoor R, Sonabend AM, Tate MC, Chandler JP, Lesniak MS, Kruser TJ  et al.  Mean Brain Dose Remains Uninfluenced by the Lesion Number for Gamma Knife Stereotactic Radiosurgery for 10+ Metastases.  World Neurosurg  2022 Jun 18;. pii:S1878-8750(22)00842-7
  3. Dmello C, Sonabend A, Arrieta VA, Zhang DY, Kanojia D, Chen L, Gould A, Zhang J, Kang SJ, Winter J  et al.  Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma.  Clin Cancer Res  2022 07 15;28(14):3156-3169. doi:10.1158/1078-0432.CCR-21-2563
  4. Najem H, Ott M, Kassab C, Rao A, Rao G, Marisetty A, Sonabend AM, Horbinski C, Verhaak R, Shankar A  et al.  Central nervous system immune interactome is a function of cancer lineage, tumor microenvironment, and STAT3 expression.  JCI Insight  2022 05 09;7(9). doi:10.1172/jci.insight.157612
  5. Arrieta VA, Chen AX, Kane JR, Kang SJ, Kassab C, Dmello C, Zhao J, Burdett KB, Upadhyayula PS, Lee-Chang C  et al.  Publisher Correction: ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma.  Nat Cancer  2022 Mar;3(3):373. doi:10.1038/s43018-022-00343-8
  6. Arrieta VA, Chen AX, Kane JR, Kang SJ, Kassab C, Dmello C, Zhao J, Burdett KB, Upadhyayula PS, Lee-Chang C  et al.  ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma.  Nat Cancer  2021 12;2(12):1372-1386. doi:10.1038/s43018-021-00260-2
  7. Zhang DY, Gould A, Happ HC, Youngblood MW, Dmello C, Kang SJ, Canney M, Stupp R, Carvill GL, Sonabend AM  Ultrasound-mediated blood-brain barrier opening increases cell-free DNA in a time-dependent manner.  Neurooncol Adv  ;3(1):vdab165. doi:10.1093/noajnl/vdab165
  8. Arrieta VA, Najem H, Petrosyan E, Lee-Chang C, Chen P, Sonabend AM, Heimberger AB  The Eclectic Nature of Glioma-Infiltrating Macrophages and Microglia.  Int J Mol Sci  2021 Dec 13;22(24). pii:13382
  9. Gould A, Zhang D, Arrieta VA, Stupp R, Sonabend AM  Delivering albumin-bound paclitaxel across the blood-brain barrier for gliomas.  Oncotarget  2021 Dec 07;12(25):2474-2475. doi:10.18632/oncotarget.28018
  10. Gonzalez-Buendia E, Zhao J, Wang L, Mukherjee S, Zhang D, Arrieta VA, Feldstein E, Kane JR, Kang SJ, Lee-Chang C  et al.  TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas.  Clin Cancer Res  2021 10 15;27(20):5669-5680. doi:10.1158/1078-0432.CCR-21-0312
  11. Fares J, Ahmed AU, Ulasov IV, Sonabend AM, Miska J, Lee-Chang C, Balyasnikova IV, Chandler JP, Portnow J, Tate MC  et al.  Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial.  Lancet Oncol  2021 08;22(8):1103-1114. pii:S1470-2045(21)00245-X
  12. Kumthekar P, Ko CH, Paunesku T, Dixit K, Sonabend AM, Bloch O, Tate M, Schwartz M, Zuckerman L, Lezon R  et al.  A first-in-human phase 0 clinical study of RNA interference-based spherical nucleic acids in patients with recurrent glioblastoma.  Sci Transl Med  2021 03 10;13(584). pii:eabb3945
  13. Sonabend AM, Stupp R, Lee-Chang C, Okada H  Glioma immunoediting, a driver of tumor evolution, and the next battle for immunotherapy.  Oncotarget  2021 Jan 05;12(1):8-9. doi:10.18632/oncotarget.27865
  14. Chastkofsky MI, Pituch KC, Katagi H, Zannikou M, Ilut L, Xiao T, Han Y, Sonabend AM, Curiel DT, Bonner ER  et al.  Mesenchymal Stem Cells Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma.  Clin Cancer Res  2021 03 15;27(6):1766-1777. doi:10.1158/1078-0432.CCR-20-1499
  15. Youngblood MW, Stupp R, Sonabend AM  Role of Resection in Glioblastoma Management.  Neurosurg Clin N Am  2021 Jan;32(1):9-22. pii:S1042-3680(20)30080-2
  16. Kam KL, Brooker SM, Mao Q, Barnea Slonim L, Yaseen NR, Brat DJ, Sonabend AM, Lukas RV  Newly diagnosed enhancing lesions: Steroid initiation may impede diagnosis of lymphoma involving the central nervous system.  J Clin Neurosci  2020 Nov;81:61-64. pii:S0967-5868(20)31491-0
  17. Lee-Chang C, Miska J, Hou D, Rashidi A, Zhang P, Burga RA, Jusué-Torres I, Xiao T, Arrieta VA, Zhang DY  et al.  Activation of 4-1BBL+ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma.  J Exp Med  2021 01 04;218(1). pii:e20200913
  18. Dunn GP, Cloughesy TF, Maus MV, Prins RM, Reardon DA, Sonabend AM  Emerging immunotherapies for malignant glioma: from immunogenomics to cell therapy.  Neuro Oncol  2020 10 14;22(10):1425-1438. doi:10.1093/neuonc/noaa154
  19. Rao G, Latha K, Ott M, Sabbagh A, Marisetty A, Ling X, Zamler D, Doucette TA, Yang Y, Kong LY  et al.  Anti-PD-1 Induces M1 Polarization in the Glioma Microenvironment and Exerts Therapeutic Efficacy in the Absence of CD8 Cytotoxic T Cells.  Clin Cancer Res  2020 09 01;26(17):4699-4712. doi:10.1158/1078-0432.CCR-19-4110
  20. Awah CU, Chen L, Bansal M, Mahajan A, Winter J, Lad M, Warnke L, Gonzalez-Buendia E, Park C, Zhang D  et al.  Ribosomal protein S11 influences glioma response to TOP2 poisons.  Oncogene  2020 07;39(27):5068-5081. doi:10.1038/s41388-020-1342-0
  21. Moreno-Jiménez S, Alegría-Loyola MA, Sonabend AM, Romano SK, Romo CG  Management of glioblastoma: a perspective from Mexico.  Chin Clin Oncol  2021 Aug;10(4):44. doi:10.21037/cco-20-129
  22. Kane JR, Zhao J, Tsujiuchi T, Laffleur B, Arrieta VA, Mahajan A, Rao G, Mela A, Dmello C, Chen L  et al.  CD8+ T-cell-Mediated Immunoediting Influences Genomic Evolution and Immune Evasion in Murine Gliomas.  Clin Cancer Res  2020 08 15;26(16):4390-4401. doi:10.1158/1078-0432.CCR-19-3104
  23. Garton ALA, Kinslow CJ, Rae AI, Mehta A, Pannullo SC, Magge RS, Ramakrishna R, McKhann GM, Sisti MB, Bruce JN  et al.  Extent of resection, molecular signature, and survival in 1p19q-codeleted gliomas.  J Neurosurg  2020 May 08;134(5):1357-1367. doi:10.3171/2020.2.JNS192767
  24. Rooney MK, Golden DW, Byun J, Lukas RV, Sonabend AM, Lesniak MS, Sachdev S  Evaluation of patient education materials for stereotactic radiosurgery from high-performing neurosurgery hospitals and professional societies.  Neurooncol Pract  2020 Jan;7(1):59-67. doi:10.1093/nop/npz031
  25. Kinslow CJ, Rae AI, Neugut AI, Adams CM, Cheng SK, Sheth SA, McKhann GM, Sisti MB, Bruce JN, Iwamoto FM  et al.  Surgery plus adjuvant radiotherapy for primary central nervous system lymphoma.  Br J Neurosurg  2020 Dec;34(6):690-696. doi:10.1080/02688697.2019.1710820
  26. Shah PV, Arrieta VA, Lee-Chang C, Sonabend AM  Cancer Immunoediting in Gliomas: Recent Advances and Implications for Immunotherapy.  J Cell Immunol  2020;2(6):352-358. doi:10.33696/immunology.2.066
  27. Zhang DY, Dmello C, Chen L, Arrieta VA, Gonzalez-Buendia E, Kane JR, Magnusson LP, Baran A, James CD, Horbinski C  et al.  Ultrasound-mediated Delivery of Paclitaxel for Glioma: A Comparative Study of Distribution, Toxicity, and Efficacy of Albumin-bound Versus Cremophor Formulations.  Clin Cancer Res  2020 01 15;26(2):477-486. doi:10.1158/1078-0432.CCR-19-2182
  28. Arrieta VA, Iwamoto F, Lukas RV, Sachdev S, Rabadan R, Sonabend AM  Can patient selection and neoadjuvant administration resuscitate PD-1 inhibitors for glioblastoma?  J Neurosurg  2019 12 06;132(5):1667-1672. doi:10.3171/2019.9.JNS192523
  29. Lukas RV, Wainwright DA, Horbinski CM, Iwamoto FM, Sonabend AM  Immunotherapy Against Gliomas: is the Breakthrough Near?  Drugs  2019 Nov;79(17):1839-1848. doi:10.1007/s40265-019-01203-z
  30. Kinslow CJ, Garton ALA, Rae AI, Marcus LP, Adams CM, McKhann GM, Sisti MB, Connolly ES, Bruce JN, Neugut AI  et al.  Extent of resection and survival for oligodendroglioma: a U.S. population-based study.  J Neurooncol  2019 Sep;144(3):591-601. doi:10.1007/s11060-019-03261-5
  31. D'Amico RS, Neira JA, Yun J, Alexiades NG, Banu M, Englander ZK, Kennedy BC, Ung TH, Rothrock RJ, Romanov A  et al.  Validation of an effective implantable pump-infusion system for chronic convection-enhanced delivery of intracerebral topotecan in a large animal model.  J Neurosurg  2019 Aug 02;:1-10. doi:10.3171/2019.3.JNS1963
  32. Sonabend AM, Stupp R  Overcoming the Blood-Brain Barrier with an Implantable Ultrasound Device.  Clin Cancer Res  2019 07 01;25(13):3750-3752. doi:10.1158/1078-0432.CCR-19-0932
  33. Boyett D, Kinslow CJ, Bruce SS, Sonabend AM, Rae AI, McKhann GM, Sisti MB, Bruce JN, Cheng SK, Wang TJC  Spinal location is prognostic of survival for solitary-fibrous tumor/hemangiopericytoma of the central nervous system.  J Neurooncol  2019 Jul;143(3):457-464. doi:10.1007/s11060-019-03177-0
  34. Zhao J, Chen AX, Gartrell RD, Silverman AM, Aparicio L, Chu T, Bordbar D, Shan D, Samanamud J, Mahajan A  et al.  Author Correction: Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma.  Nat Med  2019 Jun;25(6):1022. doi:10.1038/s41591-019-0449-8
  35. Lukas RV, Wainwright DA, Ladomersky E, Sachdev S, Sonabend AM, Stupp R  Newly Diagnosed Glioblastoma: A Review on Clinical Management.  Oncology (Williston Park)  2019 Mar 13;33(3):91-100. pii:623491
  36. Zhao J, Chen AX, Gartrell RD, Silverman AM, Aparicio L, Chu T, Bordbar D, Shan D, Samanamud J, Mahajan A  et al.  Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma.  Nat Med  2019 03;25(3):462-469. doi:10.1038/s41591-019-0349-y
  37. Rae AI, Iwamoto FM, Sonabend AM  In Reply: Craniotomy and Survival for Primary Central Nervous System Lymphoma.  Neurosurgery  2018 10 01;83(4):E192. doi:10.1093/neuros/nyy328
  38. Garrett MD, Yanagihara TK, Yeh R, McKhann GM, Sisti MB, Bruce JN, Sheth SA, Sonabend AM, Wang TJC  Monitoring Radiation Treatment Effects in Glioblastoma: FLAIR Volume as Significant Predictor of Survival.  Tomography  2017 Sep;3(3):131-137. doi:10.18383/j.tom.2017.00009
  39. Mehta A, Awah CU, Sonabend AM  Topoisomerase II Poisons for Glioblastoma; Existing Challenges and Opportunities to Personalize Therapy.  Front Neurol  2018;9:459. doi:10.3389/fneur.2018.00459
  40. Arrieta VA, Cacho-Díaz B, Zhao J, Rabadan R, Chen L, Sonabend AM  The possibility of cancer immune editing in gliomas. A critical review.  Oncoimmunology  ;7(7):e1445458. doi:10.1080/2162402X.2018.1445458
  41. Ding H, Douglass EF, Sonabend AM, Mela A, Bose S, Gonzalez C, Canoll PD, Sims PA, Alvarez MJ, Califano A  Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm.  Nat Commun  2018 04 16;9(1):1471. doi:10.1038/s41467-018-03843-3
  42. Rae AI, Mehta A, Cloney M, Kinslow CJ, Wang TJC, Bhagat G, Canoll PD, Zanazzi GJ, Sisti MB, Sheth SA  et al.  Craniotomy and Survival for Primary Central Nervous System Lymphoma.  Neurosurgery  2019 04 01;84(4):935-944. doi:10.1093/neuros/nyy096
  43. Kinslow CJ, Bruce SS, Rae AI, Sheth SA, McKhann GM, Sisti MB, Bruce JN, Sonabend AM, Wang TJC  Solitary-fibrous tumor/hemangiopericytoma of the central nervous system: a population-based study.  J Neurooncol  2018 May;138(1):173-182. doi:10.1007/s11060-018-2787-7
  44. Tai CH, Wu CC, Hwang ME, Saraf A, Grubb C, Jani A, Lapa ME, Andrews JIS, Isaacson SR, Sonabend AM  et al.  Single institution validation of a modified graded prognostic assessment of patients with breast cancer brain metastases.  CNS Oncol  2018 01;7(1):25-34. doi:10.2217/cns-2017-0023
  45. Yun J, Yang J, Cloney M, Mehta A, Singh S, Iwamoto FM, Neugut AI, Sonabend AM  Assessing the Safety of Craniotomy for Resection of Primary Central Nervous System Lymphoma: A Nationwide Inpatient Sample Analysis.  Front Neurol  2017;8:478. doi:10.3389/fneur.2017.00478
  46. Wu CC, Chaudhary KR, Na YH, Welch D, Black PJ, Sonabend AM, Canoll P, Saenger YM, Wang TJC, Wuu CS  et al.  Quality Assessment of Stereotactic Radiosurgery of a Melanoma Brain Metastases Model Using a Mouselike Phantom and the Small Animal Radiation Research Platform.  Int J Radiat Oncol Biol Phys  2017 09 01;99(1):191-201. pii:S0360-3016(17)30913-6
  47. Saraf A, Grubb CS, Hwang ME, Tai CH, Wu CC, Jani A, Lapa ME, Andrews JIS, Vanderkelen S, Isaacson SR  et al.  Breast cancer subtype and stage are prognostic of time from breast cancer diagnosis to brain metastasis development.  J Neurooncol  2017 Sep;134(2):453-463. doi:10.1007/s11060-017-2549-y
  48. Kinslow CJ, Rajpara RS, Wu CC, Bruce SS, Canoll PD, Wang SH, Sonabend AM, Sheth SA, McKhann GM, Sisti MB  et al.  Invasiveness is associated with metastasis and decreased survival in hemangiopericytoma of the central nervous system.  J Neurooncol  2017 Jun;133(2):409-417. doi:10.1007/s11060-017-2450-8
  49. Mehta AM, Sonabend AM, Bruce JN  Convection-Enhanced Delivery.  Neurotherapeutics  2017 04;14(2):358-371. doi:10.1007/s13311-017-0520-4
  50. Chang PD, Malone HR, Bowden SG, Chow DS, Gill BJA, Ung TH, Samanamud J, Englander ZK, Sonabend AM, Sheth SA  et al.  A Multiparametric Model for Mapping Cellularity in Glioblastoma Using Radiographically Localized Biopsies.  AJNR Am J Neuroradiol  2017 May;38(5):890-898. doi:10.3174/ajnr.A5112