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Northwestern University Feinberg School of Medicine
Adam Sonabend Lab

Publications

Below you'll find a list of recent publications from the Sonabend Lab and its collaborators. For a more comprehensive list, please visit Sonabend's PubMed listing.

  1. Kim KS, Habashy K, Gould A, Zhao J, Najem H, Amidei C, Saganty R, Arrieta VA, Dmello C, Chen L  et al.  Fc-enhanced anti-CTLA-4, anti-PD-1, doxorubicin, and ultrasound-mediated blood-brain barrier opening: A novel combinatorial immunotherapy regimen for gliomas.  Neuro Oncol  2024 Nov 04;26(11):2044-2060. doi:10.1093/neuonc/noae135
  2. Seetharam D, Chandar J, Ramsoomair CK, Desgraves JF, Medina AA, Hudson AJ, Amidei A, Castro JR, Govindarajan V, Wang S  et al.  Targeting ZNF638 activates antiviral immune responses and potentiates immune checkpoint inhibition in glioblastoma.  bioRxiv  2024 Oct 15;. pii:2024.10.13.618076
  3. Budhiraja S, Baisiwala S, Cho S, Chojak R, Kazi HA, Stepniak A, Perrault EN, Chen L, Park CH, Dmello C  et al.  THOC1 complexes with SIN3A to regulate R-loops and promote glioblastoma progression.  bioRxiv  2024 Sep 26;. pii:2024.09.24.614748
  4. Kim KS, Zhang J, Arrieta VA, Dmello C, Grabis E, Habashy K, Duffy J, Zhao J, Gould A, Chen L  et al.  MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, microglia phenotype, and immune checkpoint blockade efficacy.  bioRxiv  2024 Sep 18;. pii:2024.09.11.612571
  5. Habashy KJ, Abou-Mrad T, Gomez M, Arrieta VA, El-Hajj VG, Ghaith AK, Sonabend AM, El Tecle NE, Potts MB, Dahdaleh NS  Navigating the Neurosurgery Match Process: Insights from the National Resident Matching Program - Program Director Surveys.  World Neurosurg  2024 Sep;189:e476-e484. doi:10.1016/j.wneu.2024.06.088
  6. Wang S, Castro BA, Katz JL, Arrieta V, Najem H, Vazquez-Cervantes GI, Wan H, Olson IE, Hou D, Dapash M  et al.  B cell-based therapy produces antibodies that inhibit glioblastoma growth.  J Clin Invest  2024 Aug 29;134(20). pii:e177384
  7. Tripathi S, Najem H, Dussold C, Pacheco S, Du R, Sooreshjani M, Hurley L, Chandler JP, Stupp R, Sonabend AM  et al.  Pediatric glioma immune profiling identifies TIM3 as a therapeutic target in BRAF fusion pilocytic astrocytoma.  J Clin Invest  2024 Aug 13;134(19). pii:e177413
  8. Budhiraja S, McManus G, Baisiwala S, Perrault EN, Cho S, Saathoff M, Chen L, Park CH, Kazi HA, Dmello C  et al.  ARF4-mediated retrograde trafficking as a driver of chemoresistance in glioblastoma.  Neuro Oncol  2024 Aug 05;26(8):1421-1437. doi:10.1093/neuonc/noae059
  9. Nandoliya KR, Khazanchi R, Winterhalter EJ, Youngblood MW, Karras CL, Jain R, Sonabend AM, Chandler JP, Magill ST  Extent of resection and progression-free survival in vestibular schwannoma: a volumetric analysis.  J Neurosurg  2024 Aug 02;:1-9. doi:10.3171/2024.4.JNS24157
  10. Yang Y, Wadhwani N, Shimomura A, Zheng S, Chandler J, Lesniak MS, Tate MC, Sonabend AM, Kalapurakal J, Horbinski C  et al.  Long-term outcomes of central neurocytoma - an institutional experience.  J Neurooncol  2024 Aug;169(1):195-201. doi:10.1007/s11060-024-04713-3
  11. Nandoliya KR, Vignolles-Jeong J, Karras CL, Govind S, Finger G, Thirunavu V, Sonabend AM, Magill ST, Prevedello DM, Chandler JP  Clinical characteristics and outcomes after trigeminal schwannoma resection: a multi-institutional experience.  Neurosurg Rev  2024 Jul 18;47(1):340. doi:10.1007/s10143-024-02550-6
  12. Arrieta VA, Gould A, Kim KS, Habashy KJ, Dmello C, Vázquez-Cervantes GI, Palacín-Aliana I, McManus G, Amidei C, Gomez C  et al.  Ultrasound-mediated delivery of doxorubicin to the brain results in immune modulation and improved responses to PD-1 blockade in gliomas.  Nat Commun  2024 Jun 06;15(1):4698. pii:4698
  13. Habashy KJ, Dmello C, Chen L, Arrieta VA, Kim KS, Gould A, Youngblood MW, Bouchoux G, Burdett KB, Zhang H  et al.  Paclitaxel and Carboplatin in Combination with Low-intensity Pulsed Ultrasound for Glioblastoma.  Clin Cancer Res  2024 Apr 15;30(8):1619-1629. doi:10.1158/1078-0432.CCR-23-2367
  14. Carpentier A, Stupp R, Sonabend AM, Dufour H, Chinot O, Mathon B, Ducray F, Guyotat J, Baize N, Menei P  et al.  Repeated blood-brain barrier opening with a nine-emitter implantable ultrasound device in combination with carboplatin in recurrent glioblastoma: a phase I/II clinical trial.  Nat Commun  2024 Feb 23;15(1):1650. pii:1650
  15. Moscona-Nissan A, Habashy KJ, Arrieta VA, Sonabend AM, Dmello C  Combining causal and correlative approaches to discover biomarkers of response to paclitaxel.  Oncotarget  2024 Feb 08;15:117-122. doi:10.18632/oncotarget.28549
  16. Pandey S, Cholak ME, Yadali R, Sosman JA, Tetreault MP, Fang D, Pollack SM, Gnjatic S, Obeng RC, Lyerly HK  et al.  Immune Assessment Today: Optimizing and Standardizing Efforts to Monitor Immune Responses in Cancer and Beyond.  Cancers (Basel)  2024 Jan 23;16(3). pii:475
  17. Arrieta VA, Duerinck J, Burdett KB, Habashy KJ, Geens W, Gould A, Schwarze JK, Dmello C, Kim KS, Saganty R  et al.  ERK1/2 Phosphorylation Predicts Survival in Recurrent Glioblastoma Following Intracerebral and Adjuvant PD-1/CTLA-4 Immunotherapy: A REMARK-guided Analysis.  Clin Cancer Res  2024 Jan 17;30(2):379-388. doi:10.1158/1078-0432.CCR-23-1889
  18. Romay MC, Knutsen RH, Ma F, Mompeón A, Hernandez GE, Salvador J, Mirkov S, Batra A, Sullivan DP, Procissi D  et al.  Age-related loss of Notch3 underlies brain vascular contractility deficiencies, glymphatic dysfunction, and neurodegeneration in mice.  J Clin Invest  2024 Jan 16;134(2). pii:e166134
  19. Hou D, Wan H, Katz JL, Wang S, Castro BA, Vazquez-Cervantes GI, Arrieta VA, Dhiantravan S, Najem H, Rashidi A  et al.  Antigen-presenting B cells promote TCF-1+ PD1- stem-like CD8+ T-cell proliferation in glioblastoma.  Front Immunol  2023;14:1295218. pii:1295218
  20. Najem H, Arrieta VA, Duffy J, Tripathi S, Zannikou M, Dhiantravan S, Miska J, McCortney K, Steffens A, Walshon J  et al.  Prohibitin Expression in Antigen-Presenting Cells: Implications for Inciting Trigger in CNS IgG4-Related Disease.  Ann Case Rep  2024;9(1). pii:1607
  21. Fares J, Petrosyan E, Kanojia D, Dmello C, Cordero A, Duffy JT, Yeeravalli R, Sahani MH, Zhang P, Rashidi A  et al.  Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases.  J Clin Invest  2023 Dec 15;133(24). pii:e161142
  22. Nandoliya KR, Khazanchi R, Winterhalter EJ, Youngblood MW, Karras CL, Sonabend AM, Micco AG, Chandler JP, Magill ST  Validating the VS-5 Score for Predicting Outcomes After Vestibular Schwannoma Resection in an Institutional Cohort.  World Neurosurg  2023 Aug;176:e77-e82. doi:10.1016/j.wneu.2023.04.123
  23. Nassiri F, Patil V, Yefet LS, Singh O, Liu J, Dang RMA, Yamaguchi TN, Daras M, Cloughesy TF, Colman H  et al.  Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial.  Nat Med  2023 Jun;29(6):1370-1378. doi:10.1038/s41591-023-02347-y
  24. Gould A, Gonzales VAA, Dmello CC, Saganty R, Lukas RV, Zhang DY, Heimberger AB, Canney M, Carpentier A, Desseaux C  et al.  Advances in Blood-Brain Barrier Disruption to Facilitate Drug Delivery for Infiltrative Gliomas.  Adv Oncol  2023 May;3(1):77-86. doi:10.1016/j.yao.2023.01.017
  25. Sonabend AM, Gould A, Amidei C, Ward R, Schmidt KA, Zhang DY, Gomez C, Bebawy JF, Liu BP, Bouchoux G  et al.  Repeated blood-brain barrier opening with an implantable ultrasound device for delivery of albumin-bound paclitaxel in patients with recurrent glioblastoma: a phase 1 trial.  Lancet Oncol  2023 May;24(5):509-522. doi:10.1016/S1470-2045(23)00112-2
  26. Baskaran AB, Dixit KS, Sonabend AM, Horbinski CM, Abutalib SA, Lukas RV  From the ER to the OR: Initial Evaluation of Primary Central Nervous System Lymphoma.  Neurologist  2023 May 01;28(3):135-142. doi:10.1097/NRL.0000000000000475
  27. Sachdev S, Dmello C, Sonabend AM  Radiosensitization of IDH-Mutated Gliomas through ZMYND8 - a Pathway to Improved Outcomes.  Clin Cancer Res  2023 May 01;29(9):1648-1650. doi:10.1158/1078-0432.CCR-23-0018
  28. Petrosyan E, Fares J, Fernandez LG, Yeeravalli R, Dmello C, Duffy JT, Zhang P, Lee-Chang C, Miska J, Ahmed AU  et al.  Endoplasmic Reticulum Stress in the Brain Tumor Immune Microenvironment.  Mol Cancer Res  2023 May 01;21(5):389-396. doi:10.1158/1541-7786.MCR-22-0920
  29. Zhang P, Rashidi A, Zhao J, Silvers C, Wang H, Castro B, Ellingwood A, Han Y, Lopez-Rosas A, Zannikou M  et al.  STING agonist-loaded, CD47/PD-L1-targeting nanoparticles potentiate antitumor immunity and radiotherapy for glioblastoma.  Nat Commun  2023 Mar 23;14(1):1610. pii:1610
  30. Dmello C, Zhao J, Chen L, Gould A, Castro B, Arrieta VA, Zhang DY, Kim KS, Kanojia D, Zhang P  et al.  Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade.  Nat Commun  2023 Mar 22;14(1):1566. pii:1566
  31. Zannikou M, Duffy JT, Levine RN, Seblani M, Liu Q, Presser A, Arrieta VA, Chen CJ, Sonabend AM, Horbinski CM  et al.  IL15 modification enables CAR T cells to act as a dual targeting agent against tumor cells and myeloid-derived suppressor cells in GBM.  J Immunother Cancer  2023 Feb;11(2). pii:e006239
  32. Arrieta VA, Dmello C, McGrail DJ, Brat DJ, Lee-Chang C, Heimberger AB, Chand D, Stupp R, Sonabend AM  Immune checkpoint blockade in glioblastoma: from tumor heterogeneity to personalized treatment.  J Clin Invest  2023 Jan 17;133(2). pii:e163447
  33. Sita TL, Gopalakrishnan M, Rooney MK, Ho A, Savoor R, Sonabend AM, Tate MC, Chandler JP, Lesniak MS, Kruser TJ  et al.  Mean Brain Dose Remains Uninfluenced by the Lesion Number for Gamma Knife Stereotactic Radiosurgery for 10+ Metastases.  World Neurosurg  2022 Sep;165:e380-e385. doi:10.1016/j.wneu.2022.06.057
  34. Cao TQ, Wainwright DA, Lee-Chang C, Miska J, Sonabend AM, Heimberger AB, Lukas RV  Next Steps for Immunotherapy in Glioblastoma.  Cancers (Basel)  2022 Aug 20;14(16). pii:4023
  35. Dmello C, Sonabend A, Arrieta VA, Zhang DY, Kanojia D, Chen L, Gould A, Zhang J, Kang SJ, Winter J  et al.  Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma.  Clin Cancer Res  2022 Jul 15;28(14):3156-3169. doi:10.1158/1078-0432.CCR-21-2563
  36. Larkin CJ, Arrieta VA, Najem H, Li G, Zhang P, Miska J, Chen P, James CD, Sonabend AM, Heimberger AB  Myeloid Cell Classification and Therapeutic Opportunities Within the Glioblastoma Tumor Microenvironment in the Single Cell-Omics Era.  Front Immunol  2022;13:907605. pii:907605
  37. Najem H, Ott M, Kassab C, Rao A, Rao G, Marisetty A, Sonabend AM, Horbinski C, Verhaak R, Shankar A  et al.  Central nervous system immune interactome is a function of cancer lineage, tumor microenvironment, and STAT3 expression.  JCI Insight  2022 May 09;7(9). pii:e157612
  38. Arrieta VA, Chen AX, Kane JR, Kang SJ, Kassab C, Dmello C, Zhao J, Burdett KB, Upadhyayula PS, Lee-Chang C  et al.  Publisher Correction: ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma.  Nat Cancer  2022 Mar;3(3):373. doi:10.1038/s43018-022-00343-8
  39. Arrieta VA, Najem H, Petrosyan E, Lee-Chang C, Chen P, Sonabend AM, Heimberger AB  The Eclectic Nature of Glioma-Infiltrating Macrophages and Microglia.  Int J Mol Sci  2021 Dec 13;22(24). pii:13382
  40. Gould A, Zhang D, Arrieta VA, Stupp R, Sonabend AM  Delivering albumin-bound paclitaxel across the blood-brain barrier for gliomas.  Oncotarget  2021 Dec 07;12(25):2474-2475. doi:10.18632/oncotarget.28018
  41. Arrieta VA, Chen AX, Kane JR, Kang SJ, Kassab C, Dmello C, Zhao J, Burdett KB, Upadhyayula PS, Lee-Chang C  et al.  ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma.  Nat Cancer  2021 Dec;2(12):1372-1386. doi:10.1038/s43018-021-00260-2
  42. Zhang DY, Gould A, Happ HC, Youngblood MW, Dmello C, Kang SJ, Canney M, Stupp R, Carvill GL, Sonabend AM  Ultrasound-mediated blood-brain barrier opening increases cell-free DNA in a time-dependent manner.  Neurooncol Adv  2021;3(1):vdab165. pii:vdab165
  43. Gonzalez-Buendia E, Zhao J, Wang L, Mukherjee S, Zhang D, Arrieta VA, Feldstein E, Kane JR, Kang SJ, Lee-Chang C  et al.  TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas.  Clin Cancer Res  2021 Oct 15;27(20):5669-5680. doi:10.1158/1078-0432.CCR-21-0312
  44. Fares J, Ahmed AU, Ulasov IV, Sonabend AM, Miska J, Lee-Chang C, Balyasnikova IV, Chandler JP, Portnow J, Tate MC  et al.  Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial.  Lancet Oncol  2021 Aug;22(8):1103-1114. doi:10.1016/S1470-2045(21)00245-X
  45. Moreno-Jiménez S, Alegría-Loyola MA, Sonabend AM, Romano SK, Romo CG  Management of glioblastoma: a perspective from Mexico.  Chin Clin Oncol  2021 Aug;10(4):44. doi:10.21037/cco-20-129
  46. Zhang DY, Singer L, Sonabend AM, Lukas RV  Gene Therapy for the Treatment of Malignant Glioma.  Adv Oncol  2021 May;1:189-202. doi:10.1016/j.yao.2021.02.016
  47. Garton ALA, Kinslow CJ, Rae AI, Mehta A, Pannullo SC, Magge RS, Ramakrishna R, McKhann GM, Sisti MB, Bruce JN  et al.  Extent of resection, molecular signature, and survival in 1p19q-codeleted gliomas.  J Neurosurg  2021 May 01;134(5):1357-1367. doi:10.3171/2020.2.JNS192767
  48. Chastkofsky MI, Pituch KC, Katagi H, Zannikou M, Ilut L, Xiao T, Han Y, Sonabend AM, Curiel DT, Bonner ER  et al.  Mesenchymal Stem Cells Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma.  Clin Cancer Res  2021 Mar 15;27(6):1766-1777. doi:10.1158/1078-0432.CCR-20-1499
  49. Kumthekar P, Ko CH, Paunesku T, Dixit K, Sonabend AM, Bloch O, Tate M, Schwartz M, Zuckerman L, Lezon R  et al.  A first-in-human phase 0 clinical study of RNA interference-based spherical nucleic acids in patients with recurrent glioblastoma.  Sci Transl Med  2021 Mar 10;13(584). pii:eabb3945
  50. Sonabend AM, Stupp R, Lee-Chang C, Okada H  Glioma immunoediting, a driver of tumor evolution, and the next battle for immunotherapy.  Oncotarget  2021 Jan 05;12(1):8-9. doi:10.18632/oncotarget.27865