About Us
The Paller Laboratory at Northwestern University Feinberg School of Medicine investigates the use of topically-applied, nanotherapy-based gene therapy to treat skin disease, particularly diabetic ulcers, psoriasis, atopic dermatitis (eczema), skin cancer and rare genetic skin problems.
While the Paller Lab previously studied the mechanisms involving membrane-based glycosphingolipids and their modulation of growth factor receptor signaling in type 2 diabetic skin, our current research focuses on different subsets of cutaneous nerves and their impact on keratinocytes and vice versa, during wound healing and inflammatory skin diseases.
A new direction in our recent research centers in elucidating alterations in skin barrier ceramide composition through untargeted lipidomics, biochemical investigations and use of genetically altered mouse and human models, particularly in the context of atopic dermatitis/eczema and ichthyosis.
Amy Paller is the principle investigator of Feinberg's NIH-funded Skin Biology & Diseases Resource-Based Center, which includes three cores dedicated to providing service to researchers of skin biology.
View more photos from Paller Lab's recent events, celebrations, and activities.