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Northwestern University Feinberg School of Medicine
Melo-Cardenas Lab

Publications

Learn more about the work that we do in the Melo-Cardenas laboratory through our recent publications. 

View all publications on PubMed

  1. Melo-Cardenas J, Crispino JD  CALR goes rogue.  Blood  2023 Feb 23;141(8):818-820. doi:10.1182/blood.2022018788
  2. Melo-Cardenas J, Bezavada L, Crawford JC, Gurbuxani S, Cotton A, Kang G, Gossett J, Marinaccio C, Weinberg R, Hoffman R  et al.  IL-13/IL-4 signaling contributes to fibrotic progression of the myeloproliferative neoplasms.  Blood  2022 Dec 29;140(26):2805-2817. doi:10.1182/blood.2022017326
  3. Zingariello M, Verachi P, Gobbo F, Martelli F, Falchi M, Mazzarini M, Valeri M, Sarli G, Marinaccio C, Melo-Cardenas J  et al.  Resident Self-Tissue of Proinflammatory Cytokines Rather Than Their Systemic Levels Correlates with Development of Myelofibrosis in Gata1low Mice.  Biomolecules  2022 Jan 30;12(2). pii:234
  4. Melo-Cardenas J, Migliaccio AR, Crispino JD  The Role of Megakaryocytes in Myelofibrosis.  Hematol Oncol Clin North Am  2021 Apr;35(2):191-203. doi:10.1016/j.hoc.2020.11.004
  5. Xu Y, Melo-Cardenas J, Zhang Y, Gau I, Wei J, Montauti E, Zhang Y, Gao B, Jin H, Sun Z  et al.  The E3 ligase Hrd1 stabilizes Tregs by antagonizing inflammatory cytokine-induced ER stress response.  JCI Insight  2019 Mar 07;4(5). pii:e121887
  6. Wei J, Chen L, Li F, Yuan Y, Wang Y, Xia W, Zhang Y, Xu Y, Yang Z, Gao B  et al.  HRD1-ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination.  EMBO J  2018 Nov 15;37(22). pii:e98942
  7. Wei J, Yuan Y, Chen L, Xu Y, Zhang Y, Wang Y, Yang Y, Peek CB, Diebold L, Yang Y  et al.  ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes.  Nat Commun  2018 Sep 10;9(1):3659. pii:3659
  8. Yang Y, Kong S, Zhang Y, Melo-Cardenas J, Gao B, Zhang Y, Zhang DD, Zhang B, Song J, Thorp E  et al.  The endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls a critical checkpoint in B cell development in mice.  J Biol Chem  2018 Aug 17;293(33):12934-12944. doi:10.1074/jbc.RA117.001267
  9. Melo-Cardenas J, Xu Y, Wei J, Tan C, Kong S, Gao B, Montauti E, Kirsammer G, Licht JD, Yu J  et al.  USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.  Blood  2018 Jul 26;132(4):423-434. doi:10.1182/blood-2017-10-811760
  10. Kong S, Yang Y, Xu Y, Wang Y, Zhang Y, Melo-Cardenas J, Xu X, Gao B, Thorp EB, Zhang DD  et al.  Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/Fas.  Proc Natl Acad Sci U S A  2016 Sep 13;113(37):10394-9. doi:10.1073/pnas.1606742113
  11. Xu Y, Zhao F, Qiu Q, Chen K, Wei J, Kong Q, Gao B, Melo-Cardenas J, Zhang B, Zhang J  et al.  The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity.  Nat Commun  2016 Jul 15;7:12073. pii:12073
  12. Melo-Cardenas J, Zhang Y, Zhang DD, Fang D  Ubiquitin-specific peptidase 22 functions and its involvement in disease.  Oncotarget  2016 Jul 12;7(28):44848-44856. doi:10.18632/oncotarget.8602
  13. Melo-Cardenas J, Kong S, Fang D  A Hrd way for MHC-II expression.  Oncotarget  2015 Sep 08;6(26):21767-8
  14. Kochin V, Shimi T, Torvaldson E, Adam SA, Goldman A, Pack CG, Melo-Cardenas J, Imanishi SY, Goldman RD, Eriksson JE  Interphase phosphorylation of lamin A.  J Cell Sci  2014 Jun 15;127(Pt 12):2683-96. doi:10.1242/jcs.141820