Publications

Learn more about the work that we do in the Liu laboratory through our recent publications.

Yu H, Gao R, Chen S, Liu X, Wang Q, Cai W, Vemula S, Fahey AC, Henley D, Kobayashi M, Liu SZ, Qian Z, Kapur R, Broxmeyer HE, Gao Z, Xi R, Liu Y. Bmi1 Regulates Wnt Signaling in Hematopoietic Stem and Progenitor Cells. Stem Cell Rev Rep. 2021 Dec;17(6):2304-2313. doi: 10.1007/s12015-021-10253-4. Epub 2021 Sep 24. PubMed PMID: 34561772; NIHMSID:NIHMS1755661.

Broxmeyer HE, Liu Y, Kapur R, Orschell CM, Aljoufi A, Ropa JP, Trinh T, Burns S, Capitano ML. Fate of Hematopoiesis During Aging. What Do We Really Know, and What are its Implications?. Stem Cell Rev Rep. 2020 Dec;16(6):1020-1048. doi: 10.1007/s12015-020-10065-y. Epub 2020 Nov 3. Review. PubMed PMID: 33145673; PubMed Central PMCID: PMC7609374.

Kobayashi M, Lin Y, Mishra A, Shelly C, Gao R, Reeh CW, Wang PZ, Xi R, Liu Y, Wenzel P, Ghosn E, Liu Y, Yoshimoto M. Bmi1 Maintains the Self-Renewal Property of Innate-like B Lymphocytes. J Immunol. 2020 Jun 15;204(12):3262-3272. doi: 10.4049/jimmunol.2000030. Epub 2020 Apr 24. PubMed PMID: 32332108; PubMed Central PMCID: PMC7293378.

Chen S, Wang Q, Yu H, Capitano ML, Vemula S, Nabinger SC, Gao R, Yao C, Kobayashi M, Geng Z, Fahey A, Henley D, Liu SZ, Barajas S, Cai W, Wolf ER, Ramdas B, Cai Z, Gao H, Luo N, Sun Y, Wong TN, Link DC, Liu Y, Boswell HS, Mayo LD, Huang G, Kapur R, Yoder MC, Broxmeyer HE, Gao Z, Liu Y. Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway. Nat Commun. 2019 Dec 11;10(1):5649. doi: 10.1038/s41467-019-13542-2. PubMed PMID: 31827082; PubMed Central PMCID: PMC6906427.

Chen S, Liu Y. p53 involvement in clonal hematopoiesis of indeterminate potential. Curr Opin Hematol. 2019 Jul;26(4):235-240. doi: 10.1097/MOH.0000000000000509. Review. PubMed PMID: 31045645.

Nabinger SC, Chen S, Gao R, Yao C, Kobayashi M, Vemula S, Fahey AC, Wang C, Daniels C, Boswell HS, Sandusky GE, Mayo LD, Kapur R, Liu Y. Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development. Leukemia. 2019 Jun;33(6):1535-1539. doi: 10.1038/s41375-019-0377-0. Epub 2019 Jan 23. PubMed PMID: 30675010; NIHMSID:NIHMS1054718.

Cai Z, Kotzin JJ, Ramdas B, Chen S, Nelanuthala S, Palam LR, Pandey R, Mali RS, Liu Y, Kelley MR, Sandusky G, Mohseni M, Williams A, Henao-Mejia J, Kapur R. Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis. Cell Stem Cell. 2018 Dec 6;23(6):833-849.e5. doi: 10.1016/j.stem.2018.10.013. PubMed PMID: 30526882; PubMed Central PMCID: PMC6317370.

Chen S, Liu Y. Battle in stem cell niches: Canonical versus noncanonical Wnt signaling. J Leukoc Biol. 2018 Mar;103(3):377-379. doi: 10.1002/JLB.2CE1117-453RR. Epub 2018 Feb 2. PubMed PMID: 29393968.

Chen S, Gao R, Yao C, Kobayashi M, Liu SZ, Yoder MC, Broxmeyer H, Kapur R, Boswell HS, Mayo LD, Liu Y. Genotoxic stresses promote clonal expansion of hematopoietic stem cells expressing mutant p53. Leukemia. 2018 Mar;32(3):850-854. doi: 10.1038/leu.2017.325. Epub 2017 Nov 16. PubMed PMID: 29263439; PubMed Central PMCID: PMC5842141.

Sayar H, Liu Y, Gao R, Zaid MA, Cripe LD, Weisenbach J, Sargent KJ, Nassiri M, Li L, Konig H, Suvannasankha A, Pan F, Shanmugam R, Goswami C, Kapur R, Xu M, Boswell HS. Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML. Oncotarget. 2018 Jan 19;9(5):5703-5715. doi: 10.18632/oncotarget.23655. eCollection 2018 Jan 19. PubMed PMID: 29464028; PubMed Central PMCID: PMC5814168.

Yao C, Kobayashi M, Chen S, Nabinger SC, Gao R, Liu SZ, Asai T, Liu Y. Necdin modulates leukemia-initiating cell quiescence and chemotherapy response. Oncotarget. 2017 Oct 20;8(50):87607-87622. doi: 10.18632/oncotarget.20999. eCollection 2017 Oct 20. PubMed PMID: 29152105; PubMed Central PMCID: PMC5675657.

Kobayashi M, Chen S, Bai Y, Yao C, Gao R, Sun XJ, Mu C, Twiggs TA, Yu ZH, Boswell HS, Yoder MC, Kapur R, Mulloy JC, Zhang ZY, Liu Y. Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia. Leukemia. 2017 Jun;31(6):1453-1457. doi: 10.1038/leu.2017.67. Epub 2017 Feb 21. PubMed PMID: 28220038; PubMed Central PMCID: PMC5695226.

Kobayashi M, Nabinger SC, Bai Y, Yoshimoto M, Gao R, Chen S, Yao C, Dong Y, Zhang L, Rodriguez S, Yashiro-Ohtani Y, Pear WS, Carlesso N, Yoder MC, Kapur R, Kaplan MH, Daniel Lacorazza H, Zhang ZY, Liu Y. Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors. Stem Cells. 2017 Apr;35(4):1053-1064. doi: 10.1002/stem.2559. Epub 2017 Jan 19. PubMed PMID: 28009085; PubMed Central PMCID: PMC5367971.

Kobayashi M, Bai Y, Chen S, Gao R, Yao C, Cai W, Cardoso AA, Croop J, Zhang ZY, Liu Y. Phosphatase PRL2 promotes oncogenic NOTCH1-Induced T-cell leukemia. Leukemia. 2017 Mar;31(3):751-754. doi: 10.1038/leu.2016.340. Epub 2016 Dec 9. PubMed PMID: 27872499; PubMed Central PMCID: PMC5695227.

Chen S, Gao R, Kobayashi M, Yu H, Yao C, Kapur R, Yoder MC, Liu Y. Pharmacological inhibition of AKT activity in human CD34⁺ cells enhances their ability to engraft immunodeficient mice. Exp Hematol. 2017 Jan;45:74-84. doi: 10.1016/j.exphem.2016.09.003. Epub 2016 Sep 17. PubMed PMID: 27645691; PubMed Central PMCID: PMC5859321.

Ghosh J, Kobayashi M, Ramdas B, Chatterjee A, Ma P, Mali RS, Carlesso N, Liu Y, Plas DR, Chan RJ, Kapur R. S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance. J Clin Invest. 2016 Jul 1;126(7):2621-5. doi: 10.1172/JCI84565. Epub 2016 Jun 13. PubMed PMID: 27294524; PubMed Central PMCID: PMC4922705.

Gao R, Chen S, Kobayashi M, Yu H, Zhang Y, Wan Y, Young SK, Soltis A, Yu M, Vemula S, Fraenkel E, Cantor A, Antipin Y, Xu Y, Yoder MC, Wek RC, Ellis SR, Kapur R, Zhu X, Liu Y. Bmi1 promotes erythroid development through regulating ribosome biogenesis. Stem Cells. 2015 Mar;33(3):925-38. doi: 10.1002/stem.1896. PubMed PMID: 25385494; PubMed Central PMCID: PMC4380436.

Chatterjee A, Ghosh J, Ramdas B, Mali RS, Martin H, Kobayashi M, Vemula S, Canela VH, Waskow ER, Visconte V, Tiu RV, Smith CC, Shah N, Bunting KD, Boswell HS, Liu Y, Chan RJ, Kapur R. Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis. Cell Rep. 2014 Nov 20;9(4):1333-48. doi: 10.1016/j.celrep.2014.10.039. Epub 2014 Nov 13. PubMed PMID: 25456130; PubMed Central PMCID: PMC4380442.

Kobayashi M, Shelley WC, Seo W, Vemula S, Lin Y, Liu Y, Kapur R, Taniuchi I, Yoshimoto M. Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbfβ for their development. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12151-6. doi: 10.1073/pnas.1407370111. Epub 2014 Aug 4. PubMed PMID: 25092306; PubMed Central PMCID: PMC4143017.

Kobayashi M, Bai Y, Dong Y, Yu H, Chen S, Gao R, Zhang L, Yoder MC, Kapur R, Zhang ZY, Liu Y. PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal. Stem Cells. 2014 Jul;32(7):1956-67. doi: 10.1002/stem.1672. PubMed PMID: 24753135; PubMed Central PMCID: PMC4063874.

Kobayashi M, Chen S, Gao R, Bai Y, Zhang ZY, Liu Y. Phosphatase of regenerating liver in hematopoietic stem cells and hematological malignancies. Cell Cycle. 2014;13(18):2827-35. doi: 10.4161/15384101.2014.954448. Review. PubMed PMID: 25486470; PubMed Central PMCID: PMC4614371.

Vu LP, Perna F, Wang L, Voza F, Figueroa ME, Tempst P, Erdjument-Bromage H, Gao R, Chen S, Paietta E, Deblasio T, Melnick A, Liu Y, Zhao X, Nimer SD. PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex. Cell Rep. 2013 Dec 26;5(6):1625-38. doi: 10.1016/j.celrep.2013.11.025. Epub 2013 Dec 12. PubMed PMID: 24332853; PubMed Central PMCID: PMC4073674.

Asai T, Liu Y, Nimer SD. Necdin, a p53 target gene, in stem cells. Oncotarget. 2013 Jun;4(6):806-7. doi: 10.18632/oncotarget.997. PubMed PMID: 23867447; PubMed Central PMCID: PMC3757235.

Sabelli PA, Liu Y, Dante RA, Lizarraga LE, Nguyen HN, Brown SW, Klingler JP, Yu J, LaBrant E, Layton TM, Feldman M, Larkins BA. Control of cell proliferation, endoreduplication, cell size, and cell death by the retinoblastoma-related pathway in maize endosperm. Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1827-36. doi: 10.1073/pnas.1304903110. Epub 2013 Apr 22. PubMed PMID: 23610440; PubMed Central PMCID: PMC3651506.

Liu Y, Yu H, Nimer SD. PI3K-Akt pathway regulates polycomb group protein and stem cell maintenance. Cell Cycle. 2013 Jan 15;12(2):199-200. doi: 10.4161/cc.23379. Epub 2012 Jan 15. PubMed PMID: 23287474; PubMed Central PMCID: PMC3575444.

Liu Y, Liu F, Yu H, Zhao X, Sashida G, Deblasio A, Harr M, She QB, Chen Z, Lin HK, Di Giandomenico S, Elf SE, Yang Y, Miyata Y, Huang G, Menendez S, Mellinghoff IK, Rosen N, Pandolfi PP, Hedvat CV, Nimer SD. Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus. Sci Signal. 2012 Oct 23;5(247):ra77. doi: 10.1126/scisignal.2003199. PubMed PMID: 23092893; PubMed Central PMCID: PMC3784651.

Vemula S, Shi J, Mali RS, Ma P, Liu Y, Hanneman P, Koehler KR, Hashino E, Wei L, Kapur R. ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53. Blood. 2012 Oct 4;120(14):2868-78. doi: 10.1182/blood-2011-10-384172. Epub 2012 Aug 13. PubMed PMID: 22889758; PubMed Central PMCID: PMC3466968.

Hu P, Nebreda AR, Liu Y, Carlesso N, Kaplan M, Kapur R. p38α protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals. J Biol Chem. 2012 Sep 28;287(40):33215-26. doi: 10.1074/jbc.M112.355594. Epub 2012 Aug 2. PubMed PMID: 22859305; PubMed Central PMCID: PMC3460427.

Asai T, Liu Y, Di Giandomenico S, Bae N, Ndiaye-Lobry D, Deblasio A, Menendez S, Antipin Y, Reva B, Wevrick R, Nimer SD. Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells. Blood. 2012 Aug 23;120(8):1601-12. doi: 10.1182/blood-2011-11-393983. Epub 2012 Jul 9. PubMed PMID: 22776820; PubMed Central PMCID: PMC3429304.

Hu P, Carlesso N, Xu M, Liu Y, Nebreda AR, Takemoto C, Kapur R. Genetic evidence for critical roles of P38α protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms. J Biol Chem. 2012 Jun 8;287(24):20258-69. doi: 10.1074/jbc.M112.358119. Epub 2012 Apr 19. PubMed PMID: 22518842; PubMed Central PMCID: PMC3370208.

Huang G, Zhao X, Wang L, Elf S, Xu H, Zhao X, Sashida G, Zhang Y, Liu Y, Lee J, Menendez S, Yang Y, Yan X, Zhang P, Tenen DG, Osato M, Hsieh JJ, Nimer SD. The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations. Blood. 2011 Dec 15;118(25):6544-52. doi: 10.1182/blood-2010-11-317909. Epub 2011 Oct 19. PubMed PMID: 22012064; PubMed Central PMCID: PMC3242717.

Asai T, Liu Y, Bae N, Nimer SD. The p53 tumor suppressor protein regulates hematopoietic stem cell fate. J Cell Physiol. 2011 Sep;226(9):2215-21. doi: 10.1002/jcp.22561. Review. PubMed PMID: 21660944; PubMed Central PMCID: PMC3081536.

Sashida G, Bae N, Di Giandomenico S, Asai T, Gurvich N, Bazzoli E, Liu Y, Huang G, Zhao X, Menendez S, Nimer SD. The mef/elf4 transcription factor fine tunes the DNA damage response. Cancer Res. 2011 Jul 15;71(14):4857-65. doi: 10.1158/0008-5472.CAN-11-0455. Epub 2011 May 26. PubMed PMID: 21616937; PubMed Central PMCID: PMC4073677.

Sashida G, Bazzoli E, Menendez S, Liu Y, Nimer SD. The oncogenic role of the ETS transcription factors MEF and ERG. Cell Cycle. 2010 Sep 1;9(17):3457-9. doi: 10.4161/cc.9.17.13000. Epub 2010 Sep 13. Review. PubMed PMID: 20814243; PubMed Central PMCID: PMC3230474.

Miyata Y, Liu Y, Jankovic V, Sashida G, Lee JM, Shieh JH, Naoe T, Moore M, Nimer SD. Cyclin C regulates human hematopoietic stem/progenitor cell quiescence. Stem Cells. 2010 Feb;28(2):308-17. doi: 10.1002/stem.270. PubMed PMID: 19967789; PubMed Central PMCID: PMC3144254.

Liu Y, Asai T, Nimer SD. Myelodysplasia: battle in the bone marrow. Nat Med. 2010 Jan;16(1):30-2. doi: 10.1038/nm0110-30. PubMed PMID: 20057420; NIHMSID:NIHMS607881.

Liu Y, Hoya-Arias R, Nimer SD. The role of p53 in limiting somatic cell reprogramming. Cell Res. 2009 Nov;19(11):1227-8. doi: 10.1038/cr.2009.121. Epub 2009 Nov 2. PubMed PMID: 19881523.

Liu Y, Elf SE, Asai T, Miyata Y, Liu Y, Sashida G, Huang G, Di Giandomenico S, Koff A, Nimer SD. The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior. Cell Cycle. 2009 Oct 1;8(19):3120-4. doi: 10.4161/cc.8.19.9627. Review. PubMed PMID: 19755852; PubMed Central PMCID: PMC4637974.

Sashida G, Liu Y, Elf S, Miyata Y, Ohyashiki K, Izumi M, Menendez S, Nimer SD. ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation. Mol Cell Biol. 2009 Jul;29(13):3687-99. doi: 10.1128/MCB.01551-08. Epub 2009 Apr 20. PubMed PMID: 19380490; PubMed Central PMCID: PMC2698769.

Lin HK, Wang G, Chen Z, Teruya-Feldstein J, Liu Y, Chan CH, Yang WL, Erdjument-Bromage H, Nakayama KI, Nimer S, Tempst P, Pandolfi PP. Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nat Cell Biol. 2009 Apr;11(4):420-32. doi: 10.1038/ncb1849. Epub 2009 Mar 8. PubMed PMID: 19270694; PubMed Central PMCID: PMC2830812.

Liu Y, Elf SE, Miyata Y, Sashida G, Liu Y, Huang G, Di Giandomenico S, Lee JM, Deblasio A, Menendez S, Antipin J, Reva B, Koff A, Nimer SD. p53 regulates hematopoietic stem cell quiescence. Cell Stem Cell. 2009 Jan 9;4(1):37-48. doi: 10.1016/j.stem.2008.11.006. PubMed PMID: 19128791; PubMed Central PMCID: PMC2839936.

Morales M, Liu Y, Laiakis EC, Morgan WF, Nimer SD, Petrini JH. DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions. Cancer Res. 2008 Apr 1;68(7):2186-93. doi: 10.1158/0008-5472.CAN-07-2355. PubMed PMID: 18381424; PubMed Central PMCID: PMC2996041.

Yao JJ, Liu Y, Lacorazza HD, Soslow RA, Scandura JM, Nimer SD, Hedvat CV. Tumor promoting properties of the ETS protein MEF in ovarian cancer. Oncogene. 2007 Jun 7;26(27):4032-7. doi: 10.1038/sj.onc.1210170. Epub 2007 Jan 8. PubMed PMID: 17213815.

Liu Y, Hedvat CV, Mao S, Zhu XH, Yao J, Nguyen H, Koff A, Nimer SD. The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2. Mol Cell Biol. 2006 Apr;26(8):3114-23. doi: 10.1128/MCB.26.8.3114-3123.2006. PubMed PMID: 16581786; PubMed Central PMCID: PMC1446966.

Lacorazza HD, Yamada T, Liu Y, Miyata Y, Sivina M, Nunes J, Nimer SD. The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells. Cancer Cell. 2006 Mar;9(3):175-87. doi: 10.1016/j.ccr.2006.02.017. PubMed PMID: 16530702

Larkins BA, Dilkes BP, Dante RA, Coelho CM, Woo YM, Liu Y. Investigating the hows and whys of DNA endoreduplication. J Exp Bot. 2001 Feb;52(355):183-92. Review. PubMed PMID: 11283162