Research Projects

The Kim Laboratory is interested in elucidating mechanisms associated with the development and growth of uterine diseases including Endometrial Cancer, Endometriosis and Uterine Fibroids.

Endometrial Cancer

Endometrial cancer is the most common gynecologic cancer diagnosed in the United States. As risk factors for endometrial cancer increase, the incidence of endometrial cancer rises. In our laboratory, we investigate the impact of obesity and race on endometrial cancer.

NIH R01CA243249: Understanding Progesterone Receptor action in Obesity for Endometrial Cancer Prevention

NIH P20CA233304: Understanding Racial Disparity in Endometrial Cancer through Tumor Genomics

Leiomyoma (Uterine Fibroids)

Uterine fibroids, also known as leiomyomas, are benign tumors originating from the myometrium. These tumors can range from a few millimeters to over 20 cm in size. Leiomyomas are common and can occur in up to 77% of women while up to 20% of women suffer from significant morbidity, pain and discomfort, and excessive menstrual bleeding. In our laboratory we are investigating how reactive oxygen species can promote the development and growth of leiomyomas. In addition, racial disparity of leiomyomas is investigated in the context of ROS signaling. We aim to understand how targeting hormonal and ROS pathways can specifically prevent or treat leiomyomas.

NIH R01CA254367: Reactive Oxygen Species in the Initiation, Survival and Racial Disparity of Uterine Leiomyoma

Endometriosis

Endometriosis is a devastating disease that affects millions of women worldwide and characterized by the presence of endometrial tissue outside the uterus. While it is a leading cause of infertility and chronic pelvic pain in women, its etiology and pathogenesis remain largely unknown. We use cutting edge technology including induced pluripotent stem cells (iPSCs), 3D organoids and microfluidic technology. This innovative approach will allow us to journey into unchartered territories and gain a deeper understanding of the genetics of endometriosis.

NIH R01HD114195: Microphysiological modeling of Endometriosis