Northwestern University Feinberg School of Medicine

GR Scott Budinger Lab

About Our Lab

The Budinger laboratory is interested in understanding how aging biology intersects with the age-related risk of acute and chronic lung disease.  They have focused on the proteostasis network, a system of proteins that is responsible for maintaining all of the proteins in the cell in their native functional state.  In model organisms, there is a programmed signal that induces a progressive decline in function of the proteostasis network, and interruption of this pathway extends lifespan and improves resilience in the face of environmental stress.

The Budinger lab is testing whether a similar decline in the function of the proteostasis network happens in the lung, and whether this loss of “proteostasis reserve” underlies the increased susceptibility to pneumonia, and the increased risk of lung fibrosis and emphysema observed in older individuals.  The long-term goal of this work is to develop treatments that can reduce these age-related risks and preserve lung health over the lifespan.


External Collaborators

GR Scott Budinger, MD

GR Scott Budinger, MD
Chief of Pulmonary and Critical Care in the Department of Medicine
Ernest S. Bazley Professor of Airway Diseases
Professor of Medicine (Pulmonary and Critical Care) and Cell and Molecular Biology

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