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Northwestern University Feinberg School of Medicine
Apkarian Lab

Publications

Learn more about the work that we do in the Apkarian Lab through our recent publications.

  1. Quidé Y, Jahanshad N, Andoh J, Antoniou G, Apkarian AV, Ashar YK, Badran BW, Baird CL, Baxter L, Bell TR  et al.  ENIGMA-Chronic Pain: a worldwide initiative to identify brain correlates of chronic pain.  Pain  2024 Dec 01;165(12):2662-2666. doi:10.1097/j.pain.0000000000003317
  2. Vigotsky AD, Iannetti GD, Apkarian AV  Mental state decoders: game-changers or wishful thinking?  Trends Cogn Sci  2024 Oct;28(10):884-895. doi:10.1016/j.tics.2024.06.004
  3. Huang S, Vigotsky AD, Apkarian AV, Huang L  Body mass index associated with respiration predicts motion in resting-state functional magnetic resonance imaging scans.  Hum Brain Mapp  2024 Sep;45(13):e70015. pii:e70015
  4. Vigotsky AD, Cong O, Pinto CB, Barroso J, Perez J, Petersen KK, Arendt-Nielsen L, Hardt KD, Manning D, Apkarian AV  et al.  Prognostic value of preoperative mechanical hyperalgesia and neuropathic pain qualities for postoperative pain after total knee replacement.  Eur J Pain  2024 Sep;28(8):1387-1401. doi:10.1002/ejp.2295
  5. Baliki MN, Vigotsky AD, Rached G, Jabakhanji R, Huang L, Branco P, Cong O, Griffith J, Wasan AD, Schnitzer TJ  et al.  Neuropsychology of chronic back pain managed with long-term opioid use.  medRxiv  2024 Feb 08;. pii:2024.02.07.24302408
  6. Vigotsky AD, Cong O, Pinto CB, Barroso J, Perez J, Petersen KK, Arendt-Nielsen L, Hardt K, Manning D, Apkarian AV  et al.  Mechanical hyperalgesia and neuropathic pain qualities impart risk for chronic postoperative pain after total knee replacement.  medRxiv  2024 Jan 17;. pii:2024.01.16.24301372
  7. Centeno MV, Alam MS, Haldar K, Apkarian AV  Long-range action of an HDAC inhibitor treats chronic pain in a spared nerve injury rat model.  bioRxiv  2023 Dec 14;. pii:2023.12.13.571583
  8. Barroso J, Branco P, Pinto-Ramos J, Vigotsky AD, Reis AM, Schnitzer TJ, Galhardo V, Apkarian AV  Subcortical brain anatomy as a potential biomarker of persistent pain after total knee replacement in osteoarthritis.  Pain  2023 Oct 01;164(10):2306-2315. doi:10.1097/j.pain.0000000000002932
  9. Branco P, Bosak N, Bielefeld J, Cong O, Granovsky Y, Kahn I, Yarnitsky D, Apkarian AV  Structural brain connectivity predicts early acute pain after mild traumatic brain injury.  Pain  2023 Jun 01;164(6):1312-1320. doi:10.1097/j.pain.0000000000002818
  10. Branco P, Berger S, Abdullah T, Vachon-Presseau E, Cecchi G, Apkarian AV  Predicting placebo analgesia in patients with chronic pain using natural language processing: a preliminary validation study.  Pain  2023 May 01;164(5):1078-1086. doi:10.1097/j.pain.0000000000002808
  11. Wakaizumi K, Reckziegel D, Jabakhanji R, Apkarian AV, Baliki MN  Influence of exercise on pain is associated with resting-state functional connections: A cross-sectional functional brain imaging study.  Neurobiol Pain  2023;13:100125. pii:100125
  12. Tsujikawa S, DeMeulenaere KE, Centeno MV, Ghazisaeidi S, Martin ME, Tapies MR, Maneshi MM, Yamashita M, Stauderman KA, Apkarian AV  et al.  Regulation of neuropathic pain by microglial Orai1 channels.  Sci Adv  2023 Jan 27;9(4):eade7002. pii:eade7002
  13. Pinto CB, Bielefeld J, Barroso J, Yip B, Huang L, Schnitzer T, Apkarian AV  Chronic pain domains and their relationship to personality, abilities, and brain networks.  Pain  2023 Jan 01;164(1):59-71. doi:10.1097/j.pain.0000000000002657
  14. Bosak N, Branco P, Kuperman P, Buxbaum C, Cohen RM, Fadel S, Zubeidat R, Hadad R, Lawen A, Saadon-Grosman N  et al.  Brain Connectivity Predicts Chronic Pain in Acute Mild Traumatic Brain Injury.  Ann Neurol  2022 Nov;92(5):819-833. doi:10.1002/ana.26463
  15. Yang L, Vigotsky AD, Wu B, Shen B, Yan Z, Apkarian AV, Huang L  Morphometric similarity networks discriminate patients with lumbar disc herniation from healthy controls and predict pain intensity.  Front Netw Physiol  2022;2:992662. pii:992662
  16. Bao QY, Chang PC, Centeno MV, Farmer MA, Baliki M, Procissi D, Zhang W, Apkarian AV  Reversal of neuropathic pain is associated with corticostriatal functional reorganization after nerve repair in the spared nerve injury model.  Pain  2022 Oct 01;163(10):1929-1938. doi:10.1097/j.pain.0000000000002590
  17. Vachon-Presseau E, Abdullah TB, Berger SE, Huang L, Griffith JW, Schnitzer TJ, Apkarian AV  Validating a biosignature-predicting placebo pill response in chronic pain in the settings of a randomized controlled trial.  Pain  2022 May 01;163(5):910-922. doi:10.1097/j.pain.0000000000002450
  18. Tiwari SR, Vigotsky AD, Apkarian AV  On the Relationship Between Pain Variability and Relief in Randomized Clinical Trials.  Front Pain Res (Lausanne)  2022;3:844309. pii:844309
  19. Jabakhanji R, Vigotsky AD, Bielefeld J, Huang L, Baliki MN, Iannetti G, Apkarian AV  Limits of decoding mental states with fMRI.  Cortex  2022 Apr;149:101-122. doi:10.1016/j.cortex.2021.12.015
  20. Reckziegel D, Tétreault P, Ghantous M, Wakaizumi K, Petre B, Huang L, Jabakhanji R, Abdullah T, Vachon-Presseau E, Berger S  et al.  Sex-Specific Pharmacotherapy for Back Pain: A Proof-of-Concept Randomized Trial.  Pain Ther  2021 Dec;10(2):1375-1400. doi:10.1007/s40122-021-00297-2
  21. Barroso J, Branco P, Apkarian AV  Brain mechanisms of chronic pain: critical role of translational approach.  Transl Res  2021 Dec;238:76-89. doi:10.1016/j.trsl.2021.06.004
  22. Wei X, Centeno MV, Ren W, Borruto AM, Procissi D, Xu T, Jabakhanji R, Mao Z, Kim H, Li Y  et al.  Activation of the dorsal, but not the ventral, hippocampus relieves neuropathic pain in rodents.  Pain  2021 Dec 01;162(12):2865-2880. doi:10.1097/j.pain.0000000000002279
  23. Vigotsky AD, Tiwari SR, Griffith JW, Apkarian AV  What Is the Numerical Nature of Pain Relief?  Front Pain Res (Lausanne)  2021;2:756680. pii:756680
  24. Ruffle JK, Hyare H, Howard MA, Farmer AD, Apkarian AV, Williams SCR, Aziz Q, Nachev P  The autonomic brain: Multi-dimensional generative hierarchical modelling of the autonomic connectome.  Cortex  2021 Oct;143:164-179. doi:10.1016/j.cortex.2021.06.012
  25. Uc A, Andersen DK, Apkarian AV, Bellin MD, Colloca L, Drewes AM, Dunbar EK, Forsmark CE, Goodman MT, Kapural L  et al.  Pancreatic Pain-Knowledge Gaps and Research Opportunities in Children and Adults: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.  Pancreas  2021 Aug 01;50(7):906-915. doi:10.1097/MPA.0000000000001899
  26. Wakaizumi K, Vigotsky AD, Jabakhanji R, Abdallah M, Barroso J, Schnitzer TJ, Apkarian AV, Baliki MN  Psychosocial, Functional, and Emotional Correlates of Long-Term Opioid Use in Patients with Chronic Back Pain: A Cross-Sectional Case-Control Study.  Pain Ther  2021 Jun;10(1):691-709. doi:10.1007/s40122-021-00257-w
  27. Berger SE, Branco P, Vachon-Presseau E, Abdullah TB, Cecchi G, Apkarian AV  Quantitative language features identify placebo responders in chronic back pain.  Pain  2021 Jun 01;162(6):1692-1704. doi:10.1097/j.pain.0000000000002175
  28. Apkarian AV  The Necessity of Methodological Advances in Pain Research: Challenges and Opportunities.  Front Pain Res (Lausanne)  2021;2:634041. pii:634041
  29. Reckziegel D, Abdullah T, Wu B, Wu B, Huang L, Schnitzer TJ, Apkarian AV  Hippocampus shape deformation: a potential diagnostic biomarker for chronic back pain in women.  Pain  2021 May 01;162(5):1457-1467. doi:10.1097/j.pain.0000000000002143
  30. Wakaizumi K, Wu B, Huang S, Fan L, Shen B, Wu B, Zhang J, Baliki MN, Apkarian AV, Huang L  Momentary pain assessments reveal benefits of endoscopic discectomy: a prospective cohort study.  Pain Rep  2021;6(1):e906. pii:e906
  31. Barroso J, Wakaizumi K, Reis AM, Baliki M, Schnitzer TJ, Galhardo V, Apkarian AV  Reorganization of functional brain network architecture in chronic osteoarthritis pain.  Hum Brain Mapp  2021 Mar;42(4):1206-1222. doi:10.1002/hbm.25287
  32. Ren W, Centeno MV, Wei X, Wickersham I, Martina M, Apkarian AV, Surmeier DJ  Adaptive alterations in the mesoaccumbal network after peripheral nerve injury.  Pain  2021 Mar 01;162(3):895-906. doi:10.1097/j.pain.0000000000002092
  33. Yang L, Wu B, Fan L, Huang S, Vigotsky AD, Baliki MN, Yan Z, Apkarian AV, Huang L  Dissimilarity of functional connectivity uncovers the influence of participant's motion in functional magnetic resonance imaging studies.  Hum Brain Mapp  2021 Feb 15;42(3):713-723. doi:10.1002/hbm.25255
  34. Pinto CB, Bielefeld J, Jabakhanji R, Reckziegel D, Griffith JW, Apkarian AV  Neural and Genetic Bases for Human Ability Traits.  Front Hum Neurosci  2020;14:609170. pii:609170
  35. Barroso J, Vigotsky AD, Branco P, Reis AM, Schnitzer TJ, Galhardo V, Apkarian AV  Brain gray matter abnormalities in osteoarthritis pain: a cross-sectional evaluation.  Pain  2020 Sep 01;161(9):2167-2178. doi:10.1097/j.pain.0000000000001904
  36. Mioton LM, Dumanian GA, Fracol ME, Apkarian AV, Valerio IL, Souza JM, Potter BK, Tintle SM, Nanos GP, Ertl WJ  et al.  Benchmarking Residual Limb Pain and Phantom Limb Pain in Amputees through a Patient-reported Outcomes Survey.  Plast Reconstr Surg Glob Open  2020 Jul;8(7):e2977. pii:e2977
  37. Han Y, Zhang Y, Kim H, Grayson VS, Jovasevic V, Ren W, Centeno MV, Guedea AL, Meyer MAA, Wu Y  et al.  Excitatory VTA to DH projections provide a valence signal to memory circuits.  Nat Commun  2020 Mar 19;11(1):1466. pii:1466
  38. Smith BC, Vigotsky AD, Apkarian AV, Schnitzer TJ  Temporal Factors Associated With Opioid Prescriptions for Patients With Pain Conditions in an Urban Emergency Department.  JAMA Netw Open  2020 Mar 02;3(3):e200802. pii:e200802
  39. Barroso J, Wakaizumi K, Reckziegel D, Pinto-Ramos J, Schnitzer T, Galhardo V, Apkarian AV  Prognostics for pain in osteoarthritis: Do clinical measures predict pain after total joint replacement?  PLoS One  2020;15(1):e0222370. pii:e0222370
  40. Huang S, Wakaizumi K, Wu B, Shen B, Wu B, Fan L, Baliki MN, Zhan G, Apkarian AV, Huang L  Whole-brain functional network disruption in chronic pain with disk herniation.  Pain  2019 Dec;160(12):2829-2840. doi:10.1097/j.pain.0000000000001674
  41. Vachon-Presseau E, Berger SE, Abdullah TB, Griffith JW, Schnitzer TJ, Apkarian AV  Identification of traits and functional connectivity-based neurotraits of chronic pain.  PLoS Biol  2019 Aug;17(8):e3000349. pii:e3000349
  42. Dumanian GA, Potter BK, Mioton LM, Ko JH, Cheesborough JE, Souza JM, Ertl WJ, Tintle SM, Nanos GP, Valerio IL  et al.  Targeted Muscle Reinnervation Treats Neuroma and Phantom Pain in Major Limb Amputees: A Randomized Clinical Trial.  Ann Surg  2019 Aug;270(2):238-246. doi:10.1097/SLA.0000000000003088
  43. Pollema-Mays SL, Centeno MV, Chang Z, Apkarian AV, Martina M  Reduced ΔFosB expression in the rat nucleus accumbens has causal role in the neuropathic pain phenotype.  Neurosci Lett  2019 May 29;702:77-83. doi:10.1016/j.neulet.2018.11.036
  44. Apkarian AV  Definitions of nociception, pain, and chronic pain with implications regarding science and society.  Neurosci Lett  2019 May 29;702:1-2. doi:10.1016/j.neulet.2018.11.039
  45. Apkarian AV, Reckziegel D  Peripheral and central viewpoints of chronic pain, and translational implications.  Neurosci Lett  2019 May 29;702:3-5. doi:10.1016/j.neulet.2018.11.040
  46. Reckziegel D, Vachon-Presseau E, Petre B, Schnitzer TJ, Baliki MN, Apkarian AV  Deconstructing biomarkers for chronic pain: context- and hypothesis-dependent biomarker types in relation to chronic pain.  Pain  2019 May;160 Suppl 1(Suppl 1):S37-S48. doi:10.1097/j.pain.0000000000001529
  47. Apkarian AV  Reply To: Involuntary harms to the fight for newborns' analgesia, by Bellieni CV, Buonocore G.  J Pain  2019 Mar;20(3):368. doi:10.1016/j.jpain.2018.11.013