The goal of our lab is to better understand the connectivity and excitability changes that occur in the spinal cord after spinal cord injury. Specifically, we are interested in the changes that affect mobility. To do this, our lab uses a variety of in vitro and in vivo techniques to systematically measure both cellular changes within the spinal cord and gross motor output measures resulting from those changes.
Our current projects are focused on both understanding and treating involuntary muscle contractions, or spasms, that develop after spinal cord injury. Two of these projects are highlighted here. One project is aimed at characterizing spasms based on spinal cord injury location and severity. The other project is aimed at a potential new therapy targeting the CaV1.3 channel on motoneurons.
To see a list of recent publications from the Tysseling lab, click here.
To see a list of current funding and grants for the Tysseling lab, click here.