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Northwestern University Feinberg School of Medicine
Craig Horbinski Lab

Selected Publications

  1. Khan F, Lin Y, Ali H, Pang L, Dunterman M, Hsu WH, Frenis K, Grant Rowe R, Wainwright DA, McCortney K  et al.  Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression.  Nat Commun  2024 Mar 05;15(1):1987. pii:1987
  2. Romay MC, Knutsen RH, Ma F, Mompeón A, Hernandez GE, Salvador J, Mirkov S, Batra A, Sullivan DP, Procissi D  et al.  Age-related loss of Notch3 underlies brain vascular contractility deficiencies, glymphatic dysfunction, and neurodegeneration in mice.  J Clin Invest  2024 Jan 16;134(2). pii:e166134
  3. Nabors B, Portnow J, Hattangadi-Gluth J, Horbinski C  NCCN CNS tumor guidelines update for 2023.  Neuro Oncol  2023 Dec 08;25(12):2114-2116. doi:10.1093/neuonc/noad169
  4. Lukas RV, Horbinski C  Glioma Response to IDH Inhibition: Real-World Experience.  Clin Cancer Res  2023 Dec 01;29(23):4709-4710. doi:10.1158/1078-0432.CCR-23-2164
  5. Johnson M, Bell A, Lauing KL, Ladomersky E, Zhai L, Penco-Campillo M, Shah Y, Mauer E, Xiu J, Nicolaides T  et al.  Advanced Age in Humans and Mouse Models of Glioblastoma Show Decreased Survival from Extratumoral Influence.  Clin Cancer Res  2023 Dec 01;29(23):4973-4989. doi:10.1158/1078-0432.CCR-23-0834
  6. McCord M, Jamshidi P, Thirunavu V, Santana-Santos L, Vormittag-Nocito E, Dittman D, Parker S, Baczkowski J, Jennings L, Walshon J  et al.  Variant allelic frequencies of driver mutations can identify gliomas with potentially false-negative MGMT promoter methylation results.  Acta Neuropathol Commun  2023 Nov 02;11(1):175. pii:175
  7. Meredith DM, Cooley LD, Dubuc A, Morrissette J, Sussman RT, Nasrallah MP, Rathbun P, Yap KL, Wadhwani N, Bao L  et al.  ROS1 Alterations as a Potential Driver of Gliomas in Infant, Pediatric, and Adult Patients.  Mod Pathol  2023 Nov;36(11):100294. doi:10.1016/j.modpat.2023.100294
  8. Murnan KM, Horbinski C, Stegh AH  Redox Homeostasis and Beyond: The Role of Wild-Type Isocitrate Dehydrogenases for the Pathogenesis of Glioblastoma.  Antioxid Redox Signal  2023 Nov;39(13-15):923-941. doi:10.1089/ars.2023.0262
  9. Youngblood MW, Erson-Omay Z, Li C, Najem H, Coșkun S, Tyrtova E, Montejo JD, Miyagishima DF, Barak T, Nishimura S  et al.  Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas.  Nat Commun  2023 Oct 07;14(1):6279. pii:6279
  10. Khan F, Lin Y, Ali H, Pang L, Dunterman M, Hsu WH, Frenis K, Rowe RG, Wainwright D, McCortney K  et al.  LDHA-regulated tumor-macrophage symbiosis promotes glioblastoma progression.  Res Sq  2023 Oct 05;. pii:rs.3.rs-3401154
  11. Pang L, Dunterman M, Guo S, Khan F, Liu Y, Taefi E, Bahrami A, Geula C, Hsu WH, Horbinski C  et al.  Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma.  Nat Immunol  2023 Oct;24(10):1654-1670. doi:10.1038/s41590-023-01605-y
  12. Stamm B, DiBiase R, Lee J, Primdahl D, Malavia T, Dixit K, Horbinski C, Kostelecky N, Elhodaky M, Potts MB  et al.  A Woman With Multifocal Ischemic Strokes and Progressive Cognitive Impairment due to Intravascular Lymphoma.  Stroke  2023 Oct;54(10):e448-e451. doi:10.1161/STROKEAHA.123.043934
  13. Goenka A, Song X, Tiek D, Iglesia RP, Lu M, Zeng C, Horbinski C, Zhang W, Hu B, Cheng SY  Oncogenic long noncoding RNA LINC02283 enhances PDGF receptor A-mediated signaling and drives glioblastoma tumorigenesis.  Neuro Oncol  2023 Sep 05;25(9):1592-1604. doi:10.1093/neuonc/noad065
  14. Zeng C, Song X, Zhang Z, Cai Q, Cai J, Horbinski C, Hu B, Cheng SY, Zhang W  Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis.  Acta Neuropathol Commun  2023 Aug 14;11(1):133. pii:133
  15. Jo J, Diaz M, Horbinski C, Mackman N, Bagley S, Broekman M, Rak J, Perry J, Pabinger I, Key NS  et al.  Epidemiology, biology, and management of venous thromboembolism in gliomas: An interdisciplinary review.  Neuro Oncol  2023 Aug 03;25(8):1381-1394. doi:10.1093/neuonc/noad059
  16. Budhiraja S, Najem H, Tripathi S, Wadhawani NR, Horbinski C, McCord M, Lenzen AC, Heimberger AB, DeCuypere M  Immunobiology and Cytokine Modulation of the Pediatric Brain Tumor Microenvironment: A Scoping Review.  Cancers (Basel)  2023 Jul 18;15(14). pii:3655
  17. Galbraith K, Vasudevaraja V, Serrano J, Shen G, Tran I, Abdallat N, Wen M, Patel S, Movahed-Ezazi M, Faustin A  et al.  Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors-A prospective study and guidelines for clinical testing.  Neurooncol Adv  2023;5(1):vdad076. pii:vdad076
  18. Drumm MR, Wang W, Sears TK, Bell-Burdett K, Javier R, Cotton KY, Webb B, Byrne K, Unruh D, Thirunavu V  et al.  Postoperative risk of IDH-mutant glioma-associated seizures and their potential management with IDH-mutant inhibitors.  J Clin Invest  2023 Jun 15;133(12). pii:e168035
  19. Lucas CH, Mirchia K, Seo K, Najem H, Chen W, Zakimi N, Choudhury A, Liu SJ, Phillips J, Magill S  et al.  Spatial genomic, biochemical, and cellular mechanisms drive meningioma heterogeneity and evolution.  Res Sq  2023 May 15;. pii:rs.3.rs-2921804
  20. Zhang Y, Nguyen CC, Zhang NT, Fink NS, John JD, Venkatesh OG, Roe JD, Hoffman SC, Lesniak MS, Wolinsky JP  et al.  Neurological applications of belzutifan in von Hippel-Lindau disease.  Neuro Oncol  2023 May 04;25(5):827-838. doi:10.1093/neuonc/noac234
  21. Ghorbani A, Avery LM, Sohaei D, Soosaipillai A, Richer M, Horbinski C, McCortney K, Xu W, Diamandis EP, Prassas I  Discovery of novel glioma serum biomarkers by proximity extension assay.  Clin Proteomics  2023 Mar 24;20(1):12. pii:12
  22. Raleigh D, Chen W, Choudhury A, Youngblood M, Polley MY, Lucas CH, Mirchia K, Maas S, Suwala A, Won M  et al.  Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses.  Res Sq  2023 Mar 20;. pii:rs.3.rs-2663611
  23. Burdett KB, Unruh D, Drumm M, Steffens A, Lamano J, Judkins J, Schwartz M, Javier R, Amidei C, Lipp ES  et al.  Determining venous thromboembolism risk in patients with adult-type diffuse glioma.  Blood  2023 Mar 16;141(11):1322-1336. doi:10.1182/blood.2022017858
  24. Youngblood MW, Tran AN, Wang W, An S, Scholtens D, Zhang L, O'Shea K, Pokorny JL, Magill ST, Sachdev S  et al.  Docetaxel targets aggressive methylation profiles and serves as a radiosensitizer in high-risk meningiomas.  Neuro Oncol  2023 Mar 14;25(3):508-519. doi:10.1093/neuonc/noac206
  25. Jamshidi P, McCord M, Galbraith K, Santana-Santos L, Jennings LJ, Snuderl M, Horbinski C  Variant allelic frequency of driver mutations predicts success of genomic DNA methylation classification in central nervous system tumors.  Acta Neuropathol  2023 Mar;145(3):365-367. doi:10.1007/s00401-023-02542-8
  26. Sullivan J, Chandler J, Lesniak M, Tate M, Sonabend A, Kalapurakal J, Horbinski C, Lukas R, Kumthekar P, Sachdev S  Clinical outcomes for pleomorphic xanthoastrocytoma patients: an institutional experience.  Res Sq  2023 Feb 03;. pii:rs.3.rs-2535551
  27. Miller JJ, Gonzalez Castro LN, McBrayer S, Weller M, Cloughesy T, Portnow J, Andronesi O, Barnholtz-Sloan JS, Baumert BG, Berger MS  et al.  Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions.  Neuro Oncol  2023 Jan 05;25(1):4-25. doi:10.1093/neuonc/noac207
  28. Horbinski C, Nabors LB, Portnow J, Baehring J, Bhatia A, Bloch O, Brem S, Butowski N, Cannon DM, Chao S  et al.  NCCN Guidelines® Insights: Central Nervous System Cancers, Version 2.2022.  J Natl Compr Canc Netw  2023 Jan;21(1):12-20. doi:10.6004/jnccn.2023.0002
  29. Cimino PJ, Ketchum C, Turakulov R, Singh O, Abdullaev Z, Giannini C, Pytel P, Lopez GY, Colman H, Nasrallah MP  et al.  Expanded analysis of high-grade astrocytoma with piloid features identifies an epigenetically and clinically distinct subtype associated with neurofibromatosis type 1.  Acta Neuropathol  2023 Jan;145(1):71-82. doi:10.1007/s00401-022-02513-5
  30. Bollu LR, Bommi PV, Monsen PJ, Zhai L, Lauing KL, Bell A, Kim M, Ladomersky E, Yang X, Platanias LC  et al.  Identification and Characterization of a Novel Indoleamine 2,3-Dioxygenase 1 Protein Degrader for Glioblastoma.  J Med Chem  2022 Dec 08;65(23):15642-15662. doi:10.1021/acs.jmedchem.2c00771
  31. McCord M, Bartom E, Burdett K, Baran A, Eckerdt FD, Balyasnikova IV, McCortney K, Sears T, Cheng SY, Sarkaria JN  et al.  Modeling Therapy-Driven Evolution of Glioblastoma with Patient-Derived Xenografts.  Cancers (Basel)  2022 Nov 09;14(22). pii:5494
  32. Smith HL, Wadhwani N, Horbinski C  Major Features of the 2021 WHO Classification of CNS Tumors.  Neurotherapeutics  2022 Oct;19(6):1691-1704. doi:10.1007/s13311-022-01249-0
  33. Lauko A, Volovetz J, Turaga SM, Bayik D, Silver DJ, Mitchell K, Mulkearns-Hubert EE, Watson DC, Desai K, Midha M  et al.  SerpinB3 drives cancer stem cell survival in glioblastoma.  Cell Rep  2022 Sep 13;40(11):111348. doi:10.1016/j.celrep.2022.111348
  34. Horbinski C, Berger T, Packer RJ, Wen PY  Clinical implications of the 2021 edition of the WHO classification of central nervous system tumours.  Nat Rev Neurol  2022 Sep;18(9):515-529. doi:10.1038/s41582-022-00679-w
  35. Santana-Santos L, Kam KL, Dittmann D, De Vito S, McCord M, Jamshidi P, Fowler H, Wang X, Aalsburg AM, Brat DJ  et al.  Validation of Whole Genome Methylation Profiling Classifier for Central Nervous System Tumors.  J Mol Diagn  2022 Aug;24(8):924-934. doi:10.1016/j.jmoldx.2022.04.009
  36. Dmello C, Sonabend A, Arrieta VA, Zhang DY, Kanojia D, Chen L, Gould A, Zhang J, Kang SJ, Winter J  et al.  Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma.  Clin Cancer Res  2022 Jul 15;28(14):3156-3169. doi:10.1158/1078-0432.CCR-21-2563
  37. Rammohan N, Ho A, Saxena M, Bajaj A, Kruser TJ, Horbinski C, Korutz A, Tate M, Sachdev S  Tumor-associated alterations in white matter connectivity have prognostic significance in MGMT-unmethylated glioblastoma.  J Neurooncol  2022 Jul;158(3):331-339. doi:10.1007/s11060-022-04018-3
  38. Najem H, Ott M, Kassab C, Rao A, Rao G, Marisetty A, Sonabend AM, Horbinski C, Verhaak R, Shankar A  et al.  Central nervous system immune interactome is a function of cancer lineage, tumor microenvironment, and STAT3 expression.  JCI Insight  2022 May 09;7(9). pii:e157612
  39. Cheng C, Geng F, Li Z, Zhong Y, Wang H, Cheng X, Zhao Y, Mo X, Horbinski C, Duan W  et al.  Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth.  Nat Metab  2022 May;4(5):575-588. doi:10.1038/s42255-022-00568-y
  40. Xu D, Bhattacharyya S, Wang W, Ifergan I, Wong MAC, Procissi D, Yeldandi A, Bale S, Marangoni RG, Horbinski C  et al.  PLG nanoparticles target fibroblasts and MARCO+ monocytes to reverse multiorgan fibrosis.  JCI Insight  2022 Mar 08;7(5). pii:e151037
  41. Arrieta VA, Chen AX, Kane JR, Kang SJ, Kassab C, Dmello C, Zhao J, Burdett KB, Upadhyayula PS, Lee-Chang C  et al.  Publisher Correction: ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma.  Nat Cancer  2022 Mar;3(3):373. doi:10.1038/s43018-022-00343-8
  42. Pratt D, Abdullaev Z, Papanicolau-Sengos A, Ketchum C, Panneer Selvam P, Chung HJ, Lee I, Raffeld M, Gilbert MR, Armstrong TS  et al.  High-grade glioma with pleomorphic and pseudopapillary features (HPAP): a proposed type of circumscribed glioma in adults harboring frequent TP53 mutations and recurrent monosomy 13.  Acta Neuropathol  2022 Mar;143(3):403-414. doi:10.1007/s00401-022-02404-9
  43. Larkin CJ, Jennings LJ, Heimberger AB, Horbinski C  Next-Generation Sequencing of a Glioblastoma with True Epithelial Differentiation.  J Neuropathol Exp Neurol  2022 Feb 24;81(3):239-241. doi:10.1093/jnen/nlab114
  44. Javier R, Wang W, Drumm M, McCortney K, Sarkaria JN, Horbinski C  The efficacy of an unrestricted cycling ketogenic diet in preclinical models of IDH wild-type and IDH mutant glioma.  PLoS One  2022;17(2):e0257725. pii:e0257725
  45. Bitar M, Chornenkyy Y, Flanagan ME, Steffens A, McCortney K, Horbinski C  The Frequency of Focal Cortical Dysplasia-Like Histologic Features Near Adult-Type Diffuse Gliomas.  J Neuropathol Exp Neurol  2022 Jan 21;81(1):48-53. doi:10.1093/jnen/nlab120
  46. Drumm M, Templer JW, Tate M, Jennings L, Horbinski C  Markedly prolonged disease course, with breakthrough seizures, in a glioma with an isolated IDH1 mutation.  Neurooncol Adv  2022;4(1):vdac004. pii:vdac004
  47. Arrieta VA, Chen AX, Kane JR, Kang SJ, Kassab C, Dmello C, Zhao J, Burdett KB, Upadhyayula PS, Lee-Chang C  et al.  ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma.  Nat Cancer  2021 Dec;2(12):1372-1386. doi:10.1038/s43018-021-00260-2
  48. Zhai L, Bell A, Ladomersky E, Lauing KL, Bollu L, Nguyen B, Genet M, Kim M, Chen P, Mi X  et al.  Tumor Cell IDO Enhances Immune Suppression and Decreases Survival Independent of Tryptophan Metabolism in Glioblastoma.  Clin Cancer Res  2021 Dec 01;27(23):6514-6528. doi:10.1158/1078-0432.CCR-21-1392
  49. Boudreau CE, Najem H, Ott M, Horbinski C, Fang D, DeRay CM, Levine JM, Curran MA, Heimberger AB  Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma.  Clin Cancer Res  2021 Oct 15;27(20):5528-5535. doi:10.1158/1078-0432.CCR-21-1914
  50. Gonzalez-Buendia E, Zhao J, Wang L, Mukherjee S, Zhang D, Arrieta VA, Feldstein E, Kane JR, Kang SJ, Lee-Chang C  et al.  TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas.  Clin Cancer Res  2021 Oct 15;27(20):5669-5680. doi:10.1158/1078-0432.CCR-21-0312