Publications

Th17 Cells Are Preferentially Infected Very Early after Vaginal Transmission of SIV in Macaques. Stieh DJ, Matias E, Huanbin Xu, Fought A.J., Blanchard JA,  Marx PA,  Veazey RS, Hope TJ. Cell Host & Microbe 2016 doi: http://dx.doi.org/10.1016/j.chom.2016.03.005

Detection and tracking of dual-labeled hiv particles using wide-field live cell imaging to follow viral core integrity. Mamede JI, Hope TJ. Methods in Molecular Biology. 2016 Jan;1354:49-59.doi:10.1007/978-1-4939-3046-3_4.

Characterization of the Influence of Semen-Derived Enhancer of Virus Infection on the Interaction of HIV-1 with Female Reproductive Tract Tissues. Allen SA, Carias AM, Anderson MR, Okocha EA, Benning L, McRaven MD, Kelley ZL, Lurain J, Veazey RS, Hope TJ.. J Virol 2015; 89(10):5569-5580.

Visualization of HIV-1 interactions with penile and foreskin epithelia: clues for female-to- male HIV transmission. Dinh MH, Anderson MR, McRaven MD, Cianci GC, McCoombe SG, Kelley ZL, Gioia CJ, Fought AJ, Rademaker AW, Veazey RS, Hope TJ. PLoS pathogens. 2015; 11(3):e1004729.

Vaginal Challenge with an SIV-Based Dual Reporter System Reveals That Infection Can Occur throughout the Upper and Lower Female Reproductive Tract. Stieh DJ, Maric D, Kelley ZL, Anderson MR, Hattaway HZ, Beilfuss BA, Rothwangl KB, Veazey RS, Hope TJ. PLoS Pathogen 2014;10 (10):e1004440.

Complementary Assays Reveal a Low Level of CA Associated with Viral Complexes in the Nuclei of HIV-1- Infected Cells. Hulme AE, Kelley Z, Foley D, Hope TJ. Journal of Virology 2015; 89(10):5350-5361.

Identification of capsid mutations that alter the rate of HIV-1 uncoating in infected cells. Hulme AE, Kelley Z, Okocha EA, Hope TJ. Journal of Virology. 2015 Jan;89(1):643-651.doi:10.1128/JVI.03043-14.

CCR5 conformations are dynamic and modulated by localization, trafficking and G protein association. Flegler AJ, Cianci GC, Hope TJ. PLoS ONE. 2014 Feb 28;9(2):doi:10.1371/journal.pone.0089056

Differential binding of IgG and IgA to mucus of the female reproductive tract. Fahrbach KM, Malykhina O, Stieh DJ, Hope TJ. PLoS One. 2013 Oct 2;8(10):e76176.

Slower uncoating is associated with impaired replicative capability of simian-tropic HIV-1. Kono K, Takeda E, Tsutsui H, Kuroishi A, Hulme AE, Hope TJ, Nakayama EE, Shioda T. PLoS One. 2013;8(8):e72531. doi: 10.1371/journal.pone.0072531. eCollection 2013.

Defining the Interaction of HIV-1 with the Mucosal Barriers of the Female Reproductive Tract. Carias AM, McCoombe S, McRaven M, Anderson M, Galloway N, Vandergrift N, Fought AJ, Lurain J, Duplantis M, Veazey RS, Hope TJ. J Virol. 2013 Nov;87(21):11388-400. doi: 10.1128/JVI.01377-13. Epub 2013 Aug 21.

New paradigms for functional HIV-specific nonneutralizing antibodies. Forthal D, Hope TJ, Alter G. Curr Opin HIV AIDS. 2013 Sep;8(5):393-401. doi: 10.1097/COH.0b013e328363d486.

Using Antiubiquitin Antibodies to Probe the Ubiquitination State Within rhTRIM5α Cytoplasmic Bodies. Danielson CM, Hope TJ. AIDS Res Hum Retroviruses. 2013 Oct;29(10):1373-85. doi: 10.1089/AID.2013.0029. Epub 2013 Jul 26.

Human cervicovaginal mucus contains an activity that hinders HIV-1 movement. Shukair SA, Allen SA, Cianci GC, Stieh DJ, Anderson MR, Baig SM, Gioia CJ, Spongberg EJ, Kauffman SM, McRaven MD, Lakougna HY, Hammond C, Kiser PF, Hope TJ. Mucosal Immunol. 2013 Mar;6(2):427-34. doi: 10.1038/mi.2012.87. Epub 2012 Sep 19.

No difference in keratin thickness between inner and outer foreskins from elective male circumcisions in Rakai, Uganda. Dinh MH, Hirbod T, Kigozi G, Okocha EA, Cianci GC, Kong X, Prodger JL, Broliden K, Kaul R, Serwadda D, Wawer MJ, Gray RH, Hope TJ. PLoS One. 2012;7(7):e41271. doi: 10.1371/journal.pone.0041271. Epub 2012 Jul 18.

Recruitment and dynamics of proteasome association with rhTRIM5α cytoplasmic complexes during HIV-1 infection. Danielson CM, Cianci GC, Hope TJ. Traffic. 2012 Sep;13(9):1206-17. doi: 10.1111/j.1600-0854.2012.01381.x. Epub 2012 Jun 19.

Knockdown of MAP4 and DNAL1 produces a post-fusion and pre-nuclear translocation impairment in HIV-1 replication. Gallo DE, Hope TJ. Virology. 2012 Jan 5;422(1):13-21. doi: 10.1016/j.virol.2011.09.015. Epub 2011 Oct 22.

Moving ahead an HIV vaccine: to neutralize or not, a key HIV vaccine question. Hope TJ. Nat Med. 2011 Oct 11;17(10):1195-7. doi: 10.1038/nm.2528. No abstract available.

Hope TJ, Moving ahead an HIV vaccine: To neutralize or not, a key HIV vaccine question. Nature Medicine. 2011 Oct 11. PubMed PMID: 21988997.

Zanta-Boussif MA, Charrier S, Brice-Ouzet A, Martin S, Opolon P, Thrasher AJ, Hope TJ, Galy A. Validation of a mutated PRE sequence allowing high and sustained transgene expression while abrogating WHV-X protein synthesis: application to the gene therapy of WAS. Gene Ther. 2009 Mar 5. [Epub ahead of print] PubMed PMID: 19262615.

Hladik F, Hope TJ. HIV infection of the genital mucosa in women. Curr HIV/AIDS Rep. 2009 Feb;6(1):20-8. Review. PubMed PMID: 19149993.

Fischetti L, Barry SM, Hope TJ, Shattock RJ. HIV-1 infection of human penile explant tissue and protection by candidate microbicides. AIDS. 2009 Jan 28;23(3):319-28. PubMed PMID: 19114867.

Campbell EM, Hope TJ. Live cell imaging of the HIV-1 life cycle. Trends Microbiol. 2008 Dec;16(12):580-7. Epub 2008 Oct 30. Review. PubMed PMID: 18977142.

Anderson JL, Hope TJ. APOBEC3G restricts early HIV-1 replication in the cytoplasm of target cells. Virology. 2008 May 25;375(1):1-12. Epub 2008 Mar 4. PubMed PMID: 18308358.

Leblanc JJ, Perez O, Hope TJ. Probing the structural states of human immunodeficiency virus type 1 pr55gag by using monoclonal antibodies. J Virol. 2008 Mar;82(5):2570-4. Epub 2007 Dec 19. PubMed PMID: 18094163; PubMed Central PMCID: PMC2258915.

Anderson JL, Campbell EM, Figueiredo A, Hope TJ. Heat shock perturbs TRIM5alpha restriction of human immunodeficiency virus type 1. J Virol. 2008 Mar;82(5):2575-9. Epub 2007 Dec 12. PubMed PMID: 18077709; PubMed Central PMCID: PMC2258924.

Campbell EM, Perez O, Anderson JL, Hope TJ. Visualization of a proteasome-independent intermediate during restriction of HIV-1 by rhesus TRIM5alpha. J Cell Biol. 2008 Feb 11;180(3):549-61. Epub 2008 Feb 4. PubMed PMID: 18250195; PubMed Central PMCID: PMC2234241.

Fox-Canale AM, Hope TJ, Martinson J, Lurain JR, Rademaker AW, Bremer JW, Landay A, Spear GT, Lurain NS. Human cytomegalovirus and human immunodeficiency virus type-1 co-infection in human cervical tissue. Virology. 2007 Dec 5;369(1):55-68. Epub 2007 Aug 22. PubMed PMID: 17716703; PubMed Central PMCID: PMC2174066.

Yamashita M, Perez O, Hope TJ, Emerman M. Evidence for direct involvement of the capsid protein in HIV infection of nondividing cells. PLoS Pathog. 2007 Oct 26;3(10):1502-10. PubMed PMID: 17967060; PubMed Central PMCID: PMC2042020.

Fahrbach KM, Barry SM, Ayehunie S, Lamore S, Klausner M, Hope TJ. Activated CD34-derived Langerhans cells mediate transinfection with human immunodeficiency virus. J Virol. 2007 Jul;81(13):6858-68. Epub 2007 Apr 18. PubMed PMID: 17442711; PubMed Central PMCID: PMC1933306.

Campbell EM, Dodding MP, Yap MW, Wu X, Gallois-Montbrun S, Malim MH, Stoye JP, Hope TJ. TRIM5 alpha cytoplasmic bodies are highly dynamic structures. Mol Biol Cell. 2007 Jun;18(6):2102-11. Epub 2007 Mar 28. PubMed PMID: 17392513; PubMed Central PMCID: PMC1877106.

Campbell EM, Perez O, Melar M, Hope TJ. Labeling HIV-1 virions with two fluorescent proteins allows identification of virions that have productively entered the target cell. Virology. 2007 Apr 10;360(2):286-93. Epub 2006 Nov 22. PubMed PMID: 17123568; PubMed Central PMCID: PMC1885464.

Hope TJ. Bridging efficient viral infection. Nat Cell Biol. 2007 Mar;9(3):243-4. PubMed PMID: 17330113.

Melar M, Ott DE, Hope TJ. Physiological levels of virion-associated human immunodeficiency virus type 1 envelope induce coreceptor-dependent calcium flux. J Virol. 2007 Feb;81(4):1773-85. Epub 2006 Nov 22. PubMed PMID: 17121788; PubMed Central PMCID: PMC1797554.

Anderson JL, Campbell EM, Wu X, Vandegraaff N, Engelman A, Hope TJ. Proteasome inhibition reveals that a functional preintegration complex intermediate can be generated during restriction by diverse TRIM5 proteins. J Virol. 2006 Oct;80(19):9754-60. PubMed PMID: 16973579; PubMed Central PMCID: PMC1617233.

Gomez CY, Hope TJ. Mobility of human immunodeficiency virus type 1 Pr55Gag in living cells. J Virol. 2006 Sep;80(17):8796-806. PubMed PMID: 16912326; PubMed Central PMCID: PMC1563866.

Henderson HI, Hope TJ. The temperature arrested intermediate of virus-cell fusion is a functional step in HIV infection. Virol J. 2006 May 25;3:36. PubMed PMID: 16725045; PubMed Central PMCID: PMC1482684.

Wu X, Anderson JL, Campbell EM, Joseph AM, Hope TJ. Proteasome inhibitors uncouple rhesus TRIM5alpha restriction of HIV-1 reverse transcription and infection. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7465-70. Epub 2006 Apr 28. PubMed PMID: 16648264; PubMed Central PMCID: PMC1464362.

Lee JH, Murphy SC, Belshan M, Sparks WO, Wannemuehler Y, Liu S, Hope TJ, Dobbs D, Carpenter S. Characterization of functional domains of equine infectious anemia virus Rev suggests a bipartite RNA-binding domain. J Virol. 2006 Apr;80(8):3844-52. PubMed PMID: 16571801; PubMed Central PMCID: PMC1440447.

Perez O, Hope TJ. Cellular restriction factors affecting the early stages of HIV replication. Curr HIV/AIDS Rep. 2006 Feb;3(1):20-5. Review. PubMed PMID: 16522255.

Anderson JL, Hope TJ. Intracellular trafficking of retroviral vectors: obstacles and advances. Gene Ther. 2005 Dec;12(23):1667-78. Review. PubMed PMID: 16292352.

Barry SM, Melar M, Gallay P, Hope TJ. Review of the twelfth West Coast Retrovirus Meeting. Retrovirology. 2005 Nov 17;2:72. Review. PubMed PMID: 16293194; PubMed Central PMCID: PMC1315336.

Campbell EM, Hope TJ. Gene therapy progress and prospects: viral trafficking during infection. Gene Ther. 2005 Sep;12(18):1353-9. Review. PubMed PMID: 16151445.

Fazal F, Gu L, Ihnatovych I, Han Y, Hu W, Antic N, Carreira F, Blomquist JF, Hope TJ, Ucker DS, de Lanerolle P. Inhibiting myosin light chain kinase induces apoptosis in vitro and in vivo. Mol Cell Biol. 2005 Jul;25(14):6259-66. PubMed PMID: 15988034; PubMed Central PMCID: PMC1168802.

Choi EA, Hope TJ. Mutational analysis of bovine leukemia virus Rex: identification of a dominant-negative inhibitor. J Virol. 2005 Jun;79(11):7172-81. PubMed PMID: 15890956; PubMed Central PMCID: PMC1112096.

Gomez C, Hope TJ. The ins and outs of HIV replication. Cell Microbiol. 2005 May;7(5):621-6. Review. PubMed PMID: 15839891.

Hofmann WA, Stojiljkovic L, Fuchsova B, Vargas GM, Mavrommatis E, Philimonenko V, Kysela K, Goodrich JA, Lessard JL, Hope TJ, Hozak P, de Lanerolle P. Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II. Nat Cell Biol. 2004 Nov;6(11):1094-101. Epub 2004 Oct 24. PubMed PMID: 15502823.

Steffens CM, Hope TJ. Mobility of the human immunodeficiency virus (HIV) receptor CD4 and coreceptor CCR5 in living cells: implications for HIV fusion and entry events. J Virol. 2004 Sep;78(17):9573-8. PubMed PMID: 15308751; PubMed Central PMCID: PMC506925.

Campbell EM, Nunez R, Hope TJ. Disruption of the actin cytoskeleton can complement the ability of Nef to enhance human immunodeficiency virus type 1 infectivity. J Virol. 2004 Jun;78(11):5745-55. PubMed PMID: 15140972; PubMed Central PMCID: PMC415815.

Anderson JL, Hope TJ. HIV accessory proteins and surviving the host cell. Curr HIV/AIDS Rep. 2004 Apr;1(1):47-53. Review. PubMed PMID: 16091223.

Singh SP, McDonald D, Hope TJ, Prabhakar BS. Upon thyrotropin binding the thyrotropin receptor is internalized and localized to endosome. Endocrinology. 2004 Feb;145(2):1003-10. Epub 2003 Oct 23. PubMed PMID: 14576174.

Anderson JL, Hope TJ. Recent Insights into HIV Accessory Proteins. Curr Infect Dis Rep. 2003 Oct;5(5):439-450. PubMed PMID: 13678574.

Campbell EM, Hope TJ. Role of the cytoskeleton in nuclear import. Adv Drug Deliv Rev. 2003 Jun 16;55(6):761-71. Review. PubMed PMID: 12788539.

McDonald D, Wu L, Bohks SM, KewalRamani VN, Unutmaz D, Hope TJ. Recruitment of HIV and its receptors to dendritic cell-T cell junctions. Science. 2003 May 23;300(5623):1295-7. Epub 2003 May 1. PubMed PMID: 12730499.

Sarma T, Voyno-Yasenetskaya T, Hope TJ, Rasenick MM. Heterotrimeric G-proteins associate with microtubules during differentiation in PC12 pheochromocytoma cells. FASEB J. 2003 May;17(8):848-59. PubMed PMID: 12724344.

Steffens CM, Hope TJ. Localization of CD4 and CCR5 in living cells. J Virol. 2003 Apr;77(8):4985-91. PubMed PMID: 12663805; PubMed Central PMCID: PMC152144.

McDonald D, Vodicka MA, Lucero G, Svitkina TM, Borisy GG, Emerman M, Hope TJ. Visualization of the intracellular behavior of HIV in living cells. J Cell Biol. 2002 Nov 11;159(3):441-52. Epub 2002 Nov 4. PubMed PMID: 12417576; PubMed Central PMCID: PMC2173076.

Brandt SM, Mariani R, Holland AU, Hope TJ, Landau NR. Association of chemokine-mediated block to HIV entry with coreceptor internalization. J Biol Chem. 2002 May 10;277(19):17291-9. Epub 2002 Jan 8. PubMed PMID: 11782464.

Popa I, Harris ME, Donello JE, Hope TJ. CRM1-dependent function of a cis-acting RNA export element. Mol Cell Biol. 2002 Apr;22(7):2057-67. PubMed PMID: 11884594; PubMed Central PMCID: PMC133666.

Loeb JE, Weitzman MD, Hope TJ. Enhancement of green fluorescent protein expression in adeno-associated virus with the woodchuck hepatitis virus post-transcriptional regulatory element. Methods Mol Biol. 2002;183:331-40. PubMed PMID: 12136769.

Steffens CM, Hope TJ. Recent advances in the understanding of HIV accessory protein function. AIDS. 2001;15 Suppl 5:S21-6. Review. PubMed PMID: 11816170.

Gupta K, Ott D, Hope TJ, Siliciano RF, Boeke JD. A human nuclear shuttling protein that interacts with human immunodeficiency virus type 1 matrix is packaged into virions. J Virol. 2000 Dec;74(24):11811-24. PubMed PMID: 11090181; PubMed Central PMCID: PMC112464.

Mariani R, Rutter G, Harris ME, Hope TJ, Kräusslich HG, Landau NR. A block to human immunodeficiency virus type 1 assembly in murine cells. J Virol. 2000 Apr;74(8):3859-70. PubMed PMID: 10729160; PubMed Central PMCID: PMC111894.

Déjardin J, Bompard-Maréchal G, Audit M, Hope TJ, Sitbon M, Mougel M. A novel subgenomic murine leukemia virus RNA transcript results from alternative splicing. J Virol. 2000 Apr;74(8):3709-14. PubMed PMID: 10729146; PubMed Central PMCID: PMC111880.

Burton M, Upadhyaya CD, Maier B, Hope TJ, Semmes OJ. Human T-cell leukemia virus type 1 Tax shuttles between functionally discrete subcellular targets. J Virol. 2000 Mar;74(5):2351-64. PubMed PMID: 10666266; PubMed Central PMCID: PMC111717.

Harris ME, Hope TJ. RNA export: insights from viral models. Essays Biochem. 2000;36:115-27. Review. PubMed PMID: 12471907.

Johnson C, Van Antwerp D, Hope TJ. An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IkappaBalpha. EMBO J. 1999 Dec 1;18(23):6682-93. PubMed PMID: 10581242; PubMed Central PMCID: PMC1171731.

Audit M, Déjardin J, Hohl B, Sidobre C, Hope TJ, Mougel M, Sitbon M. Introduction of a cis-acting mutation in the capsid-coding gene of moloney murine leukemia virus extends its leukemogenic properties. J Virol. 1999 Dec;73(12):10472-9. PubMed PMID: 10559365; PubMed Central PMCID: PMC113102.

Jiang W, McDonald D, Hope TJ, Hunter T. Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. EMBO J. 1999 Oct 15;18(20):5703-13. PubMed PMID: 10523313; PubMed Central PMCID: PMC1171637.

Loeb JE, Cordier WS, Harris ME, Weitzman MD, Hope TJ. Enhanced expression of transgenes from adeno-associated virus vectors with the woodchuck hepatitis virus posttranscriptional regulatory element: implications for gene therapy. Hum Gene Ther. 1999 Sep 20;10(14):2295-305. PubMed PMID: 10515449.

Hope TJ. The ins and outs of HIV Rev. Arch Biochem Biophys. 1999 May 15;365(2):186-91. Review. PubMed PMID: 10328811.

Tang H, McDonald D, Middlesworth T, Hope TJ, Wong-Staal F. The carboxyl terminus of RNA helicase A contains a bidirectional nuclear transport domain. Mol Cell Biol. 1999 May;19(5):3540-50. PubMed PMID: 10207077; PubMed Central PMCID: PMC84146.

Zufferey R, Donello JE, Trono D, Hope TJ. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J Virol. 1999 Apr;73(4):2886-92. PubMed PMID: 10074136; PubMed Central PMCID: PMC104046.

Stommel JM, Marchenko ND, Jimenez GS, Moll UM, Hope TJ, Wahl GM. A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J. 1999 Mar 15;18(6):1660-72. PubMed PMID: 10075936; PubMed Central PMCID: PMC1171253.

Otero GC, Hope TJ. Splicing-independent expression of the herpes simplex virus type 1 thymidine kinase gene is mediated by three cis-acting RNA subelements. J Virol. 1998 Dec;72(12):9889-96. PubMed PMID: 9811725; PubMed Central PMCID: PMC110501.

Jiang W, Jimenez G, Wells NJ, Hope TJ, Wahl GM, Hunter T, Fukunaga R. PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. Mol Cell. 1998 Dec;2(6):877-85. PubMed PMID: 9885575.

Smith GJ 3rd, Donello JE, Lück R, Steger G, Hope TJ. The hepatitis B virus post-transcriptional regulatory element contains two conserved RNA stem-loops which are required for function. Nucleic Acids Res. 1998 Nov 1;26(21):4818-27. PubMed PMID: 9776740; PubMed Central PMCID: PMC147918.

Otero GC, Harris ME, Donello JE, Hope TJ. Leptomycin B inhibits equine infectious anemia virus Rev and feline immunodeficiency virus rev function but not the function of the hepatitis B virus posttranscriptional regulatory element. J Virol. 1998 Sep;72(9):7593-7. PubMed PMID: 9696859; PubMed Central PMCID: PMC110012.

Harris ME, Gontarek RR, Derse D, Hope TJ. Differential requirements for alternative splicing and nuclear export functions of equine infectious anemia virus Rev protein. Mol Cell Biol. 1998 Jul;18(7):3889-99. PubMed PMID: 9632773; PubMed Central PMCID: PMC108973.

Taagepera S, McDonald D, Loeb JE, Whitaker LL, McElroy AK, Wang JY, Hope TJ. Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7457-62. PubMed PMID: 9636171; PubMed Central PMCID: PMC22649.

Donello JE, Loeb JE, Hope TJ. Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element. J Virol. 1998 Jun;72(6):5085-92. PubMed PMID: 9573279; PubMed Central PMCID: PMC110072.

Belshan M, Harris ME, Shoemaker AE, Hope TJ, Carpenter S. Biological characterization of Rev variation in equine infectious anemia virus. J Virol. 1998 May;72(5):4421-6. PubMed PMID: 9557734; PubMed Central PMCID: PMC109674.

Aladjem MI, Spike BT, Rodewald LW, Hope TJ, Klemm M, Jaenisch R, Wahl GM. ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage. Curr Biol. 1998 Jan 29;8(3):145-55. PubMed PMID: 9443911.

Hope TJ. Viral RNA export. Chem Biol. 1997 May;4(5):335-44. Review. PubMed PMID: 9195877.

Kim FJ, Beeche AA, Hunter JJ, Chin DJ, Hope TJ. Characterization of the nuclear export signal of human T-cell lymphotropic virus type 1 Rex reveals that nuclear export is mediated by position-variable hydrophobic interactions. Mol Cell Biol. 1996 Sep;16(9):5147-55. PubMed PMID: 8756672; PubMed Central PMCID: PMC231515.

Donello JE, Beeche AA, Smith GJ 3rd, Lucero GR, Hope TJ. The hepatitis B virus posttranscriptional regulatory element is composed of two subelements. J Virol. 1996 Jul;70(7):4345-51. PubMed PMID: 8676457; PubMed Central PMCID: PMC190367.

Elder ME, Hope TJ, Parslow TG, Umetsu DT, Wara DW, Cowan MJ. Severe combined immunodeficiency with absence of peripheral blood CD8+ T cells due to ZAP-70 deficiency. Cell Immunol. 1995 Oct 1;165(1):110-7. PubMed PMID: 7671314.

Zhu L, Hope TJ, Hall J, Davies A, Stern M, Muller-Eberhard U, Stern R, Parslow TG. Molecular cloning of a mammalian hyaluronidase reveals identity with hemopexin, a serum heme-binding protein. J Biol Chem. 1994 Dec 23;269(51):32092-7. PubMed PMID: 7798203.

Elder ME, Lin D, Clever J, Chan AC, Hope TJ, Weiss A, Parslow TG. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science. 1994 Jun 10;264(5165):1596-9. PubMed PMID: 8202712.

Mancuso VA, Hope TJ, Zhu L, Derse D, Phillips T, Parslow TG. Posttranscriptional effector domains in the Rev proteins of feline immunodeficiency virus and equine infectious anemia virus. J Virol. 1994 Mar;68(3):1998-2001. PubMed PMID: 8107262; PubMed Central PMCID: PMC236666.

McDonald D, Hope TJ, Parslow TG. Posttranscriptional regulation by the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex proteins through a heterologous RNA binding site. J Virol. 1992 Dec;66(12):7232-8. PubMed PMID: 1433516; PubMed Central PMCID: PMC240426.

Hope TJ, Klein NP, Elder ME, Parslow TG. trans-dominant inhibition of human immunodeficiency virus type 1 Rev occurs through formation of inactive protein complexes. J Virol. 1992 Apr;66(4):1849-55. PubMed PMID: 1548742; PubMed Central PMCID: PMC288971.

Hope TJ, Bond BL, McDonald D, Klein NP, Parslow TG. Effector domains of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex are functionally interchangeable and share an essential peptide motif. J Virol. 1991 Nov;65(11):6001-7. PubMed PMID: 1920623; PubMed Central PMCID: PMC250265.

Zapp ML, Hope TJ, Parslow TG, Green MR. Oligomerization and RNA binding domains of the type 1 human immunodeficiency virus Rev protein: a dual function for an arginine-rich binding motif. Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7734-8. PubMed PMID: 1715576; PubMed Central PMCID: PMC52377.

Huang XJ, Hope TJ, Bond BL, McDonald D, Grahl K, Parslow TG. Minimal Rev-response element for type 1 human immunodeficiency virus. J Virol. 1991 Apr;65(4):2131-4. PubMed PMID: 2002556; PubMed Central PMCID: PMC240087.

Hope TJ, McDonald D, Huang XJ, Low J, Parslow TG. Mutational analysis of the human immunodeficiency virus type 1 Rev transactivator: essential residues near the amino terminus. J Virol. 1990 Nov;64(11):5360-6. PubMed PMID: 2120472; PubMed Central PMCID: PMC248585.

Hope TJ, Huang XJ, McDonald D, Parslow TG. Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator: mapping cryptic functions of the arginine-rich motif. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7787-91. PubMed PMID: 2217212; PubMed Central PMCID: PMC54833.

Hope TJ, Aguilera RJ, Minie ME, Sakano H. Endonucleolytic activity that cleaves immunoglobulin recombination sequences. Science. 1986 Mar 7;231(4742):1141-5. PubMed PMID: 3003919.

Aguilera RJ, Hope TJ, Sakano H. Characterization of immunoglobulin enhancer deletions in murine plasmacytomas. EMBO J. 1985 Dec 30;4(13B):3689-93. PubMed PMID: 4092693; PubMed Central PMCID: PMC554719.



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