What We Do
Our laboratory focuses on understanding the genetic and epigenetic pathways to prostate cancer. A number of key transcription factors, including the Androgen Receptor, the Polycomb group protein EZH2, and the TMPRSS2:ERG gene fusions, have been related to epigenetic changes and implicated in prostate cancer. However, their downstream pathways remain largely unknown. Using 'omics' approaches we have identified a number of target genes and molecular pathways of these transcription factors. Our study will elucidate the specific pathways of these transcription factors and how they may crosstalk with each other to form an intertwined network. Findings from our study will then be applied to understand the hormone-refractory prostate tumors and help the design of novel therapeutic targets.
04/17/2018: New paper with collaborators published in EMBO Reports: PRDM4 mediates YAP-induced cell invasion by activating leukocyte-specific integrin β2 expression.
02/26/2018: New postdoc Dr. Tan Song joined us from Capital Normal University, Beijing. Welcome, Song!
02/05/2018: New paper published in Nature Communications: BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1.
01/15/2018: Dr. Xiaohai Wang joined us from Shanghai General Hospital as a Visiting Scholar. Welcome, Xiaohai!
10/16/2017: Bioinformatics postdoc Dr. Gang Zhen joined us from Peking University, China. Welcome, Gang!
09/11/2017: New postdoc Dr. Xiaoyan Zhu joined us from Marquette University, Wisconsin. Welcome, Xiaoyan!
08/25/2017: Dr. Angela Yang has graduated and joined Jackson laboratory as a postdoctoral fellow. Congratulations, Angela!
08/17/2017: New paper published in Cancer Research: PADI2-mediated citrullination promotes prostate cancer progression.
06/01/2017: Rakshitha Jagadish from UIC joined the lab for her Master thesis project.
04/01/2017: Galina Gritsina joined the lab as a DGP gradaute student. Welcome, Galina!
03/20/2017: New paper published in Oncogene: FOXA1 inhibits prostate cancer neuroendocrine differentiation.
03/07/2017: New paper published in Cell Reports: CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response.
02/01/2017: Nathan Damaschke joined the lab as a postdoctoral fellow. Welcome, Nate!
11/04/2016: New paper published in Cancer Research: Polycomb-mediated disruption of an androgen receptor feedback loop drives castration-resistant prostate cancer.
09/01/2016: New postdoc Dr. Yongik Lee started in the lab. Welcome, Yongik!
08/31/2016: Dr. Jung Kim has graduated and moved back to Maryland to join NCI as a CRTA fellow at DCEG. Congratulations, Jung.
08/26/2016: DGP graduate student Kevin Park joined the lab. Welcome, Kevin!
07/26/2016: Will is awarded Katten Muchin Rosenman award. Congratulations!
07/12/2016: Will is selected to receive the Heme/Onc division Rizvi travel award. Congratulations!
06/07/2016: New paper published in Mol Endocrinol: KAT8 regulates androgen signaling in prostate cancer cells.
06/01/2016: New paper published in Nucleic Acids Research: FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function.
05/04/2016: New paper published in BMC Genomics: The common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulation.
Melo-Cardenas J, Xu Y, Wei J, Tan C, Kong S, Gao B, Montauti E, Kirsammer G, Licht JD, Yu J, Ji P, Crispino JD, Fang D. USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism. Blood. 2018 July 26. PMID: 29844011
Geng H, Bu HF, Liu F, Wu L, Pfeifer K, Chou PM, Wang X, Sun J, Lu L, Pandey A, Bartolomei MS, De Plaen IG, Wang P, Yu J, Qian J, Tan XD. In Inflamed Intestinal Tissues and Epithelial Cells, Interleukin 22 Signaling Increases Expression of H19 Long Noncoding RNA, Which Promotes Mucosal Regeneration. Gastroenterology. 2018 July 01. PMID: 29621481
Zhu S, Zhao D, Yan L, Jiang W, Kim JS, Gu B, Liu Q, Wang R, Xia B, Zhao JC, Song G, Mi W, Wang RF, Shi X, Lam HM, Dong X, Yu J, Chen K, Cao Q. BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1. Nat Commun. 2018 Feb 5. PMID: 29402932
Wang L, Song G, Zhang X, Feng T, Pan J, Chen W, Yang M, Bai X, Pang Y, Yu J, Han J, Han B. PADI2-mediated citrullination promotes prostate cancer progression. Cancer Research. 2017 August 17. PMID: 28819028
Kim J, Jin H, Zhao JC, Yang YA, Li Y, Yang X, Dong X, Yu J. FOXA1 inhibits prostate cancer neuroendocrine differentiation. Oncogene. 2017 March 20. PMID: 28319070
Qadir AS, Ceppi P, Brockway S, Law C, Mu L, Khodarev NN, Kim J, Zhao JC, Putzbach W, Murmann AE, Chen Z, Chen W, Liu X, Salomon AR, Liu H, Weichselbaum RR, Yu J, Peter ME. CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response. Cell Rep. 2017 March 07. PMID: 28273453
Fong KW, Zhao JC, Kim J, Li S, Yang YA, Song B, Rittie L, Hu M, Yang X, Perbal B, Yu J. Polycomb-mediated disruption of an androgen receptor feedback loop drives castration-resistant prostate cancer. Cancer Res. 2016 Nov 4. PMID: 27815387
Kim JY, Yu J, Abdulkadir SA, Chakravarti D. KAT8 regulates androgen signaling in prostate cancer cells. Mol Endocrinol. 2016 June 07. PMID: 27257062
Yang YA, Zhao JC, Fong KW, Kim J, Li S, Song C, Song B, Zheng B, He C, Yu J. FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function. Nucleic Acids Res. 2016 June 01. PMID: 27268279
Zhao JC, Li XY, Guo MX, Yu J, Yan C. The common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulation. BMC Genomics. 2016 May 04. PMID: 27146783
Zhao JC, Fong KW, Jin HJ, Yang YA, Kim J, Yu J. FOXA1 acts upstream of GATA2 and AR in hormonal regulation of gene expression. Oncogene. 2016 Jan 11. PMID: 26751772