12/01/2022: New paper published in Mol Cell: PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing.
08/05/2022: New paper published in Oncogene: FOXA1 inhibits hypoxia programs through transcriptional repression of HIF1A.
05/10/2022: Feinberg School of Medicine news: New Regulator of Prostate Cancer Metastasis Discovered.
04/25/2022: Milestone Achievement! New paper published in Nature Genetics: HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer.
03/22/2022: New postdoc Dr. Ahmad Hasan Othman started in the lab. Welcome, Ahmad!
01/03/2022: New postdoc Dr. Najma Shaheen started in the lab. Welcome, Najma!
09/07/2021: New postdoc Dr. Hongshun Shi started in the lab. Welcome, Hongshun!
08/04/2021: New paper published in Oncogene: Going beyond Polycomb: EZH2 functions in prostate cancer.
07/01/2021: Dr. Shivani Agarwal joined us as a Research Assistant Professor. Welcome, Shivani!
06/01/2021: Sophia Marie Lamperis joined the lab as a DGP gradaute student. Welcome, Sophia!
04/20/2021: Feinberg School of Medicine news: Uncovering the Function of Prostate Cancer Protein.
04/07/2021: New paper published in Science Advances: Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer.
02/01/2021: New postdoc Dr. Jawad Akhtar joined us from Lahore University of Management Sciences. Welcome, Jawad!
12/11/2020: Dr. Kevin park has graduated and joined Pfizer. Congratulations, Kevin!
11/30/2020: New postdoc Dr. Wanqing Xie started in the lab. Welcome, Wanqing!
08/19/2020: New paper published in Nature Communications: Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.
08/14/2020: New paper published in Science Advances: Epithelial cell-specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice.
12/01/2019: Dr. Zhuoyuan Lin joined the lab as a visiting scholar. Welcome, Zhuoyuan!
08/28/2019: New paper published in Oncogene: BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer.
08/01/2019: New postdocs Dr. Ezinne Mong and Dr. Fang Wang joined us. Welcome!
07/19/2019: New paper published in Cell Research: Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression.
07/01/2019: New paper published in Journal of Clinical Investigation: N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer.
05/01/2019: Lourdes Brea joined the lab as a DGP gradaute student. Welcome, Luly!
04/25/2019: New paper published in American Journal of Clinical and Experimental Urology: Immune modulatory functions of EZH2 in the tumor microenvironment: implications in cancer immunotherapy.
04/05/2019: New paper published in Cancer Research: Activation of MAPK signaling by CXCR7 leads to enzalutamide resistance in prostate cancer.
03/29/2019: New paper published in Asian J Androl: Transcriptional repression by androgen receptor: roles in castration-resistant prostate cancer.
03/14/2019: Feinberg School of Medicine Research Newsletter: Uncovering Genetic and Epigenetic Pathways to Prostate Cancer.
01/23/2019: Feinberg School of Medicine news: Study Suggests New Strategy to Treat Advanced Prostate Cancer.
12/14/2018: Feinberg School of Medicine news: New Understanding of Enzyme’s Role in Prostate Cancer.
12/04/2018: Feinberg School of Medicine news: New Therapeutic Target Identified in Prostate Cancer.
12/03/2018: New paper published in Cell Reports: Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator.
12/03/2018: New postdoc Dr. Guihua Zeng joined us from University of New Mexico. Welcome, Guihua!
12/01/2018: New paper published in Journal of Clinical Investigation: Targeting FOXA1-mediated repression of TGF-β signaling suppresses castration-resistant prostate cancer progression.
11/27/2018: New paper published in Nature Communications: TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression.
10/23/2018: Jindan is named Assistant Director for Education and Training at the Lurie Cancer Center.
04/17/2018: New paper with collaborators published in EMBO Reports: PRDM4 mediates YAP-induced cell invasion by activating leukocyte-specific integrin β2 expression.
02/26/2018: New postdoc Dr. Tan Song joined us from Capital Normal University, Beijing. Welcome, Song!
02/05/2018: New paper published in Nature Communications: BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1.
01/15/2018: Dr. Xiaohai Wang joined us from Shanghai General Hospital as a Visiting Scholar. Welcome, Xiaohai!
10/16/2017: Bioinformatics postdoc Dr. Gang Zhen joined us from Peking University, China. Welcome, Gang!
09/11/2017: New postdoc Dr. Xiaoyan Zhu joined us from Marquette University, Wisconsin. Welcome, Xiaoyan!
08/25/2017: Dr. Angela Yang has graduated and joined Jackson laboratory as a postdoctoral fellow. Congratulations, Angela!
08/17/2017: New paper published in Cancer Research: PADI2-mediated citrullination promotes prostate cancer progression.
06/01/2017: Rakshitha Jagadish from UIC joined the lab for her Master thesis project.
04/01/2017: Galina Gritsina joined the lab as a DGP gradaute student. Welcome, Galina!
03/20/2017: New paper published in Oncogene: FOXA1 inhibits prostate cancer neuroendocrine differentiation.
03/07/2017: New paper published in Cell Reports: CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response.
02/01/2017: Nathan Damaschke joined the lab as a postdoctoral fellow. Welcome, Nate!11/04/2016: New paper published in Cancer Research: Polycomb-mediated disruption of an androgen receptor feedback loop drives castration-resistant prostate cancer.
09/01/2016: New postdoc Dr. Yongik Lee started in the lab. Welcome, Yongik!
08/31/2016: Dr. Jung Kim has graduated and moved back to Maryland to join NCI as a CRTA fellow at DCEG. Congratulations, Jung!
08/26/2016: DGP graduate student Kevin Park joined the lab. Welcome, Kevin!
07/26/2016: Will is awarded Katten Muchin Rosenman award. Congratulations!
07/12/2016: Will is selected to receive the Heme/Onc division Rizvi travel award. Congratulations!
06/07/2016: New paper published in Mol Endocrinol: KAT8 regulates androgen signaling in prostate cancer cells.
06/01/2016: New paper published in Nucleic Acids Research: FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function.
05/04/2016: New paper published in BMC Genomics: The common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulation.
01/11/2016: New paper published in Oncogene: FOXA1 acts upstream of GATA2 and AR in hormonal regulation of gene expression.
12/18/2015: Harsha has successfully graduated from the Northwestern MBP program. Congratulations!
12/13/2015: Xiaodong Lu joined the lab as a postdoctoral fellow. Welcome, Xiaodong!
10/20/2015: New paper published in Oncotarget: miR-573 inhibits prostate cancer metastasis by regulating epithelial-mesenchymal transition.
09/24/2015: New paper published in Cell Reports: LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer.
09/18/2015: New paper published in Oncogene: LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer.
09/01/2015: Jung graduated and joined the lab as a postdoctoral fellow. Congratulations and Welcome again!
08/14/2015: New paper published in Cell Research: A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis.
07/29/2015: Angela is awarded Katten Muchin Rosenman Travel Scholarship. Congratulations, Angela!
07/10/2015: Angela is awraded a $500 DGP Travel Award. Congratulations, Angela!
06/19/2015: New paper published in Genes Dis: Current perspectives on FOXA1 regulation of androgen receptor signaling and prostate cancer.
05/21/2015: Tao Tao joined the lab as a visiting scholar. Welcome, Tao!
12/15/2014: New paper published in Oncogene: The role of TXNDC5 in castration-resistant prostate cancer-involvement of androgen receptor signaling pathway.
12/01/2014: Shangze Li joined the lab as a postdoctoral fellow. Welcome, Shangze!
08/20/2014: Jung received the third annual Driskill Scholars Award. Congratulations, Jung!
05/30/2014: New paper published in Nature Communications: Cooperativity and equilibrium with FOXA1 define the androgen receptor transcriptional program.
05/12/2014: Review article published in The Application of Clinical Genetics: Influence of oncogenic transcription factors on chromatin conformation and implications in prostate cancer.
05/01/2014: Bing Song joined the lab as a postdoctoral fellow. Welcome, Bing!
01/15/2014: Dr. Xingyang Xue joined the lab as a visiting scholar. Welcome, Xingyang!
12/26/2013: Our paper, ERG is a critical regulator of Wnt/LEF1 signaling in prostate cancer is selected as 2013 hot topics in prostate cancer by AACR.
11/26/2013: Hongjian is awarded the Katten Muchin Rosenman Travel Scholarship. Congratulations, Hongjian!
11/04/2013: New paper published in Oncogene: TMPRSS2-ERG gene fusions induce prostate tumorigenesis by modulating microRNA miR-200c.
10/17/2013: Review article published in Translational Andrology and Urology: Androgen receptor genomic regulation.
09/02/2013: Will Fong joined the lab as a postdoctoral fellow. Welcome, Will!
08/02/2013: New paper published in Cancer Research: ERG is a critical regulator of Wnt/LEF1 signaling in prostate cancer.
07/12/2013: Jung was selected for a CBCC fellowship. Congratulations!!!
07/10/2013: Angela is awarded a T32 training grant. Congratulations, Angela!
06/04/2013: Angela successfully passed DGP Qualifying Exam. Congratulations, Angela!
05/08/2013: Jindan won the 2013 Agilent Early Career Professor Award. Congratulations, Jindan!
05/03/2013: Review article published in Protein Cell: EZH2, an epigenetic driver of prostate cancer.
04/27/2013: New paper published in EMBO J: BRCA1 is a negative modulator of the PRC2 complex.
04/01/2013: Jung was selected to give an oral presentation at ENDO 2013 and won the Endocrine Society outstanding abstract awards. Congratulations, Jung!
03/29/2013: New paper published in Cancer Research: Androgen-receptor independent function of FoxA1 in prostate cancer metastasis.
03/20/2013: Jung got a Katten Muchin Rosenman Travel Scholarship grant. Congratulations, Jung!
02/22/2013: The Yu lab was awarded an R01 grant from NIH/NCI. Congratulatons!!!
01/14/2013: New paper published in Oncogene: CCN3/NOV gene expression in human prostate cancer is directly suppressed by the androgen receptor.
12/04/2012: Hongjian won an Endocrine Society Travel Award for GLNRC. Congratulations, Hongjian!
10/13/2012: Jung was selected to give an oral presentation at the GLNRC and won a presentation award for travel and/or ENDO registration. Congratulations, Jung!
08/10/2012: Jung got a T32 Training Grant award. Congratulations, Jung!
07/16/2012: New paper published in Oncogene: The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer.
06/19/2012: DGP graduate student Angela Yang has joined the lab for her dissertation work. Welcome, Angela!
06/08/2012: Cheng graduated from Northwestern University and joined Genzyme. Congratulations, Cheng!
06/07/2012: Jung passed DGP Preliminary Exam. Congratulations, Jung!
06/01/2012: Postdoctoral fellow Ali Zhang started in the lab. Welcome, Ali!
05/20/2012: Jindan gave a talk at the 2012 AUA Research Forum: "Showcasing Young Investigators" and won the second place.
04/01/2012: Fujun left to start a new postdoctoral position at the University of Virginia.
03/20/2012: Jindan gave a talk at Winship Cancer Institute, Emory University.
03/19/2012: Jindan gave a talk at the 8th Annual National Symposium on Prostate Cancer at Clark Atlanta University.
02/20/2012: Jindan was selected to be featured at the AUA Research Forum: "Showcasing Young Investigators". Jindan was initially nominated by Dr. Zhou Wang, current President of the Society of Basic Urological Research (SBUR).
02/08/2012: Jindan gave a talk at Advances in Prostate Cancer Research Conference at Orlando.
01/15/2012: Graduate student Cheng Cheng has joined the lab for her bioinformatics projects. Welcome, Cheng!
01/13/2012: Review article published in BBA-Reviews on Cancer: Interrogating genomic and epigenomic data to understand prostate cancer. Featured on the cover.
01/05/2012: New paper published in Genes Dev: Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis.
12/22/2011: New paper published in Genome Res: Cooperation between Polycomb and androgen receptor during oncogenic transformation.
11/12/2011: Jindan gave a talk at the Society of Basic Urologic Research (SBUR) Fall Symposium at Las Vegas.
09/21/2011: Jindan received an American Cancer Society Research Scholar Grant.
09/12/2011: New paper published in Cancer Res: Definition of a FoxA1 Cistrome that is Crucial for G1-S Phase Cell- Cycle Transit in Castration-Resistant Prostate Cancer.
08/16/2011: New paper published in Cancer Cell: Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer.
08/01/2011: Jindan gave a talk at the Gordon Research Conference: Hormone Action in Development & Cancer.
07/07/2011: New paper published in Genome Res: Deep sequencing reveals distinct patterns of DNA methylation in prostate cancer.
06/20/2011: Jindan gave a talk at the STIP (the Solid Tumor Investigation Program) meeting.
06/19/2011: IGP graduate student Jung Kim has joined the lab for her thesis work. Welcome, Jung!
05/25/2011: Jindan gave a talk at the H Foundation Basic Science Symposium: Genomics, Epigenomics, and Signaling in Cancer.
05/17/2011: New paper published in Cancer Cell: Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer.
04/01/2011: New paper published in Genes Dev: The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity.
03/09/2011: Longtao Wu was awarded a travel grant to attend the Department of Defense IMPaCT meeting during March 9-12 in Orlando, FL. Congratulations, Longtao.
02/25/2011: Jindan Yu was invited to give a seminar at Vancouver Prostate Centre, Canada
02/14/2011: Jindan Yu was invited to give a talk at the University of California, San Diego, CA
01/17/2011: New review article published in Asian J Androl: Cancer cell migration: when red light switched to green.
12/12/2010: New paper published in Neoplasia: ERG Cooperates with Androgen Receptor in Regulating Trefoil Factor 3 in Prostate Cancer Disease Progression.
11/22/2010: Postdoc Fujun Qin starts in the lab
08/23/2010: Dr. Ferdinand Kappes visited the lab for 2 weeks
07/19/2010: Postdoc Hongjian Jin starts in the lab
07/12/2010: New paper published in Oncogene: The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer.
07/02/2010: New paper published in BMC Bioinformatics: HPeak: an HMM-based algorithm for defining read-enriched regions in ChIP-Seq data.
05/18/2010: New paper published in Cancer Cell: An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
01/06/2010: New paper accepted in Nucleic Acids Research: On the detection and refinement of transcription factor binding sites using ChIP-Seq data.