Northwestern University Feinberg School of Medicine

Sustained Long-Acting Protection From HIV (SLAP HIV) Program

Message from the Program Directors

Welcome to the Sustained Long-Acting Protection from HIV (SLAP-HIV) website which is designed to provide general information relating to our research program to develop sustained release formulations for long-acting pre-exposure prophylaxis (PrEP) and our team of researchers working together towards this critical goal.

The objective of the SLAP-HIV program is to develop and clinically test a long-acting formulation to deliver drugs preventing HIV acquisition for up to a year. To achieve this goal, we must utilize highly potent fourth generation antiretrovirals engineered in a context that will slowly release the drug. Such a configuration should solve problems of compliance associated with the current PrEP approach of taking a pill every day.

The SLAP-HIV program is centered at Northwestern University, but includes researchers from across the US to advance the goal of developing a long acting formulation and advancing it through a phase 1 clinical trial to establish basic questions of safety.  The SLAP-HIV team brings together broad expertise in multiple disciplines of HIV research to achieve the goals of the program.

Enjoy learning about our program and its potential to make the world a better place.


Thomas J. Hope, PhD


Patrick F. Kiser, PhD