Synaptic receptors trafficking regulationWe investigate the molecular mechanisms of receptor trafficking regulation by imaging overexpressed mutants in primary neuronal cultures.Synaptic receptors trafficking regulationWe investigate the molecular mechanisms of receptor trafficking regulation by imaging overexpressed mutants in primary neuronal cultures.
Advanced microscopy approachesSuper-resolution microscopy allows us to elucidate the dynamics and precise subcellular localization of synaptic proteins.Advanced microscopy approachesSuper-resolution microscopy allows us to elucidate the dynamics and precise subcellular localization of synaptic proteins.
About Our Lab
The Sanz-Clemente Lab is interested in the molecular mechanisms underlying glutamate receptor trafficking in normal and altered conditions. We use a multidisciplinary approach including biochemistry, cell and molecular biology, pharmacology as well as a variety of imaging techniques and the analysis of genetically-altered mouse lines for elucidating how synaptic receptors are controlled during development, in response to experience or other stimuli and what is their impact on synaptic function. Similarly, we investigate how the dysregulation of these mechanisms lead to synaptic alterations and, eventually, to neurological disorders.
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Selected Publications
- Activated CamKII couples GluN2B and casein kinase 2 to control synaptic NMDA receptors. Sanz-Clemente A, Gray JA, Ogilvie KA, Nicoll RA, Roche KW. Cell Reports. 2013; 3(3):607-14. PMID 23478024
- Casein kinase 2 regulates the NR2 subunit composition of synaptic NMDA receptors. Sanz-Clemente A, Matta JA, Isaac JT, Roche KW. Neuron. 2010; 67(6)984-96. PMID: 20869595
